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Uterine carcinosarcoma

MedGen UID:
83678
•Concept ID:
C0280630
•
Neoplastic Process
Synonyms: Carcinosarcoma of the Uterus; carcinosarcoma of the uterus; Carcinosarcoma of uterus; Malignant Mixed Mesodermal (Mullerian) Tumor of the Uterus; malignant mixed mesodermal (Mullerian) tumor of the uterus; malignant mixed mesodermal (Mullerian) tumour of the uterus; Malignant Mixed Mesodermal (Müllerian) Tumor of the Uterus; malignant mixed mesodermal (Müllerian) tumor of the uterus; malignant mixed mesodermal (Müllerian) tumour of the uterus; Malignant mixed Mullerian tumor of uterus; mixed mullerian sarcoma of uterus; Uterine Carcinosarcoma; uterine carcinosarcoma; uterine carcinosarcoma/uterine malignant mixed mullerian tumor; uterine carcinosarcoma/uterine malignant mixed mullerian tumour; Uterine Malignant Mixed Mesodermal (Mullerian) Tumor; uterine malignant mixed mesodermal (Mullerian) tumor; uterine malignant mixed mesodermal (Mullerian) tumour; Uterine Malignant Mixed Mesodermal (Müllerian) Tumor; uterine malignant mixed mesodermal (Müllerian) tumor; uterine malignant mixed mesodermal (Müllerian) tumour; uterus carcinosarcoma
SNOMED CT: Uterine carcinosarcoma (702369008); Carcinosarcoma of uterus (702369008); Malignant mixed Mullerian tumor of uterus (702369008)
 
Monarch Initiative: MONDO:0006485

Definition

A usually aggressive malignant neoplasm arising from the uterine corpus and less often the cervix. It is characterized by the presence of two components: a malignant epithelial component and a sarcomatous component. In the uterine corpus the epithelial component is usually glandular whereas in the cervix is usually non-glandular. Carcinosarcoma of the cervix, although it is aggressive, it may have a better prognosis compared to the uterine corpus carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Abandon ifosfamide-based regimen and use paclitaxel-carboplatin regimen for the treatment of uterine carcinosarcoma.
Yang ST, Wang PH
J Chin Med Assoc 2022 May 1;85(5):649-650. Epub 2022 May 2 doi: 10.1097/JCMA.0000000000000729. PMID: 35385437
Uterine Carcinosarcomas - Diagnosis and Management.
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Clinical utility of CA-125 in the management of uterine carcinosarcoma.
Matsuo K, Ross MS, Yunokawa M, Johnson MS, Machida H, Omatsu K, Klobocista MM, Im DD, Satoh S, Baba T, Ikeda Y, Bush SH, Hasegawa K, Blake EA, Takekuma M, Shida M, Nishimura M, Adachi S, Pejovic T, Takeuchi S, Yokoyama T, Ueda Y, Iwasaki K, Miyake TM, Yanai S, Nagano T, Takano T, Shahzad MM, Ueland FR, Kelley JL, Roman LD
J Gynecol Oncol 2018 Nov;29(6):e88. doi: 10.3802/jgo.2018.29.e88. PMID: 30207096Free PMC Article

Recent clinical studies

Etiology

Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2-Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial.
Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
Management and Prognosis of Patients with Recurrent or Persistent/Progressive Uterine Carcinosarcoma.
Tung HJ, Chiang CY, Chang WY, Wu RC, Huang HJ, Yang LY, Lin CY, Wang CC, Chao A, Lai CH
Curr Oncol 2022 Oct 13;29(10):7607-7623. doi: 10.3390/curroncol29100601. PMID: 36290878Free PMC Article
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Cancer risks associated with the germline MITF(E318K) variant.
Guhan SM, Artomov M, McCormick S, Njauw C-, Stratigos AJ, Shannon K, Ellisen LW, Tsao H
Sci Rep 2020 Oct 13;10(1):17051. doi: 10.1038/s41598-020-74237-z. PMID: 33051548Free PMC Article
TCGA Classification of Endometrial Cancer: the Place of Carcinosarcoma.
Travaglino A, Raffone A, Gencarelli A, Mollo A, Guida M, Insabato L, Santoro A, Zannoni GF, Zullo F
Pathol Oncol Res 2020 Oct;26(4):2067-2073. Epub 2020 May 29 doi: 10.1007/s12253-020-00829-9. PMID: 32472441

