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Advanced HER2-Negative Breast Carcinoma

MedGen UID:
1713969
Concept ID:
C5239115
Neoplastic Process
Synonyms: Advanced HER2 Negative Breast Adenocarcinoma; Advanced HER2 Negative Breast Carcinoma

Definition

A HER2-negative breast adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced HER2-Negative Breast Carcinoma

Professional guidelines

PubMed

O'Sullivan CC, Clarke R, Goetz MP, Robertson J
JAMA Oncol 2023 Sep 1;9(9):1273-1282. doi: 10.1001/jamaoncol.2023.2000. PMID: 37382948Free PMC Article
Cortesi L, Rugo HS, Jackisch C
Target Oncol 2021 May;16(3):255-282. Epub 2021 Mar 12 doi: 10.1007/s11523-021-00796-4. PMID: 33710534Free PMC Article
Hurvitz SA, Gelmon KA, Tolaney SM
Am Soc Clin Oncol Educ Book 2017;37:76-92. doi: 10.1200/EDBK_175630. PMID: 28561711

Recent clinical studies

Etiology

Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
André F, Ciruelos E, Rubovszky G, Campone M, Loibl S, Rugo HS, Iwata H, Conte P, Mayer IA, Kaufman B, Yamashita T, Lu YS, Inoue K, Takahashi M, Pápai Z, Longin AS, Mills D, Wilke C, Hirawat S, Juric D; SOLAR-1 Study Group
N Engl J Med 2019 May 16;380(20):1929-1940. doi: 10.1056/NEJMoa1813904. PMID: 31091374
Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Hegg R, Im SA, Shaw Wright G, Henschel V, Molinero L, Chui SY, Funke R, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Trial Investigators
N Engl J Med 2018 Nov 29;379(22):2108-2121. Epub 2018 Oct 20 doi: 10.1056/NEJMoa1809615. PMID: 30345906
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564
Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, Harbeck N, Lipatov ON, Walshe JM, Moulder S, Gauthier E, Lu DR, Randolph S, Diéras V, Slamon DJ
N Engl J Med 2016 Nov 17;375(20):1925-1936. doi: 10.1056/NEJMoa1607303. PMID: 27959613

Diagnosis

Shirley M
Drugs 2024 Mar;84(3):337-346. doi: 10.1007/s40265-024-01998-6. PMID: 38388873
Cantini L, Trapani D, Guidi L, Boscolo Bielo L, Scafetta R, Koziej M, Vidal L, Saini KS, Curigliano G
Cancer Treat Rev 2024 Feb;123:102669. Epub 2023 Dec 10 doi: 10.1016/j.ctrv.2023.102669. PMID: 38141462
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Cristofanilli M, Turner NC, Bondarenko I, Ro J, Im SA, Masuda N, Colleoni M, DeMichele A, Loi S, Verma S, Iwata H, Harbeck N, Zhang K, Theall KP, Jiang Y, Bartlett CH, Koehler M, Slamon D
Lancet Oncol 2016 Apr;17(4):425-439. Epub 2016 Mar 3 doi: 10.1016/S1470-2045(15)00613-0. PMID: 26947331

Therapy

Slamon D, Lipatov O, Nowecki Z, McAndrew N, Kukielka-Budny B, Stroyakovskiy D, Yardley DA, Huang CS, Fasching PA, Crown J, Bardia A, Chia S, Im SA, Ruiz-Borrego M, Loi S, Xu B, Hurvitz S, Barrios C, Untch M, Moroose R, Visco F, Afenjar K, Fresco R, Severin I, Ji Y, Ghaznawi F, Li Z, Zarate JP, Chakravartty A, Taran T, Hortobagyi G
N Engl J Med 2024 Mar 21;390(12):1080-1091. doi: 10.1056/NEJMoa2305488. PMID: 38507751
Bidard FC, Kaklamani VG, Neven P, Streich G, Montero AJ, Forget F, Mouret-Reynier MA, Sohn JH, Taylor D, Harnden KK, Khong H, Kocsis J, Dalenc F, Dillon PM, Babu S, Waters S, Deleu I, García Sáenz JA, Bria E, Cazzaniga M, Lu J, Aftimos P, Cortés J, Liu S, Tonini G, Laurent D, Habboubi N, Conlan MG, Bardia A
J Clin Oncol 2022 Oct 1;40(28):3246-3256. Epub 2022 May 18 doi: 10.1200/JCO.22.00338. PMID: 35584336Free PMC Article
Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Hegg R, Im SA, Shaw Wright G, Henschel V, Molinero L, Chui SY, Funke R, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Trial Investigators
N Engl J Med 2018 Nov 29;379(22):2108-2121. Epub 2018 Oct 20 doi: 10.1056/NEJMoa1809615. PMID: 30345906
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564

