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Metastatic HER2-Positive Breast Carcinoma

MedGen UID:
1793161
Concept ID:
C5556720
Neoplastic Process
Synonym: Metastatic HER2 Positive Breast Carcinoma

Definition

HER2-positive breast carcinoma that has spread from the original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic HER2-Positive Breast Carcinoma

Professional guidelines

PubMed

de Bono JS, Tolcher AW, Rowinsky EK
Semin Oncol 2003 Oct;30(5 Suppl 16):79-92. doi: 10.1053/j.seminoncol.2003.08.010. PMID: 14613029

Recent clinical studies

Etiology

Stanowicka-Grada M, Senkus E
Curr Treat Options Oncol 2023 Nov;24(11):1633-1650. Epub 2023 Oct 25 doi: 10.1007/s11864-023-01137-5. PMID: 37878202Free PMC Article
Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Iwamoto T, Kajiwara Y, Zhu Y, Iha S
Chin Clin Oncol 2020 Jun;9(3):27. Epub 2020 Mar 13 doi: 10.21037/cco.2020.01.06. PMID: 32192349
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814

Diagnosis

Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Loibl S, Poortmans P, Morrow M, Denkert C, Curigliano G
Lancet 2021 May 8;397(10286):1750-1769. Epub 2021 Apr 1 doi: 10.1016/S0140-6736(20)32381-3. PMID: 33812473
Bailleux C, Eberst L, Bachelot T
Br J Cancer 2021 Jan;124(1):142-155. Epub 2020 Nov 30 doi: 10.1038/s41416-020-01175-y. PMID: 33250512Free PMC Article
Swain SM, Baselga J, Kim SB, Ro J, Semiglazov V, Campone M, Ciruelos E, Ferrero JM, Schneeweiss A, Heeson S, Clark E, Ross G, Benyunes MC, Cortés J; CLEOPATRA Study Group
N Engl J Med 2015 Feb 19;372(8):724-34. doi: 10.1056/NEJMoa1413513. PMID: 25693012Free PMC Article

Therapy

Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Med Lett Drugs Ther 2022 Nov 14;64(1663):e192-e193. PMID: 36384768
Bailleux C, Eberst L, Bachelot T
Br J Cancer 2021 Jan;124(1):142-155. Epub 2020 Nov 30 doi: 10.1038/s41416-020-01175-y. PMID: 33250512Free PMC Article
Kunte S, Abraham J, Montero AJ
Cancer 2020 Oct 1;126(19):4278-4288. Epub 2020 Jul 28 doi: 10.1002/cncr.33102. PMID: 32721042
Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators
N Engl J Med 2020 Feb 13;382(7):610-621. Epub 2019 Dec 11 doi: 10.1056/NEJMoa1914510. PMID: 31825192Free PMC Article

Prognosis

Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Loibl S, Poortmans P, Morrow M, Denkert C, Curigliano G
Lancet 2021 May 8;397(10286):1750-1769. Epub 2021 Apr 1 doi: 10.1016/S0140-6736(20)32381-3. PMID: 33812473
Gianni L, Pienkowski T, Im YH, Tseng LM, Liu MC, Lluch A, Starosławska E, de la Haba-Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi GV, Magazzù D, McNally V, Douthwaite H, Ross G, Valagussa P
Lancet Oncol 2016 Jun;17(6):791-800. Epub 2016 May 11 doi: 10.1016/S1470-2045(16)00163-7. PMID: 27179402
Tolaney SM, Barry WT, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis M, Shapira I, Wolff AC, Carey LA, Overmoyer BA, Partridge AH, Guo H, Hudis CA, Krop IE, Burstein HJ, Winer EP
N Engl J Med 2015 Jan 8;372(2):134-41. doi: 10.1056/NEJMoa1406281. PMID: 25564897Free PMC Article

Clinical prediction guides

Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Saura C, Oliveira M, Feng YH, Dai MS, Chen SW, Hurvitz SA, Kim SB, Moy B, Delaloge S, Gradishar W, Masuda N, Palacova M, Trudeau ME, Mattson J, Yap YS, Hou MF, De Laurentiis M, Yeh YM, Chang HT, Yau T, Wildiers H, Haley B, Fagnani D, Lu YS, Crown J, Lin J, Takahashi M, Takano T, Yamaguchi M, Fujii T, Yao B, Bebchuk J, Keyvanjah K, Bryce R, Brufsky A; NALA Investigators
J Clin Oncol 2020 Sep 20;38(27):3138-3149. Epub 2020 Jul 17 doi: 10.1200/JCO.20.00147. PMID: 32678716Free PMC Article
Iwamoto T, Kajiwara Y, Zhu Y, Iha S
Chin Clin Oncol 2020 Jun;9(3):27. Epub 2020 Mar 13 doi: 10.21037/cco.2020.01.06. PMID: 32192349
Li J, Chen Z, Su K, Zeng J
Int J Clin Exp Pathol 2015;8(7):8500-5. Epub 2015 Jul 1 PMID: 26339424Free PMC Article
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814

Recent systematic reviews

Soares LR, Vilbert M, Rosa VDL, Oliveira JL, Deus MM, Freitas-Junior R
ESMO Open 2023 Aug;8(4):101613. Epub 2023 Jul 23 doi: 10.1016/j.esmoop.2023.101613. PMID: 37481956Free PMC Article
Yu Y, Huang K, Lin Y, Zhang J, Song C
Cancer Med 2023 Jul;12(14):15090-15100. Epub 2023 May 31 doi: 10.1002/cam4.6180. PMID: 37255389Free PMC Article
Conforti F, Pala L, Sala I, Oriecuia C, De Pas T, Specchia C, Graffeo R, Pagan E, Queirolo P, Pennacchioli E, Colleoni M, Viale G, Bagnardi V, Gelber RD
BMJ 2021 Dec 21;375:e066381. doi: 10.1136/bmj-2021-066381. PMID: 34933868Free PMC Article
Schettini F, Pascual T, Conte B, Chic N, Brasó-Maristany F, Galván P, Martínez O, Adamo B, Vidal M, Muñoz M, Fernández-Martinez A, Rognoni C, Griguolo G, Guarneri V, Conte PF, Locci M, Brase JC, Gonzalez-Farre B, Villagrasa P, De Placido S, Schiff R, Veeraraghavan J, Rimawi MF, Osborne CK, Pernas S, Perou CM, Carey LA, Prat A
Cancer Treat Rev 2020 Mar;84:101965. Epub 2020 Jan 17 doi: 10.1016/j.ctrv.2020.101965. PMID: 32000054Free PMC Article
Wilcken N, Zdenkowski N, White M, Snyder R, Pittman K, Mainwaring P, Green M, Francis P, De Boer R, Colosimo M, Chua S, Chirgwin J, Beith J, Bell R
Asia Pac J Clin Oncol 2014 Jun;10 Suppl S4:1-14. doi: 10.1111/ajco.12206. PMID: 24797445

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