Diagnosis

Beyond Serous: Treatment Options for Rare Endometrial Cancers.
Crane E
Curr Treat Options Oncol 2022 Nov;23(11):1590-1600. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01014-7. PMID: 36205807
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Uterine Carcinosarcomas.
Sagebiel TL, Bhosale PR, Patnana M, Faria SC, Devine CE
Semin Ultrasound CT MR 2019 Aug;40(4):295-301. Epub 2019 Mar 9 doi: 10.1053/j.sult.2019.03.004. PMID: 31375170
Uterine carcinosarcoma.
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326
Uterine carcinosarcoma.
El-Nashar SA, Mariani A
Clin Obstet Gynecol 2011 Jun;54(2):292-304. doi: 10.1097/GRF.0b013e31821ac635. PMID: 21508698

Therapy

Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2-Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial.
Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
Abandon ifosfamide-based regimen and use paclitaxel-carboplatin regimen for the treatment of uterine carcinosarcoma.
Yang ST, Wang PH
J Chin Med Assoc 2022 May 1;85(5):649-650. Epub 2022 May 2 doi: 10.1097/JCMA.0000000000000729. PMID: 35385437
Randomized Phase III Trial of Paclitaxel and Carboplatin Versus Paclitaxel and Ifosfamide in Patients With Carcinosarcoma of the Uterus or Ovary: An NRG Oncology Trial.
Powell MA, Filiaci VL, Hensley ML, Huang HQ, Moore KN, Tewari KS, Copeland LJ, Secord AA, Mutch DG, Santin A, Warshal DP, Spirtos NM, DiSilvestro PA, Ioffe OB, Miller DS
J Clin Oncol 2022 Mar 20;40(9):968-977. Epub 2022 Jan 10 doi: 10.1200/JCO.21.02050. PMID: 35007153Free PMC Article
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Uterine carcinosarcoma.
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326

Prognosis

Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
TCGA Classification of Endometrial Cancer: the Place of Carcinosarcoma.
Travaglino A, Raffone A, Gencarelli A, Mollo A, Guida M, Insabato L, Santoro A, Zannoni GF, Zullo F
Pathol Oncol Res 2020 Oct;26(4):2067-2073. Epub 2020 May 29 doi: 10.1007/s12253-020-00829-9. PMID: 32472441
Uterine Carcinosarcomas.
Sagebiel TL, Bhosale PR, Patnana M, Faria SC, Devine CE
Semin Ultrasound CT MR 2019 Aug;40(4):295-301. Epub 2019 Mar 9 doi: 10.1053/j.sult.2019.03.004. PMID: 31375170
Uterine sarcomas.
Ganjoo KN
Curr Probl Cancer 2019 Aug;43(4):283-288. Epub 2019 Jun 14 doi: 10.1016/j.currproblcancer.2019.06.001. PMID: 31235185
Uterine carcinosarcoma.
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326

Clinical prediction guides

Clinical and multiparametric MRI features for differentiating uterine carcinosarcoma from endometrioid adenocarcinoma.
Chen X, Guo Q, Chen X, Zheng W, Kang Y, Cao D
BMC Med Imaging 2024 Feb 19;24(1):48. doi: 10.1186/s12880-024-01225-4. PMID: 38373912Free PMC Article
APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2-Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial.
Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
The BRCAness Landscape of Cancer.
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
Cancer risks associated with the germline MITF(E318K) variant.
Guhan SM, Artomov M, McCormick S, Njauw C-, Stratigos AJ, Shannon K, Ellisen LW, Tsao H
Sci Rep 2020 Oct 13;10(1):17051. doi: 10.1038/s41598-020-74237-z. PMID: 33051548Free PMC Article

Recent systematic reviews

Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
TCGA Classification of Endometrial Cancer: the Place of Carcinosarcoma.
Travaglino A, Raffone A, Gencarelli A, Mollo A, Guida M, Insabato L, Santoro A, Zannoni GF, Zullo F
Pathol Oncol Res 2020 Oct;26(4):2067-2073. Epub 2020 May 29 doi: 10.1007/s12253-020-00829-9. PMID: 32472441
Target Therapies for Uterine Carcinosarcomas: Current Evidence and Future Perspectives.
Vitale SG, Laganà AS, Capriglione S, Angioli R, La Rosa VL, Lopez S, Valenti G, Sapia F, Sarpietro G, Butticè S, Tuscano C, Fanale D, Tropea A, Rossetti D
Int J Mol Sci 2017 May 20;18(5) doi: 10.3390/ijms18051100. PMID: 28531111Free PMC Article
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma.
Galaal K, van der Heijden E, Godfrey K, Naik R, Kucukmetin A, Bryant A, Das N, Lopes AD
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD006812. doi: 10.1002/14651858.CD006812.pub3. PMID: 23450572Free PMC Article
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma.
Galaal K, Godfrey K, Naik R, Kucukmetin A, Bryant A
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006812. doi: 10.1002/14651858.CD006812.pub2. PMID: 21249682Free PMC Article

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