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No Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

MedGen UID:
1792875
Concept ID:
C5556434
Neoplastic Process
Synonyms: No Specific Molecular Profile Endometrial Endometrioid Carcinoma; NSMP Endometrial Endometrioid Adenocarcinoma; NSMP Endometrial Endometrioid Carcinoma

Definition

An endometrial endometrioid adenocarcinoma characterized by the absence of POLE gene mutations, mismatch repair (MMR) deficiency, and p53 gene mutations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNo Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

Professional guidelines

PubMed

Jia P, Zhang Y
BMC Womens Health 2024 Nov 15;24(1):607. doi: 10.1186/s12905-024-03449-6. PMID: 39548429Free PMC Article
Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
Stelloo E, Nout RA, Osse EM, Jürgenliemk-Schulz IJ, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Nijman HW, Putter H, Bosse T, Creutzberg CL, Smit VT
Clin Cancer Res 2016 Aug 15;22(16):4215-24. Epub 2016 Mar 22 doi: 10.1158/1078-0432.CCR-15-2878. PMID: 27006490

Recent clinical studies

Etiology

Segarra-Vidal B, Cummins Rodriguez MD
Int J Gynecol Cancer 2022 Dec 5;32(12):1631. doi: 10.1136/ijgc-2022-003992. PMID: 36600509
Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF
Int J Mol Sci 2022 Oct 2;23(19) doi: 10.3390/ijms231911684. PMID: 36232987Free PMC Article
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher D, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Mariani A, Leitao MM Jr, Makker V, Rustum NA, Vergote I, Zannoni GF, Tan DSP, McCormack M, Bini M, Lopez S, Raspagliesi F, Panici PB, di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2022 Mar;164(3):658-666. Epub 2022 Jan 19 doi: 10.1016/j.ygyno.2022.01.012. PMID: 35063279
Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
Bosse T, Nout RA, McAlpine JN, McConechy MK, Britton H, Hussein YR, Gonzalez C, Ganesan R, Steele JC, Harrison BT, Oliva E, Vidal A, Matias-Guiu X, Abu-Rustum NR, Levine DA, Gilks CB, Soslow RA
Am J Surg Pathol 2018 May;42(5):561-568. doi: 10.1097/PAS.0000000000001020. PMID: 29505428Free PMC Article

Diagnosis

Zhang X, Yao J, Niu N, Li X, Liu Y, Huo L, Euscher ED, Wang H, Bell D, Sood AK, Wang G, Lawson BC, Ramalingam P, Malpica A, Sahin AA, Ding Q, Liu J
Mod Pathol 2023 Feb;36(2):100001. Epub 2023 Jan 9 doi: 10.1016/j.modpat.2022.100001. PMID: 36853778
Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF
Int J Mol Sci 2022 Oct 2;23(19) doi: 10.3390/ijms231911684. PMID: 36232987Free PMC Article
Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
Bosse T, Nout RA, McAlpine JN, McConechy MK, Britton H, Hussein YR, Gonzalez C, Ganesan R, Steele JC, Harrison BT, Oliva E, Vidal A, Matias-Guiu X, Abu-Rustum NR, Levine DA, Gilks CB, Soslow RA
Am J Surg Pathol 2018 May;42(5):561-568. doi: 10.1097/PAS.0000000000001020. PMID: 29505428Free PMC Article
Stelloo E, Nout RA, Osse EM, Jürgenliemk-Schulz IJ, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Nijman HW, Putter H, Bosse T, Creutzberg CL, Smit VT
Clin Cancer Res 2016 Aug 15;22(16):4215-24. Epub 2016 Mar 22 doi: 10.1158/1078-0432.CCR-15-2878. PMID: 27006490

Therapy

Xue Y, Dong Y, Lou Y, Lv Q, Shan W, Wang C, Chen X
J Gynecol Oncol 2023 Jul;34(4):e53. Epub 2023 Mar 10 doi: 10.3802/jgo.2023.34.e53. PMID: 36929579Free PMC Article
Momeni-Boroujeni A, Nguyen B, Vanderbilt CM, Ladanyi M, Abu-Rustum NR, Aghajanian C, Ellenson LH, Weigelt B, Soslow RA
Mod Pathol 2022 Sep;35(9):1269-1278. Epub 2022 Apr 1 doi: 10.1038/s41379-022-01066-y. PMID: 35365770Free PMC Article
D'Alessandris N, Travaglino A, Santoro A, Arciuolo D, Scaglione G, Raffone A, Inzani F, Zannoni GF
Gynecol Oncol 2021 Nov;163(2):427-432. Epub 2021 Aug 24 doi: 10.1016/j.ygyno.2021.08.011. PMID: 34446267
Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
Stelloo E, Nout RA, Osse EM, Jürgenliemk-Schulz IJ, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Nijman HW, Putter H, Bosse T, Creutzberg CL, Smit VT
Clin Cancer Res 2016 Aug 15;22(16):4215-24. Epub 2016 Mar 22 doi: 10.1158/1078-0432.CCR-15-2878. PMID: 27006490

Prognosis

Jamieson A, Huvila J, Chiu D, Thompson EF, Scott S, Salvador S, Vicus D, Helpman L, Gotlieb W, Kean S, Samouelian V, Köbel M, Kinloch M, Parra-Harran C, Offman S, Grondin K, Irving J, Lum A, Senz J, Leung S, McConechy MK, Plante M, Kommoss S, Huntsman DG, Talhouk A, Gilks CB, McAlpine JN
Mod Pathol 2023 Apr;36(4):100085. Epub 2023 Jan 25 doi: 10.1016/j.modpat.2022.100085. PMID: 36788084
Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF
Int J Mol Sci 2022 Oct 2;23(19) doi: 10.3390/ijms231911684. PMID: 36232987Free PMC Article
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher D, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Mariani A, Leitao MM Jr, Makker V, Rustum NA, Vergote I, Zannoni GF, Tan DSP, McCormack M, Bini M, Lopez S, Raspagliesi F, Panici PB, di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2022 Mar;164(3):658-666. Epub 2022 Jan 19 doi: 10.1016/j.ygyno.2022.01.012. PMID: 35063279
Vermij L, Smit V, Nout R, Bosse T
Histopathology 2020 Jan;76(1):52-63. doi: 10.1111/his.14015. PMID: 31846532Free PMC Article
Bosse T, Nout RA, McAlpine JN, McConechy MK, Britton H, Hussein YR, Gonzalez C, Ganesan R, Steele JC, Harrison BT, Oliva E, Vidal A, Matias-Guiu X, Abu-Rustum NR, Levine DA, Gilks CB, Soslow RA
Am J Surg Pathol 2018 May;42(5):561-568. doi: 10.1097/PAS.0000000000001020. PMID: 29505428Free PMC Article

Clinical prediction guides

de Nonneville A, Kalbacher E, Cannone F, Guille A, Adelaïde J, Finetti P, Cappiello M, Lambaudie E, Ettore G, Charafe E, Mamessier E, Provansal M, Bertucci F, Sabatier R
Mol Oncol 2024 Oct;18(10):2586-2600. Epub 2024 Jun 25 doi: 10.1002/1878-0261.13679. PMID: 38923749Free PMC Article
Alafraidi M, Hoang L, Howitt BE, Longacre TA, McAlpine JN, Jamieson A, Singh N, Gilks CB, Pors J
Histopathology 2024 Oct;85(4):660-670. Epub 2024 Jun 18 doi: 10.1111/his.15241. PMID: 38890776
Hammer PM, Wang A, Vermij L, Zdravkovic S, Heilbroner L, Ryan E, Geisick RLP, Charu V, Longacre TA, Suarez CJ, Ho C, Jenkins TM, Mills AM, Bosse T, Howitt BE
Am J Surg Pathol 2024 Aug 1;48(8):953-964. Epub 2024 May 23 doi: 10.1097/PAS.0000000000002250. PMID: 38780000
Lin DI, Fine A, Danziger NA, Huang RSP, Mata DA, Decker B, Killian JK, Ramkissoon SH, Lechpammer M, Janovitz T, Ross JS, Sokol ES, Elvin JA
Gynecol Oncol 2022 Mar;164(3):558-565. Epub 2022 Jan 5 doi: 10.1016/j.ygyno.2021.12.030. PMID: 34998597
Bosse T, Nout RA, McAlpine JN, McConechy MK, Britton H, Hussein YR, Gonzalez C, Ganesan R, Steele JC, Harrison BT, Oliva E, Vidal A, Matias-Guiu X, Abu-Rustum NR, Levine DA, Gilks CB, Soslow RA
Am J Surg Pathol 2018 May;42(5):561-568. doi: 10.1097/PAS.0000000000001020. PMID: 29505428Free PMC Article

Recent systematic reviews

Travaglino A, Raffone A, Raimondo D, Reppuccia S, Ruggiero A, Arena A, Casadio P, Zullo F, Insabato L, Seracchioli R, Mollo A
Arch Gynecol Obstet 2022 Aug;306(2):423-431. Epub 2022 Jan 16 doi: 10.1007/s00404-021-06385-0. PMID: 35034160Free PMC Article
Travaglino A, Raffone A, Raimondo D, Arciuolo D, Angelico G, Valente M, Scaglione G, D'alessandris N, Casadio P, Inzani F, Mollo A, Santoro A, Seracchioli R, Franco Zannoni G
Int J Gynaecol Obstet 2022 Jul;158(1):13-20. Epub 2021 Oct 11 doi: 10.1002/ijgo.13937. PMID: 34536971Free PMC Article
D'Alessandris N, Travaglino A, Santoro A, Arciuolo D, Scaglione G, Raffone A, Inzani F, Zannoni GF
Gynecol Oncol 2021 Nov;163(2):427-432. Epub 2021 Aug 24 doi: 10.1016/j.ygyno.2021.08.011. PMID: 34446267

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