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Recurrent HER2-Negative Breast Carcinoma

MedGen UID:
1709081
Concept ID:
C5239116
Neoplastic Process
Synonyms: Recurrent HER2 Negative Breast Adenocarcinoma; Recurrent HER2 Negative Breast Carcinoma; Relapsed HER2 Negative Breast Carcinoma

Definition

The reemergence of HER2-negative breast adenocarcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent HER2-Negative Breast Carcinoma

Professional guidelines

PubMed

Wekking D, Lambertini M, Dessì M, Denaro N, Bardanzellu F, Garrone O, Scartozzi M, Solinas C
Semin Oncol 2023 Dec;50(6):131-139. Epub 2024 Jan 13 doi: 10.1053/j.seminoncol.2024.01.002. PMID: 38245458
Burstein HJ, Somerfield MR, Barton DL, Dorris A, Fallowfield LJ, Jain D, Johnston SRD, Korde LA, Litton JK, Macrae ER, Peterson LL, Vikas P, Yung RL, Rugo HS
J Clin Oncol 2021 Dec 10;39(35):3959-3977. Epub 2021 Jul 29 doi: 10.1200/JCO.21.01392. PMID: 34324367Free PMC Article
Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH, Allred DC, Bartlett JM, Bilous M, Fitzgibbons P, Hanna W, Jenkins RB, Mangu PB, Paik S, Perez EA, Press MF, Spears PA, Vance GH, Viale G, Hayes DF; American Society of Clinical Oncology; College of American Pathologists
J Clin Oncol 2013 Nov 1;31(31):3997-4013. Epub 2013 Oct 7 doi: 10.1200/JCO.2013.50.9984. PMID: 24101045

Recent clinical studies

Etiology

Johnston SRD, Toi M, O'Shaughnessy J, Rastogi P, Campone M, Neven P, Huang CS, Huober J, Jaliffe GG, Cicin I, Tolaney SM, Goetz MP, Rugo HS, Senkus E, Testa L, Del Mastro L, Shimizu C, Wei R, Shahir A, Munoz M, San Antonio B, André V, Harbeck N, Martin M; monarchE Committee Members
Lancet Oncol 2023 Jan;24(1):77-90. Epub 2022 Dec 6 doi: 10.1016/S1470-2045(22)00694-5. PMID: 36493792Free PMC Article
Kalinsky K, Barlow WE, Gralow JR, Meric-Bernstam F, Albain KS, Hayes DF, Lin NU, Perez EA, Goldstein LJ, Chia SKL, Dhesy-Thind S, Rastogi P, Alba E, Delaloge S, Martin M, Kelly CM, Ruiz-Borrego M, Gil-Gil M, Arce-Salinas CH, Brain EGC, Lee ES, Pierga JY, Bermejo B, Ramos-Vazquez M, Jung KH, Ferrero JM, Schott AF, Shak S, Sharma P, Lew DL, Miao J, Tripathy D, Pusztai L, Hortobagyi GN
N Engl J Med 2021 Dec 16;385(25):2336-2347. Epub 2021 Dec 1 doi: 10.1056/NEJMoa2108873. PMID: 34914339Free PMC Article
Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF, Geyer CE Jr, Dees EC, Goetz MP, Olson JA Jr, Lively T, Badve SS, Saphner TJ, Wagner LI, Whelan TJ, Ellis MJ, Paik S, Wood WC, Ravdin PM, Keane MM, Gomez Moreno HL, Reddy PS, Goggins TF, Mayer IA, Brufsky AM, Toppmeyer DL, Kaklamani VG, Berenberg JL, Abrams J, Sledge GW Jr
N Engl J Med 2018 Jul 12;379(2):111-121. Epub 2018 Jun 3 doi: 10.1056/NEJMoa1804710. PMID: 29860917Free PMC Article
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814

