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Pregnancy disorder

MedGen UID:
56248
•Concept ID:
C0151864
•
Disease or Syndrome
Synonyms: complication of pregnancy or childbirth; complication, pregnancy; Complications, pregnancy; Disorder of pregnancy; disorder of pregnancy; disorder of pregnancy, childbirth, or puerperium; pregnancy complication; pregnancy disease; Pregnancy Disorder; pregnancy disorder
SNOMED CT: Disorder of pregnancy (173300003)
 
Monarch Initiative: MONDO:0024575

Definition

A disorder that is related to pregnancy. Representative examples include ectopic pregnancy, toxemia of pregnancy, and gestational trophoblastic tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPregnancy disorder

Professional guidelines

PubMed

Delivery outcomes in the subsequent pregnancy following the conservative management of placenta accreta spectrum disorder: a systematic review and meta-analysis.
Javinani A, Qaderi S, Hessami K, Shainker SA, Shamshirsaz AA, Fox KA, Mustafa HJ, Subramaniam A, Khandelwal M, Sandlin AT, Duzyj CM, Lyell DJ, Zuckerwise LC, Newton JM, Kingdom JC, Harrison RK, Shrivastava VK, Greiner AL, Loftin R, Genc MR, Atasi LK, Abdel-Razeq SS, Bennett KA, Carusi DA, Einerson BD, Gilner JB, Carver AR, Silver RM, Shamshirsaz AA
Am J Obstet Gynecol 2024 May;230(5):485-492.e7. Epub 2023 Nov 2 doi: 10.1016/j.ajog.2023.10.047. PMID: 37918506
The role of angiogenic factors in the management of preeclampsia.
Flint EJ, Cerdeira AS, Redman CW, Vatish M
Acta Obstet Gynecol Scand 2019 Jun;98(6):700-707. Epub 2019 Feb 22 doi: 10.1111/aogs.13540. PMID: 30667052
Pathophysiology and Current Clinical Management of Preeclampsia.
Amaral LM, Wallace K, Owens M, LaMarca B
Curr Hypertens Rep 2017 Aug;19(8):61. doi: 10.1007/s11906-017-0757-7. PMID: 28689331Free PMC Article

Recent clinical studies

Etiology

A Narrative Review on the Pathophysiology of Preeclampsia.
Torres-Torres J, Espino-Y-Sosa S, Martinez-Portilla R, Borboa-Olivares H, Estrada-Gutierrez G, Acevedo-Gallegos S, Ruiz-Ramirez E, Velasco-Espin M, Cerda-Flores P, Ramirez-Gonzalez A, Rojas-Zepeda L
Int J Mol Sci 2024 Jul 10;25(14) doi: 10.3390/ijms25147569. PMID: 39062815Free PMC Article
Noninvasive preeclampsia prediction using plasma cell-free RNA signatures.
Zhou S, Li J, Yang W, Xue P, Yin Y, Wang Y, Tian P, Peng H, Jiang H, Xu W, Huang S, Zhang R, Wei F, Sun HX, Zhang J, Zhao L
Am J Obstet Gynecol 2023 Nov;229(5):553.e1-553.e16. Epub 2023 May 19 doi: 10.1016/j.ajog.2023.05.015. PMID: 37211139
GDM-complicated pregnancies: focus on adipokines.
Mallardo M, Ferraro S, Daniele A, Nigro E
Mol Biol Rep 2021 Dec;48(12):8171-8180. Epub 2021 Oct 15 doi: 10.1007/s11033-021-06785-0. PMID: 34652617Free PMC Article
Pre-eclampsia.
Chappell LC, Cluver CA, Kingdom J, Tong S
Lancet 2021 Jul 24;398(10297):341-354. Epub 2021 May 27 doi: 10.1016/S0140-6736(20)32335-7. PMID: 34051884
Recurrent pregnancy loss.
Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ
Nat Rev Dis Primers 2020 Dec 10;6(1):98. doi: 10.1038/s41572-020-00228-z. PMID: 33303732

