U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prostate adenocarcinoma

MedGen UID:
764
Concept ID:
C0007112
Neoplastic Process
Synonym: Adenocarcinoma of prostate
SNOMED CT: Adenocarcinoma of prostate (399490008)
 
Monarch Initiative: MONDO:0005082

Definition

An adenocarcinoma arising from the prostate gland. It is one of the most common malignant tumors afflicting men. The majority of adenocarcinomas arise in the peripheral zone and a minority occurs in the central or the transitional zone of the prostate gland. Grading of prostatic adenocarcinoma predicts disease progression and correlates with survival. Several grading systems have been proposed, of which the Gleason system is the most commonly used. Gleason sums of 2 to 4 represent well-differentiated disease, 5 to 7 moderately differentiated disease and 8 to 10 poorly differentiated disease. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic adenocarcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease. [from NCI]

Professional guidelines

PubMed

Zaidi S, Park J, Chan JM, Roudier MP, Zhao JL, Gopalan A, Wadosky KM, Patel RA, Sayar E, Karthaus WR, Kates DH, Chaudhary O, Xu T, Masilionis I, Mazutis L, Chaligné R, Obradovic A, Linkov I, Barlas A, Jungbluth AA, Rekhtman N, Silber J, Manova-Todorova K, Watson PA, True LD, Morrissey C, Scher HI, Rathkopf DE, Morris MJ, Goodrich DW, Choi J, Nelson PS, Haffner MC, Sawyers CL
Proc Natl Acad Sci U S A 2024 Jul 9;121(28):e2322203121. Epub 2024 Jul 5 doi: 10.1073/pnas.2322203121. PMID: 38968122Free PMC Article
Stish BJ, Davis BJ, Mynderse LA, Deufel CL, Choo R
Surg Oncol Clin N Am 2017 Jul;26(3):491-513. Epub 2017 May 11 doi: 10.1016/j.soc.2017.01.008. PMID: 28576185
Li Y, Mongan J, Behr SC, Sud S, Coakley FV, Simko J, Westphalen AC
Radiographics 2016 Jul-Aug;36(4):1055-75. Epub 2016 Jun 17 doi: 10.1148/rg.2016150226. PMID: 27315446

Recent clinical studies

Etiology

Baldeosingh SC, Rowe SP, Greco SC, Paller CJ, Goel R
Clin Nucl Med 2021 Nov 1;46(11):919-921. doi: 10.1097/RLU.0000000000003672. PMID: 34582137Free PMC Article
Wong VCK, Shen L, Nasser E, Adams DN, Mansberg R
Clin Nucl Med 2020 Mar;45(3):238-240. doi: 10.1097/RLU.0000000000002910. PMID: 31977467
Tsepaeva OV, Nemtarev AV, Abdullin TI, Grigor'eva LR, Kuznetsova EV, Akhmadishina RA, Ziganshina LE, Cong HH, Mironov VF
J Nat Prod 2017 Aug 25;80(8):2232-2239. Epub 2017 Aug 7 doi: 10.1021/acs.jnatprod.7b00105. PMID: 28782948
Pomerantz M
Surg Pathol Clin 2015 Dec;8(4):581-5. doi: 10.1016/j.path.2015.09.002. PMID: 26612216
Singh PB, Matanhelia SS, Martin FL
Eur J Cancer 2008 May;44(7):928-36. Epub 2008 Apr 1 doi: 10.1016/j.ejca.2008.02.051. PMID: 18381236

Diagnosis

Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Shah NS, Chow A, Bhanot UK, Linkov I, Asher M, Yu HA, Qiu J, de Stanchina E, Patel RA, Morrissey C, Haffner MC, Koche RP, Sawyers CL, Rudin CM
Sci Transl Med 2023 Aug 2;15(707):eadf7006. doi: 10.1126/scitranslmed.adf7006. PMID: 37531417Free PMC Article
Schulz WA, Sørensen KD
Int J Mol Sci 2019 Sep 26;20(19) doi: 10.3390/ijms20194775. PMID: 31561442Free PMC Article
Amin A
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):514-521. doi: 10.1097/PAI.0000000000000508. PMID: 28362706
Tang EK, Chu PT, Goan YG, Hsieh PP, Lin JC
Ann Thorac Surg 2016 Dec;102(6):e555-e556. doi: 10.1016/j.athoracsur.2016.05.051. PMID: 27847080
Pomerantz M
Surg Pathol Clin 2015 Dec;8(4):581-5. doi: 10.1016/j.path.2015.09.002. PMID: 26612216

