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Lung occult adenocarcinoma

MedGen UID:
277443
•Concept ID:
C1335096
•
Neoplastic Process
Synonyms: lung occult adenocarcinoma; Occult Adenocarcinoma of Lung; occult adenocarcinoma of lung; Occult Adenocarcinoma of the Lung; occult adenocarcinoma of the lung; Occult Lung Adenocarcinoma; occult lung adenocarcinoma
 
Monarch Initiative: MONDO:0004127

Definition

A lung adenocarcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung occult adenocarcinoma

Professional guidelines

PubMed

Treatment for patients with unknown primary carcinoma and unfavorable prognostic factors.
Greco FA, Pavlidis N
Semin Oncol 2009 Feb;36(1):65-74. doi: 10.1053/j.seminoncol.2008.10.005. PMID: 19179190
Diagnosis and management of neck metastases from an unknown primary.
Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F
Acta Otorhinolaryngol Ital 2005 Feb;25(1):2-12. PMID: 16080309Free PMC Article
Molecular differential diagnosis of renal carcinoma: from microscopes to microsatellites.
Steiner G, Sidransky D
Am J Pathol 1996 Dec;149(6):1791-5. PMID: 8952515Free PMC Article

Recent clinical studies

Etiology

Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Malignancies in Deceased Organ Donors: The Spanish Experience.
Mahíllo B, Martín S, Molano E, Navarro A, Castro P, Pont T, Andrés A, Galán J, López M, Oliver E, Martínez A, Mosteiro F, Roque R, Pérez-Redondo M, Cid-Cumplido M, Ballesteros MA, Daga D, Quindós B, Sancho M, Royo-Villanova M, Bernabé E, Muñoz R, Chacón JI, Coll E, Domínguez-Gil B
Transplantation 2022 Sep 1;106(9):1814-1823. Epub 2022 Apr 1 doi: 10.1097/TP.0000000000004117. PMID: 35421045
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621
Diagnosis of roentgenographically occult lung cancer by sputum cytology.
Petty TL, Tockman MS, Palcic B
Clin Chest Med 2002 Mar;23(1):59-64. doi: 10.1016/s0272-5231(03)00060-1. PMID: 11901920
Treatment of patients with cancer of unknown primary site.
Hainsworth JD, Greco FA
Important Adv Oncol 1991:173-90. PMID: 1869276

Diagnosis

Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Malignancies in Deceased Organ Donors: The Spanish Experience.
Mahíllo B, Martín S, Molano E, Navarro A, Castro P, Pont T, Andrés A, Galán J, López M, Oliver E, Martínez A, Mosteiro F, Roque R, Pérez-Redondo M, Cid-Cumplido M, Ballesteros MA, Daga D, Quindós B, Sancho M, Royo-Villanova M, Bernabé E, Muñoz R, Chacón JI, Coll E, Domínguez-Gil B
Transplantation 2022 Sep 1;106(9):1814-1823. Epub 2022 Apr 1 doi: 10.1097/TP.0000000000004117. PMID: 35421045
Preoperative evaluation of pancreatic adenocarcinoma.
Parsons CM, Sutcliffe JL, Bold RJ
J Hepatobiliary Pancreat Surg 2008;15(4):429-35. Epub 2008 Aug 1 doi: 10.1007/s00534-007-1240-7. PMID: 18670846
Diagnosis of roentgenographically occult lung cancer by sputum cytology.
Petty TL, Tockman MS, Palcic B
Clin Chest Med 2002 Mar;23(1):59-64. doi: 10.1016/s0272-5231(03)00060-1. PMID: 11901920
Bronchial carcinoid tumors.
Davila DG, Dunn WF, Tazelaar HD, Pairolero PC
Mayo Clin Proc 1993 Aug;68(8):795-803. doi: 10.1016/s0025-6196(12)60641-7. PMID: 8331983

