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Female reproductive organ cancer

MedGen UID:
195944
•Concept ID:
C0699889
•
Neoplastic Process
Synonym: Malignant Female Reproductive System Neoplasm
 
Monarch Initiative: MONDO:0001416

Definition

A primary or metastatic malignant neoplasm involving the female reproductive system. Representative examples include endometrial carcinoma, cervical carcinoma, ovarian carcinoma, uterine corpus leiomyosarcoma, adenosarcoma, malignant mixed mesodermal (mullerian) tumor, and gestational choriocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFemale reproductive organ cancer

Professional guidelines

PubMed

Diagnosis and management of uterine fibroids: current trends and future strategies.
Ahmad A, Kumar M, Bhoi NR, Badruddeen, Akhtar J, Khan MI, Ajmal M, Ahmad M
J Basic Clin Physiol Pharmacol 2023 May 1;34(3):291-310. Epub 2023 Mar 30 doi: 10.1515/jbcpp-2022-0219. PMID: 36989026
Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline.
Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, Rosenthal SM, Safer JD, Tangpricha V, T'Sjoen GG
J Clin Endocrinol Metab 2017 Nov 1;102(11):3869-3903. doi: 10.1210/jc.2017-01658. PMID: 28945902
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Curated

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Suggested Reading

PubMed

Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version.
PDQ Cancer Genetics Editorial Board
2002 PMID: 26389258
Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version.
PDQ Cancer Genetics Editorial Board
2002 PMID: 26389210

Recent clinical studies

Etiology

Mitochondrial Dysfunction in PCOS: Insights into Reproductive Organ Pathophysiology.
Siemers KM, Klein AK, Baack ML
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713123. PMID: 37685928Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer.
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article
The Microbiome and Genitourinary Cancer: A Collaborative Review.
Markowski MC, Boorjian SA, Burton JP, Hahn NM, Ingersoll MA, Maleki Vareki S, Pal SK, Sfanos KS
Eur Urol 2019 Apr;75(4):637-646. Epub 2019 Jan 15 doi: 10.1016/j.eururo.2018.12.043. PMID: 30655087Free PMC Article
Epithelial ovarian cancer.
Ng JS, Low JJ, Ilancheran A
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):337-45. Epub 2012 Jan 24 doi: 10.1016/j.bpobgyn.2011.12.005. PMID: 22281513

Diagnosis

Revolutionizing the female reproductive system research using microfluidic chip platform.
Yan J, Wu T, Zhang J, Gao Y, Wu JM, Wang S
J Nanobiotechnology 2023 Dec 19;21(1):490. doi: 10.1186/s12951-023-02258-7. PMID: 38111049Free PMC Article
Endocrine disorders and fertility and pregnancy: An update.
Bendarska-Czerwińska A, Zmarzły N, Morawiec E, Panfil A, Bryś K, Czarniecka J, Ostenda A, Dziobek K, Sagan D, Boroń D, Michalski P, Pallazo-Michalska V, Grabarek BO
Front Endocrinol (Lausanne) 2022;13:970439. Epub 2023 Jan 17 doi: 10.3389/fendo.2022.970439. PMID: 36733805Free PMC Article
Role of m6A modification in female infertility and reproductive system diseases.
Chen J, Fang Y, Xu Y, Sun H
Int J Biol Sci 2022;18(9):3592-3604. Epub 2022 May 16 doi: 10.7150/ijbs.69771. PMID: 35813486Free PMC Article
The Role of Microbiota in the Immunopathogenesis of Endometrial Cancer.
Sobstyl M, Brecht P, Sobstyl A, Mertowska P, Grywalska E
Int J Mol Sci 2022 May 20;23(10) doi: 10.3390/ijms23105756. PMID: 35628566Free PMC Article
Endometrial Cancer: Genetic, Metabolic Characteristics, Therapeutic Strategies and Nanomedicine.
Cai Y, Wang B, Xu W, Liu K, Gao Y, Guo C, Chen J, Kamal MA, Yuan C
Curr Med Chem 2021;28(42):8755-8781. doi: 10.2174/0929867328666210705144456. PMID: 34225603

