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Disorder of the genitourinary system

MedGen UID:
508335
•Concept ID:
C0080276
•
Disease or Syndrome
Synonyms: Disease, Genitourinary; Disease, Urogenital; Genitourinary Disease; Genitourinary Diseases; Urogenital Disease; Urogenital Diseases
SNOMED CT: Disorder of the genitourinary system (42030000); Urogenital disorder (42030000); Disorder of genitourinary system (42030000); Syndrome of the genitourinary system (42030000); Urogenital disease (42030000)

Definition

A non-neoplastic or neoplastic disorder that affects the genitourinary system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of the genitourinary system

Professional guidelines

PubMed

KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group
Kidney Int 2024 Apr;105(4S):S117-S314. doi: 10.1016/j.kint.2023.10.018. PMID: 38490803
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases.
Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group
Kidney Int 2021 Oct;100(4S):S1-S276. doi: 10.1016/j.kint.2021.05.021. PMID: 34556256
Clinical practice guideline on diagnosis and treatment of hyponatraemia.
Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn EJ, Ichai C, Joannidis M, Soupart A, Zietse R, Haller M, van der Veer S, Van Biesen W, Nagler E; Hyponatraemia Guideline Development Group
Eur J Endocrinol 2014 Mar;170(3):G1-47. Epub 2014 Feb 25 doi: 10.1530/EJE-13-1020. PMID: 24569125

Recent clinical studies

Etiology

Safety of Vaginal Estrogen Therapy for Genitourinary Syndrome of Menopause in Women With a History of Breast Cancer.
Agrawal P, Singh SM, Able C, Dumas K, Kohn J, Kohn TP, Clifton M
Obstet Gynecol 2023 Sep 1;142(3):660-668. Epub 2023 Aug 3 doi: 10.1097/AOG.0000000000005294. PMID: 37535961
Practical Treatment Considerations in the Management of Genitourinary Syndrome of Menopause.
Kagan R, Kellogg-Spadt S, Parish SJ
Drugs Aging 2019 Oct;36(10):897-908. doi: 10.1007/s40266-019-00700-w. PMID: 31452067Free PMC Article
The Burden of Candidate Pathogenic Variants for Kidney and Genitourinary Disorders Emerging From Exome Sequencing.
Rasouly HM, Groopman EE, Heyman-Kantor R, Fasel DA, Mitrotti A, Westland R, Bier L, Weng C, Ren Z, Copeland B, Krithivasan P, Chung WK, Sanna-Cherchi S, Goldstein DB, Gharavi AG
Ann Intern Med 2019 Jan 1;170(1):11-21. Epub 2018 Nov 27 doi: 10.7326/M18-1241. PMID: 30476936
Artificial sphincter.
Amend B, Toomey P, Sievert KD
Curr Opin Urol 2013 Nov;23(6):520-7. doi: 10.1097/01.MOU.0000434591.02823.d0. PMID: 24080811
The dynias.
Wesselmann U, Reich SG
Semin Neurol 1996 Mar;16(1):63-74. doi: 10.1055/s-2008-1040961. PMID: 8879059

Diagnosis

Genitourinary Syndrome of Menopause.
Cox S, Nasseri R, Rubin RS, Santiago-Lastra Y
Med Clin North Am 2023 Mar;107(2):357-369. doi: 10.1016/j.mcna.2022.10.017. PMID: 36759102
Genitourinary syndrome of menopause.
Briggs P
Post Reprod Health 2020 Jun;26(2):111-114. Epub 2019 Oct 23 doi: 10.1177/2053369119884144. PMID: 31645194
Practical Treatment Considerations in the Management of Genitourinary Syndrome of Menopause.
Kagan R, Kellogg-Spadt S, Parish SJ
Drugs Aging 2019 Oct;36(10):897-908. doi: 10.1007/s40266-019-00700-w. PMID: 31452067Free PMC Article
Diffusion-Weighted Genitourinary Imaging.
Maurer MH, Härmä KH, Thoeny H
Radiol Clin North Am 2017 Mar;55(2):393-411. Epub 2016 Dec 5 doi: 10.1016/j.rcl.2016.10.014. PMID: 28126222
Low back pain.
Deyo RA, Weinstein JN
N Engl J Med 2001 Feb 1;344(5):363-70. doi: 10.1056/NEJM200102013440508. PMID: 11172169

Therapy

Critical analysis of methods for assessing genitourinary syndrome of menopause used in clinical trials.
Lima SMRR, Honorato JV
Menopause 2019 Dec;26(12):1436-1442. doi: 10.1097/GME.0000000000001406. PMID: 31644509
Practical Treatment Considerations in the Management of Genitourinary Syndrome of Menopause.
Kagan R, Kellogg-Spadt S, Parish SJ
Drugs Aging 2019 Oct;36(10):897-908. doi: 10.1007/s40266-019-00700-w. PMID: 31452067Free PMC Article
Clinical trial design: The nobility of randomization.
Michael NL
Sci Transl Med 2017 Dec 6;9(419) doi: 10.1126/scitranslmed.aaq0810. PMID: 29212710
A primer on clinical trial design.
Ellimoottil C, Vijan S, Flanigan RC
Urol Oncol 2015 Mar;33(3):116-21. Epub 2015 Jan 23 doi: 10.1016/j.urolonc.2014.12.014. PMID: 25624092
Recurrent spontaneous abortion.
McIntyre JA, Coulam CB, Faulk WP
Am J Reprod Immunol 1989 Nov-Dec;21(3-4):100-4. doi: 10.1111/j.1600-0897.1989.tb01011.x. PMID: 2534830

