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Digestive System Intraepithelial Neoplasia

MedGen UID:
181583
•Concept ID:
C0920207
•
Neoplastic Process
Synonyms: Gastrointestinal Intraepithelial Neoplasia; Gastrointestinal Noninvasive Neoplasia; Gastrointestinal System Intraepithelial Neoplasia

Definition

A non-invasive neoplastic process that affects the epithelium of any part of the digestive system. It is characterized by the presence of morphologic features of dysplasia (e.g., architectural and cytological epithelial alterations) or, in a minority of cases, lack of such morphologic features, as in colonic sessile serrated adenomas/polyps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Intraepithelial Neoplasia

Professional guidelines

PubMed

Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Pancreatic Acinar-to-Ductal Metaplasia and Pancreatic Cancer.
Wang L, Xie D, Wei D
Methods Mol Biol 2019;1882:299-308. doi: 10.1007/978-1-4939-8879-2_26. PMID: 30378064
An overview of anal intraepithelial neoplasia.
Buzard CL, Rizzolo D
JAAPA 2018 Jul;31(7):1-5. doi: 10.1097/01.JAA.0000534979.69236.e7. PMID: 29957613
Gastrointestinal dysplasia.
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738
Hereditary gastric cancer.
Carneiro F
Pathologe 2012 Nov;33 Suppl 2:231-4. doi: 10.1007/s00292-012-1677-6. PMID: 23052347

Diagnosis

Anal and Perianal Preneoplastic Lesions.
Loughrey MB, Shepherd NA
Gastroenterol Clin North Am 2024 Mar;53(1):201-220. Epub 2023 Oct 16 doi: 10.1016/j.gtc.2023.09.007. PMID: 38280748
Pathophysiological and clinical aspects of gastric hyperplastic polyps.
Markowski AR, Markowska A, Guzinska-Ustymowicz K
World J Gastroenterol 2016 Oct 28;22(40):8883-8891. doi: 10.3748/wjg.v22.i40.8883. PMID: 27833379Free PMC Article
Ectopic pancreatitis.
Hoven N, Spilseth B
Minn Med 2014 Oct;97(10):36-7. PMID: 25651633
Management of gastric polyps: an endoscopy-based approach.
Shaib YH, Rugge M, