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Recurrent Endometrial Mixed Cell Adenocarcinoma

MedGen UID:
1663352
•Concept ID:
C4744400
•
Neoplastic Process
Synonym: Recurrent Endometrial Mixed Epithelial Carcinoma

Definition

The reemergence of endometrial mixed cell adenocarcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Endometrial Mixed Cell Adenocarcinoma

Professional guidelines

PubMed

The role of adjuvant treatment for early-stage uterine clear cell carcinomas.
Orellana TJ, Garrett AA, Soong TR, Rives T, Courtney-Brooks M, Taylor SE, Lesnock J, Berger J, Boisen M, Coffman L, Buckanovich R, Mahdi H, Comerci JC, Beriwal S, Sukumvanich P, Edwards RP, Bhargava R, Olawaiye AB
Gynecol Oncol 2023 Mar;170:77-83. Epub 2023 Jan 13 doi: 10.1016/j.ygyno.2022.12.024. PMID: 36641903Free PMC Article
Clinicopathologic features and treatment in patients with early stage uterine clear cell carcinoma: A 16-year experience.
Armbruster SD, Previs R, Soliman PT, Westin SN, Fellman B, Jhingran A, Fleming ND
Gynecol Oncol 2019 Aug;154(2):328-332. Epub 2019 Jun 18 doi: 10.1016/j.ygyno.2019.06.001. PMID: 31221496Free PMC Article
An Assessment of Prognostic Factors, Adjuvant Treatment, and Outcomes of Stage IA Polyp-Limited Versus Endometrium-Limited Type II Endometrial Carcinoma.
Liang LW, Perez AR, Cangemi NA, Zhou Q, Iasonos A, Abu-Rustum N, Alektiar KM, Makker V
Int J Gynecol Cancer 2016 Mar;26(3):497-504. doi: 10.1097/IGC.0000000000000635. PMID: 26825840Free PMC Article

Recent clinical studies

Etiology

Adjuvant brachytherapy for FIGO stage I serous or clear cell endometrial cancer.
Jeans EB, Breen WG, Mullikin TC, Looker BA, Mariani A, Keeney GL, Haddock MG, Petersen IA
Int J Gynecol Cancer 2021 Jun;31(6):859-867. Epub 2021 Feb 9 doi: 10.1136/ijgc-2020-002217. PMID: 33563642Free PMC Article
How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?
Thomakos N, Dimopoulou S, Sotiropoulou M, Machairiotis N, Pandraklakis A, Haidopoulos D, Liontos M, Bamias A, Rodolakis A
Horm Mol Biol Clin Investig 2020 Dec 18;42(1):105-111. doi: 10.1515/hmbci-2020-0042. PMID: 33781006
Clusterin immunoexpression is associated with early stage endometrial carcinomas.
Al-Maghrabi JA, Butt NS, Anfinan N, Sait K, Sait H, Bajouh O, Khabaz MN
Acta Histochem 2016 May;118(4):430-4. Epub 2016 Apr 11 doi: 10.1016/j.acthis.2016.04.003. PMID: 27079858
Comparison of pure and mixed-type clear cell carcinoma of the ovary: a clinicopathological analysis of 341 Chinese patients.
Ye S, You Y, Yang J, Cao D, Bai H, Huang H, Wu M, Chen J, Lang J, Shen K
Int J Gynecol Cancer 2014 Nov;24(9):1590-6. doi: 10.1097/IGC.0000000000000275. PMID: 25254564
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038

Diagnosis

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Primary mixed large cell neuroendocrine and high grade serous carcinoma of the endometrium.
Hardy LE, Chaudry Z, Wan K, Ayres C
BMJ Case Rep 2020 Sep 2;13(9) doi: 10.1136/bcr-2020-234977. PMID: 32878852Free PMC Article
Clusterin immunoexpression is associated with early stage endometrial carcinomas.
Al-Maghrabi JA, Butt NS, Anfinan N, Sait K, Sait H, Bajouh O, Khabaz MN
Acta Histochem 2016 May;118(4):430-4. Epub 2016 Apr 11 doi: 10.1016/j.acthis.2016.04.003. PMID: 27079858
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767

Therapy

Quality-of-Life Outcomes and Toxic Effects Among Patients With Cancers of the Uterus Treated With Stereotactic Pelvic Adjuvant Radiation Therapy: The SPARTACUS Phase 1/2 Nonrandomized Controlled Trial.
Leung E, Gladwish AP, Davidson M, Taggar A, Velker V, Barnes E, Mendez L, Donovan E, Gien LT, Covens A, Vicus D, Kupets R, MacKay H, Han K, Cheung P, Zhang L, Loblaw A, D'Souza DP
JAMA Oncol 2022 Jun 1;8(6):1-9. doi: 10.1001/jamaoncol.2022.0362. PMID: 35420695Free PMC Article
Low-dose adjuvant vaginal cylinder brachytherapy for early-stage non-endometrioid endometrial cancer: recurrence risk and survival outcomes.
Smart A, Buscariollo D, Alban G, Buzurovic I, Cheng T, Pretz J, Krechmer B, King M, Lee L
Int J Gynecol Cancer 2020 Dec;30(12):1908-1914. Epub 2020 Jul 12 doi: 10.1136/ijgc-2020-001623. PMID: 32655012
Carboplatin and nonpegylated liposomal doxorubicin in primary advanced or recurrent endometrial cancer: a phase 2 trial conducted by AGO Austria.
Volgger B, Zeimet AG, Reinthaller A, Petru E, Schauer C, Klein M, Sevelda-Schwarzgruber U, Bogner G, Wolfram G, Marth C
Int J Gynecol Cancer 2015 Feb;25(2):257-62. doi: 10.1097/IGC.0000000000000352. PMID: 25611899
Gemcitabine for advanced endometrial cancer: a retrospective study of the Memorial sloan-Kettering Cancer Center experience.
Grisham RN, Adaniel C, Hyman DM, Ma W, Iasonos A, Aghajanian C, Konner J
Int J Gynecol Cancer 2012 Jun;22(5):807-11. doi: 10.1097/IGC.0b013e31824a33a2. PMID: 22635030Free PMC Article
Gynecologic tumors in tamoxifen-treated women with breast cancer.
Seoud MA, Johnson J, Weed JC Jr
Obstet Gynecol 1993 Aug;82(2):165-9. PMID: 8393156

Prognosis

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
How do different histologic components of mixed endometrial carcinomas affect prognosis? Does it really matter?
Thomakos N, Dimopoulou S, Sotiropoulou M, Machairiotis N, Pandraklakis A, Haidopoulos D, Liontos M, Bamias A, Rodolakis A
Horm Mol Biol Clin Investig 2020 Dec 18;42(1):105-111. doi: 10.1515/hmbci-2020-0042. PMID: 33781006
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767
Estrogen and progesterone receptors in endometrial cancer and their prognostic relevance.
Kleine W, Maier T, Geyer H, Pfleiderer A
Gynecol Oncol 1990 Jul;38(1):59-65. doi: 10.1016/0090-8258(90)90012-a. PMID: 2141316

Clinical prediction guides

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Clinicopathological analysis of mixed endometrial carcinomas: clinical relevance of different neoplastic components.
Rossi ED, Bizzarro T, Monterossi G, Inzani F, Fanfani F, Scambia G, Zannoni GF
Hum Pathol 2017 Apr;62:99-107. Epub 2016 Dec 30 doi: 10.1016/j.humpath.2016.12.015. PMID: 28041971
Clusterin immunoexpression is associated with early stage endometrial carcinomas.
Al-Maghrabi JA, Butt NS, Anfinan N, Sait K, Sait H, Bajouh O, Khabaz MN
Acta Histochem 2016 May;118(4):430-4. Epub 2016 Apr 11 doi: 10.1016/j.acthis.2016.04.003. PMID: 27079858
Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases.
Scarfone G, Secomandi R, Parazzini F, Viganò R, Mangili G, Frigerio L, Villa A, Tateo S, Ricci E, Bolis G
Arch Gynecol Obstet 2013 Feb;287(2):351-6. Epub 2012 Oct 26 doi: 10.1007/s00404-012-2586-x. PMID: 23100038
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767

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