Diagnosis

H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia.
Deng J, Zhao HJ, Zhong Y, Hu C, Meng J, Wang C, Lan X, Wang X, Chen ZJ, Yan J, Wang W, Li Y
EBioMedicine 2023 Jul;93:104664. Epub 2023 Jun 16 doi: 10.1016/j.ebiom.2023.104664. PMID: 37331163Free PMC Article
Noninvasive preeclampsia prediction using plasma cell-free RNA signatures.
Zhou S, Li J, Yang W, Xue P, Yin Y, Wang Y, Tian P, Peng H, Jiang H, Xu W, Huang S, Zhang R, Wei F, Sun HX, Zhang J, Zhao L
Am J Obstet Gynecol 2023 Nov;229(5):553.e1-553.e16. Epub 2023 May 19 doi: 10.1016/j.ajog.2023.05.015. PMID: 37211139
Pre-eclampsia.
Chappell LC, Cluver CA, Kingdom J, Tong S
Lancet 2021 Jul 24;398(10297):341-354. Epub 2021 May 27 doi: 10.1016/S0140-6736(20)32335-7. PMID: 34051884
Recurrent pregnancy loss.
Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ
Nat Rev Dis Primers 2020 Dec 10;6(1):98. doi: 10.1038/s41572-020-00228-z. PMID: 33303732
Pelvic floor exercises during and after pregnancy: a systematic review of their role in preventing pelvic floor dysfunction.
Harvey MA
J Obstet Gynaecol Can 2003 Jun;25(6):487-98. doi: 10.1016/s1701-2163(16)30310-3. PMID: 12806450

Therapy

Pre-eclampsia.
Chappell LC, Cluver CA, Kingdom J, Tong S
Lancet 2021 Jul 24;398(10297):341-354. Epub 2021 May 27 doi: 10.1016/S0140-6736(20)32335-7. PMID: 34051884
Maternal microbiome in preeclampsia pathophysiology and implications on offspring health.
Ishimwe JA
Physiol Rep 2021 May;9(10):e14875. doi: 10.14814/phy2.14875. PMID: 34042284Free PMC Article
Pathophysiology and Current Clinical Management of Preeclampsia.
Amaral LM, Wallace K, Owens M, LaMarca B
Curr Hypertens Rep 2017 Aug;19(8):61. doi: 10.1007/s11906-017-0757-7. PMID: 28689331Free PMC Article
Pelvic floor exercises during and after pregnancy: a systematic review of their role in preventing pelvic floor dysfunction.
Harvey MA
J Obstet Gynaecol Can 2003 Jun;25(6):487-98. doi: 10.1016/s1701-2163(16)30310-3. PMID: 12806450
Autoimmune disease and pregnancy.
Jones WR
Aust N Z J Obstet Gynaecol 1994 Jun;34(3):251-8. doi: 10.1111/j.1479-828x.1994.tb01067.x. PMID: 7848194

Prognosis

Noninvasive preeclampsia prediction using plasma cell-free RNA signatures.
Zhou S, Li J, Yang W, Xue P, Yin Y, Wang Y, Tian P, Peng H, Jiang H, Xu W, Huang S, Zhang R, Wei F, Sun HX, Zhang J, Zhao L
Am J Obstet Gynecol 2023 Nov;229(5):553.e1-553.e16. Epub 2023 May 19 doi: 10.1016/j.ajog.2023.05.015. PMID: 37211139
GDM-complicated pregnancies: focus on adipokines.
Mallardo M, Ferraro S, Daniele A, Nigro E
Mol Biol Rep 2021 Dec;48(12):8171-8180. Epub 2021 Oct 15 doi: 10.1007/s11033-021-06785-0. PMID: 34652617Free PMC Article
Pre-eclampsia.
Chappell LC, Cluver CA, Kingdom J, Tong S
Lancet 2021 Jul 24;398(10297):341-354. Epub 2021 May 27 doi: 10.1016/S0140-6736(20)32335-7. PMID: 34051884
Recurrent pregnancy loss.
Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ
Nat Rev Dis Primers 2020 Dec 10;6(1):98. doi: 10.1038/s41572-020-00228-z. PMID: 33303732
Preeclampsia and Extracellular Vesicles.
Gilani SI, Weissgerber TL, Garovic VD, Jayachandran M
Curr Hypertens Rep 2016 Sep;18(9):68. doi: 10.1007/s11906-016-0678-x. PMID: 27590522Free PMC Article

Clinical prediction guides

Early prediction of pre-eclampsia using circulating placental exosomes: Newer insights.
Rao A, Shinde U, Das DK, Balasinor N, Madan T
Indian J Med Res 2023 Oct 1;158(4):385-396. Epub 2023 Sep 25 doi: 10.4103/ijmr.ijmr_2143_22. PMID: 37987999Free PMC Article
Noninvasive preeclampsia prediction using plasma cell-free RNA signatures.
Zhou S, Li J, Yang W, Xue P, Yin Y, Wang Y, Tian P, Peng H, Jiang H, Xu W, Huang S, Zhang R, Wei F, Sun HX, Zhang J, Zhao L
Am J Obstet Gynecol 2023 Nov;229(5):553.e1-553.e16. Epub 2023 May 19 doi: 10.1016/j.ajog.2023.05.015. PMID: 37211139
Recurrent pregnancy loss.
Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ
Nat Rev Dis Primers 2020 Dec 10;6(1):98. doi: 10.1038/s41572-020-00228-z. PMID: 33303732
The role of angiogenic factors in the management of preeclampsia.
Flint EJ, Cerdeira AS, Redman CW, Vatish M
Acta Obstet Gynecol Scand 2019 Jun;98(6):700-707. Epub 2019 Feb 22 doi: 10.1111/aogs.13540. PMID: 30667052
The perplexing pregnancy disorder preeclampsia: what next?
Roberts JM
Physiol Genomics 2018 Jun 1;50(6):459-467. Epub 2018 Mar 30 doi: 10.1152/physiolgenomics.00017.2018. PMID: 29602298

Recent systematic reviews

Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review.
Wang T, Jiang R, Yao Y, Xu T, Li N
Hypertens Pregnancy 2024 Dec;43(1):2329068. Epub 2024 Mar 15 doi: 10.1080/10641955.2024.2329068. PMID: 38488570
Efficient administration of a combination of nifedipine and sildenafil citrate versus only nifedipine on clinical outcomes in women with threatened preterm labor: a systematic review and meta-analysis.
Manouchehri E, Makvandi S, Razi M, Sahebari M, Larki M
BMC Pediatr 2024 Feb 10;24(1):106. doi: 10.1186/s12887-024-04588-3. PMID: 38341578Free PMC Article
The impact of flood on pregnancy outcomes: A review article.
Partash N, Naghipour B, Rahmani SH, Pashaei Asl Y, Arjmand A, Ashegvatan A, Faridaalaee G
Taiwan J Obstet Gynecol 2022 Jan;61(1):10-14. doi: 10.1016/j.tjog.2021.11.005. PMID: 35181015
Increasing prevalence of gestational diabetes mellitus when carrying the T variant allele of the MTHFR gene C677T polymorphism: a systematic review and meta-analysis.
Chen Y, Lu M, Nie J, Liu J, Liu Y, Meng Y, Sun X, Ji C, Zhang J, Yang X
Arch Gynecol Obstet 2022 May;305(5):1193-1202. Epub 2021 Oct 25 doi: 10.1007/s00404-021-06303-4. PMID: 34694432
Pelvic floor exercises during and after pregnancy: a systematic review of their role in preventing pelvic floor dysfunction.
Harvey MA
J Obstet Gynaecol Can 2003 Jun;25(6):487-98. doi: 10.1016/s1701-2163(16)30310-3. PMID: 12806450

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