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Herpes gestationis

MedGen UID:
9233
•Concept ID:
C0019343
•
Disease or Syndrome
Synonyms: Gestational pemphigoid; Pemphigoid gestationis
SNOMED CT: Pemphigoid gestationis (86081009); Herpes gestationis (86081009); Dermatitis herpetiformis of pregnancy (86081009)
 
Monarch Initiative: MONDO:0006558
Orphanet: ORPHA63275

Definition

A rare autoimmune bullous skin disease characterized by pruritus with or without polymorphic skin eruption, affecting pregnant women typically during the second and third trimester. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHerpes gestationis
Follow this link to review classifications for Herpes gestationis in Orphanet.

Professional guidelines

PubMed

Focus on primary care: pruritic dermatological conditions in pregnancy.
Sherard GB 3rd, Atkinson SM Jr
Obstet Gynecol Surv 2001 Jul;56(7):427-32. doi: 10.1097/00006254-200107000-00022. PMID: 11435950
Pyridoxine in the treatment of herpes gestationis.
FOSNAUGH RP, BRYAN HG, ORDERS RL
Arch Dermatol 1961 Jul;84:90-5. doi: 10.1001/archderm.1961.01580130096014. PMID: 13700942
Herpes gestationis; treatment with ACTH and cortisone.
ZAKON SJ, LEADER LO, SIEGEL I
Obstet Gynecol 1953 Jul;2(1):78-80. PMID: 13073084

Recent clinical studies

Etiology

Subepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.
Montagnon CM, Tolkachjov SN, Murrell DF, Camilleri MJ, Lehman JS
J Am Acad Dermatol 2021 Jul;85(1):1-14. Epub 2021 Mar 5 doi: 10.1016/j.jaad.2020.11.076. PMID: 33684496
Herpes gestationis.
Shornick JK
Dermatol Clin 1993 Jul;11(3):527-33. PMID: 8365037
Herpes gestationis.
Jørgensen EH, Clemmensen O, Anagnostaki L
Acta Obstet Gynecol Scand 1987;66(2):175-7. doi: 10.3109/00016348709083043. PMID: 3303816
Bullous dermatoses of pregnancy.
Honeyman JF, Eguiguren G, Pinto A, Honeyman AR, de la Parra MA, Navarrete W
Arch Dermatol 1981 May;117(5):264-7. PMID: 7013716
Herpes gestationis and the Rh factor.
CAWLEY EP, WHEELER CE, WILHITE PA
South Med J 1952 Sep;45(9):827-32. doi: 10.1097/00007611-195209000-00011. PMID: 13005060

Diagnosis

Subepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.
Montagnon CM, Tolkachjov SN, Murrell DF, Camilleri MJ, Lehman JS
J Am Acad Dermatol 2021 Jul;85(1):1-14. Epub 2021 Mar 5 doi: 10.1016/j.jaad.2020.11.076. PMID: 33684496
Pemphigoid 'herpes' gestationis.
Mayou SC, Black MM, Holmes RC
Semin Dermatol 1988 Jun;7(2):104-10. PMID: 3153431
Herpes gestationis.
Shornick JK
J Am Acad Dermatol 1987 Oct;17(4):539-56. doi: 10.1016/s0190-9622(87)70237-0. PMID: 3312312
Bullous pemphigoid.
Korman N
J Am Acad Dermatol 1987 May;16(5 Pt 1):907-24. doi: 10.1016/s0190-9622(87)70115-7. PMID: 3294944
Herpes gestationis.
Br Med J 1969 Nov 29;4(5682):516. PMID: 5354849Free PMC Article

Therapy

Pemphigoid 'herpes' gestationis.
Mayou SC, Black MM, Holmes RC
Semin Dermatol 1988 Jun;7(2):104-10. PMID: 3153431
Herpes gestationis.
Mahmoud F, De Silva K
Ceylon Med J 1972 Jun;17(2):99-101. PMID: 4659144
Herpes gestationis.
Greenbaum CH
Arch Dermatol 1971 Feb;103(2):218-9. doi: 10.1001/archderm.103.2.218. PMID: 5552346
Herpes gestationis.
Br Med J 1969 Nov 29;4(5682):516. PMID: 5354849Free PMC Article
Herpes gestationis.
OMENS D, OMENS H, BIELINSKI S
AMA Arch Derm Syphilol 1951 Nov;64(5):649-50. PMID: 14867900

Prognosis

Interleukin-1 levels in blister fluids of some skin diseases with blister formation.
Imaizumi T, Nomura K, Hashimoto I, Sawada Y
Clin Physiol Biochem 1990;8(4):179-83. PMID: 2078919
Pemphigoid 'herpes' gestationis.
Mayou SC, Black MM, Holmes RC
Semin Dermatol 1988 Jun;7(2):104-10. PMID: 3153431
Bullous pemphigoid.
Korman N
J Am Acad Dermatol 1987 May;16(5 Pt 1):907-24. doi: 10.1016/s0190-9622(87)70115-7. PMID: 3294944
Bullous dermatoses of pregnancy.
Honeyman JF, Eguiguren G, Pinto A, Honeyman AR, de la Parra MA, Navarrete W
Arch Dermatol 1981 May;117(5):264-7. PMID: 7013716
Herpes gestationis. A new assessment of incidence, diagnosis, and fetal prognosis.
Kolodny RC
Am J Obstet Gynecol 1969 May 1;104(1):39-45. doi: 10.1016/s0002-9378(16)34138-2. PMID: 5777701

Clinical prediction guides

New observations on pemphigoid 'herpes' gestationis.
Black MM
Dermatology 1994;189 Suppl 1:50-1. doi: 10.1159/000246929. PMID: 8049563
Cloning of partial cDNA for mouse 180-kDa bullous pemphigoid antigen (BPAG2), a highly conserved collagenous protein of the cutaneous basement membrane zone.
Li K, Guidice GJ, Tamai K, Do HC, Sawamura D, Diaz LA, Uitto J
J Invest Dermatol 1992 Sep;99(3):258-63. doi: 10.1111/1523-1747.ep12616611. PMID: 1512460
The role of complement-derived mediators in inflammatory skin diseases.
Tagami H
Arch Dermatol Res 1992;284 Suppl 1:S2-9. doi: 10.1007/BF00638232. PMID: 1285651
Interleukin-1 levels in blister fluids of some skin diseases with blister formation.
Imaizumi T, Nomura K, Hashimoto I, Sawada Y
Clin Physiol Biochem 1990;8(4):179-83. PMID: 2078919
Bullous pemphigoid, herpes gestationis and linear dermatitis herpetiformis: circulating anti-basement membrane zone antibodies; in vitro studies.
Pehamberger H, Gschnait F, Konrad K, Holubar K
J Invest Dermatol 1980 Feb;74(2):105-8. doi: 10.1111/1523-1747.ep12520017. PMID: 6985947

Recent systematic reviews

Specific dermatoses of pregnancy: an evidence-based systematic review.
Kroumpouzos G, Cohen LM
Am J Obstet Gynecol 2003 Apr;188(4):1083-92. doi: 10.1067/mob.2003.129. PMID: 12712115

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