Therapy

Predicting occult lymph node metastasis in solid-predominantly invasive lung adenocarcinoma across multiple centers using radiomics-deep learning fusion model.
Tian W, Yan Q, Huang X, Feng R, Shan F, Geng D, Zhang Z
Cancer Imaging 2024 Jan 12;24(1):8. doi: 10.1186/s40644-024-00654-2. PMID: 38216999Free PMC Article
Occult lymph node metastasis is not a favorable factor for resected NSCLC patients.
Cai JS, Yang F, Wang X
BMC Cancer 2023 Sep 4;23(1):822. doi: 10.1186/s12885-023-11189-3. PMID: 37667180Free PMC Article
Malignancies in Deceased Organ Donors: The Spanish Experience.
Mahíllo B, Martín S, Molano E, Navarro A, Castro P, Pont T, Andrés A, Galán J, López M, Oliver E, Martínez A, Mosteiro F, Roque R, Pérez-Redondo M, Cid-Cumplido M, Ballesteros MA, Daga D, Quindós B, Sancho M, Royo-Villanova M, Bernabé E, Muñoz R, Chacón JI, Coll E, Domínguez-Gil B
Transplantation 2022 Sep 1;106(9):1814-1823. Epub 2022 Apr 1 doi: 10.1097/TP.0000000000004117. PMID: 35421045
Cabergoline in severe ectopic or occult Cushing's syndrome.
Ilie MD, Raverot V, Tronc F, Vasiljevic A, Borson-Chazot F, Raverot G
Eur J Endocrinol 2019 Jul 1;181(1):K1-K9. doi: 10.1530/EJE-18-1014. PMID: 31048558
Occult retroperitoneal carcinoid tumor with flushing and solitary lung metastasis.
Jackson JA, Shipman HD
West J Med 1989 Oct;151(4):461-3. PMID: 2588586Free PMC Article

Prognosis

A gene-based score for the risk stratification of stage IA lung adenocarcinoma.
Xiong Y, Ma Y, Liu K, Lei J, Zhao J, Zhu J, Wang W, Wen M, Wang X, Sun Y, Zhao Y, Han Y, Jiang T, Liu Y
Respir Res 2024 Jan 4;25(1):18. doi: 10.1186/s12931-023-02647-4. PMID: 38178073Free PMC Article
Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621
Bronchial carcinoid tumors.
Davila DG, Dunn WF, Tazelaar HD, Pairolero PC
Mayo Clin Proc 1993 Aug;68(8):795-803. doi: 10.1016/s0025-6196(12)60641-7. PMID: 8331983

Clinical prediction guides

Predicting occult lymph node metastasis in solid-predominantly invasive lung adenocarcinoma across multiple centers using radiomics-deep learning fusion model.
Tian W, Yan Q, Huang X, Feng R, Shan F, Geng D, Zhang Z
Cancer Imaging 2024 Jan 12;24(1):8. doi: 10.1186/s40644-024-00654-2. PMID: 38216999Free PMC Article
A gene-based score for the risk stratification of stage IA lung adenocarcinoma.
Xiong Y, Ma Y, Liu K, Lei J, Zhao J, Zhu J, Wang W, Wen M, Wang X, Sun Y, Zhao Y, Han Y, Jiang T, Liu Y
Respir Res 2024 Jan 4;25(1):18. doi: 10.1186/s12931-023-02647-4. PMID: 38178073Free PMC Article
Stroke and cancer.
Zuber M
Rev Neurol (Paris) 2023 Jun;179(5):417-424. Epub 2023 Apr 4 doi: 10.1016/j.neurol.2023.03.009. PMID: 37024364
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Malignancy in myositis.
Zahr ZA, Baer AN
Curr Rheumatol Rep 2011 Jun;13(3):208-15. doi: 10.1007/s11926-011-0169-7. PMID: 21336621

Recent systematic reviews

Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.
Klimek M
Postgrad Med 2019 Jun;131(5):309-318. Epub 2019 Apr 5 doi: 10.1080/00325481.2019.1595982. PMID: 30900501
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

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