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Unresectable Cholangiocarcinoma

MedGen UID:: 209022
•Concept ID:: C0862953
•: Neoplastic Process

Synonym:

Non-Resectable Cholangiocarcinoma

Definition

Cholangiocarcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVUnresectable Cholangiocarcinoma

Disease
- Neoplasm
  - Epithelial neoplasm
    - Carcinoma
      - Adenocarcinoma
        Cholangiocarcinoma
        Unresectable Cholangiocarcinoma
        Unresectable Distal Bile Duct Adenocarcinoma
        Unresectable Intrahepatic Cholangiocarcinoma

Professional guidelines

PubMed

The multidisciplinary management of cholangiocarcinoma.

Ohaegbulam KC, Koethe Y, Fung A, Mayo SC, Grossberg AJ, Chen EY, Sharzehi K, Kardosh A, Farsad K, Rocha FG, Thomas CR, Nabavizadeh N
Cancer 2023 Jan 15;129(2):184-214. Epub 2022 Nov 16 doi: 10.1002/cncr.34541. PMID: 36382577

Moving the Needle Forward With Locoregional Treatment in Unresectable Cholangiocarcinoma-The Jury Is Still Out.

Scott AJ, Shroff RT
JAMA Oncol 2020 Jan 1;6(1):29-31. doi: 10.1001/jamaoncol.2019.3691. PMID: 31670748

Diagnosis and treatment of cholangiocarcinoma.

Boberg KM, Schrumpf E
Curr Gastroenterol Rep 2004 Feb;6(1):52-9. doi: 10.1007/s11894-004-0026-1. PMID: 14720454

See all (19)

Recent clinical studies

Etiology

Liver Transplant for Nonhepatocellular Carcinoma Malignancy.

Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003

Intrahepatic chemotherapy for unresectable cholangiocarcinoma: review of literature and personal experience.

Massani M, Nistri C, Ruffolo C, Bonariol R, Pauletti B, Bonariol L, Caratozzolo E, Morana G, Bassi N
Updates Surg 2015 Dec;67(4):389-400. doi: 10.1007/s13304-015-0330-3. PMID: 26468142

Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma.

Mattiucci GC, Autorino R, D'Agostino GR, Deodato F, Macchia G, Perri V, Tringali A, Morganti AG, Mutignani M, Valentini V
Crit Rev Oncol Hematol 2014 Apr;90(1):58-67. Epub 2013 Nov 2 doi: 10.1016/j.critrevonc.2013.10.007. PMID: 24289902

Photodynamic therapy for unresectable cholangiocarcinoma.

Tomizawa Y, Tian J
Dig Dis Sci 2012 Feb;57(2):274-83. Epub 2011 Nov 6 doi: 10.1007/s10620-011-1957-7. PMID: 22057285

Diagnosis and treatment of cholangiocarcinoma.

Boberg KM, Schrumpf E
Curr Gastroenterol Rep 2004 Feb;6(1):52-9. doi: 10.1007/s11894-004-0026-1. PMID: 14720454

See all (56)

Diagnosis

Local Therapy in Advanced Cholangiocarcinoma: A Review of Current Endoscopic, Medical, and Oncologic Treatment Options.

Jung CFM, Lavole J, Barret M, Abou Ali E, Palmieri LJ, Dermine S, Barré A, Chaussade S, Coriat R
Oncology 2019;97(4):191-201. Epub 2019 Jul 2 doi: 10.1159/000500832. PMID: 31266042

Photodynamic therapy for unresectable cholangiocarcinoma.

Tomizawa Y, Tian J
Dig Dis Sci 2012 Feb;57(2):274-83. Epub 2011 Nov 6 doi: 10.1007/s10620-011-1957-7. PMID: 22057285

Endoscopic palliation of cholangiocarcinoma.

Chahal P, Baron TH
Curr Opin Gastroenterol 2006 Sep;22(5):551-60. doi: 10.1097/01.mog.0000239872.12081.a4. PMID: 16891889

Diagnosis and treatment of cholangiocarcinoma.

Boberg KM, Schrumpf E
Curr Gastroenterol Rep 2004 Feb;6(1):52-9. doi: 10.1007/s11894-004-0026-1. PMID: 14720454

Cholangiocarcinoma.

Yeo CJ, Pitt HA, Cameron JL
Surg Clin North Am 1990 Dec;70(6):1429-47. doi: 10.1016/s0039-6109(16)45293-x. PMID: 2174191

See all (41)

Therapy

Liver Transplant for Nonhepatocellular Carcinoma Malignancy.

Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003

Locoregional therapy for cholangiocarcinoma.

Kuhlmann JB, Blum HE
Curr Opin Gastroenterol 2013 May;29(3):324-8. doi: 10.1097/MOG.0b013e32835d9dea. PMID: 23337933

Photodynamic therapy for unresectable cholangiocarcinoma.

Tomizawa Y, Tian J
Dig Dis Sci 2012 Feb;57(2):274-83. Epub 2011 Nov 6 doi: 10.1007/s10620-011-1957-7. PMID: 22057285

Diagnosis and treatment of cholangiocarcinoma.

