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Microsatellite Stable Endometrial Carcinoma

MedGen UID:
1792734
Concept ID:
C5556293
Neoplastic Process

Definition

Endometrial carcinoma characterized by the absence of microsatellite instability. [from NCI]

Professional guidelines

PubMed

Bogani G, Monk BJ, Powell MA, Westin SN, Slomovitz B, Moore KN, Eskander RN, Raspagliesi F, Barretina-Ginesta MP, Colombo N, Mirza MR
Ann Oncol 2024 May;35(5):414-428. Epub 2024 Feb 29 doi: 10.1016/j.annonc.2024.02.006. PMID: 38431043
Karpel HC, Slomovitz B, Coleman RL, Pothuri B
Curr Opin Obstet Gynecol 2023 Jun 1;35(3):270-278. Epub 2023 Mar 20 doi: 10.1097/GCO.0000000000000855. PMID: 36943683
Stelloo E, Nout RA, Osse EM, Jürgenliemk-Schulz IJ, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Nijman HW, Putter H, Bosse T, Creutzberg CL, Smit VT
Clin Cancer Res 2016 Aug 15;22(16):4215-24. Epub 2016 Mar 22 doi: 10.1158/1078-0432.CCR-15-2878. PMID: 27006490

Recent clinical studies

Etiology

Powell MA, Bjørge L, Willmott L, Novák Z, Black D, Gilbert L, Sharma S, Valabrega G, Landrum LM, Gropp-Meier M, Stuckey A, Boere I, Gold MA, Segev Y, Gill SE, Gennigens C, Sebastianelli A, Shahin MS, Pothuri B, Monk BJ, Buscema J, Coleman RL, Slomovitz BM, Ring KL, Herzog TJ, Balas MM, Grimshaw M, Stevens S, Lai DW, McCourt C, Mirza MR
Ann Oncol 2024 Aug;35(8):728-738. Epub 2024 Jun 10 doi: 10.1016/j.annonc.2024.05.546. PMID: 38866180
Bogani G, Monk BJ, Powell MA, Westin SN, Slomovitz B, Moore KN, Eskander RN, Raspagliesi F, Barretina-Ginesta MP, Colombo N, Mirza MR
Ann Oncol 2024 May;35(5):414-428. Epub 2024 Feb 29 doi: 10.1016/j.annonc.2024.02.006. PMID: 38431043
Karpel HC, Slomovitz B, Coleman RL, Pothuri B
Curr Opin Obstet Gynecol 2023 Jun 1;35(3):270-278. Epub 2023 Mar 20 doi: 10.1097/GCO.0000000000000855. PMID: 36943683
Karpel H, Slomovitz B, Coleman RL, Pothuri B
Int J Gynecol Cancer 2023 Mar 6;33(3):343-350. doi: 10.1136/ijgc-2022-003676. PMID: 36878569
Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault M, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson MA, Janjigian Y, O'Reilly EM, Segal N, Saltz LB, Reidy-Lagunes D, Varghese AM, Bajorin D, Carlo MI, Cadoo K, Walsh MF, Weiser M, Aguilar JG, Klimstra DS, Diaz LA Jr, Baselga J, Zhang L, Ladanyi M, Hyman DM, Solit DB, Robson ME, Taylor BS, Offit K, Berger MF, Stadler ZK
J Clin Oncol 2019 Feb 1;37(4):286-295. Epub 2018 Oct 30 doi: 10.1200/JCO.18.00283. PMID: 30376427Free PMC Article

Diagnosis

Xiao Y, Yu X, Wang Y, Song G, Liu M, Wang D, Wang H
Sci Rep 2024 Feb 14;14(1):3738. doi: 10.1038/s41598-024-53338-z. PMID: 38355782Free PMC Article
Mendiola M, Heredia-Soto V, Ruz-Caracuel I, Baillo A, Ramon-Patino JL, Escudero FJ, Miguel M, Pelaez-Garcia A, Hernandez A, Feliu J, Hardisson D, Redondo A
Int J Mol Sci 2023 Sep 23;24(19) doi: 10.3390/ijms241914468. PMID: 37833916Free PMC Article
Gómez-Raposo C, Merino Salvador M, Aguayo Zamora C, García de Santiago B, Casado Sáenz E
Crit Rev Oncol Hematol 2021 May;161:103306. Epub 2021 Apr 8 doi: 10.1016/j.critrevonc.2021.103306. PMID: 33839243
Stelloo E, Jansen AML, Osse EM, Nout RA, Creutzberg CL, Ruano D, Church DN, Morreau H, Smit VTHBM, van Wezel T, Bosse T
Ann Oncol 2017 Jan 1;28(1):96-102. doi: 10.1093/annonc/mdw542. PMID: 27742654
Stelloo E, Nout RA, Osse EM, Jürgenliemk-Schulz IJ, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Nijman HW, Putter H, Bosse T, Creutzberg CL, Smit VT
Clin Cancer Res 2016 Aug 15;22(16):4215-24. Epub 2016 Mar 22 doi: 10.1158/1078-0432.CCR-15-2878. PMID: 27006490

