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Pancreatic Poorly Differentiated Ductal Adenocarcinoma

MedGen UID:
459367
•Concept ID:
C2987141
•
Neoplastic Process

Definition

A pancreatic ductal adenocarcinoma characterized by the presence of small and irregular malignant glandular structures, solid sheets of malignant cells, and single malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Poorly Differentiated Ductal Adenocarcinoma

Professional guidelines

PubMed

Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article
Pancreatic ductal adenocarcinoma contains an effector and regulatory immune cell infiltrate that is altered by multimodal neoadjuvant treatment.
Shibuya KC, Goel VK, Xiong W, Sham JG, Pollack SM, Leahy AM, Whiting SH, Yeh MM, Yee C, Riddell SR, Pillarisetty VG
PLoS One 2014;9(5):e96565. Epub 2014 May 2 doi: 10.1371/journal.pone.0096565. PMID: 24794217Free PMC Article
Differential diagnosis of pancreatic tumors using ultrasound contrast imaging.
Sofuni A, Iijima H, Moriyasu F, Nakayama D, Shimizu M, Nakamura K, Itokawa F, Itoi T
J Gastroenterol 2005 May;40(5):518-25. doi: 10.1007/s00535-005-1578-z. PMID: 15942718

Recent clinical studies

Etiology

Impact of Histological Features on Adjuvant Chemotherapy for Invasive Intraductal Papillary Mucinous Carcinoma.
Furukawa T, Takamatsu M, Inoue Y, Okamoto T, Mie T, Yamada Y, Takeda T, Kasuga A, Matsuyama M, Sasaki T, Ozaka M, Oba A, Ito H, Ono Y, Sato T, Takahashi YU, Saiura A, Sasahira N
Anticancer Res 2022 May;42(5):2645-2655. doi: 10.21873/anticanres.15742. PMID: 35489761
Poorly differentiated histologic grade correlates with worse survival in SMAD4 negative pancreatic adenocarcinoma patients.
Park JY, King J, Reber H, Joe Hines O, Mederos MA, Wang HL, Dawson D, Wainberg Z, Donahue T, Girgis M
J Surg Oncol 2021 Feb;123(2):389-398. Epub 2020 Nov 4 doi: 10.1002/jso.26279. PMID: 33146409
Non-Ductal Tumors of the Pancreas.
Dhillon J
Monogr Clin Cytol 2020;26:92-108. Epub 2020 Sep 28 doi: 10.1159/000455737. PMID: 32987393
Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer.
Pan Y, Lu F, Fei Q, Yu X, Xiong P, Yu X, Dang Y, Hou Z, Lin W, Lin X, Zhang Z, Pan M, Huang H
J Hematol Oncol 2019 Nov 27;12(1):124. doi: 10.1186/s13045-019-0822-6. PMID: 31771616Free PMC Article
One year survival with poorly differentiated metastatic pancreatic carcinoma following chemoembolization with gemcitabine and cisplatin.
Brown DB, Gonsalves CF, Yeo CJ, Witkiewicz AK, Carr BI
Oncol Rep 2010 Sep;24(3):767-9. doi: 10.3892/or_00000919. PMID: 20664985

Diagnosis

Identification and Clinical Significance of Pancreatic Cancer Stem Cells and Their Chemotherapeutic Drug Resistance.
Kuo YC, Kou HW, Hsu CP, Lo CH, Hwang TL
Int J Mol Sci 2023 Apr 15;24(8) doi: 10.3390/ijms24087331. PMID: 37108495Free PMC Article
Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma.
Mao F, Duan H, Allamyradov A, Xin Z, Du Y, Wang X, Xu P, Li Z, Qian J, Yao J
Aging (Albany NY) 2021 Jan 20;13(3):4096-4114. doi: 10.18632/aging.202377. PMID: 33493138Free PMC Article
Non-Ductal Tumors of the Pancreas.
Dhillon J
Monogr Clin Cytol 2020;26:92-108. Epub 2020 Sep 28 doi: 10.1159/000455737. PMID: 32987393
Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils.
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
One year survival with poorly differentiated metastatic pancreatic carcinoma following chemoembolization with gemcitabine and cisplatin.
Brown DB, Gonsalves CF, Yeo CJ, Witkiewicz AK, Carr BI
Oncol Rep 2010 Sep;24(3):767-9. doi: 10.3892/or_00000919. PMID: 20664985

