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Female Reproductive System Precancerous Condition

MedGen UID:
272628
•Concept ID:
C1333604
•
Disease or Syndrome

Definition

A precancerous lesion that arises from the female reproductive system. Representative examples include atypical endometrial hyperplasia, endometrial intraepithelial neoplasia, and cervical intraepithelial neoplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFemale Reproductive System Precancerous Condition

Professional guidelines

PubMed

A common clinical dilemma: Management of abnormal vaginal cytology and human papillomavirus test results.
Khan MJ, Massad LS, Kinney W, Gold MA, Mayeaux EJ Jr, Darragh TM, Castle PE, Chelmow D, Lawson HW, Huh WK
Gynecol Oncol 2016 May;141(2):364-370. Epub 2016 Feb 22 doi: 10.1016/j.ygyno.2015.11.023. PMID: 26915529Free PMC Article
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee
Obstet Gynecol 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. PMID: 23090535Free PMC Article
High-grade cervical dysplasia: pathophysiology, diagnosis, and treatment.
Zsemlye M
Obstet Gynecol Clin North Am 2008 Dec;35(4):615-21; ix. doi: 10.1016/j.ogc.2008.09.008. PMID: 19061820

Recent clinical studies

Etiology

Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features.
Wepy C, Nucci MR, Parra-Herran C
Int J Gynecol Pathol 2024 Jan 1;43(1):70-77. Epub 2023 Mar 13 doi: 10.1097/PGP.0000000000000952. PMID: 37043650
HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer.
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article
New concepts for an old problem: the diagnosis of endometrial hyperplasia.
Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066Free PMC Article

Diagnosis

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
The Origin of Ovarian Cancer Species and Precancerous Landscape.
Shih IM, Wang Y, Wang TL
Am J Pathol 2021 Jan;191(1):26-39. Epub 2020 Oct 1 doi: 10.1016/j.ajpath.2020.09.006. PMID: 33011111Free PMC Article
Vulvar Neoplasms, Benign and Malignant.
Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635
New concepts for an old problem: the diagnosis of endometrial hyperplasia.
Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066Free PMC Article
My approach to the interpretation of endometrial biopsies and curettings.
McCluggage WG
J Clin Pathol 2006 Aug;59(8):801-12. doi: 10.1136/jcp.2005.029702. PMID: 16873562Free PMC Article

Therapy

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
Cervicovaginal microbiome and natural history of HPV in a longitudinal study.
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses.
Arbyn M, Smith SB, Temin S, Sultana F, Castle P; Collaboration on Self-Sampling and HPV Testing
BMJ 2018 Dec 5;363:k4823. doi: 10.1136/bmj.k4823. PMID: 30518635Free PMC Article
Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model.
Jin BY, Campbell TE, Draper LM, Stevanović S, Weissbrich B, Yu Z, Restifo NP, Rosenberg SA, Trimble CL, Hinrichs CS
JCI Insight 2018 Apr 19;3(8) doi: 10.1172/jci.insight.99488. PMID: 29669936Free PMC Article
Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis.
Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis E
BMJ 2016 Jul 28;354:i3633. doi: 10.1136/bmj.i3633. PMID: 27469988Free PMC Article

Prognosis

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
Cervicovaginal microbiome and natural history of HPV in a longitudinal study.
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
Vulval squamous cell carcinoma and its precursors.
Singh N, Gilks CB
Histopathology 2020 Jan;76(1):128-138. doi: 10.1111/his.13989. PMID: 31846523
Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial.
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Controversies in borderline ovarian tumors.
Seong SJ, Kim DH, Kim MK, Song T
J Gynecol Oncol 2015 Oct;26(4):343-9. Epub 2015 Sep 23 doi: 10.3802/jgo.2015.26.4.343. PMID: 26404125Free PMC Article

Clinical prediction guides

Identification of cervical cancer stem cells using single-cell transcriptomes of normal cervix, cervical premalignant lesions, and cervical cancer.
Zhang T, Zhuang L, Muaibati M, Wang D, Abasi A, Tong Q, Ma D, Jin L, Huang X
EBioMedicine 2023 Jun;92:104612. Epub 2023 May 22 doi: 10.1016/j.ebiom.2023.104612. PMID: 37224771Free PMC Article
Cervical cytology reproducibility and associated clinical and demographic factors.
Hwang H, Follen M, Guillaud M, Scheurer M, MacAulay C, MacAulay C, Staerkel GA, van Niekerk D, Yamal JM
Diagn Cytopathol 2020 Jan;48(1):35-42. Epub 2019 Oct 22 doi: 10.1002/dc.24325. PMID: 31639288Free PMC Article
Prediction of Premalignant and Malignant Endometrial Polyps by Clinical and Hysteroscopic Features.
Shor S, Pansky M, Maymon R, Vaknin Z, Smorgick N
J Minim Invasive Gynecol 2019 Nov-Dec;26(7):1311-1315. Epub 2019 Jan 4 doi: 10.1016/j.jmig.2018.12.018. PMID: 30611972
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee
Obstet Gynecol 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. PMID: 23090535Free PMC Article
The importance of cryosurgery in gynecological practice.
Wojciech R
Ginekol Pol 2011 Aug;82(8):618-22. PMID: 21957608

Recent systematic reviews

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis.
Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L, Brusselaers N
BJOG 2020 Jan;127(2):171-180. Epub 2019 Jul 17 doi: 10.1111/1471-0528.15854. PMID: 31237400
Precancerous Cervical Lesion Among HIV-Positive Women in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.
Weldegebreal F, Worku T
Cancer Control 2019 Jan-Dec;26(1):1073274819845872. doi: 10.1177/1073274819845872. PMID: 31043067Free PMC Article
Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis.
Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis E
BMJ 2016 Jul 28;354:i3633. doi: 10.1136/bmj.i3633. PMID: 27469988Free PMC Article
Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis.
Gillet E, Meys JF, Verstraelen H, Verhelst R, De Sutter P, Temmerman M, Vanden Broeck D
PLoS One 2012;7(10):e45201. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0045201. PMID: 23056195Free PMC Article

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