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Urothelial neoplasm

MedGen UID:
275551
•Concept ID:
C1519840
•
Neoplastic Process
Synonyms: neoplasm of urothelium; Transitional Cell Neoplasm of the Urinary Tract; transitional cell neoplasm of the urinary tract; tumor of urothelium; tumour of urothelium; Urothelial Neoplasm; urothelial neoplasm; urothelium neoplasm; urothelium neoplasm (disease); urothelium tumor; urothelium tumour
 
Monarch Initiative: MONDO:0024337

Definition

A benign or malignant neoplasm that arises from the urothelial lining of the urinary tract (bladder, renal pelvis, ureter, or urethra). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrothelial neoplasm

Recent clinical studies

Etiology

Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Contemporary Grading and Staging of Urothelial Neoplasms of the Urinary Bladder: New Concepts and Approaches to Challenging Scenarios.
Gallan AJ, Choy B, Paner GP
Surg Pathol Clin 2018 Dec;11(4):775-795. doi: 10.1016/j.path.2018.07.006. PMID: 30447841
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article

Diagnosis

Nephrogenic Adenoma Intermixed With Urothelial Carcinoma.
Kryvenko ON, Wasco MJ, Williamson SR
Arch Pathol Lab Med 2022 May 1;147(5):552-558. doi: 10.5858/arpa.2021-0620-OA. PMID: 35976666
Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
Contemporary Grading and Staging of Urothelial Neoplasms of the Urinary Bladder: New Concepts and Approaches to Challenging Scenarios.
Gallan AJ, Choy B, Paner GP
Surg Pathol Clin 2018 Dec;11(4):775-795. doi: 10.1016/j.path.2018.07.006. PMID: 30447841
Multimodality imaging in ureteric and periureteric pathologic abnormalities.
Wasnik AP, Elsayes KM, Kaza RK, Al-Hawary MM, Cohan RH, Francis IR
AJR Am J Roentgenol 2011 Dec;197(6):W1083-92. doi: 10.2214/AJR.11.6623. PMID: 22109323

Therapy

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Update on early instillation of chemotherapy after transurethral resection of non-muscle-invasive bladder cancer.
Oosterlinck W, Decaestecker K
Expert Rev Anticancer Ther 2018 May;18(5):437-443. Epub 2018 Mar 15 doi: 10.1080/14737140.2018.1451748. PMID: 29528758
Efficacy and Tolerability of Bacillus Calmette-Guérin Therapy as the First-Line Therapy for Upper Urinary Tract Carcinoma In Situ.
Tomisaki I, Kubo T, Minato A, Fujimoto N
Cancer Invest 2018 Feb 7;36(2):152-157. Epub 2018 Feb 2 doi: 10.1080/07357907.2018.1430815. PMID: 29393701
De Novo Bladder Urothelial Neoplasm in Renal Transplant Recipients: A Retrospective, Multicentered Study.
Palazzetti A, Bosio A, Dalmasso E, Destefanis P, Fop F, Pisano F, Segoloni G, Biancone L, Volpe A, Di Domenico A, Terrone C, Iesari S, Famulari A, Todeschini P, Frea B, Gontero P
Urol Int 2018;100(2):185-192. Epub 2018 Jan 17 doi: 10.1159/000481917. PMID: 29342465
Cisplatin-based combination chemotherapy in septuagenarians with metastatic urothelial cancer.
Galsky MD, Krege S, Lin CC, Hahn N, Ecke TH, Moshier E, Sonpavde G, Godbold J, Oh WK, Bamias A
Urol Oncol 2014 Jan;32(1):30.e15-21. Epub 2013 Feb 18 doi: 10.1016/j.urolonc.2012.11.001. PMID: 23428534

Prognosis

Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Noninvasive papillary urothelial neoplasia (NIPUN): Renaming cancer.
Jones TD, Cheng L
Urol Oncol 2021 May;39(5):286-290. Epub 2021 Jan 1 doi: 10.1016/j.urolonc.2020.12.007. PMID: 35550107
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Pearls and Pitfalls in Diagnosing Pediatric Urinary Bladder Masses.
Shelmerdine SC, Lorenzo AJ, Gupta AA, Chavhan GB
Radiographics 2017 Oct;37(6):1872-1891. doi: 10.1148/rg.2017170031. PMID: 29019749
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article

Clinical prediction guides

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Grading of Urothelial Carcinoma and The New "World Health Organisation Classification of Tumours of the Urinary System and Male Genital Organs 2016".
Compérat EM, Burger M, Gontero P, Mostafid AH, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Sylvester RJ, Zigeuner R, Babjuk M
Eur Urol Focus 2019 May;5(3):457-466. Epub 2018 Jan 20 doi: 10.1016/j.euf.2018.01.003. PMID: 29366854
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

Recent systematic reviews

Impact of implementing the first edition of the Paris system for reporting: A systematic review and meta-analysis.
Farahani SJ, Li J, Minder B, Vielh P, Glisic M, Muka T
Cytopathology 2024 Sep;35(5):616-633. Epub 2024 Jun 27 doi: 10.1111/cyt.13407. PMID: 38934101
Active surveillance for non-muscle invasive bladder cancer: A systematic review and pooled-analysis.
Petrelli F, Giannatempo P, Maccagnano C, Contieri R, Hurle R
Cancer Treat Res Commun 2021;27:100369. Epub 2021 Apr 3 doi: 10.1016/j.ctarc.2021.100369. PMID: 33838570

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      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

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