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Lung occult adenocarcinoma

MedGen UID:
277443
•Concept ID:
C1335096
•
Neoplastic Process
Synonyms: lung occult adenocarcinoma; Occult Adenocarcinoma of Lung; occult adenocarcinoma of lung; Occult Adenocarcinoma of the Lung; occult adenocarcinoma of the lung; Occult Lung Adenocarcinoma; occult lung adenocarcinoma
 
Monarch Initiative: MONDO:0004127

Definition

A lung adenocarcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung occult adenocarcinoma

Professional guidelines

PubMed

Treatment for patients with unknown primary carcinoma and unfavorable prognostic factors.
Greco FA, Pavlidis N
Semin Oncol 2009 Feb;36(1):65-74. doi: 10.1053/j.seminoncol.2008.10.005. PMID: 19179190
Diagnosis and management of neck metastases from an unknown primary.
Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F
Acta Otorhinolaryngol Ital 2005 Feb;25(1):2-12. PMID: 16080309Free PMC Article
Molecular differential diagnosis of renal carcinoma: from microscopes to microsatellites.
Steiner G, Sidransky D
Am J Pathol 1996 Dec;149(6):1791-5. PMID: 8952515Free PMC Article

Recent clinical studies

Etiology

Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Incidence and survival analyses for occult lung cancer between 2004 and 2015: a population-based study.
Wu LL, Li CW, Lin WK, Qiu LH, Xie D
BMC Cancer 2021 Sep 9;21(1):1009. doi: 10.1186/s12885-021-08741-4. PMID: 34496775Free PMC Article
Predicting occult lymph node metastasis by nomogram in patients with lung adenocarcinoma ≤2 cm.
Wang Z, Wu Y, Wang L, Gong L, Han C, Liang N, Li S
Future Oncol 2021 Jun;17(16):2005-2013. Epub 2021 Mar 31 doi: 10.2217/fon-2020-0905. PMID: 33784826
Merkel cell carcinoma of the head and neck.
Pellitteri PK, Takes RP, Lewis JS Jr, Devaney KO, Harlor EJ, Strojan P, Rodrigo JP, Suárez C, Rinaldo A, Medina JE, Woolgar JA, Ferlito A
Head Neck 2012 Sep;34(9):1346-54. Epub 2011 Jun 20 doi: 10.1002/hed.21787. PMID: 21692131
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621

Diagnosis

Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859
Bronchial carcinoid tumors.
Davila DG, Dunn WF, Tazelaar HD, Pairolero PC
Mayo Clin Proc 1993 Aug;68(8):795-803. doi: 10.1016/s0025-6196(12)60641-7. PMID: 8331983

Therapy

Predicting occult lymph node metastasis in solid-predominantly invasive lung adenocarcinoma across multiple centers using radiomics-deep learning fusion model.
Tian W, Yan Q, Huang X, Feng R, Shan F, Geng D, Zhang Z
Cancer Imaging 2024 Jan 12;24(1):8. doi: 10.1186/s40644-024-00654-2. PMID: 38216999Free PMC Article
Occult lymph node metastasis is not a favorable factor for resected NSCLC patients.
Cai JS, Yang F, Wang X
BMC Cancer 2023 Sep 4;23(1):822. doi: 10.1186/s12885-023-11189-3. PMID: 37667180Free PMC Article
The predictive power of artificial intelligence on mediastinal lymphnode metastasis.
Kawaguchi Y, Matsuura Y, Kondo Y, Ichinose J, Nakao M, Okumura S, Mun M
Gen Thorac Cardiovasc Surg 2021 Dec;69(12):1545-1552. Epub 2021 Jun 16 doi: 10.1007/s11748-021-01671-9. PMID: 34181182
Occult mediastinal lymph node metastasis in FDG-PET/CT node-negative lung adenocarcinoma patients: Risk factors and histopathological study.
Miao H, Shaolei L, Nan L, Yumei L, Shanyuan Z, Fangliang L, Yue Y
Thorac Cancer 2019 Jun;10(6):1453-1460. Epub 2019 May 24 doi: 10.1111/1759-7714.13093. PMID: 31127706Free PMC Article
Tumors of unknown origin.
Greco FA, Hainsworth JD
CA Cancer J Clin 1992 Mar-Apr;42(2):96-115. doi: 10.3322/canjclin.42.2.96. PMID: 1540854

Prognosis

Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Incidence and survival analyses for occult lung cancer between 2004 and 2015: a population-based study.
Wu LL, Li CW, Lin WK, Qiu LH, Xie D
BMC Cancer 2021 Sep 9;21(1):1009. doi: 10.1186/s12885-021-08741-4. PMID: 34496775Free PMC Article
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621
Bronchial carcinoid tumors.
Davila DG, Dunn WF, Tazelaar HD, Pairolero PC
Mayo Clin Proc 1993 Aug;68(8):795-803. doi: 10.1016/s0025-6196(12)60641-7. PMID: 8331983

Clinical prediction guides

A gene-based score for the risk stratification of stage IA lung adenocarcinoma.
Xiong Y, Ma Y, Liu K, Lei J, Zhao J, Zhu J, Wang W, Wen M, Wang X, Sun Y, Zhao Y, Han Y, Jiang T, Liu Y
Respir Res 2024 Jan 4;25(1):18. doi: 10.1186/s12931-023-02647-4. PMID: 38178073Free PMC Article
Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Predicting occult lymph node metastasis by nomogram in patients with lung adenocarcinoma ≤2 cm.
Wang Z, Wu Y, Wang L, Gong L, Han C, Liang N, Li S
Future Oncol 2021 Jun;17(16):2005-2013. Epub 2021 Mar 31 doi: 10.2217/fon-2020-0905. PMID: 33784826
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621

Recent systematic reviews

Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.
Klimek M
Postgrad Med 2019 Jun;131(5):309-318. Epub 2019 Apr 5 doi: 10.1080/00325481.2019.1595982. PMID: 30900501
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

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