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Invasive Breast Lobular Carcinoma, Signet Ring Variant

MedGen UID:
364344
•Concept ID:
C1883029
•
Neoplastic Process
Synonyms: Invasive Breast Lobular Carcinoma, Signet-Ring Variant; Invasive Lobular Breast Carcinoma, Signet Ring Variant; Signet Ring Cell Lobular Breast Carcinoma

Definition

An invasive lobular carcinoma characterized by the presence of malignant epithelial cells with large intracytoplasmic lumina that cause displacement of the nuclei towards one pole of the cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Breast Lobular Carcinoma, Signet Ring Variant

Professional guidelines

PubMed

Comparison of Treatment Outcome Between Invasive Lobular and Ductal Carcinomas in Patients Receiving Partial Breast Irradiation With Intraoperative Electrons.
Leonardi MC, Maisonneuve P, Mastropasqua MG, Cattani F, Fanetti G, Morra A, Lazzari R, Bazzani F, Caputo M, Rotmensz N, Gerardi MA, Ricotti R, Enrica Galimberti V, Veronesi P, Dicuonzo S, Viale G, Jereczek-Fossa BA, Orecchia R
Int J Radiat Oncol Biol Phys 2017 Sep 1;99(1):173-181. Epub 2017 May 4 doi: 10.1016/j.ijrobp.2017.04.033. PMID: 28816144
Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.
van der Post RS, Vogelaar IP, Carneiro F, Guilford P, Huntsman D, Hoogerbrugge N, Caldas C, Schreiber KE, Hardwick RH, Ausems MG, Bardram L, Benusiglio PR, Bisseling TM, Blair V, Bleiker E, Boussioutas A, Cats A, Coit D, DeGregorio L, Figueiredo J, Ford JM, Heijkoop E, Hermens R, Humar B, Kaurah P, Keller G, Lai J, Ligtenberg MJ, O'Donovan M, Oliveira C, Pinheiro H, Ragunath K, Rasenberg E, Richardson S, Roviello F, Schackert H, Seruca R, Taylor A, Ter Huurne A, Tischkowitz M, Joe ST, van Dijck B, van Grieken NC, van Hillegersberg R, van Sandick JW, Vehof R, van Krieken JH, Fitzgerald RC
J Med Genet 2015 Jun;52(6):361-74. Epub 2015 May 15 doi: 10.1136/jmedgenet-2015-103094. PMID: 25979631Free PMC Article

Recent clinical studies

Etiology

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Invasive lobular carcinoma of the breast: clinicopathological features and patient outcomes.
Bozkurt E, Kaya C, Ucak R, Demircioglu MK, Guven O, Mihmanli M
Ann Ital Chir 2021;92:494-499. PMID: 34795114
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Invasive lobular carcinoma of the breast: cytometric and immunohistochemical characteristics of 96 cases.
Skotnicki P, Ryś J, Blecharz P, Reinfuss M, Jakubowicz J, Ambicka A, Kruczak A, Lackowska B
Pol J Pathol 2012 Jun;63(2):112-20. PMID: 22864775
Unusual malignant epithelial tumors of the gallbladder.
Albores-Saavedra J, Molberg K, Henson DE
Semin Diagn Pathol 1996 Nov;13(4):326-38. PMID: 8946610

Diagnosis

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Invasive Lobular Carcinoma With Extracellular Mucin: Not All Mucinous Mammary Carcinomas Are Ductal!
Singh K, DiazGomez B, Wang Y, Ou J, Hansen K
Int J Surg Pathol 2019 Feb;27(1):55-58. Epub 2018 Jul 23 doi: 10.1177/1066896918788660. PMID: 30032676
Invasive lobular carcinoma of the breast: cytometric and immunohistochemical characteristics of 96 cases.
Skotnicki P, Ryś J, Blecharz P, Reinfuss M, Jakubowicz J, Ambicka A, Kruczak A, Lackowska B
Pol J Pathol 2012 Jun;63(2):112-20. PMID: 22864775
Pleomorphic variant of invasive lobular carcinoma of the breast.
Weidner N, Semple JP
Hum Pathol 1992 Oct;23(10):1167-71. doi: 10.1016/0046-8177(92)90035-2. PMID: 1398644