Therapy

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
The microbiome and gynaecological cancer development, prevention and therapy.
Łaniewski P, Ilhan ZE, Herbst-Kralovetz MM
Nat Rev Urol 2020 Apr;17(4):232-250. Epub 2020 Feb 18 doi: 10.1038/s41585-020-0286-z. PMID: 32071434Free PMC Article
Preservation of fertility in patients with cancer (Review).
Del-Pozo-Lérida S, Salvador C, Martínez-Soler F, Tortosa A, Perucho M, Giménez-Bonafé P
Oncol Rep 2019 May;41(5):2607-2614. Epub 2019 Mar 14 doi: 10.3892/or.2019.7063. PMID: 30896846
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Lancet 2005 May 14-20;365(9472):1687-717. doi: 10.1016/S0140-6736(05)66544-0. PMID: 15894097

Prognosis

Gynecological Cancers and Microbiota Dynamics: Insights into Pathogenesis and Therapy.
Cocomazzi G, Del Pup L, Contu V, Maggio G, Parmegiani L, Ciampaglia W, De Ruvo D, Faioli R, Maglione A, Baldini GM, Baldini D, Pazienza V
Int J Mol Sci 2024 Feb 13;25(4) doi: 10.3390/ijms25042237. PMID: 38396914Free PMC Article
Revolutionizing the female reproductive system research using microfluidic chip platform.
Yan J, Wu T, Zhang J, Gao Y, Wu JM, Wang S
J Nanobiotechnology 2023 Dec 19;21(1):490. doi: 10.1186/s12951-023-02258-7. PMID: 38111049Free PMC Article
The RANKL/RANK system in female reproductive organ tumors: A preclinical and clinical overview.
Monzó-Miralles A, Martín-González V, Smith-Ballester S, Iglesias-Miguel V, Cano A
Adv Clin Exp Med 2021 Sep;30(9):879-883. doi: 10.17219/acem/140422. PMID: 34435475
The Microbiome and Genitourinary Cancer: A Collaborative Review.
Markowski MC, Boorjian SA, Burton JP, Hahn NM, Ingersoll MA, Maleki Vareki S, Pal SK, Sfanos KS
Eur Urol 2019 Apr;75(4):637-646. Epub 2019 Jan 15 doi: 10.1016/j.eururo.2018.12.043. PMID: 30655087Free PMC Article
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985

Clinical prediction guides

Reducing Ovarian Cancer Mortality Through Early Detection: Approaches Using Circulating Biomarkers.
Trinidad CV, Tetlow AL, Bantis LE, Godwin AK
Cancer Prev Res (Phila) 2020 Mar;13(3):241-252. doi: 10.1158/1940-6207.CAPR-19-0184. PMID: 32132118Free PMC Article
Mitochondrial dynamics regulating chemoresistance in gynecological cancers.
Kong B, Tsuyoshi H, Orisaka M, Shieh DB, Yoshida Y, Tsang BK
Ann N Y Acad Sci 2015 Sep;1350:1-16. doi: 10.1111/nyas.12883. PMID: 26375862
PELVIS Syndrome.
Girard C, Bigorre M, Guillot B, Bessis D
Arch Dermatol 2006 Jul;142(7):884-8. doi: 10.1001/archderm.142.7.884. PMID: 16847205
Screening for endometrial cancer.
Robertson G
Med J Aust 2003 Jun 16;178(12):657-9. doi: 10.5694/j.1326-5377.2003.tb05400.x. PMID: 12797861
Tamoxifen and endometrial cancer: tamoxifen effects on the human female genital tract.
Cohen CJ
Semin Oncol 1997 Feb;24(1 Suppl 1):S1-55-S1-64. PMID: 9045317

Recent systematic reviews

Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Integrating HPV vaccination programs with enhanced cervical cancer screening and treatment, a systematic review.
Wirtz C, Mohamed Y, Engel D, Sidibe A, Holloway M, Bloem P, Kumar S, Brotherton J, Reis V, Morgan C
Vaccine 2022 Mar 31;40 Suppl 1:A116-A123. Epub 2021 Dec 1 doi: 10.1016/j.vaccine.2021.11.013. PMID: 34863615
Hormone Therapy and Other Treatments for Symptoms of Menopause.
Hill DA, Crider M, Hill SR
Am Fam Physician 2016 Dec 1;94(11):884-889. PMID: 27929271
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

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    Curated

    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

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    Reviews

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