Therapy

Identification and Clinical Significance of Pancreatic Cancer Stem Cells and Their Chemotherapeutic Drug Resistance.
Kuo YC, Kou HW, Hsu CP, Lo CH, Hwang TL
Int J Mol Sci 2023 Apr 15;24(8) doi: 10.3390/ijms24087331. PMID: 37108495Free PMC Article
Robotic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: Analysis of surgical outcomes and long-term prognosis in a high-volume center.
Zhang XP, Xu S, Zhao ZM, Liu Q, Zhao GD, Hu MG, Tan XL, Liu R
Hepatobiliary Pancreat Dis Int 2023 Apr;22(2):140-146. Epub 2022 Sep 20 doi: 10.1016/j.hbpd.2022.09.006. PMID: 36171169
Resected pancreatic adenocarcinoma: An Asian institution's experience.
Ng KYY, Chow EWX, Jiang B, Lim C, Goh BKP, Lee SY, Teo JY, Tan DMY, Cheow PC, Ooi LLPJ, Chow PKH, Lee JJX, Kam JH, Koh YX, Jeyaraj PR, Tan EK, Choo SP, Chan CY, Chung AYF, Tai D
Cancer Rep (Hoboken) 2021 Oct;4(5):e1393. Epub 2021 May 3 doi: 10.1002/cnr2.1393. PMID: 33939335Free PMC Article
Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells.
Enane FO, Saunthararajah Y, Korc M
Cell Death Dis 2018 Sep 6;9(9):912. doi: 10.1038/s41419-018-0919-9. PMID: 30190481Free PMC Article
One year survival with poorly differentiated metastatic pancreatic carcinoma following chemoembolization with gemcitabine and cisplatin.
Brown DB, Gonsalves CF, Yeo CJ, Witkiewicz AK, Carr BI
Oncol Rep 2010 Sep;24(3):767-9. doi: 10.3892/or_00000919. PMID: 20664985

Prognosis

Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer.
De Sanctis F, Dusi S, Caligola S, Anselmi C, Petrova V, Rossi B, Angelini G, Erdeljan M, Wöll S, Schlitter AM, Metzler T, Steiger K, Borok Z, Bailey P, Bauer A, Halin C, Boschi F, Giugno R, Canè S, Lawlor R, Corbo V, Scarpa A, Constantin G, Ugel S, Vascotto F, Sahin U, Türeci Ö, Bronte V
Immunity 2024 Jun 11;57(6):1378-1393.e14. Epub 2024 May 14 doi: 10.1016/j.immuni.2024.04.021. PMID: 38749447
Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer.
Di Chiaro P, Nacci L, Arco F, Brandini S, Polletti S, Palamidessi A, Donati B, Soriani C, Gualdrini F, Frigè G, Mazzarella L, Ciarrocchi A, Zerbi A, Spaggiari P, Scita G, Rodighiero S, Barozzi I, Diaferia GR, Natoli G
Cancer Cell 2024 Apr 8;42(4):662-681.e10. Epub 2024 Mar 21 doi: 10.1016/j.ccell.2024.02.017. PMID: 38518775
Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells.
Wang X, Miao J, Wang S, Shen R, Zhang S, Tian Y, Li M, Zhu D, Yao A, Bao W, Zhang Q, Tang X, Wang X, Li J
Mol Cancer 2022 Jun 22;21(1):133. doi: 10.1186/s12943-022-01596-8. PMID: 35733218Free PMC Article
Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils.
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Enomoto A, Takahashi M
Cancer Res 2019 Oct 15;79(20):5367-5381. Epub 2019 Aug 22 doi: 10.1158/0008-5472.CAN-19-0454. PMID: 31439548

Clinical prediction guides

A bioprinted sea-and-island multicellular model for dissecting human pancreatic tumor-stroma reciprocity and adaptive metabolism.
Li M, Freeman S, Franco-Barraza J, Cai KQ, Kim A, Jin S, Cukierman E, Ye K
Biomaterials 2024 Oct;310:122631. Epub 2024 May 24 doi: 10.1016/j.biomaterials.2024.122631. PMID: 38815457Free PMC Article
Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer.
Di Chiaro P, Nacci L, Arco F, Brandini S, Polletti S, Palamidessi A, Donati B, Soriani C, Gualdrini F, Frigè G, Mazzarella L, Ciarrocchi A, Zerbi A, Spaggiari P, Scita G, Rodighiero S, Barozzi I, Diaferia GR, Natoli G
Cancer Cell 2024 Apr 8;42(4):662-681.e10. Epub 2024 Mar 21 doi: 10.1016/j.ccell.2024.02.017. PMID: 38518775
Poorly differentiated histologic grade correlates with worse survival in SMAD4 negative pancreatic adenocarcinoma patients.
Park JY, King J, Reber H, Joe Hines O, Mederos MA, Wang HL, Dawson D, Wainberg Z, Donahue T, Girgis M
J Surg Oncol 2021 Feb;123(2):389-398. Epub 2020 Nov 4 doi: 10.1002/jso.26279. PMID: 33146409
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Enomoto A, Takahashi M
Cancer Res 2019 Oct 15;79(20):5367-5381. Epub 2019 Aug 22 doi: 10.1158/0008-5472.CAN-19-0454. PMID: 31439548

Recent systematic reviews

Phenotypical and potential functional characteristics of different immune cells expressing CD28H/B7-H5 and their relationship with cancer prognosis.
Zhong C, Lang Q, Yu J, Wu S, Xu F, Tian Y
Clin Exp Immunol 2020 Apr;200(1):12-21. Epub 2020 Feb 4 doi: 10.1111/cei.13413. PMID: 31901178Free PMC Article
Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells.
Enane FO, Saunthararajah Y, Korc M
Cell Death Dis 2018 Sep 6;9(9):912. doi: 10.1038/s41419-018-0919-9. PMID: 30190481Free PMC Article

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