U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Rectal Adenocarcinoma

MedGen UID:
1784958
•Concept ID:
C5446470
•
Neoplastic Process

Definition

Rectal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Rectal Adenocarcinoma

Professional guidelines

PubMed

Treatment-induced evolutionary dynamics in nonmetastatic locally advanced rectal adenocarcinoma.
Felder SI, Fleming JB, Gatenby RA
Adv Cancer Res 2021;151:39-67. Epub 2021 Apr 9 doi: 10.1016/bs.acr.2021.02.003. PMID: 34148619
Nonsurgical Management of Rectal Cancer.
Akce M, El-Rayes BF
J Oncol Pract 2019 Mar;15(3):123-131. doi: 10.1200/JOP.18.00769. PMID: 30861368
Impact of histological subtype on treatment outcomes in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation.
Shinde RS, Katdare N, Kumar NAN, Bhamre R, Desouza A, Ostwal V, Engineer R, Saklani A
Acta Oncol 2018 Dec;57(12):1721-1723. Epub 2018 Sep 28 doi: 10.1080/0284186X.2018.1502893. PMID: 30264625

Recent clinical studies

Etiology

Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy.
Bercz A, Park BK, Pappou E, Nemirovsky D, Sarkar R, Yamner M, Omer D, Verheij FS, Alvarez J, Atri P, Reyngold M, Yaeger R, Wei IH, Wu A, Raj N, Widmar M, Hajj C, Kim MJ, Rao D, Nash GM, Williams V, Shia J, Segal NH, Diaz L, Ganesh K, Weiser MR, Gollub MJ, Paty PB, Horvat N, Zinovoy M, Roth O'Brien D, Sanchez-Vega F, Saltz LB, Crane CH, Cercek A, Gonen M, Garcia-Aguilar J, Smith JJ, Romesser PB
Ann Oncol 2024 Nov;35(11):1003-1014. Epub 2024 Sep 11 doi: 10.1016/j.annonc.2024.07.729. PMID: 39266364Free PMC Article
Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiotherapy in patients with locally advanced rectal cancer: long-term results of the UNICANCER-PRODIGE 23 trial.
Conroy T, Castan F, Etienne PL, Rio E, Mesgouez-Nebout N, Evesque L, Vendrely V, Artignan X, Bouché O, Gargot D, Boige V, Bonichon-Lamichhane N, Louvet C, Morand C, de la Fouchardière C, Boilève A, Delaye M, Gourgou S, Pezzella V, Borg C
Ann Oncol 2024 Oct;35(10):873-881. Epub 2024 Jul 8 doi: 10.1016/j.annonc.2024.06.019. PMID: 38986769
Different neoadjuvant therapies for locally advanced rectal cancer: A systematic review and network meta-analysis.
Petrelli F, Trevisan F, Tomasello G, De Stefani A, Viti M, Garrone O, Luciani A, Ghidini M
Crit Rev Oncol Hematol 2022 Dec;180:103853. Epub 2022 Oct 15 doi: 10.1016/j.critrevonc.2022.103853. PMID: 36252747
High vs. Standard Radiotherapy Dose in Locally Advanced Rectal Adenocarcinoma Patients Treated With Neoadjuvant Long Course Chemoradiotherapy: A Population-based Study.
Liang JA, Kuo YC, Chao KSC, Chen WT, Ke TW, Chou SH, Li CC, Chien CR
Anticancer Res 2022 Feb;42(2):1143-1150. doi: 10.21873/anticanres.15578. PMID: 35093918
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial.
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740

