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Carcinoid heart disease

MedGen UID:
762
Concept ID:
C0007093
Disease or Syndrome
Synonyms: Carcinoid Heart Disease; Carcinoid Heart Diseases; Heart Disease, Carcinoid; Heart Diseases, Carcinoid
SNOMED CT: Carcinoid heart disease (36222008)
 
Monarch Initiative: MONDO:0043529

Definition

Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoid heart disease

Professional guidelines

PubMed

Jin C, Sharma AN, Thevakumar B, Majid M, Al Chalaby S, Takahashi N, Tanious A, Arockiam AD, Beri N, Amsterdam EA
Cardiology 2021;146(1):65-73. Epub 2020 Oct 16 doi: 10.1159/000507847. PMID: 33070143
Castillo J, Silvay G, Weiner M
J Cardiothorac Vasc Anesth 2018 Apr;32(2):1023-1031. Epub 2017 Nov 20 doi: 10.1053/j.jvca.2017.11.027. PMID: 29273478
Fox DJ, Khattar RS
Heart 2004 Oct;90(10):1224-8. doi: 10.1136/hrt.2004.040329. PMID: 15367531Free PMC Article

Recent clinical studies

Etiology

Delhomme C, Walter T, Arangalage D, Suc G, Hentic O, Cachier A, Alkhoder S, François L, Lombard-Bohas C, Iung B, Ruszniewski P, de Mestier L
J Neuroendocrinol 2023 Apr;35(4):e13262. Epub 2023 Apr 2 doi: 10.1111/jne.13262. PMID: 37005217
Pushparaji B, Donisan T, Balanescu DV, Palaskas N, Kim P, Lopez-Mattei J, Cilingiroglu M, Hassan SA, Boudoulas KD, Marmagkiolis K, Hajjar LA, Iliescu CA
Curr Oncol Rep 2021 Sep 27;23(11):133. doi: 10.1007/s11912-021-01113-y. PMID: 34570291
Joish VN, Shah S, Tierce JC, Patel D, McKee C, Lapuerta P, Zacks J
Future Oncol 2019 Apr;15(12):1397-1406. Epub 2019 Feb 8 doi: 10.2217/fon-2018-0960. PMID: 30734573
Fred HL, Thangam M
Tex Heart Inst J 2016 Dec;43(6):472-557. Epub 2016 Dec 1 doi: 10.14503/THIJ-16-6085. PMID: 28154499Free PMC Article
Yuan SM
Braz J Cardiovasc Surg 2016 Sep-Oct;31(5):400-405. doi: 10.5935/1678-9741.20160079. PMID: 27982350Free PMC Article

Diagnosis

Grozinsky-Glasberg S, Davar J, Hofland J, Dobson R, Prasad V, Pascher A, Denecke T, Tesselaar MET, Panzuto F, Albåge A, Connolly HM, Obadia JF, Riechelmann R, Toumpanakis C
J Neuroendocrinol 2022 Jul;34(7):e13146. Epub 2022 May 25 doi: 10.1111/jne.13146. PMID: 35613326Free PMC Article
Dangol RK, Henricus MM
N Engl J Med 2022 May 26;386(21):e56. Epub 2022 May 21 doi: 10.1056/NEJMicm2118205. PMID: 35593702
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Bhattacharyya S, Davar J, Dreyfus G, Caplin ME
Circulation 2007 Dec 11;116(24):2860-5. doi: 10.1161/CIRCULATIONAHA.107.701367. PMID: 18071089
Sippel RS, Chen H
Surg Oncol Clin N Am 2006 Jul;15(3):463-78. doi: 10.1016/j.soc.2006.05.002. PMID: 16882492

