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High Grade Esophageal Glandular Intraepithelial Neoplasia

MedGen UID:
232160
•Concept ID:
C1333449
•
Neoplastic Process
Synonyms: Esophageal High-Grade Glandular Intraepithelial Neoplasia; High-Grade Esophageal Glandular Dysplasia; High-Grade Esophageal Glandular Intraepithelial Neoplasia

Definition

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal glandular epithelium. [from NCI]

Recent clinical studies

Etiology

Transforming human papillomavirus infection and the esophageal transformation zone: prime time for total excision/ablative therapy?
Rajendra S, Sharma P
Dis Esophagus 2019 Jul 1;32(7) doi: 10.1093/dote/doz008. PMID: 31304554
Comparison of six immunohistochemical markers for the histologic diagnosis of neoplasia in Barrett's esophagus.
Weimann A, Rieger A, Zimmermann M, Gross M, Hoffmann P, Slevogt H, Morawietz L
Virchows Arch 2010 Nov;457(5):537-45. Epub 2010 Sep 16 doi: 10.1007/s00428-010-0972-y. PMID: 20844891
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170
Barrett's oesophagus: from metaplasia to dysplasia and cancer.
Fléjou JF
Gut 2005 Mar;54 Suppl 1(Suppl 1):i6-12. doi: 10.1136/gut.2004.041525. PMID: 15711008Free PMC Article
Immunohistochemical analysis of cyclooxygenase-2 expression in premalignant and malignant esophageal glandular and squamous lesions in Cixian, China.
Zhang W, Wang L, Chang A, Jin Y, Rao J
Cancer Detect Prev 2003;27(4):243-9. doi: 10.1016/s0361-090x(03)00072-2. PMID: 12893070

Diagnosis

Primary high-grade neuroendocrine carcinoma of the esophagus: a clinicopathologic and immunohistochemical study of 42 resection cases.
Huang Q, Wu H, Nie L, Shi J, Lebenthal A, Chen J, Sun Q, Yang J, Huang L, Ye Q
Am J Surg Pathol 2013 Apr;37(4):467-83. doi: 10.1097/PAS.0b013e31826d2639. PMID: 23426118
Comparison of six immunohistochemical markers for the histologic diagnosis of neoplasia in Barrett's esophagus.
Weimann A, Rieger A, Zimmermann M, Gross M, Hoffmann P, Slevogt H, Morawietz L
Virchows Arch 2010 Nov;457(5):537-45. Epub 2010 Sep 16 doi: 10.1007/s00428-010-0972-y. PMID: 20844891
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Therapy

Transforming human papillomavirus infection and the esophageal transformation zone: prime time for total excision/ablative therapy?
Rajendra S, Sharma P
Dis Esophagus 2019 Jul 1;32(7) doi: 10.1093/dote/doz008. PMID: 31304554
Properties of the neosquamous epithelium after radiofrequency ablation of Barrett's esophagus containing neoplasia.
Pouw RE, Gondrie JJ, Rygiel AM, Sondermeijer CM, ten Kate FJ, Odze RD, Vieth M, Krishnadath KK, Bergman JJ
Am J Gastroenterol 2009 Jun;104(6):1366-73. Epub 2009 Apr 21 doi: 10.1038/ajg.2009.88. PMID: 19491850

Prognosis

Primary high-grade neuroendocrine carcinoma of the esophagus: a clinicopathologic and immunohistochemical study of 42 resection cases.
Huang Q, Wu H, Nie L, Shi J, Lebenthal A, Chen J, Sun Q, Yang J, Huang L, Ye Q
Am J Surg Pathol 2013 Apr;37(4):467-83. doi: 10.1097/PAS.0b013e31826d2639. PMID: 23426118
Properties of the neosquamous epithelium after radiofrequency ablation of Barrett's esophagus containing neoplasia.
Pouw RE, Gondrie JJ, Rygiel AM, Sondermeijer CM, ten Kate FJ, Odze RD, Vieth M, Krishnadath KK, Bergman JJ
Am J Gastroenterol 2009 Jun;104(6):1366-73. Epub 2009 Apr 21 doi: 10.1038/ajg.2009.88. PMID: 19491850
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Clinical prediction guides

Primary high-grade neuroendocrine carcinoma of the esophagus: a clinicopathologic and immunohistochemical study of 42 resection cases.
Huang Q, Wu H, Nie L, Shi J, Lebenthal A, Chen J, Sun Q, Yang J, Huang L, Ye Q
Am J Surg Pathol 2013 Apr;37(4):467-83. doi: 10.1097/PAS.0b013e31826d2639. PMID: 23426118
Comparison of six immunohistochemical markers for the histologic diagnosis of neoplasia in Barrett's esophagus.
Weimann A, Rieger A, Zimmermann M, Gross M, Hoffmann P, Slevogt H, Morawietz L
Virchows Arch 2010 Nov;457(5):537-45. Epub 2010 Sep 16 doi: 10.1007/s00428-010-0972-y. PMID: 20844891
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170
Immunohistochemical analysis of cyclooxygenase-2 expression in premalignant and malignant esophageal glandular and squamous lesions in Cixian, China.
Zhang W, Wang L, Chang A, Jin Y, Rao J
Cancer Detect Prev 2003;27(4):243-9. doi: 10.1016/s0361-090x(03)00072-2. PMID: 12893070

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