Therapy

Bogani G, Monk BJ, Powell MA, Westin SN, Slomovitz B, Moore KN, Eskander RN, Raspagliesi F, Barretina-Ginesta MP, Colombo N, Mirza MR
Ann Oncol 2024 May;35(5):414-428. Epub 2024 Feb 29 doi: 10.1016/j.annonc.2024.02.006. PMID: 38431043
Karpel HC, Slomovitz B, Coleman RL, Pothuri B
Curr Opin Obstet Gynecol 2023 Jun 1;35(3):270-278. Epub 2023 Mar 20 doi: 10.1097/GCO.0000000000000855. PMID: 36943683
Mahdi H, Chelariu-Raicu A, Slomovitz BM
Int J Gynecol Cancer 2023 Mar 6;33(3):351-357. doi: 10.1136/ijgc-2022-003675. PMID: 36878570Free PMC Article
Karpel H, Slomovitz B, Coleman RL, Pothuri B
Int J Gynecol Cancer 2023 Mar 6;33(3):343-350. doi: 10.1136/ijgc-2022-003676. PMID: 36878569
Oaknin A, Gilbert L, Tinker AV, Brown J, Mathews C, Press J, Sabatier R, O'Malley DM, Samouelian V, Boni V, Duska L, Ghamande S, Ghatage P, Kristeleit R, Leath C III, Guo W, Im E, Zildjian S, Han X, Duan T, Veneris J, Pothuri B
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003777. PMID: 35064011Free PMC Article

Prognosis

Oaknin A, Pothuri B, Gilbert L, Sabatier R, Brown J, Ghamande S, Mathews C, O'Malley DM, Kristeleit R, Boni V, Gravina A, Banerjee S, Miller R, Pikiel J, Mirza MR, Dewal N, Antony G, Dong Y, Zografos E, Veneris J, Tinker AV
Clin Cancer Res 2023 Nov 14;29(22):4564-4574. doi: 10.1158/1078-0432.CCR-22-3915. PMID: 37363992Free PMC Article
Karpel HC, Slomovitz B, Coleman RL, Pothuri B
Curr Opin Obstet Gynecol 2023 Jun 1;35(3):270-278. Epub 2023 Mar 20 doi: 10.1097/GCO.0000000000000855. PMID: 36943683
Karpel H, Slomovitz B, Coleman RL, Pothuri B
Int J Gynecol Cancer 2023 Mar 6;33(3):343-350. doi: 10.1136/ijgc-2022-003676. PMID: 36878569
Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault M, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson MA, Janjigian Y, O'Reilly EM, Segal N, Saltz LB, Reidy-Lagunes D, Varghese AM, Bajorin D, Carlo MI, Cadoo K, Walsh MF, Weiser M, Aguilar JG, Klimstra DS, Diaz LA Jr, Baselga J, Zhang L, Ladanyi M, Hyman DM, Solit DB, Robson ME, Taylor BS, Offit K, Berger MF, Stadler ZK
J Clin Oncol 2019 Feb 1;37(4):286-295. Epub 2018 Oct 30 doi: 10.1200/JCO.18.00283. PMID: 30376427Free PMC Article
Stelloo E, Jansen AML, Osse EM, Nout RA, Creutzberg CL, Ruano D, Church DN, Morreau H, Smit VTHBM, van Wezel T, Bosse T
Ann Oncol 2017 Jan 1;28(1):96-102. doi: 10.1093/annonc/mdw542. PMID: 27742654

Clinical prediction guides

Patel SP, Alonso-Gordoa T, Banerjee S, Wang D, Naidoo J, Standifer NE, Palmer DC, Cheng LY, Kourtesis P, Ascierto ML, Das M, Diamond JR, Hellmann MD, Carneiro BA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-007340. PMID: 38309722Free PMC Article
Oaknin A, Pothuri B, Gilbert L, Sabatier R, Brown J, Ghamande S, Mathews C, O'Malley DM, Kristeleit R, Boni V, Gravina A, Banerjee S, Miller R, Pikiel J, Mirza MR, Dewal N, Antony G, Dong Y, Zografos E, Veneris J, Tinker AV
Clin Cancer Res 2023 Nov 14;29(22):4564-4574. doi: 10.1158/1078-0432.CCR-22-3915. PMID: 37363992Free PMC Article
Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault M, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson MA, Janjigian Y, O'Reilly EM, Segal N, Saltz LB, Reidy-Lagunes D, Varghese AM, Bajorin D, Carlo MI, Cadoo K, Walsh MF, Weiser M, Aguilar JG, Klimstra DS, Diaz LA Jr, Baselga J, Zhang L, Ladanyi M, Hyman DM, Solit DB, Robson ME, Taylor BS, Offit K, Berger MF, Stadler ZK
J Clin Oncol 2019 Feb 1;37(4):286-295. Epub 2018 Oct 30 doi: 10.1200/JCO.18.00283. PMID: 30376427Free PMC Article
Stelloo E, Jansen AML, Osse EM, Nout RA, Creutzberg CL, Ruano D, Church DN, Morreau H, Smit VTHBM, van Wezel T, Bosse T
Ann Oncol 2017 Jan 1;28(1):96-102. doi: 10.1093/annonc/mdw542. PMID: 27742654
Palles C, Cazier JB, Howarth KM, Domingo E, Jones AM, Broderick P, Kemp Z, Spain SL, Guarino E, Salguero I, Sherborne A, Chubb D, Carvajal-Carmona LG, Ma Y, Kaur K, Dobbins S, Barclay E, Gorman M, Martin L, Kovac MB, Humphray S; CORGI Consortium; WGS500 Consortium, Lucassen A, Holmes CC, Bentley D, Donnelly P, Taylor J, Petridis C, Roylance R, Sawyer EJ, Kerr DJ, Clark S, Grimes J, Kearsey SE, Thomas HJ, McVean G, Houlston RS, Tomlinson I
Nat Genet 2013 Feb;45(2):136-44. Epub 2012 Dec 23 doi: 10.1038/ng.2503. PMID: 23263490Free PMC Article

Recent systematic reviews

Ferrari FA, Uccella S, Franchi M, Scambia G, Fanfani F, Fagotti A, Pavone M, Raspagliesi F, Bogani G
Int J Gynecol Cancer 2025 Jan;35(1):100016. Epub 2024 Dec 18 doi: 10.1016/j.ijgc.2024.100016. PMID: 39878274

Supplemental Content

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