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Advanced HER2-Positive Breast Carcinoma

MedGen UID:
1793162
Concept ID:
C5556721
Neoplastic Process
Synonym: Advanced HER2 Positive Breast Carcinoma

Definition

HER2-positive breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced HER2-Positive Breast Carcinoma

Professional guidelines

PubMed

Karpel HC, Slomovitz B, Coleman RL, Pothuri B
Curr Opin Obstet Gynecol 2023 Jun 1;35(3):270-278. Epub 2023 Mar 20 doi: 10.1097/GCO.0000000000000855. PMID: 36943683
Najjar MK, Manore SG, Regua AT, Lo HW
Genes (Basel) 2022 Nov 8;13(11) doi: 10.3390/genes13112065. PMID: 36360302Free PMC Article
Maximiano S, Magalhães P, Guerreiro MP, Morgado M
BioDrugs 2016 Apr;30(2):75-86. doi: 10.1007/s40259-016-0162-9. PMID: 26892619

Recent clinical studies

Etiology

Hurvitz SA, Hegg R, Chung WP, Im SA, Jacot W, Ganju V, Chiu JWY, Xu B, Hamilton E, Madhusudan S, Iwata H, Altintas S, Henning JW, Curigliano G, Perez-Garcia JM, Kim SB, Petry V, Huang CS, Li W, Frenel JS, Antolin S, Yeo W, Bianchini G, Loi S, Tsurutani J, Egorov A, Liu Y, Cathcart J, Ashfaque S, Cortés J
Lancet 2023 Jan 14;401(10371):105-117. Epub 2022 Dec 7 doi: 10.1016/S0140-6736(22)02420-5. PMID: 36495879
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Aebi S, Karlsson P, Wapnir IL
Breast 2022 Mar;62 Suppl 1(Suppl 1):S58-S62. Epub 2021 Dec 15 doi: 10.1016/j.breast.2021.12.011. PMID: 34930650Free PMC Article
Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators
N Engl J Med 2020 Feb 13;382(7):610-621. Epub 2019 Dec 11 doi: 10.1056/NEJMoa1914510. PMID: 31825192Free PMC Article
Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY, Diéras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K; EMILIA Study Group
N Engl J Med 2012 Nov 8;367(19):1783-91. Epub 2012 Oct 1 doi: 10.1056/NEJMoa1209124. PMID: 23020162Free PMC Article

Diagnosis

Cantini L, Trapani D, Guidi L, Boscolo Bielo L, Scafetta R, Koziej M, Vidal L, Saini KS, Curigliano G
Cancer Treat Rev 2024 Feb;123:102669. Epub 2023 Dec 10 doi: 10.1016/j.ctrv.2023.102669. PMID: 38141462
Swain SM, Shastry M, Hamilton E
Nat Rev Drug Discov 2023 Feb;22(2):101-126. Epub 2022 Nov 7 doi: 10.1038/s41573-022-00579-0. PMID: 36344672Free PMC Article
Ren S, Wang J, Ying J, Mitsudomi T, Lee DH, Wang Z, Chu Q, Mack PC, Cheng Y, Duan J, Fan Y, Han B, Hui Z, Liu A, Liu J, Lu Y, Ma Z, Shi M, Shu Y, Song Q, Song X, Song Y, Wang C, Wang X, Wang Z, Xu Y, Yao Y, Zhang L, Zhao M, Zhu B, Zhang J, Zhou C, Hirsch FR
ESMO Open 2022 Feb;7(1):100395. Epub 2022 Feb 8 doi: 10.1016/j.esmoop.2022.100395. PMID: 35149428Free PMC Article
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Zimmer AS, Van Swearingen AED, Anders CK
Cancer Rep (Hoboken) 2022 Apr;5(4):e1274. Epub 2020 Sep 3 doi: 10.1002/cnr2.1274. PMID: 32881421Free PMC Article

