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Cervical Mucoepidermoid Carcinoma

MedGen UID:
1793125
•Concept ID:
C5556684
•
Neoplastic Process

Definition

A rare carcinoma that arises from the cervix. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Mucoepidermoid Carcinoma

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.
Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment.
Healey WV, Perzin KH, Smith L
Cancer 1970 Aug;26(2):368-88. doi: 10.1002/1097-0142(197008)26:2<368::aid-cncr2820260219>3.0.co;2-k. PMID: 5451215

Recent clinical studies

Etiology

A molecular guide to systemic therapy in salivary gland carcinoma.
Weaver AN, Lakritz S, Mandair D, Ulanja MB, Bowles DW
Head Neck 2023 May;45(5):1315-1326. Epub 2023 Mar 1 doi: 10.1002/hed.27307. PMID: 36859797
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Diagnosis and Management of Malignant Salivary Gland Tumors of the Parotid Gland.
Lewis AG, Tong T, Maghami E
Otolaryngol Clin North Am 2016 Apr;49(2):343-80. doi: 10.1016/j.otc.2015.11.001. PMID: 27040585
Sinonasal carcinomas: epidemiology, pathology, and management.
Haerle SK, Gullane PJ, Witterick IJ, Zweifel C, Gentili F
Neurosurg Clin N Am 2013 Jan;24(1):39-49. Epub 2012 Sep 10 doi: 10.1016/j.nec.2012.08.004. PMID: 23174356

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
The Evaluation and Management of Carcinoma of the Minor Salivary Glands.
Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489
Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.
Schvartsman G, Pinto NA, Bell D, Ferrarotto R
Head Neck 2019 Jan;41(1):239-247. Epub 2018 Dec 15 doi: 10.1002/hed.25468. PMID: 30552848
Mucoepidermoid carcinoma.
Devaraju R, Gantala R, Aitha H, Gotoor SG
BMJ Case Rep 2014 Aug 1;2014:bcr-2013-202776. doi: 10.1136/bcr-2013-202776. PMID: 25085946Free PMC Article
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Therapy

Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.
Schvartsman G, Pinto NA, Bell D, Ferrarotto R
Head Neck 2019 Jan;41(1):239-247. Epub 2018 Dec 15 doi: 10.1002/hed.25468. PMID: 30552848
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Mucoepidermoid carcinoma post-radioactive iodine treatment of papillary thyroid carcinoma: unique presentation and putative etiologic association.
Saluja K, Butler RT, Pytynia KB, Zhao B, Karni RJ, Weber RS, El-Naggar AK
Hum Pathol 2017 Oct;68:189-192. Epub 2017 May 10 doi: 10.1016/j.humpath.2017.04.019. PMID: 28499545
Sinonasal carcinomas: epidemiology, pathology, and management.
Haerle SK, Gullane PJ, Witterick IJ, Zweifel C, Gentili F
Neurosurg Clin N Am 2013 Jan;24(1):39-49. Epub 2012 Sep 10 doi: 10.1016/j.nec.2012.08.004. PMID: 23174356
Internal jugular vein patency in patients undergoing microvascular reconstruction.
Wax MK, Quraishi H, Rodman S, Granke K
Laryngoscope 1997 Sep;107(9):1245-8. doi: 10.1097/00005537-199709000-00016. PMID: 9292611

