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Recurrent Uterine Corpus Carcinosarcoma

MedGen UID:
1651247
•Concept ID:
C4744399
•
Neoplastic Process

Definition

The reemergence of uterine corpus carcinosarcoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Uterine Corpus Carcinosarcoma

Professional guidelines

PubMed

Treatment, results and prognostic factors in stage I and II sarcomas of the corpus uteri.
Vongtama V, Karlen JR, Piver SM, Tsukada Y, Moore RH
AJR Am J Roentgenol 1976 Jan;126(1):139-47. doi: 10.2214/ajr.126.1.139. PMID: 175673

Recent clinical studies

Etiology

Phase 2 study of anastrozole in rare cohorts of patients with estrogen receptor/progesterone receptor positive leiomyosarcomas and carcinosarcomas of the uterine corpus: The PARAGON trial (ANZGOG 0903).
Edmondson RJ, O'Connell RL, Banerjee S, Mileshkin L, Sykes P, Beale P, Fisher A, Bonaventura A, Millan D, Nottley S, Benson C, Hamilton A, Sjoquist K, Alexander L, Kelly C, Carty K, Divers L, Bradshaw N, Friedlander M; PARAGON investigators
Gynecol Oncol 2021 Dec;163(3):524-530. Epub 2021 Oct 5 doi: 10.1016/j.ygyno.2021.09.010. PMID: 34625284
FIGO 2018 stage IB endocervical adenocarcinomas: an international study of outcomes informed by prognostic biomarkers.
Stolnicu S, Boros M, Hoang L, Almadani N, de Brot L, Baiocchi G, Bonvolim G, Parra-Herran C, Lerias S, Felix A, Roma A, Pesci A, Oliva E, Park K, Soslow RA, Abu-Rustum NR
Int J Gynecol Cancer 2021 Feb;31(2):177-184. Epub 2020 Nov 11 doi: 10.1136/ijgc-2020-001893. PMID: 33177150Free PMC Article
Recent progress: gynecologic oncology group trials in uterine corpus tumors.
King LP, Miller DS
Rev Recent Clin Trials 2009 May;4(2):70-4. doi: 10.2174/157488709788186012. PMID: 19463102
Endometrial stromal sarcomas with extensive endometrioid glandular differentiation: report of a series with emphasis on the potential for misdiagnosis and discussion of the differential diagnosis.
McCluggage WG, Ganesan R, Herrington CS
Histopathology 2009 Feb;54(3):365-73. doi: 10.1111/j.1365-2559.2009.03230.x. PMID: 19236513
Pathologic variables and adjuvant therapy as predictors of recurrence and survival for patients with surgically evaluated carcinosarcoma of the uterus.
Yamada SD, Burger RA, Brewster WR, Anton D, Kohler MF, Monk BJ
Cancer 2000 Jun 15;88(12):2782-6. doi: 10.1002/1097-0142(20000615)88:12<2782::aid-cncr17>3.0.co;2-k. PMID: 10870061

Diagnosis

Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Primary osteosarcoma of the uterine cervix: A case report.
Tsuji K, Watanabe Y, Tokunaga H, Shimada M, Watanabe M, Yaegashi N
J Obstet Gynaecol Res 2017 Nov;43(11):1781-1783. Epub 2017 Aug 17 doi: 10.1111/jog.13443. PMID: 28815813
Humoral hypercalcemia caused by uterine corpus carcinosarcoma consisting of squamous cell carcinoma in its epithelial component.
Takamatsu S, Matsumura N, Baba T, Mandai M, Mikami Y, Konishi I
J Obstet Gynaecol Res 2014 Jan;40(1):263-7. Epub 2013 Sep 5 doi: 10.1111/jog.12136. PMID: 24033661
Carcinosarcoma of the corpus uteri (Malignant Müllerian Mixed Tumor): a case report in Yaoundé (Cameroon).
Sando Z, Fouelifack FY, Fouogue JT, Fouedjio JH, Anoudem CE, Nangue C
Pan Afr Med J 2013;16:145. Epub 2013 Dec 19 doi: 10.11604/pamj.2013.16.145.3497. PMID: 24876903Free PMC Article
Primary carcinosarcoma of the vagina.
Shibata R, Umezawa A, Takehara K, Aoki D, Nozawa S, Hata J
Pathol Int 2003 Feb;53(2):106-10. doi: 10.1046/j.1440-1827.2003.01442.x. PMID: 12588439

Therapy

Phase 2 study of anastrozole in rare cohorts of patients with estrogen receptor/progesterone receptor positive leiomyosarcomas and carcinosarcomas of the uterine corpus: The PARAGON trial (ANZGOG 0903).
Edmondson RJ, O'Connell RL, Banerjee S, Mileshkin L, Sykes P, Beale P, Fisher A, Bonaventura A, Millan D, Nottley S, Benson C, Hamilton A, Sjoquist K, Alexander L, Kelly C, Carty K, Divers L, Bradshaw N, Friedlander M; PARAGON investigators
Gynecol Oncol 2021 Dec;163(3):524-530. Epub 2021 Oct 5 doi: 10.1016/j.ygyno.2021.09.010. PMID: 34625284
Humoral hypercalcemia caused by uterine corpus carcinosarcoma consisting of squamous cell carcinoma in its epithelial component.
Takamatsu S, Matsumura N, Baba T, Mandai M, Mikami Y, Konishi I
J Obstet Gynaecol Res 2014 Jan;40(1):263-7. Epub 2013 Sep 5 doi: 10.1111/jog.12136. PMID: 24033661
Recent progress: gynecologic oncology group trials in uterine corpus tumors.
King LP, Miller DS
Rev Recent Clin Trials 2009 May;4(2):70-4. doi: 10.2174/157488709788186012. PMID: 19463102
Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET.
Torizuka T, Kanno T, Futatsubashi M, Okada H, Yoshikawa E, Nakamura F, Takekuma M, Maeda M, Ouchi Y
J Nucl Med 2003 Jul;44(7):1051-6. PMID: 12843219

Prognosis

Mesonephric-like Carcinosarcoma of the Uterine Corpus: Clinicopathological, Molecular and Prognostic Characteristics in Comparison With Uterine Mesonephric-like Adenocarcinoma and Conventional Endometrial Carcinosarcoma.
Park S, Park E, Kim HS
Cancer Genomics Proteomics 2022 Nov-Dec;19(6):747-760. doi: 10.21873/cgp.20357. PMID: 36316041Free PMC Article
Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Primary osteosarcoma of the uterine cervix: A case report.
Tsuji K, Watanabe Y, Tokunaga H, Shimada M, Watanabe M, Yaegashi N
J Obstet Gynaecol Res 2017 Nov;43(11):1781-1783. Epub 2017 Aug 17 doi: 10.1111/jog.13443. PMID: 28815813
Carcinosarcoma of the corpus uteri (Malignant Müllerian Mixed Tumor): a case report in Yaoundé (Cameroon).
Sando Z, Fouelifack FY, Fouogue JT, Fouedjio JH, Anoudem CE, Nangue C
Pan Afr Med J 2013;16:145. Epub 2013 Dec 19 doi: 10.11604/pamj.2013.16.145.3497. PMID: 24876903Free PMC Article
Treatment, results and prognostic factors in stage I and II sarcomas of the corpus uteri.
Vongtama V, Karlen JR, Piver SM, Tsukada Y, Moore RH
AJR Am J Roentgenol 1976 Jan;126(1):139-47. doi: 10.2214/ajr.126.1.139. PMID: 175673

Clinical prediction guides

Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET.
Torizuka T, Kanno T, Futatsubashi M, Okada H, Yoshikawa E, Nakamura F, Takekuma M, Maeda M, Ouchi Y
J Nucl Med 2003 Jul;44(7):1051-6. PMID: 12843219
Pathologic variables and adjuvant therapy as predictors of recurrence and survival for patients with surgically evaluated carcinosarcoma of the uterus.
Yamada SD, Burger RA, Brewster WR, Anton D, Kohler MF, Monk BJ
Cancer 2000 Jun 15;88(12):2782-6. doi: 10.1002/1097-0142(20000615)88:12<2782::aid-cncr17>3.0.co;2-k. PMID: 10870061

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