Therapy

Dvir K, Giordano S, Leone JP
Int J Mol Sci 2024 Jul 9;25(14) doi: 10.3390/ijms25147517. PMID: 39062758Free PMC Article
Cantini L, Trapani D, Guidi L, Boscolo Bielo L, Scafetta R, Koziej M, Vidal L, Saini KS, Curigliano G
Cancer Treat Rev 2024 Feb;123:102669. Epub 2023 Dec 10 doi: 10.1016/j.ctrv.2023.102669. PMID: 38141462
Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators
N Engl J Med 2020 Feb 13;382(7):610-621. Epub 2019 Dec 11 doi: 10.1056/NEJMoa1914510. PMID: 31825192Free PMC Article
Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY, Diéras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K; EMILIA Study Group
N Engl J Med 2012 Nov 8;367(19):1783-91. Epub 2012 Oct 1 doi: 10.1056/NEJMoa1209124. PMID: 23020162Free PMC Article
Gianni L, Pienkowski T, Im YH, Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi G, Szado T, Ratnayake J, Ross G, Valagussa P
Lancet Oncol 2012 Jan;13(1):25-32. Epub 2011 Dec 6 doi: 10.1016/S1470-2045(11)70336-9. PMID: 22153890

Prognosis

Dvir K, Giordano S, Leone JP
Int J Mol Sci 2024 Jul 9;25(14) doi: 10.3390/ijms25147517. PMID: 39062758Free PMC Article
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Gianni L, Pienkowski T, Im YH, Tseng LM, Liu MC, Lluch A, Starosławska E, de la Haba-Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi GV, Magazzù D, McNally V, Douthwaite H, Ross G, Valagussa P
Lancet Oncol 2016 Jun;17(6):791-800. Epub 2016 May 11 doi: 10.1016/S1470-2045(16)00163-7. PMID: 27179402
Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY, Diéras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K; EMILIA Study Group
N Engl J Med 2012 Nov 8;367(19):1783-91. Epub 2012 Oct 1 doi: 10.1056/NEJMoa1209124. PMID: 23020162Free PMC Article

Clinical prediction guides

Dvir K, Giordano S, Leone JP
Int J Mol Sci 2024 Jul 9;25(14) doi: 10.3390/ijms25147517. PMID: 39062758Free PMC Article
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Tsurutani J, Iwata H, Krop I, Jänne PA, Doi T, Takahashi S, Park H, Redfern C, Tamura K, Wise-Draper TM, Saito K, Sugihara M, Singh J, Jikoh T, Gallant G, Li BT
Cancer Discov 2020 May;10(5):688-701. Epub 2020 Mar 25 doi: 10.1158/2159-8290.CD-19-1014. PMID: 32213540Free PMC Article
Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators
N Engl J Med 2020 Feb 13;382(7):610-621. Epub 2019 Dec 11 doi: 10.1056/NEJMoa1914510. PMID: 31825192Free PMC Article

Recent systematic reviews

Giordano SH, Franzoi MAB, Temin S, Anders CK, Chandarlapaty S, Crews JR, Kirshner JJ, Krop IE, Lin NU, Morikawa A, Patt DA, Perlmutter J, Ramakrishna N, Davidson NE
J Clin Oncol 2022 Aug 10;40(23):2612-2635. Epub 2022 May 31 doi: 10.1200/JCO.22.00519. PMID: 35640077
Martin AP, Downing J, Cochrane M, Collins B, Francis B, Haycox A, Alfirevic A, Pirmohamed M
Crit Rev Oncol Hematol 2018 Oct;130:92-107. Epub 2018 Aug 3 doi: 10.1016/j.critrevonc.2018.07.012. PMID: 30196916
Hedayatizadeh-Omran A, Rafiei A, Alizadeh-Navaei R, Tehrani M, Valadan R, Moradzadeh K, Panbechi M, Taghavi SM
Asian Pac J Cancer Prev 2015;16(4):1431-4. doi: 10.7314/apjcp.2015.16.4.1431. PMID: 25743811
Kümler I, Tuxen MK, Nielsen DL
Cancer Treat Rev 2014 Mar;40(2):259-70. Epub 2013 Sep 11 doi: 10.1016/j.ctrv.2013.09.002. PMID: 24080156
Dent S, Oyan B, Honig A, Mano M, Howell S
Cancer Treat Rev 2013 Oct;39(6):622-31. Epub 2013 Feb 19 doi: 10.1016/j.ctrv.2013.01.002. PMID: 23434074

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