Boberg KM, Schrumpf E
Curr Gastroenterol Rep 2004 Feb;6(1):52-9. doi: 10.1007/s11894-004-0026-1. PMID: 14720454

Cholangiocarcinoma.

Yeo CJ, Pitt HA, Cameron JL
Surg Clin North Am 1990 Dec;70(6):1429-47. doi: 10.1016/s0039-6109(16)45293-x. PMID: 2174191

See all (68)

Prognosis

Immune checkpoint inhibitors in cholangiocarcinoma.

Beri N
Immunotherapy 2023 May;15(7):541-551. Epub 2023 Apr 25 doi: 10.2217/imt-2022-0288. PMID: 37096964

Update on Treatment Options for Advanced Bile Duct Tumours: Radioembolisation for Advanced Cholangiocarcinoma.

Najran P, Lamarca A, Mullan D, McNamara MG, Westwood T, Hubner RA, Lawrence J, Manoharan P, Bell J, Valle JW
Curr Oncol Rep 2017 Jul;19(7):50. doi: 10.1007/s11912-017-0603-8. PMID: 28656502 Free PMC Article

Locoregional therapy for cholangiocarcinoma.

Kuhlmann JB, Blum HE
Curr Opin Gastroenterol 2013 May;29(3):324-8. doi: 10.1097/MOG.0b013e32835d9dea. PMID: 23337933

Photodynamic therapy for unresectable cholangiocarcinoma.

Tomizawa Y, Tian J
Dig Dis Sci 2012 Feb;57(2):274-83. Epub 2011 Nov 6 doi: 10.1007/s10620-011-1957-7. PMID: 22057285

Diagnosis and treatment of cholangiocarcinoma.

Boberg KM, Schrumpf E
Curr Gastroenterol Rep 2004 Feb;6(1):52-9. doi: 10.1007/s11894-004-0026-1. PMID: 14720454

See all (50)

Clinical prediction guides

Immune checkpoint inhibitors in cholangiocarcinoma.

Beri N
Immunotherapy 2023 May;15(7):541-551. Epub 2023 Apr 25 doi: 10.2217/imt-2022-0288. PMID: 37096964

Liver transplantation for perihilar cholangiocarcinoma: patient selection and outcomes.

Acher AW, Weber SM, Pawlik TM
Expert Rev Gastroenterol Hepatol 2021 May;15(5):555-566. Epub 2021 Feb 26 doi: 10.1080/17474124.2021.1890584. PMID: 33577361

Clinical Outcomes of Patients With Unresectable Cholangiocarcinoma Treated With Proton Beam Therapy.

Hung SP, Huang BS, Hsieh CE, Lee CH, Tsang NM, Chang JT, Chen JS, Chou WC, Tseng JH, Hong JH
Am J Clin Oncol 2020 Mar;43(3):180-186. doi: 10.1097/COC.0000000000000646. PMID: 31764017

Photodynamic therapy for unresectable cholangiocarcinoma: a comparative effectiveness systematic review and meta-analyses.

Leggett CL, Gorospe EC, Murad MH, Montori VM, Baron TH, Wang KK
Photodiagnosis Photodyn Ther 2012 Sep;9(3):189-95. Epub 2012 Apr 11 doi: 10.1016/j.pdpdt.2012.03.002. PMID: 22959798

Stereotactic body radiotherapy for unresectable cholangiocarcinoma.

Kopek N, Holt MI, Hansen AT, Høyer M
Radiother Oncol 2010 Jan;94(1):47-52. Epub 2009 Dec 4 doi: 10.1016/j.radonc.2009.11.004. PMID: 19963295

See all (31)

Recent systematic reviews

Photodynamic Therapy (PDT), Radiofrequency Ablation (RFA) With Biliary Stents in Palliative Treatment of Unresectable Extrahepatic Cholangiocarcinoma: A Systematic Review and Meta-analysis.

Mohan BP, Chandan S, Khan SR, Kassab LL, Ponnada S, Artifon ELA, Otoch JP, McDonough S, Adler DG
J Clin Gastroenterol 2022 Feb 1;56(2):e153-e160. doi: 10.1097/MCG.0000000000001524. PMID: 33780214

Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: A systematic review and meta-analysis.

Moole H, Tathireddy H, Dharmapuri S, Moole V, Boddireddy R, Yedama P, Dharmapuri S, Uppu A, Bondalapati N, Duvvuri A
World J Gastroenterol 2017 Feb 21;23(7):1278-1288. doi: 10.3748/wjg.v23.i7.1278. PMID: 28275308 Free PMC Article

Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma.

Photodynamic therapy for unresectable cholangiocarcinoma: a comparative effectiveness systematic review and meta-analyses.

Leggett CL, Gorospe EC, Murad MH, Montori VM, Baron TH, Wang KK
Photodiagnosis Photodyn Ther 2012 Sep;9(3):189-95. Epub 2012 Apr 11 doi: 10.1016/j.pdpdt.2012.03.002. PMID: 22959798

Systematic review: photodynamic therapy for unresectable cholangiocarcinoma.

Gao F, Bai Y, Ma SR, Liu F, Li ZS
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):125-31. Epub 2009 May 20 doi: 10.1007/s00534-009-0109-3. PMID: 19455276

See all (6)

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Unresectable Cholangiocarcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Recent activity