Diagnosis

Shirley M
Drugs 2024 Mar;84(3):337-346. doi: 10.1007/s40265-024-01998-6. PMID: 38388873
Nelson DR, Brown J, Morikawa A, Method M
PLoS One 2022;17(2):e0264637. Epub 2022 Feb 25 doi: 10.1371/journal.pone.0264637. PMID: 35213669Free PMC Article
Lopez-Tarruella S, Echavarria I, Jerez Y, Herrero B, Gamez S, Martin M
Future Oncol 2022 Mar;18(8):1003-1022. Epub 2022 Jan 31 doi: 10.2217/fon-2021-0668. PMID: 35094535
Toi M, Imoto S, Ishida T, Ito Y, Iwata H, Masuda N, Mukai H, Saji S, Shimizu A, Ikeda T, Haga H, Saeki T, Aogi K, Sugie T, Ueno T, Kinoshita T, Kai Y, Kitada M, Sato Y, Jimbo K, Sato N, Ishiguro H, Takada M, Ohashi Y, Ohno S
Lancet Oncol 2021 Jan;22(1):74-84. doi: 10.1016/S1470-2045(20)30534-9. PMID: 33387497
Cristofanilli M, Turner NC, Bondarenko I, Ro J, Im SA, Masuda N, Colleoni M, DeMichele A, Loi S, Verma S, Iwata H, Harbeck N, Zhang K, Theall KP, Jiang Y, Bartlett CH, Koehler M, Slamon D
Lancet Oncol 2016 Apr;17(4):425-439. Epub 2016 Mar 3 doi: 10.1016/S1470-2045(15)00613-0. PMID: 26947331

Therapy

Slamon D, Lipatov O, Nowecki Z, McAndrew N, Kukielka-Budny B, Stroyakovskiy D, Yardley DA, Huang CS, Fasching PA, Crown J, Bardia A, Chia S, Im SA, Ruiz-Borrego M, Loi S, Xu B, Hurvitz S, Barrios C, Untch M, Moroose R, Visco F, Afenjar K, Fresco R, Severin I, Ji Y, Ghaznawi F, Li Z, Zarate JP, Chakravartty A, Taran T, Hortobagyi G
N Engl J Med 2024 Mar 21;390(12):1080-1091. doi: 10.1056/NEJMoa2305488. PMID: 38507751
Johnston SRD, Toi M, O'Shaughnessy J, Rastogi P, Campone M, Neven P, Huang CS, Huober J, Jaliffe GG, Cicin I, Tolaney SM, Goetz MP, Rugo HS, Senkus E, Testa L, Del Mastro L, Shimizu C, Wei R, Shahir A, Munoz M, San Antonio B, André V, Harbeck N, Martin M; monarchE Committee Members
Lancet Oncol 2023 Jan;24(1):77-90. Epub 2022 Dec 6 doi: 10.1016/S1470-2045(22)00694-5. PMID: 36493792Free PMC Article
Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber RD, de Azambuja E, Fielding A, Balmaña J, Domchek SM, Gelmon KA, Hollingsworth SJ, Korde LA, Linderholm B, Bandos H, Senkus E, Suga JM, Shao Z, Pippas AW, Nowecki Z, Huzarski T, Ganz PA, Lucas PC, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger GG, Costantino JP, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani SR, Yothers G, Campbell C, Geyer CE Jr; OlympiA Clinical Trial Steering Committee and Investigators
N Engl J Med 2021 Jun 24;384(25):2394-2405. Epub 2021 Jun 3 doi: 10.1056/NEJMoa2105215. PMID: 34081848Free PMC Article
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564
Tolaney SM, Barry WT, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis M, Shapira I, Wolff AC, Carey LA, Overmoyer BA, Partridge AH, Guo H, Hudis CA, Krop IE, Burstein HJ, Winer EP
N Engl J Med 2015 Jan 8;372(2):134-41. doi: 10.1056/NEJMoa1406281. PMID: 25564897Free PMC Article

Prognosis

Kalinsky K, Barlow WE, Gralow JR, Meric-Bernstam F, Albain KS, Hayes DF, Lin NU, Perez EA, Goldstein LJ, Chia SKL, Dhesy-Thind S, Rastogi P, Alba E, Delaloge S, Martin M, Kelly CM, Ruiz-Borrego M, Gil-Gil M, Arce-Salinas CH, Brain EGC, Lee ES, Pierga JY, Bermejo B, Ramos-Vazquez M, Jung KH, Ferrero JM, Schott AF, Shak S, Sharma P, Lew DL, Miao J, Tripathy D, Pusztai L, Hortobagyi GN
N Engl J Med 2021 Dec 16;385(25):2336-2347. Epub 2021 Dec 1 doi: 10.1056/NEJMoa2108873. PMID: 34914339Free PMC Article
Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF, Geyer CE Jr, Dees EC, Goetz MP, Olson JA Jr, Lively T, Badve SS, Saphner TJ, Wagner LI, Whelan TJ, Ellis MJ, Paik S, Wood WC, Ravdin PM, Keane MM, Gomez Moreno HL, Reddy PS, Goggins TF, Mayer IA, Brufsky AM, Toppmeyer DL, Kaklamani VG, Berenberg JL, Abrams J, Sledge GW Jr
N Engl J Med 2018 Jul 12;379(2):111-121. Epub 2018 Jun 3 doi: 10.1056/NEJMoa1804710. PMID: 29860917Free PMC Article
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564
Tolaney SM, Barry WT, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis M, Shapira I, Wolff AC, Carey LA, Overmoyer BA, Partridge AH, Guo H, Hudis CA, Krop IE, Burstein HJ, Winer EP
N Engl J Med 2015 Jan 8;372(2):134-41. doi: 10.1056/NEJMoa1406281. PMID: 25564897Free PMC Article