Therapy

Pushparaji B, Donisan T, Balanescu DV, Palaskas N, Kim P, Lopez-Mattei J, Cilingiroglu M, Hassan SA, Boudoulas KD, Marmagkiolis K, Hajjar LA, Iliescu CA
Curr Oncol Rep 2021 Sep 27;23(11):133. doi: 10.1007/s11912-021-01113-y. PMID: 34570291
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Patel C, Mathur M, Escarcega RO, Bove AA
Am Heart J 2014 Jun;167(6):789-95. Epub 2014 Apr 5 doi: 10.1016/j.ahj.2014.03.018. PMID: 24890526
Dave SH
Proc R Soc Med 1974 May;67(5):321-2. PMID: 4835272Free PMC Article

Prognosis

Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Hassan SA, Banchs J, Iliescu C, Dasari A, Lopez-Mattei J, Yusuf SW
Heart 2017 Oct;103(19):1488-1495. Epub 2017 Jun 8 doi: 10.1136/heartjnl-2017-311261. PMID: 28596302
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Patel C, Mathur M, Escarcega RO, Bove AA
Am Heart J 2014 Jun;167(6):789-95. Epub 2014 Apr 5 doi: 10.1016/j.ahj.2014.03.018. PMID: 24890526
Kulke MH, Mayer RJ
N Engl J Med 1999 Mar 18;340(11):858-68. doi: 10.1056/NEJM199903183401107. PMID: 10080850

Clinical prediction guides

Cope J, Maclean R, Hota S, Ramage JK, Mullholland N, Clement D, Brown S, Piper S, MaCarthy P, Wendler O, Srirajaskanthan R
Nucl Med Commun 2023 Nov 1;44(11):968-976. Epub 2023 Sep 4 doi: 10.1097/MNM.0000000000001749. PMID: 37661777
Suc G, Cachier A, Hentic O, Bazire B, Sannier A, Delhomme C, Nataf P, Laschet J, Deschamps L, Garbarz E, Ou P, Caligiuri G, Iung B, Ruszniewski P, de Mestier L, Arangalage D
Heart 2023 Dec 20;110(2):132-139. doi: 10.1136/heartjnl-2023-322945. PMID: 37463732
Baron T, Bergsten J, Albåge A, Lundin L, Sörensen J, Öberg K, Flachskampf FA
JACC Cardiovasc Imaging 2021 Nov;14(11):2240-2253. Epub 2021 Apr 14 doi: 10.1016/j.jcmg.2020.12.030. PMID: 33865761
Joish VN, Shah S, Tierce JC, Patel D, McKee C, Lapuerta P, Zacks J
Future Oncol 2019 Apr;15(12):1397-1406. Epub 2019 Feb 8 doi: 10.2217/fon-2018-0960. PMID: 30734573
Bernheim AM, Connolly HM, Hobday TJ, Abel MD, Pellikka PA
Prog Cardiovasc Dis 2007 May-Jun;49(6):439-51. doi: 10.1016/j.pcad.2006.12.002. PMID: 17498524

Recent systematic reviews

O'Malley TJ, Jimenez DC, Saxena A, Weber MP, Samuels LE, Entwistle JW, Guy TS, Massey HT, Morris RJ, Tchantchaleishvili V
Surgery 2021 Aug;170(2):390-396. Epub 2021 Mar 31 doi: 10.1016/j.surg.2021.02.054. PMID: 33812754
Buchanan-Hughes A, Pashley A, Feuilly M, Marteau F, Pritchard DM, Singh S
Neuroendocrinology 2021;111(1-2):1-15. Epub 2020 Feb 25 doi: 10.1159/000506744. PMID: 32097914
Joish VN, Shah S, Tierce JC, Patel D, McKee C, Lapuerta P, Zacks J
Future Oncol 2019 Apr;15(12):1397-1406. Epub 2019 Feb 8 doi: 10.2217/fon-2018-0960. PMID: 30734573
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Seymour N, Sawh SC
Can J Anaesth 2013 May;60(5):492-9. Epub 2013 Jan 18 doi: 10.1007/s12630-012-9879-1. PMID: 23328959

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