Prognosis

Worldwide trends in cervical cancer incidence and mortality, with predictions for the next 15 years.
Lin S, Gao K, Gu S, You L, Qian S, Tang M, Wang J, Chen K, Jin M
Cancer 2021 Nov 1;127(21):4030-4039. Epub 2021 Aug 9 doi: 10.1002/cncr.33795. PMID: 34368955
Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369Free PMC Article
The frequency and outcome of lupus nephritis: results from an international inception cohort study.
Hanly JG, O'Keeffe AG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Fortin P, Gladman DD, Sanchez-Guerrero J, Petri M, Bruce IN, Dooley MA, Ramsey-Goldman R, Aranow C, Alarcón GS, Fessler BJ, Steinsson K, Nived O, Sturfelt GK, Manzi S, Khamashta MA, van Vollenhoven RF, Zoma AA, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Stoll T, Inanc M, Kalunian KC, Kamen DL, Maddison P, Peschken CA, Jacobsen S, Askanase A, Theriault C, Thompson K, Farewell V
Rheumatology (Oxford) 2016 Feb;55(2):252-62. Epub 2015 Sep 5 doi: 10.1093/rheumatology/kev311. PMID: 26342222Free PMC Article
Genitourinary trauma.
Shewakramani S, Reed KC
Emerg Med Clin North Am 2011 Aug;29(3):501-18. doi: 10.1016/j.emc.2011.04.009. PMID: 21782071
Obstetric hemorrhage.
Devine PC
Semin Perinatol 2009 Apr;33(2):76-81. doi: 10.1053/j.semperi.2008.12.004. PMID: 19324235

Clinical prediction guides

Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System).
Panebianco V, Narumi Y, Altun E, Bochner BH, Efstathiou JA, Hafeez S, Huddart R, Kennish S, Lerner S, Montironi R, Muglia VF, Salomon G, Thomas S, Vargas HA, Witjes JA, Takeuchi M, Barentsz J, Catto JWF
Eur Urol 2018 Sep;74(3):294-306. Epub 2018 May 10 doi: 10.1016/j.eururo.2018.04.029. PMID: 29755006Free PMC Article
The PROMIS of MRI.
Ahmed HU
BJU Int 2016 Jul;118(1):7. doi: 10.1111/bju.13547. PMID: 27311545
Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy.
Marconi L, Dabestani S, Lam TB, Hofmann F, Stewart F, Norrie J, Bex A, Bensalah K, Canfield SE, Hora M, Kuczyk MA, Merseburger AS, Mulders PFA, Powles T, Staehler M, Ljungberg B, Volpe A
Eur Urol 2016 Apr;69(4):660-673. Epub 2015 Aug 29 doi: 10.1016/j.eururo.2015.07.072. PMID: 26323946
An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction.
Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN; International Urogynecological Association; International Continence Society
Neurourol Urodyn 2010;29(1):4-20. doi: 10.1002/nau.20798. PMID: 19941278
Amniotic fluid assessment.
Williams K
Obstet Gynecol Surv 1993 Dec;48(12):795-800. doi: 10.1097/00006254-199312000-00005. PMID: 8309662

Recent systematic reviews

Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis.
Zheng SH, Chen XX, Chen Y, Wu ZC, Chen XQ, Li XL
Reprod Biol Endocrinol 2023 Aug 29;21(1):79. doi: 10.1186/s12958-023-01126-1. PMID: 37644533Free PMC Article
European Association of Urology Guidelines on the Diagnosis and Management of Female Non-neurogenic Lower Urinary Tract Symptoms. Part 1: Diagnostics, Overactive Bladder, Stress Urinary Incontinence, and Mixed Urinary Incontinence.
Nambiar AK, Arlandis S, Bø K, Cobussen-Boekhorst H, Costantini E, de Heide M, Farag F, Groen J, Karavitakis M, Lapitan MC, Manso M, Arteaga SM, Riogh ANA, O'Connor E, Omar MI, Peyronnet B, Phé V, Sakalis VI, Sihra N, Tzelves L, van Poelgeest-Pomfret ML, van den Bos TWL, van der Vaart H, Harding CK
Eur Urol 2022 Jul;82(1):49-59. Epub 2022 Feb 23 doi: 10.1016/j.eururo.2022.01.045. PMID: 35216856
Pelvic floor muscle training for preventing and treating urinary and faecal incontinence in antenatal and postnatal women.
Woodley SJ, Lawrenson P, Boyle R, Cody JD, Mørkved S, Kernohan A, Hay-Smith EJC
Cochrane Database Syst Rev 2020 May 6;5(5):CD007471. doi: 10.1002/14651858.CD007471.pub4. PMID: 32378735Free PMC Article
INFERTILITY AND SEXUAL DYSFUNCTIONS: A SYSTEMATIC LITERATURE REVIEW.
Starc A, Trampuš M, Pavan Jukić D, Rotim C, Jukić T, Polona Mivšek A
Acta Clin Croat 2019 Sep;58(3):508-515. doi: 10.20471/acc.2019.58.03.15. PMID: 31969764Free PMC Article
Prevalence of antenatal and postnatal anxiety: systematic review and meta-analysis.
Dennis CL, Falah-Hassani K, Shiri R
Br J Psychiatry 2017 May;210(5):315-323. Epub 2017 Mar 16 doi: 10.1192/bjp.bp.116.187179. PMID: 28302701

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