Diagnosis

Technical feasibility of salvage endoscopic submucosal dissection after chemoradiation for locally advanced rectal adenocarcinoma.
Leung G, Nishimura M, Hingorani N, Lin IH, Weiser MR, Garcia-Aguilar J, Pappou EP, Paty PB, Schattner MA
Gastrointest Endosc 2022 Aug;96(2):359-367. Epub 2022 Feb 17 doi: 10.1016/j.gie.2022.02.014. PMID: 35183541
High vs. Standard Radiotherapy Dose in Locally Advanced Rectal Adenocarcinoma Patients Treated With Neoadjuvant Long Course Chemoradiotherapy: A Population-based Study.
Liang JA, Kuo YC, Chao KSC, Chen WT, Ke TW, Chou SH, Li CC, Chien CR
Anticancer Res 2022 Feb;42(2):1143-1150. doi: 10.21873/anticanres.15578. PMID: 35093918
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial.
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Nonsurgical Management of Rectal Cancer.
Akce M, El-Rayes BF
J Oncol Pract 2019 Mar;15(3):123-131. doi: 10.1200/JOP.18.00769. PMID: 30861368
Predictive Biomarkers to Chemoradiation in Locally Advanced Rectal Cancer.
Conde-Muíño R, Cuadros M, Zambudio N, Segura-Jiménez I, Cano C, Palma P
Biomed Res Int 2015;2015:921435. Epub 2015 Oct 4 doi: 10.1155/2015/921435. PMID: 26504848Free PMC Article

Therapy

Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiotherapy in patients with locally advanced rectal cancer: long-term results of the UNICANCER-PRODIGE 23 trial.
Conroy T, Castan F, Etienne PL, Rio E, Mesgouez-Nebout N, Evesque L, Vendrely V, Artignan X, Bouché O, Gargot D, Boige V, Bonichon-Lamichhane N, Louvet C, Morand C, de la Fouchardière C, Boilève A, Delaye M, Gourgou S, Pezzella V, Borg C
Ann Oncol 2024 Oct;35(10):873-881. Epub 2024 Jul 8 doi: 10.1016/j.annonc.2024.06.019. PMID: 38986769
Different neoadjuvant therapies for locally advanced rectal cancer: A systematic review and network meta-analysis.
Petrelli F, Trevisan F, Tomasello G, De Stefani A, Viti M, Garrone O, Luciani A, Ghidini M
Crit Rev Oncol Hematol 2022 Dec;180:103853. Epub 2022 Oct 15 doi: 10.1016/j.critrevonc.2022.103853. PMID: 36252747
Locally advanced rectal adenocarcinoma: Treatment sequences, intensification, and rectal organ preservation.
Bigness A, Imanirad I, Sahin IH, Xie H, Frakes J, Hoffe S, Laskowitz D, Felder S
CA Cancer J Clin 2021 May;71(3):198-208. Epub 2021 Feb 16 doi: 10.3322/caac.21661. PMID: 33592118
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial.
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Preoperative chemoradiation for locally advanced rectal adenocarcinoma-the University of Florida experience.
Mendenhall WM, Vauthey JN, Zlotecki RA, Marsh RD, Copeland EM 3rd
Semin Surg Oncol 2003;21(4):261-4. doi: 10.1002/ssu.10045. PMID: 14648784

Prognosis

Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy.
Bercz A, Park BK, Pappou E, Nemirovsky D, Sarkar R, Yamner M, Omer D, Verheij FS, Alvarez J, Atri P, Reyngold M, Yaeger R, Wei IH, Wu A, Raj N, Widmar M, Hajj C, Kim MJ, Rao D, Nash GM, Williams V, Shia J, Segal NH, Diaz L, Ganesh K, Weiser MR, Gollub MJ, Paty PB, Horvat N, Zinovoy M, Roth O'Brien D, Sanchez-Vega F, Saltz LB, Crane CH, Cercek A, Gonen M, Garcia-Aguilar J, Smith JJ, Romesser PB
Ann Oncol 2024 Nov;35(11):1003-1014. Epub 2024 Sep 11 doi: 10.1016/j.annonc.2024.07.729. PMID: 39266364Free PMC Article
High vs. Standard Radiotherapy Dose in Locally Advanced Rectal Adenocarcinoma Patients Treated With Neoadjuvant Long Course Chemoradiotherapy: A Population-based Study.
Liang JA, Kuo YC, Chao KSC, Chen WT, Ke TW, Chou SH, Li CC, Chien CR
Anticancer Res 2022 Feb;42(2):1143-1150. doi: 10.21873/anticanres.15578. PMID: 35093918
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial.
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Molecular profiling of locally-advanced rectal adenocarcinoma using microRNA expression (Review).
Pettit C, Walston S, Wald P, Webb A, Williams TM
Int J Oncol 2017 Aug;51(2):393-404. Epub 2017 Jun 14 doi: 10.3892/ijo.2017.4045. PMID: 28627602
Preoperative chemoradiation for locally advanced rectal adenocarcinoma-the University of Florida experience.
Mendenhall WM, Vauthey JN, Zlotecki RA, Marsh RD, Copeland EM 3rd
Semin Surg Oncol 2003;21(4):261-4. doi: 10.1002/ssu.10045. PMID: 14648784

