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Refractory Rectal Adenocarcinoma

MedGen UID:
1691064
•Concept ID:
C5206377
•
Neoplastic Process

Definition

Rectal adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Rectal Adenocarcinoma

Professional guidelines

PubMed

Bowel rest, intravenous hydration, and continuous high-dose infusion of octreotide acetate for the treatment of chemotherapy-induced diarrhea in patients with colorectal carcinoma.
Petrelli NJ, Rodriguez-Bigas M, Rustum Y, Herrera L, Creaven P
Cancer 1993 Sep 1;72(5):1543-6. doi: 10.1002/1097-0142(19930901)72:5<1543::aid-cncr2820720509>3.0.co;2-z. PMID: 8348489
Treatment of advanced-stage colorectal adenocarcinoma with fluorouracil and high-dose leucovorin calcium: a pilot study.
Hines JD, Zakem MH, Adelstein DJ, Rustum YM
J Clin Oncol 1988 Jan;6(1):142-6. doi: 10.1200/JCO.1988.6.1.142. PMID: 3257256
Hyperthermic pelvic isolation-perfusion in the treatment of refractory pelvic cancer.
Wile A, Smolin M
Arch Surg 1987 Nov;122(11):1321-5. doi: 10.1001/archsurg.1987.01400230107019. PMID: 3675195

Recent clinical studies

Etiology

Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study.
Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Metastatic rectal neuroendocrine carcinoma presenting with treatment-refractory immune thrombocytopenia: A case report and literature review.
Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
Abnormal Neuronal Response to Rectal and Anal Stimuli in Patients Treated for Distal Rectal Cancer With High-Dose Chemoradiotherapy Followed By Watchful Waiting.
Haas S, Møller Faaborg P, Brock C, Krogh K, Gram M, Lundby L, Mohr Drewes A, Laurberg S, Christensen P
Dis Colon Rectum 2020 Sep;63(9):1234-1241. doi: 10.1097/DCR.0000000000001610. PMID: 33216494
Treatment-resistant severe capecitabine-induced diarrhoea resolved with oral budesonide.
Shumar J, Junga Z, Johnson JT, Goldkind L
BMJ Case Rep 2019 Dec 1;12(11) doi: 10.1136/bcr-2019-231544. PMID: 31791985Free PMC Article
HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab.
Sclafani F, Roy A, Cunningham D, Wotherspoon A, Peckitt C, Gonzalez de Castro D, Tabernero J, Glimelius B, Cervantes A, Eltahir Z, Oates J, Chau I
Ann Oncol 2013 Dec;24(12):3123-8. Epub 2013 Oct 20 doi: 10.1093/annonc/mdt408. PMID: 24146218

Diagnosis

Metastatic rectal neuroendocrine carcinoma presenting with treatment-refractory immune thrombocytopenia: A case report and literature review.
Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
Bowel obstruction caused by colonic metastasis of lung adenocarcinoma: a case report and literature review.
Parker NA, McBride C, Forge J, Lalich D
World J Surg Oncol 2019 Apr 8;17(1):63. doi: 10.1186/s12957-019-1611-y. PMID: 30961608Free PMC Article
Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma.
Nomiya T, Akamatsu H, Harada M, Ota I, Hagiwara Y, Ichikawa M, Miwa M, Kawashiro S, Hagiwara M, Chin M, Hashizume E, Nemoto K
World J Gastroenterol 2014 Dec 28;20(48):18480-6. doi: 10.3748/wjg.v20.i48.18480. PMID: 25561820Free PMC Article
Invasive adenocarcinoma of the prostate with urethral tumor.
Hung CF, Lee CH, Hung SW, Chiu KY, Cheng CL, Yang CR, Chen CJ, Li JR
J Chin Med Assoc 2010 Feb;73(2):101-3. doi: 10.1016/S1726-4901(10)70010-1. PMID: 20171591
Differential diagnosis between endogenous and exogenous insulin-induced refractory hypoglycemia in a nondiabetic patient.
Bauman WA, Yalow RS
N Engl J Med 1980 Jul 24;303(4):198-9. doi: 10.1056/NEJM198007243030406. PMID: 6991943