Clinical prediction guides

Magbanua MJM, Brown Swigart L, Ahmed Z, Sayaman RW, Renner D, Kalashnikova E, Hirst GL, Yau C, Wolf DM, Li W, Delson AL, Asare S, Liu MC, Albain K, Chien AJ, Forero-Torres A, Isaacs C, Nanda R, Tripathy D, Rodriguez A, Sethi H, Aleshin A, Rabinowitz M, Perlmutter J, Symmans WF, Yee D, Hylton NM, Esserman LJ, DeMichele AM, Rugo HS, van 't Veer LJ
Cancer Cell 2023 Jun 12;41(6):1091-1102.e4. Epub 2023 May 4 doi: 10.1016/j.ccell.2023.04.008. PMID: 37146605Free PMC Article
Kalinsky K, Barlow WE, Gralow JR, Meric-Bernstam F, Albain KS, Hayes DF, Lin NU, Perez EA, Goldstein LJ, Chia SKL, Dhesy-Thind S, Rastogi P, Alba E, Delaloge S, Martin M, Kelly CM, Ruiz-Borrego M, Gil-Gil M, Arce-Salinas CH, Brain EGC, Lee ES, Pierga JY, Bermejo B, Ramos-Vazquez M, Jung KH, Ferrero JM, Schott AF, Shak S, Sharma P, Lew DL, Miao J, Tripathy D, Pusztai L, Hortobagyi GN
N Engl J Med 2021 Dec 16;385(25):2336-2347. Epub 2021 Dec 1 doi: 10.1056/NEJMoa2108873. PMID: 34914339Free PMC Article
Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF, Geyer CE Jr, Dees EC, Goetz MP, Olson JA Jr, Lively T, Badve SS, Saphner TJ, Wagner LI, Whelan TJ, Ellis MJ, Paik S, Wood WC, Ravdin PM, Keane MM, Gomez Moreno HL, Reddy PS, Goggins TF, Mayer IA, Brufsky AM, Toppmeyer DL, Kaklamani VG, Berenberg JL, Abrams J, Sledge GW Jr
N Engl J Med 2018 Jul 12;379(2):111-121. Epub 2018 Jun 3 doi: 10.1056/NEJMoa1804710. PMID: 29860917Free PMC Article
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814

Recent systematic reviews

Burstein HJ, Somerfield MR, Barton DL, Dorris A, Fallowfield LJ, Jain D, Johnston SRD, Korde LA, Litton JK, Macrae ER, Peterson LL, Vikas P, Yung RL, Rugo HS
J Clin Oncol 2021 Dec 10;39(35):3959-3977. Epub 2021 Jul 29 doi: 10.1200/JCO.21.01392. PMID: 34324367Free PMC Article
Agostinetto E, Vian L, Caparica R, Bruzzone M, Ceppi M, Lambertini M, Pondé N, de Azambuja E
ESMO Open 2021 Apr;6(2):100091. Epub 2021 Mar 18 doi: 10.1016/j.esmoop.2021.100091. PMID: 33743330Free PMC Article
Salvo EM, Ramirez AO, Cueto J, Law EH, Situ A, Cameron C, Samjoo IA
Breast 2021 Jun;57:5-17. Epub 2021 Feb 20 doi: 10.1016/j.breast.2021.02.009. PMID: 33677313Free PMC Article
Alvarez-Lopez I, Bezares S, Dalmau Portulas E, García-Martínez E, García-Sáenz JÁ, Gil-Gil M, Martínez de Dueñas E, Ribelles N, Santaballa Bertrán A
Clin Transl Oncol 2020 Aug;22(8):1364-1377. Epub 2020 Feb 12 doi: 10.1007/s12094-019-02269-7. PMID: 32052382Free PMC Article
Moja L, Tagliabue L, Balduzzi S, Parmelli E, Pistotti V, Guarneri V, D'Amico R
Cochrane Database Syst Rev 2012 Apr 18;2012(4):CD006243. doi: 10.1002/14651858.CD006243.pub2. PMID: 22513938Free PMC Article

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