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Cervical Undifferentiated Carcinoma

MedGen UID:
167261
•Concept ID:
C0850327
•
Neoplastic Process

Definition

A rare carcinoma that arises from the cervix and is characterized by the lack of specific cellular differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Undifferentiated Carcinoma

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Nasopharyngeal carcinoma: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up(†).
Bossi P, Chan AT, Licitra L, Trama A, Orlandi E, Hui EP, Halámková J, Mattheis S, Baujat B, Hardillo J, Smeele L, van Herpen C, Castro A, Machiels JP; ESMO Guidelines Committee. Electronic address: [email protected]; EURACAN
Ann Oncol 2021 Apr;32(4):452-465. Epub 2020 Dec 25 doi: 10.1016/j.annonc.2020.12.007. PMID: 33358989

Recent clinical studies

Etiology

Modern treatment of sinonasal undifferentiated carcinoma.
Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Management of lateral neck nodes in common and aggressive variants of thyroid cancer.
Shaha AR
Curr Opin Otolaryngol Head Neck Surg 2022 Apr 1;30(2):130-136. doi: 10.1097/MOO.0000000000000790. PMID: 35255050
Contemporary management of the neck in nasopharyngeal carcinoma.
Ng WT, Tsang RKY, Beitler JJ, de Bree R, Coca-Pelaz A, Eisbruch A, Guntinas-Lichius O, Lee AWM, Mäkitie AA, Mendenhall WM, Nuyts S, Rinaldo A, Robbins KT, Rodrigo JP, Silver CE, Simo R, Smee R, Strojan P, Takes RP, Ferlito A
Head Neck 2021 Jun;43(6):1949-1963. Epub 2021 Mar 29 doi: 10.1002/hed.26685. PMID: 33780074
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Eroded cervix.
Kroll UM
Br Med J 1970 Jun 13;2(5710):640-3. doi: 10.1136/bmj.2.5710.640. PMID: 5429107Free PMC Article

Diagnosis

Enlarging verrucous neck plaques.
Sadowsky LM, Mohammadi TM, Ladizinski B
Int J Dermatol 2020 Jul;59(7):e225-e227. Epub 2019 Sep 25 doi: 10.1111/ijd.14655. PMID: 31556093
Sinonasal Undifferentiated Carcinoma.
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835
Cervical lymph node evaluation and diagnosis.
Bryson TC, Shah GV, Srinivasan A, Mukherji SK
Otolaryngol Clin North Am 2012 Dec;45(6):1363-83. doi: 10.1016/j.otc.2012.08.007. PMID: 23153753
Retropharyngeal and prevertebral spaces: anatomic imaging and diagnosis.
Debnam JM, Guha-Thakurta N
Otolaryngol Clin North Am 2012 Dec;45(6):1293-310. doi: 10.1016/j.otc.2012.08.004. PMID: 23153750Free PMC Article
Eroded cervix.
Kroll UM
Br Med J 1970 Jun 13;2(5710):640-3. doi: 10.1136/bmj.2.5710.640. PMID: 5429107Free PMC Article

Therapy

Modern treatment of sinonasal undifferentiated carcinoma.
Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Near infrared photoimmunotherapy for cancers: A translational perspective.
Maruoka Y, Wakiyama H, Choyke PL, Kobayashi H
EBioMedicine 2021 Aug;70:103501. Epub 2021 Jul 28 doi: 10.1016/j.ebiom.2021.103501. PMID: 34332294Free PMC Article
Head and neck cancer: metronomic chemotherapy.
De Felice F, Musio D, Tombolini V
BMC Cancer 2015 Oct 12;15:677. doi: 10.1186/s12885-015-1705-z. PMID: 26459302Free PMC Article
The current role of systemic chemotherapy in the primary treatment of head and neck cancer.
Busch CJ, Tribius S, Schafhausen P, Knecht R
Cancer Treat Rev 2015 Mar;41(3):217-21. Epub 2015 Feb 7 doi: 10.1016/j.ctrv.2015.02.002. PMID: 25687982
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Prognosis

Management of lateral neck nodes in common and aggressive variants of thyroid cancer.
Shaha AR
Curr Opin Otolaryngol Head Neck Surg 2022 Apr 1;30(2):130-136. doi: 10.1097/MOO.0000000000000790. PMID: 35255050
Contemporary management of the neck in nasopharyngeal carcinoma.
Ng WT, Tsang RKY, Beitler JJ, de Bree R, Coca-Pelaz A, Eisbruch A, Guntinas-Lichius O, Lee AWM, Mäkitie AA, Mendenhall WM, Nuyts S, Rinaldo A, Robbins KT, Rodrigo JP, Silver CE, Simo R, Smee R, Strojan P, Takes RP, Ferlito A
Head Neck 2021 Jun;43(6):1949-1963. Epub 2021 Mar 29 doi: 10.1002/hed.26685. PMID: 33780074
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
Sinonasal Undifferentiated Carcinoma.
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835
Eroded cervix.
Kroll UM
Br Med J 1970 Jun 13;2(5710):640-3. doi: 10.1136/bmj.2.5710.640. PMID: 5429107Free PMC Article

Clinical prediction guides

MRI-based deep learning and radiomics for prediction of occult cervical lymph node metastasis and prognosis in early-stage oral and oropharyngeal squamous cell carcinoma: a diagnostic study.
Lan T, Kuang S, Liang P, Ning C, Li Q, Wang L, Wang Y, Lin Z, Hu H, Yang L, Li J, Liu J, Li Y, Wu F, Chai H, Song X, Huang Y, Duan X, Zeng D, Li J, Cao H
Int J Surg 2024 Aug 1;110(8):4648-4659. doi: 10.1097/JS9.0000000000001578. PMID: 38729119Free PMC Article
Surgical Management of the Neck in Oral Cavity Squamous Cell Carcinoma.
Mihulka O, Nisenbaum E, Nicolli E
Crit Rev Oncog 2024;29(3):25-31. doi: 10.1615/CritRevOncog.2023050817. PMID: 38683152
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review.
Attard A, Paladino NC, Lo Monte AI, Falco N, Melfa G, Rotolo G, Rizzuto S, Gulotta E, Salamone G, Bonventre S, Scerrino G, Cocorullo G
BMC Surg 2019 Apr 24;18(Suppl 1):112. doi: 10.1186/s12893-018-0435-y. PMID: 31074393Free PMC Article

Recent systematic reviews

Transoral robotic surgery vs. non-robotic surgeries for oropharyngeal squamous cell carcinoma: systematic review and meta-analysis.
Chen H, Liu Y, Huang D, Zhang X, She L
J Robot Surg 2023 Oct;17(5):2537-2546. Epub 2023 Aug 4 doi: 10.1007/s11701-023-01689-6. PMID: 37542007
Oxidative stress-related biomarkers in oral squamous cell carcinoma patients: a systematic review and meta-analysis.
Zhou Q, Ye F, Zhou Y
Biomark Med 2023 Mar;17(6):337-347. Epub 2023 Jun 7 doi: 10.2217/bmm-2022-0846. PMID: 37284735
2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Human papillomavirus infection and oral squamous cell carcinoma - a systematic review.
Melo BAC, Vilar LG, Oliveira NR, Lima PO, Pinheiro MB, Domingueti CP, Pereira MC
Braz J Otorhinolaryngol 2021 May-Jun;87(3):346-352. Epub 2020 Nov 29 doi: 10.1016/j.bjorl.2020.10.017. PMID: 33339760Free PMC Article
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article

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