Therapy

Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study.
Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors.
Tsimberidou AM, Beer PA, Cartwright CA, Haymaker C, Vo HH, Kiany S, Cecil ARL, Dow J, Haque K, Silva FA, Coe L, Berryman H, Bone EA, Nogueras-Gonzalez GM, Vining D, McElwaine-Johnn H, Wistuba II
Clin Cancer Res 2021 Jul 1;27(13):3584-3594. Epub 2021 May 4 doi: 10.1158/1078-0432.CCR-21-0238. PMID: 33947698
Abnormal Neuronal Response to Rectal and Anal Stimuli in Patients Treated for Distal Rectal Cancer With High-Dose Chemoradiotherapy Followed By Watchful Waiting.
Haas S, Møller Faaborg P, Brock C, Krogh K, Gram M, Lundby L, Mohr Drewes A, Laurberg S, Christensen P
Dis Colon Rectum 2020 Sep;63(9):1234-1241. doi: 10.1097/DCR.0000000000001610. PMID: 33216494
Treatment-resistant severe capecitabine-induced diarrhoea resolved with oral budesonide.
Shumar J, Junga Z, Johnson JT, Goldkind L
BMJ Case Rep 2019 Dec 1;12(11) doi: 10.1136/bcr-2019-231544. PMID: 31791985Free PMC Article
Chemotherapy versus chemoimmunotherapy in advanced adenocarcinoma of the colon and rectum: a prospective randomized study.
Richards F 2nd, Muss HB, Cooper R, White DR, Stuart JJ, Howard V, Barnes P, Rhyne L, Spurr CL
Cancer 1979 Jan;43(1):91-6. doi: 10.1002/1097-0142(197901)43:1<91::aid-cncr2820430114>3.0.co;2-r. PMID: 367576

Prognosis

Metastatic rectal neuroendocrine carcinoma presenting with treatment-refractory immune thrombocytopenia: A case report and literature review.
Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors.
Tsimberidou AM, Beer PA, Cartwright CA, Haymaker C, Vo HH, Kiany S, Cecil ARL, Dow J, Haque K, Silva FA, Coe L, Berryman H, Bone EA, Nogueras-Gonzalez GM, Vining D, McElwaine-Johnn H, Wistuba II
Clin Cancer Res 2021 Jul 1;27(13):3584-3594. Epub 2021 May 4 doi: 10.1158/1078-0432.CCR-21-0238. PMID: 33947698
Bowel obstruction caused by colonic metastasis of lung adenocarcinoma: a case report and literature review.
Parker NA, McBride C, Forge J, Lalich D
World J Surg Oncol 2019 Apr 8;17(1):63. doi: 10.1186/s12957-019-1611-y. PMID: 30961608Free PMC Article
Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma.
Nomiya T, Akamatsu H, Harada M, Ota I, Hagiwara Y, Ichikawa M, Miwa M, Kawashiro S, Hagiwara M, Chin M, Hashizume E, Nemoto K
World J Gastroenterol 2014 Dec 28;20(48):18480-6. doi: 10.3748/wjg.v20.i48.18480. PMID: 25561820Free PMC Article
HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab.
Sclafani F, Roy A, Cunningham D, Wotherspoon A, Peckitt C, Gonzalez de Castro D, Tabernero J, Glimelius B, Cervantes A, Eltahir Z, Oates J, Chau I
Ann Oncol 2013 Dec;24(12):3123-8. Epub 2013 Oct 20 doi: 10.1093/annonc/mdt408. PMID: 24146218

Clinical prediction guides

Surgery for ulcerative colitis complicated with colorectal cancer: when ileal pouch-anal anastomosis is the right choice.
Tonelli F, Di Martino C, Amorosi A, Mini E, Nesi G
Updates Surg 2022 Apr;74(2):637-647. Epub 2022 Feb 25 doi: 10.1007/s13304-022-01250-4. PMID: 35217982Free PMC Article
First-in-human phase I/Ib open-label dose-escalation study of GWN323 (anti-GITR) as a single agent and in combination with spartalizumab (anti-PD-1) in patients with advanced solid tumors and lymphomas.
Piha-Paul SA, Geva R, Tan TJ, Lim DW, Hierro C, Doi T, Rahma O, Lesokhin A, Luke JJ, Otero J, Nardi L, Singh A, Xyrafas A, Chen X, Mataraza J, Bedard PL
J Immunother Cancer 2021 Aug;9(8) doi: 10.1136/jitc-2021-002863. PMID: 34389618Free PMC Article
Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors.
Tsimberidou AM, Beer PA, Cartwright CA, Haymaker C, Vo HH, Kiany S, Cecil ARL, Dow J, Haque K, Silva FA, Coe L, Berryman H, Bone EA, Nogueras-Gonzalez GM, Vining D, McElwaine-Johnn H, Wistuba II
Clin Cancer Res 2021 Jul 1;27(13):3584-3594. Epub 2021 May 4 doi: 10.1158/1078-0432.CCR-21-0238. PMID: 33947698
HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab.
Sclafani F, Roy A, Cunningham D, Wotherspoon A, Peckitt C, Gonzalez de Castro D, Tabernero J, Glimelius B, Cervantes A, Eltahir Z, Oates J, Chau I
Ann Oncol 2013 Dec;24(12):3123-8. Epub 2013 Oct 20 doi: 10.1093/annonc/mdt408. PMID: 24146218
Invasive adenocarcinoma of the prostate with urethral tumor.
Hung CF, Lee CH, Hung SW, Chiu KY, Cheng CL, Yang CR, Chen CJ, Li JR
J Chin Med Assoc 2010 Feb;73(2):101-3. doi: 10.1016/S1726-4901(10)70010-1. PMID: 20171591

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