Therapy

Yamada Y, Venkadakrishnan VB, Mizuno K, Bakht M, Ku SY, Garcia MM, Beltran H
Sci Transl Med 2023 Nov 15;15(722):eadf6732. doi: 10.1126/scitranslmed.adf6732. PMID: 37967200Free PMC Article
Sweeney CJ, Martin AJ, Stockler MR, Begbie S, Cheung L, Chi KN, Chowdhury S, Frydenberg M, Horvath LG, Joshua AM, Lawrence NJ, Marx G, McCaffrey J, McDermott R, McJannett M, North SA, Parnis F, Parulekar W, Pook DW, Reaume MN, Sandhu SK, Tan A, Tan TH, Thomson A, Vera-Badillo F, Williams SG, Winter D, Yip S, Zhang AY, Zielinski RR, Davis ID; ENZAMET trial investigators and Australian and New Zealand Urogenital and Prostate Cancer Trials Group
Lancet Oncol 2023 Apr;24(4):323-334. doi: 10.1016/S1470-2045(23)00063-3. PMID: 36990608
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Sjögreen Gleisner K, Chouin N, Gabina PM, Cicone F, Gnesin S, Stokke C, Konijnenberg M, Cremonesi M, Verburg FA, Bernhardt P, Eberlein U, Gear J
Eur J Nucl Med Mol Imaging 2022 May;49(6):1778-1809. Epub 2022 Mar 14 doi: 10.1007/s00259-022-05727-7. PMID: 35284969Free PMC Article
Murthy V, Maitre P, Kannan S, Panigrahi G, Krishnatry R, Bakshi G, Prakash G, Pal M, Menon S, Phurailatpam R, Mokal S, Chaurasiya D, Popat P, Sable N, Agarwal A, Rangarajan V, Joshi A, Noronha V, Prabhash K, Mahantshetty U
J Clin Oncol 2021 Apr 10;39(11):1234-1242. Epub 2021 Jan 26 doi: 10.1200/JCO.20.03282. PMID: 33497252

Prognosis

Xu H, Li YF, Yi XY, Zheng XN, Yang Y, Wang Y, Liao DZ, Zhang JP, Tan P, Xiong XY, Jin X, Gong LN, Qiu S, Cao DH, Li H, Wei Q, Yang L, Ai JZ
Mil Med Res 2023 Dec 12;10(1):64. doi: 10.1186/s40779-023-00500-9. PMID: 38082365Free PMC Article
Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Shah NS, Chow A, Bhanot UK, Linkov I, Asher M, Yu HA, Qiu J, de Stanchina E, Patel RA, Morrissey C, Haffner MC, Koche RP, Sawyers CL, Rudin CM
Sci Transl Med 2023 Aug 2;15(707):eadf7006. doi: 10.1126/scitranslmed.adf7006. PMID: 37531417Free PMC Article
Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Schulz WA, Sørensen KD
Int J Mol Sci 2019 Sep 26;20(19) doi: 10.3390/ijms20194775. PMID: 31561442Free PMC Article
Amin A
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):514-521. doi: 10.1097/PAI.0000000000000508. PMID: 28362706

Clinical prediction guides

Estephan F, Lap CJ, Banagan J, Antonio M, Liu S, Diao G, Rozalen AZ, Rajendran R, Krasnow S, Subrahmanyam R, Nava VE, Jain M
Ann Diagn Pathol 2023 Dec;67:152219. Epub 2023 Oct 20 doi: 10.1016/j.anndiagpath.2023.152219. PMID: 38622987
Mardasi E, Russon A, Mansberg V, Bui C, Mansberg R
Clin Nucl Med 2023 May 1;48(5):451-452. Epub 2023 Feb 8 doi: 10.1097/RLU.0000000000004600. PMID: 36754360
Berchuck JE, Baca SC, McClure HM, Korthauer K, Tsai HK, Nuzzo PV, Kelleher KM, He M, Steinharter JA, Zacharia S, Spisak S, Seo JH, Conteduca V, Elemento O, Auh J, Sigouros M, Corey E, Hirsch MS, Taplin ME, Choueiri TK, Pomerantz MM, Beltran H, Freedman ML
Clin Cancer Res 2022 Mar 1;28(5):928-938. doi: 10.1158/1078-0432.CCR-21-3762. PMID: 34907080Free PMC Article
O'Sullivan B, Tanner R, Kelly P, Fahy G
BMJ Case Rep 2021 Feb 11;14(2) doi: 10.1136/bcr-2020-238076. PMID: 33574044Free PMC Article
Tang EK, Chu PT, Goan YG, Hsieh PP, Lin JC
Ann Thorac Surg 2016 Dec;102(6):e555-e556. doi: 10.1016/j.athoracsur.2016.05.051. PMID: 27847080

Recent systematic reviews

Mansur G, Alsavaf MB, Pasquini L, Abouammo MD, Biswas C, Kumar P, Raval RR, Kobalka P, Carrau RL, Prevedello DM
Pituitary 2024 Oct;27(5):455-467. Epub 2024 Aug 14 doi: 10.1007/s11102-024-01441-9. PMID: 39141205Free PMC Article
Abufaraj M, Ramadan R, Alkhatib A
Curr Oncol 2024 Mar 21;31(3):1618-1632. doi: 10.3390/curroncol31030123. PMID: 38534956Free PMC Article
Santandreu-Morales I, Redondo-Cerezo E, Martín-Enguix D
Med Clin (Barc) 2023 Mar 10;160(5):206-212. Epub 2022 Dec 14 doi: 10.1016/j.medcli.2022.11.001. PMID: 36526448
Choto ET, Mduluza T, Sibanda EN, Mutapi F, Chimbari MJ
Afr J Reprod Health 2020 Dec;24(4):185-197. doi: 10.29063/ajrh2020/v24i4.19. PMID: 34077083
Neto AS, Tobias-Machado M, Wroclawski ML, Fonseca FL, Teixeira GK, Amarante RD, Wroclawski ER, Del Giglio A
J Urol 2010 Sep;184(3):842-50. doi: 10.1016/j.juro.2010.04.077. PMID: 20663525

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...