Prognosis

Bidard FC, Kaklamani VG, Neven P, Streich G, Montero AJ, Forget F, Mouret-Reynier MA, Sohn JH, Taylor D, Harnden KK, Khong H, Kocsis J, Dalenc F, Dillon PM, Babu S, Waters S, Deleu I, García Sáenz JA, Bria E, Cazzaniga M, Lu J, Aftimos P, Cortés J, Liu S, Tonini G, Laurent D, Habboubi N, Conlan MG, Bardia A
J Clin Oncol 2022 Oct 1;40(28):3246-3256. Epub 2022 May 18 doi: 10.1200/JCO.22.00338. PMID: 35584336Free PMC Article
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Goetz MP, Toi M, Campone M, Sohn J, Paluch-Shimon S, Huober J, Park IH, Trédan O, Chen SC, Manso L, Freedman OC, Garnica Jaliffe G, Forrester T, Frenzel M, Barriga S, Smith IC, Bourayou N, Di Leo A
J Clin Oncol 2017 Nov 10;35(32):3638-3646. Epub 2017 Oct 2 doi: 10.1200/JCO.2017.75.6155. PMID: 28968163
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564

Clinical prediction guides

Dvir K, Giordano S, Leone JP
Int J Mol Sci 2024 Jul 9;25(14) doi: 10.3390/ijms25147517. PMID: 39062758Free PMC Article
Goetz MP, Toi M, Huober J, Sohn J, Trédan O, Park IH, Campone M, Chen SC, Manso LM, Paluch-Shimon S, Freedman OC, O'Shaughnessy J, Pivot X, Tolaney SM, Hurvitz SA, Llombart-Cussac A, André V, Saha A, van Hal G, Shahir A, Iwata H, Johnston SRD
Ann Oncol 2024 Aug;35(8):718-727. Epub 2024 May 8 doi: 10.1016/j.annonc.2024.04.013. PMID: 38729566
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Lu YS, Im SA, Colleoni M, Franke F, Bardia A, Cardoso F, Harbeck N, Hurvitz S, Chow L, Sohn J, Lee KS, Campos-Gomez S, Villanueva Vazquez R, Jung KH, Babu KG, Wheatley-Price P, De Laurentiis M, Im YH, Kuemmel S, El-Saghir N, O'Regan R, Gasch C, Solovieff N, Wang C, Wang Y, Chakravartty A, Ji Y, Tripathy D
Clin Cancer Res 2022 Mar 1;28(5):851-859. doi: 10.1158/1078-0432.CCR-21-3032. PMID: 34965945Free PMC Article
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092

Recent systematic reviews

Kappel C, Elliott MJ, Kumar V, Nadler MB, Desnoyers A, Amir E
Sci Rep 2024 Feb 7;14(1):3129. doi: 10.1038/s41598-024-53151-8. PMID: 38326452Free PMC Article
Wang T, Shen G, Li J, Huo X, Wang M, Liu Z, Zhao F, Ren D, Zhao J
Curr Cancer Drug Targets 2023;23(9):718-730. doi: 10.2174/1568009623666230407101128. PMID: 37026492
Harbeck N, Bartlett M, Spurden D, Hooper B, Zhan L, Rosta E, Cameron C, Mitra D, Zhou A
Future Oncol 2021 Jun;17(16):2107-2122. Epub 2021 Mar 5 doi: 10.2217/fon-2020-1264. PMID: 33663223
Raphael J, Lefebvre C, Allan A, Helou J, Boldt G, Vandenberg T, Blanchette PS
Target Oncol 2020 Dec;15(6):723-732. doi: 10.1007/s11523-020-00770-6. PMID: 33151471
Brandão M, Maurer C, Ziegelmann PK, Pondé NF, Ferreira A, Martel S, Piccart M, de Azambuja E, Debiasi M, Lambertini M
ESMO Open 2020 Aug;5(4) doi: 10.1136/esmoopen-2020-000842. PMID: 32847835Free PMC Article

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