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Adenocarcinoma

MedGen UID:
122
Concept ID:
C0001418
Neoplastic Process
Synonyms: Adenocarcinomas; Adenoma, Malignant; Adenomas, Malignant; Malignant Adenoma; Malignant Adenomas
SNOMED CT: Adenocarcinoma (1187332001)
 
Monarch Initiative: MONDO:0004970

Definition

A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma

Professional guidelines

PubMed

Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

Recent clinical studies

Etiology

Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Moore A, Donahue T
JAMA 2019 Oct 8;322(14):1426. doi: 10.1001/jama.2019.14699. PMID: 31593274Free PMC Article
Erickson LA
Mayo Clin Proc 2018 Aug;93(8):1153-1154. doi: 10.1016/j.mayocp.2018.05.012. PMID: 30077210
Bond-Smith G, Banga N, Hammond TM, Imber CJ
BMJ 2012 May 16;344:e2476. doi: 10.1136/bmj.e2476. PMID: 22592847
Chao CT, Chang FC, Wu VC, Chen JC; Taiwan Primary Aldosteronism Investigation Study Group
Kidney Int 2011 Jan;79(2):260. doi: 10.1038/ki.2010.445. PMID: 21191395

Diagnosis

Erickson LA
Mayo Clin Proc 2021 Aug;96(8):2285-2287. doi: 10.1016/j.mayocp.2021.06.009. PMID: 34353478
Obaitan I, Jansson-Knodell C, Fayad N
Gastroenterology 2021 Jan;160(1):36-38. Epub 2020 Apr 16 doi: 10.1053/j.gastro.2020.04.029. PMID: 32305333
Hernandez-Prera JC
Head Neck Pathol 2019 Sep;13(3):415-422. Epub 2018 Sep 5 doi: 10.1007/s12105-018-0964-9. PMID: 30187348Free PMC Article
Klapperich ME, Buhalog BA, Hinshaw MA
Dermatol Online J 2018 Apr 15;24(4) PMID: 29906012
Leivo I
Head Neck Pathol 2017 Sep;11(3):295-300. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0800-7. PMID: 28321774Free PMC Article

Therapy

Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Agarwal N, Azad A, Carles J, Chowdhury S, McGregor B, Merseburger AS, Oudard S, Saad F, Soares A, Benzaghou F, Kerloeguen Y, Kimura A, Mohamed N, Panneerselvam A, Wang F, Pal S
Future Oncol 2022 Mar;18(10):1185-1198. Epub 2022 Jan 17 doi: 10.2217/fon-2021-1096. PMID: 35034502
Nehlsen AD, Goodman KA
J Surg Oncol 2021 May;123(6):1460-1466. doi: 10.1002/jso.26313. PMID: 33831248
Zhang T, Park SE, Hong C, George DJ
Future Oncol 2017 Apr;13(8):755-765. Epub 2016 Nov 15 doi: 10.2217/fon-2016-0358. PMID: 27842445
Crawford ED
Urology 1989 Oct;34(4 Suppl):22-6; discussion 46-56. doi: 10.1016/0090-4295(89)90231-8. PMID: 2508291

Prognosis

McDow AD, Pitt SC
Surg Clin North Am 2019 Aug;99(4):599-610. Epub 2019 May 13 doi: 10.1016/j.suc.2019.04.003. PMID: 31255194
McTiernan A, Friedenreich CM, Katzmarzyk PT, Powell KE, Macko R, Buchner D, Pescatello LS, Bloodgood B, Tennant B, Vaux-Bjerke A, George SM, Troiano RP, Piercy KL; 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*
Med Sci Sports Exerc 2019 Jun;51(6):1252-1261. doi: 10.1249/MSS.0000000000001937. PMID: 31095082Free PMC Article
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article
Patel SH, Kooby DA
Surg Clin North Am 2011 Oct;91(5):1039-77. doi: 10.1016/j.suc.2011.06.009. PMID: 21889029
Paras FA Jr, Maclennan GT
J Urol 2008 Aug;180(2):720. Epub 2008 Jun 13 doi: 10.1016/j.juro.2008.05.039. PMID: 18554640

Clinical prediction guides

Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179
Bateman AC, Shepherd NA
J Clin Pathol 2015 Aug;68(8):585-91. Epub 2015 Apr 30 doi: 10.1136/jclinpath-2015-203016. PMID: 25934843
O'Neill OM, Johnston BT, Coleman HG
World J Gastroenterol 2013 Sep 21;19(35):5806-12. doi: 10.3748/wjg.v19.i35.5806. PMID: 24124325Free PMC Article
Robert ME
J Clin Gastroenterol 2003 May-Jun;36(5 Suppl):S19-25; discussion S26-8. doi: 10.1097/00004836-200305001-00004. PMID: 12702961
Compton CC
Dig Dis 1999;17(2):67-79. doi: 10.1159/000016908. PMID: 10545712

Recent systematic reviews

Wood LD, Adsay NV, Basturk O, Brosens LAA, Fukushima N, Hong SM, Kim SJ, Lee JW, Luchini C, Noë M, Pitman MB, Scarpa A, Singhi AD, Tanaka M, Furukawa T
Pancreatology 2023 Nov;23(7):878-891. Epub 2023 Aug 11 doi: 10.1016/j.pan.2023.08.002. PMID: 37604731
Rees JR, Lao-Sirieix P, Wong A, Fitzgerald RC
Cochrane Database Syst Rev 2021 Mar 4;3(3):CD004060. doi: 10.1002/14651858.CD004060.pub3. PMID: 33661543Free PMC Article
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article
Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P, Forastiere F, Saldiva P, Yorifuji T, Loomis D
Environ Health Perspect 2014 Sep;122(9):906-11. Epub 2014 Jun 6 doi: 10.1289/ehp/1408092. PMID: 24911630Free PMC Article
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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