Clinical prediction guides

Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy.
Bercz A, Park BK, Pappou E, Nemirovsky D, Sarkar R, Yamner M, Omer D, Verheij FS, Alvarez J, Atri P, Reyngold M, Yaeger R, Wei IH, Wu A, Raj N, Widmar M, Hajj C, Kim MJ, Rao D, Nash GM, Williams V, Shia J, Segal NH, Diaz L, Ganesh K, Weiser MR, Gollub MJ, Paty PB, Horvat N, Zinovoy M, Roth O'Brien D, Sanchez-Vega F, Saltz LB, Crane CH, Cercek A, Gonen M, Garcia-Aguilar J, Smith JJ, Romesser PB
Ann Oncol 2024 Nov;35(11):1003-1014. Epub 2024 Sep 11 doi: 10.1016/j.annonc.2024.07.729. PMID: 39266364Free PMC Article
High vs. Standard Radiotherapy Dose in Locally Advanced Rectal Adenocarcinoma Patients Treated With Neoadjuvant Long Course Chemoradiotherapy: A Population-based Study.
Liang JA, Kuo YC, Chao KSC, Chen WT, Ke TW, Chou SH, Li CC, Chien CR
Anticancer Res 2022 Feb;42(2):1143-1150. doi: 10.21873/anticanres.15578. PMID: 35093918
Treatment-induced evolutionary dynamics in nonmetastatic locally advanced rectal adenocarcinoma.
Felder SI, Fleming JB, Gatenby RA
Adv Cancer Res 2021;151:39-67. Epub 2021 Apr 9 doi: 10.1016/bs.acr.2021.02.003. PMID: 34148619
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial.
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Molecular profiling of locally-advanced rectal adenocarcinoma using microRNA expression (Review).
Pettit C, Walston S, Wald P, Webb A, Williams TM
Int J Oncol 2017 Aug;51(2):393-404. Epub 2017 Jun 14 doi: 10.3892/ijo.2017.4045. PMID: 28627602

Recent systematic reviews

Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma.
Tan X, Zhang Y, Wu X, Fang Q, Xu Y, Li S, Yuan J, Peng X, Fu K, Xiao S
BMC Gastroenterol 2024 Aug 13;24(1):263. doi: 10.1186/s12876-024-03359-9. PMID: 39138423Free PMC Article
Different neoadjuvant therapies for locally advanced rectal cancer: A systematic review and network meta-analysis.
Petrelli F, Trevisan F, Tomasello G, De Stefani A, Viti M, Garrone O, Luciani A, Ghidini M
Crit Rev Oncol Hematol 2022 Dec;180:103853. Epub 2022 Oct 15 doi: 10.1016/j.critrevonc.2022.103853. PMID: 36252747
FDG PET/CT Can Assess the Response of Locally Advanced Rectal Cancer to Neoadjuvant Chemoradiotherapy: Evidence From Meta-analysis and Systematic Review.
Rymer B, Curtis NJ, Siddiqui MR, Chand M
Clin Nucl Med 2016 May;41(5):371-5. doi: 10.1097/RLU.0000000000001166. PMID: 26914561

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...