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Stage II Oral Cavity Adenoid Cystic Carcinoma

MedGen UID:
124725
•Concept ID:
C0280352
•
Neoplastic Process
Synonyms: Stage II Adenoid Cystic Carcinoma of Mouth; Stage II Adenoid Cystic Carcinoma of Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Mouth; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Mouth Adenoid Cystic Carcinoma; Stage II Oral Cavity Adenoid Cystic Carcinoma AJCC v6; Stage II Oral Cavity Adenoid Cystic Carcinoma AJCC v7

Definition

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage II Oral Cavity Adenoid Cystic Carcinoma

Professional guidelines

PubMed

Characteristics, management of the neck, and oncological outcomes of malignant minor salivary gland tumours in the oral and sinonasal regions.
Lee SY, Shin HA, Rho KJ, Chung HJ, Kim SH, Choi EC
Br J Oral Maxillofac Surg 2013 Oct;51(7):e142-7. Epub 2012 Aug 28 doi: 10.1016/j.bjoms.2012.05.004. PMID: 22939317
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116
Malignant parotid tumors in 110 consecutive patients: treatment results and prognosis.
Pedersen D, Overgaard J, Søgaard H, Elbrønd O, Overgaard M
Laryngoscope 1992 Sep;102(9):1064-9. doi: 10.1288/00005537-199209000-00019. PMID: 1518354

Recent clinical studies

Etiology

Radical resection and reconstruction in patients with adenoid cystic carcinoma in the minor salivary glands of the palate.
Chen WL, Wang Y, Zhou B, Liao JK, Chen R
Head Face Med 2022 Mar 16;18(1):10. doi: 10.1186/s13005-022-00312-7. PMID: 35296329Free PMC Article
Adenoid cystic carcinoma of head and neck. A 5-year retrospective study: Experience in a single third-level reference center.
Gamboa-Hoil SI, Silva-Godínez JC, Abrego-Vásquez JA
Cir Cir 2020;88(1):34-40. doi: 10.24875/CIRU.19000919. PMID: 31967612
Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis.
Hämetoja H, Hirvonen K, Hagström J, Leivo I, Saarilahti K, Apajalahti S, Haglund C, Mäkitie A, Bäck L
Virchows Arch 2017 Dec;471(6):785-792. Epub 2017 Jun 10 doi: 10.1007/s00428-017-2163-6. PMID: 28600602
Head and neck adenoid cystic carcinoma: A prospective multicenter REFCOR study of 95 cases.
Meyers M, Granger B, Herman P, Janot F, Garrel R, Fakhry N, Poissonnet G, Baujat B; REFCOR members
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):13-7. Epub 2015 Oct 20 doi: 10.1016/j.anorl.2015.09.009. PMID: 26493113
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116

Diagnosis

Adenoid cystic carcinoma of head and neck. A 5-year retrospective study: Experience in a single third-level reference center.
Gamboa-Hoil SI, Silva-Godínez JC, Abrego-Vásquez JA
Cir Cir 2020;88(1):34-40. doi: 10.24875/CIRU.19000919. PMID: 31967612
Tumors of the sublingual gland: a national clinicopathologic study of 29 cases.
Andreasen S, Bjørndal K, Agander TK, Wessel I, Homøe P
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3847-3856. Epub 2016 Mar 25 doi: 10.1007/s00405-016-4000-y. PMID: 27015666
Head and neck adenoid cystic carcinoma: A prospective multicenter REFCOR study of 95 cases.
Meyers M, Granger B, Herman P, Janot F, Garrel R, Fakhry N, Poissonnet G, Baujat B; REFCOR members
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):13-7. Epub 2015 Oct 20 doi: 10.1016/j.anorl.2015.09.009. PMID: 26493113
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116
Malignant salivary gland tumors in Quito, Ecuador.
Pacheco-Ojeda L, Domeisen H, Narvaez M, Tixi R, Vivar N
ORL J Otorhinolaryngol Relat Spec 2000 Nov-Dec;62(6):296-302. doi: 10.1159/000027772. PMID: 11054011

Therapy

Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116
Photodynamic therapy of head and neck cancers.
Biel MA
Methods Mol Biol 2010;635:281-93. doi: 10.1007/978-1-60761-697-9_18. PMID: 20552353

Prognosis

Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis.
Hämetoja H, Hirvonen K, Hagström J, Leivo I, Saarilahti K, Apajalahti S, Haglund C, Mäkitie A, Bäck L
Virchows Arch 2017 Dec;471(6):785-792. Epub 2017 Jun 10 doi: 10.1007/s00428-017-2163-6. PMID: 28600602
Tumors of the sublingual gland: a national clinicopathologic study of 29 cases.
Andreasen S, Bjørndal K, Agander TK, Wessel I, Homøe P
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3847-3856. Epub 2016 Mar 25 doi: 10.1007/s00405-016-4000-y. PMID: 27015666
Head and neck adenoid cystic carcinoma: A prospective multicenter REFCOR study of 95 cases.
Meyers M, Granger B, Herman P, Janot F, Garrel R, Fakhry N, Poissonnet G, Baujat B; REFCOR members
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):13-7. Epub 2015 Oct 20 doi: 10.1016/j.anorl.2015.09.009. PMID: 26493113
Expression of the membrane-cytoskeletal linker Ezrin in salivary gland adenoid cystic carcinoma.
Wang YY, Chen WL, Huang ZQ, Yang ZH, Zhang B, Wang JG, Li HG, Li JS
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 Jul;112(1):96-104. Epub 2011 May 6 doi: 10.1016/j.tripleo.2011.02.018. PMID: 21550270
Malignant salivary gland tumors in Quito, Ecuador.
Pacheco-Ojeda L, Domeisen H, Narvaez M, Tixi R, Vivar N
ORL J Otorhinolaryngol Relat Spec 2000 Nov-Dec;62(6):296-302. doi: 10.1159/000027772. PMID: 11054011

Clinical prediction guides

Adenoid cystic carcinoma of head and neck. A 5-year retrospective study: Experience in a single third-level reference center.
Gamboa-Hoil SI, Silva-Godínez JC, Abrego-Vásquez JA
Cir Cir 2020;88(1):34-40. doi: 10.24875/CIRU.19000919. PMID: 31967612
Minor salivary gland carcinomas of oral cavity and oropharynx.
Chijiwa H, Sakamoto K, Umeno H, Nakashima T, Suzuki G, Hayafuchi N
J Laryngol Otol Suppl 2009;(31):52-7. doi: 10.1017/S002221510900509X. PMID: 19460205
Postoperative irradiation of minor salivary gland malignancies of the head and neck.
Le QT, Birdwell S, Terris DJ, Gabalski EC, Varghese A, Fee We Jr, Goffinet DR
Radiother Oncol 1999 Aug;52(2):165-71. doi: 10.1016/s0167-8140(99)00084-5. PMID: 10577702
Prognostic factors in minor salivary gland cancer.
Anderson JN Jr, Beenken SW, Crowe R, Soong SJ, Peters G, Maddox WA, Urist MM
Head Neck 1995 Nov-Dec;17(6):480-6. doi: 10.1002/hed.2880170605. PMID: 8847206
Malignant salivary tumors--analysis of prognostic factors and survival.
O'Brien CJ, Soong SJ, Herrera GA, Urist MM, Maddox WA
Head Neck Surg 1986 Nov-Dec;9(2):82-92. doi: 10.1002/hed.2890090204. PMID: 3623942

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