Therapy

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report.
Zhang L, Min Q, Bi J, Yu X, Liang Y, Shao M
BMC Womens Health 2023 Mar 23;23(1):119. doi: 10.1186/s12905-023-02285-4. PMID: 36949419Free PMC Article
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Comparison of Treatment Outcome Between Invasive Lobular and Ductal Carcinomas in Patients Receiving Partial Breast Irradiation With Intraoperative Electrons.
Leonardi MC, Maisonneuve P, Mastropasqua MG, Cattani F, Fanetti G, Morra A, Lazzari R, Bazzani F, Caputo M, Rotmensz N, Gerardi MA, Ricotti R, Enrica Galimberti V, Veronesi P, Dicuonzo S, Viale G, Jereczek-Fossa BA, Orecchia R
Int J Radiat Oncol Biol Phys 2017 Sep 1;99(1):173-181. Epub 2017 May 4 doi: 10.1016/j.ijrobp.2017.04.033. PMID: 28816144

Prognosis

Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report.
Zhang L, Min Q, Bi J, Yu X, Liang Y, Shao M
BMC Womens Health 2023 Mar 23;23(1):119. doi: 10.1186/s12905-023-02285-4. PMID: 36949419Free PMC Article
Invasive lobular carcinoma with extracellular mucin (ILCEM): clinicopathologic and molecular characterization of a rare entity.
Soong TR, Dillon DA, Rice-Stitt TL, Wieczorek TJ, Baker GM, Darvishian F, Collins LC, Lester SC, Schnitt SJ, Harrison BT
Mod Pathol 2022 Oct;35(10):1370-1382. Epub 2022 Apr 27 doi: 10.1038/s41379-022-01084-w. PMID: 35477749
Invasive lobular carcinoma of the breast: clinicopathological features and patient outcomes.
Bozkurt E, Kaya C, Ucak R, Demircioglu MK, Guven O, Mihmanli M
Ann Ital Chir 2021;92:494-499. PMID: 34795114
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Signet ring cell carcinoma of the eccrine sweat glands in the eyelid.
Wollensak G, Witschel H, Böhm N
Ophthalmology 1996 Nov;103(11):1788-93. doi: 10.1016/s0161-6420(96)30426-0. PMID: 8942871

Clinical prediction guides

Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Signet-ring cell/histiocytoid carcinoma in the axilla: A case report with genetic analysis using next-generation sequencing.
Ito Y, Ishida M, Ohe C, Miyasaka C, Tsuta K
J Cutan Pathol 2021 Jan;48(1):102-105. Epub 2020 Sep 30 doi: 10.1111/cup.13838. PMID: 32770562
Comparison of Treatment Outcome Between Invasive Lobular and Ductal Carcinomas in Patients Receiving Partial Breast Irradiation With Intraoperative Electrons.
Leonardi MC, Maisonneuve P, Mastropasqua MG, Cattani F, Fanetti G, Morra A, Lazzari R, Bazzani F, Caputo M, Rotmensz N, Gerardi MA, Ricotti R, Enrica Galimberti V, Veronesi P, Dicuonzo S, Viale G, Jereczek-Fossa BA, Orecchia R
Int J Radiat Oncol Biol Phys 2017 Sep 1;99(1):173-181. Epub 2017 May 4 doi: 10.1016/j.ijrobp.2017.04.033. PMID: 28816144
E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma.
Lim MG, Adsay NV, Grignon DJ, Osunkoya AO
Mod Pathol 2011 Feb;24(2):241-7. Epub 2010 Sep 3 doi: 10.1038/modpathol.2010.187. PMID: 20818341

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