Prognosis

Update on the Treatment of Salivary Gland Carcinomas.
Gillard DM, Farzal Z, Ryan WR
Surg Oncol Clin N Am 2024 Oct;33(4):747-760. Epub 2024 Jul 16 doi: 10.1016/j.soc.2024.04.008. PMID: 39244292
Molecular Mechanisms of Carcinogenesis in Pediatric Airways Tumors.
Soloperto D, Gazzini S, Cerullo R
Int J Mol Sci 2023 Jan 22;24(3) doi: 10.3390/ijms24032195. PMID: 36768522Free PMC Article
Poorly differentiated mucoepidermoid carcinoma of the thyroid.
Lee K, Mirza O, Dobbs S, Jayaram S
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-236539. PMID: 33318270Free PMC Article
Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.
Schvartsman G, Pinto NA, Bell D, Ferrarotto R
Head Neck 2019 Jan;41(1):239-247. Epub 2018 Dec 15 doi: 10.1002/hed.25468. PMID: 30552848
Salivary mucoepidermoid carcinoma revisited.
Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Rinaldo A, Strojan P, Haigentz M Jr, Mendenhall WM, Takes RP, Vander Poorten V, Ferlito A
Eur Arch Otorhinolaryngol 2015 Apr;272(4):799-819. Epub 2014 Apr 26 doi: 10.1007/s00405-014-3053-z. PMID: 24771140

Clinical prediction guides

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Mucoepidermoid Carcinoma of the Parotid: Very Close Margins and Adjuvant Radiotherapy.
Zenga J, Yu Z, Parikh A, Chen JX, Lin DT, Emerick KS, Faquin WC, Varvares MA, Deschler DG
ORL J Otorhinolaryngol Relat Spec 2019;81(1):55-62. Epub 2019 Apr 2 doi: 10.1159/000497438. PMID: 30939481
Oncogenic DNA viruses found in salivary gland tumors.
Chen AA, Gheit T, Stellin M, Lupato V, Spinato G, Fuson R, Menegaldo A, Mckay-Chopin S, Dal Cin E, Tirelli G, Da Mosto MC, Tommasino M, Boscolo-Rizzo P
Oral Oncol 2017 Dec;75:106-110. Epub 2017 Nov 10 doi: 10.1016/j.oraloncology.2017.11.005. PMID: 29224806
Aggressive Salivary Malignancies at Early Stage: Outcomes and Implications for Treatment.
Eppsteiner RW, Fowlkes JW, Anderson CM, Robinson RA, Pagedar NA
Ann Otol Rhinol Laryngol 2017 Jul;126(7):525-529. Epub 2017 May 5 doi: 10.1177/0003489417702655. PMID: 28474964
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Recent systematic reviews

Diagnostic Reliability of CRTC1/3::MAML2 Gene Fusion Transcripts in Discriminating Histologically Similar Intraosseous Mucoepidermoid Carcinoma from Glandular Odontogenic Cyst: A Systematic Review and Meta-analysis.
Keerthika R, Devi A, Kamboj M, Sivakumar N, Vijayakumar G, Narwal A, Girdhar A
Head Neck Pathol 2023 Mar;17(1):233-245. Epub 2022 Nov 10 doi: 10.1007/s12105-022-01494-x. PMID: 36357765Free PMC Article
Clinicopathological Predictors of Survival for Parotid Mucoepidermoid Carcinoma: A Systematic Review.
Cheng EY, Kim JH, Grose EM, Philteos J, Levin M, de Almeida J, Goldstein D
Otolaryngol Head Neck Surg 2023 Apr;168(4):611-618. Epub 2023 Feb 5 doi: 10.1177/01945998221086845. PMID: 35316125
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Why is the histomorphological diagnosis of tumours of minor salivary glands much more difficult?
Ihrler S, Agaimy A, Guntinas-Lichius O, Haas CJ, Mollenhauer M, Sandison A, Greber L
Histopathology 2021 Nov;79(5):779-790. Epub 2021 Aug 18 doi: 10.1111/his.14421. PMID: 34042205
Survival and characteristics of pediatric salivary gland cancer: A systematic review and meta-analysis.
Zamani M, Grønhøj C, Schmidt Jensen J, von Buchwald C, Charabi BW, Hjuler T
Pediatr Blood Cancer 2019 Mar;66(3):e27543. Epub 2018 Oct 30 doi: 10.1002/pbc.27543. PMID: 30378272

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