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Advanced Adenocarcinoma

MedGen UID:
1693607
•Concept ID:
C5204526
•
Neoplastic Process

Definition

An adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Adenocarcinoma

Professional guidelines

PubMed

Primary Surgery Not Inferior to Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma.
Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
Management of locally advanced adenocarcinoma of the pancreas.
Ryan DP, Willett CG
Hematol Oncol Clin North Am 2002 Feb;16(1):95-103. doi: 10.1016/s0889-8588(01)00009-0. PMID: 12063831

Recent clinical studies

Etiology

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
The immune microenvironment landscape shows treatment-specific differences in rectal cancer patients.
Graham Martínez C, Barella Y, Kus Öztürk S, Ansems M, Gorris MAJ, van Vliet S, Marijnen CAM, Nagtegaal ID
Front Immunol 2022;13:1011498. Epub 2022 Sep 27 doi: 10.3389/fimmu.2022.1011498. PMID: 36238289Free PMC Article
Preoperative chemotherapy versus chemoradiotherapy in locally advanced adenocarcinomas of the oesophagogastric junction (POET): Long-term results of a controlled randomised trial.
Stahl M, Walz MK, Riera-Knorrenschild J, Stuschke M, Sandermann A, Bitzer M, Wilke H, Budach W
Eur J Cancer 2017 Aug;81:183-190. doi: 10.1016/j.ejca.2017.04.027. PMID: 28628843
Perioperative Chemotherapy in Elderly Patients with Locally Advanced Adenocarcinoma of the Stomach and the Esophagogastric Junction: A Retrospective Cohort Analysis of Toxicity and Efficacy at the National Center for Tumor Diseases, Heidelberg.
Haag GM, Byl A, Jäger D, Berger AK
Oncology 2017;92(5):291-298. Epub 2017 Mar 2 doi: 10.1159/000458531. PMID: 28249280
Barrett's esophagus.
Bird-Lieberman EL, Fitzgerald RC
Gastroenterol Clin North Am 2008 Dec;37(4):921-42, x. doi: 10.1016/j.gtc.2008.09.003. PMID: 19028325

Diagnosis

Hypertensive late hemothorax following left pneumonectomy.
Rus O, Motas C, Motas N, Achim D, Horvat T
Chirurgia (Bucur) 2014 Nov-Dec;109(6):827-31. PMID: 25560508
Pathology of lung cancer.
Travis WD
Clin Chest Med 2011 Dec;32(4):669-92. doi: 10.1016/j.ccm.2011.08.005. PMID: 22054879
Barrett's esophagus.
Bird-Lieberman EL, Fitzgerald RC
Gastroenterol Clin North Am 2008 Dec;37(4):921-42, x. doi: 10.1016/j.gtc.2008.09.003. PMID: 19028325
Preoperative chemoradiation for resectable and locally advanced adenocarcinoma of the pancreas.
Evans DB
J Gastrointest Surg 2001 Jan-Feb;5(1):2-5. doi: 10.1016/s1091-255x(01)80002-0. PMID: 11370617
Biochemical rationale for the 5-fluorouracil leucovorin combination and update of clinical experience.
Rustum YM
J Chemother 1990 Feb;2 Suppl 1:5-11. doi: 10.1080/1120009x.1990.11738998. PMID: 2195138

Therapy

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Immunotherapy in Gastric Cancer.
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study.
Türeci O, Sahin U, Schulze-Bergkamen H, Zvirbule Z, Lordick F, Koeberle D, Thuss-Patience P, Ettrich T, Arnold D, Bassermann F, Al-Batran SE, Wiechen K, Dhaene K, Maurus D, Gold M, Huber C, Krivoshik A, Arozullah A, Park JW, Schuler M
Ann Oncol 2019 Sep 1;30(9):1487-1495. doi: 10.1093/annonc/mdz199. PMID: 31240302Free PMC Article
Oncogenic drivers, targeted therapies, and acquired resistance in non-small-cell lung cancer.
Gower A, Wang Y, Giaccone G
J Mol Med (Berl) 2014 Jul;92(7):697-707. Epub 2014 May 23 doi: 10.1007/s00109-014-1165-y. PMID: 24852181Free PMC Article
Preoperative chemoradiation for resectable and locally advanced adenocarcinoma of the pancreas.
Evans DB
J Gastrointest Surg 2001 Jan-Feb;5(1):2-5. doi: 10.1016/s1091-255x(01)80002-0. PMID: 11370617

Prognosis

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Advanced Non-Small Cell Lung Cancer.
Malik PS, Jain D, Kumar L
Oncology 2016;91 Suppl 1:26-34. Epub 2016 Jul 28 doi: 10.1159/000447578. PMID: 27462979
Alveolar hemorrhage associated with pemetrexed administration.
Kurimoto R, Sekine I, Iwasawa S, Sakaida E, Tada Y, Tatsumi K, Takahashi Y, Nakatani Y, Imai C, Takiguchi Y
Intern Med 2015;54(7):833-6. Epub 2015 Apr 1 doi: 10.2169/internalmedicine.54.3414. PMID: 25832952
Barrett's esophagus.
Bird-Lieberman EL, Fitzgerald RC
Gastroenterol Clin North Am 2008 Dec;37(4):921-42, x. doi: 10.1016/j.gtc.2008.09.003. PMID: 19028325
Surgical management of locally advanced adenocarcinoma of the rectum.
Devine RM, Dozois RR
World J Surg 1992 May-Jun;16(3):486-9. doi: 10.1007/BF02104452. PMID: 1589985
Combination chemotherapy for advanced adenocarcinoma of the lung. A review.
Sørensen JB, Hansen HH
Cancer Chemother Pharmacol 1988;21(2):103-16. doi: 10.1007/BF00257355. PMID: 3280152

Clinical prediction guides

Immunotherapy in Gastric Cancer.
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with non small cell lung cancer: a multi-institutional national retrospective study.
El Yacoubi H, Sow ML, Kettani F, Gamra L, Mestari A, Jabri L, Elghissassi I, Errihani H
BMC Cancer 2020 May 27;20(1):479. doi: 10.1186/s12885-020-06973-4. PMID: 32460789Free PMC Article
Spinal cord ischemia after endoscopic ultrasound guided celiac plexus neurolysis: case report and review of the literature.
Köker IH, Aralaşmak A, Ünver N, Asil T, Şentürk H
Scand J Gastroenterol 2017 Oct;52(10):1158-1161. Epub 2017 Jun 18 doi: 10.1080/00365521.2017.1335771. PMID: 28625083
Hypertensive late hemothorax following left pneumonectomy.
Rus O, Motas C, Motas N, Achim D, Horvat T
Chirurgia (Bucur) 2014 Nov-Dec;109(6):827-31. PMID: 25560508
Chemotherapy for advanced adenocarcinoma and squamous cell carcinoma of the lung with etoposide and cisplatin.
Dhingra HM, Valdivieso M, Booser DJ, Umsawasdi T, Carr DT, Chiuten DF, Murphy WK, Issell BF, Spitzer G, Farha P
Cancer Treat Rep 1984 Apr;68(4):671-3. PMID: 6538811

Recent systematic reviews

Prevalence of highly actionable mutations among Indian patients with advanced non-small cell lung cancer: A systematic review and meta-analysis.
Raman R, Ramamohan V, Rathore A, Jain D, Mohan A, Vashistha V
Asia Pac J Clin Oncol 2023 Feb;19(1):158-171. Epub 2022 May 30 doi: 10.1111/ajco.13802. PMID: 35634796
Molecular-targeted first-line therapy for advanced gastric cancer.
Song H, Zhu J, Lu D
Cochrane Database Syst Rev 2016 Jul 19;7(7):CD011461. doi: 10.1002/14651858.CD011461.pub2. PMID: 27432490Free PMC Article
Endoscopic stenting for gastric outlet obstruction in patients with unresectable antro pyloric cancer. Systematic review of the literature and final results of a prospective study. The point of view of a surgical group.
Fiori E, Lamazza A, Demasi E, Decesare A, Schillaci A, Sterpetti AV
Am J Surg 2013 Aug;206(2):210-7. Epub 2013 Jun 2 doi: 10.1016/j.amjsurg.2012.08.018. PMID: 23735668
Short versus long duration infusions of paclitaxel for any adenocarcinoma.
Williams C, Collingwood M, Simera I, Grafton C
Cochrane Database Syst Rev 2003;(1):CD003911. doi: 10.1002/14651858.CD003911. PMID: 12535492
Short versus long duration infusions of paclitaxel for any adenocarcinoma.
Williams C, Collingwood M, Simera I, Grafton C
Cochrane Database Syst Rev 2002;(4):CD003911. doi: 10.1002/14651858.CD003911. PMID: 12519619

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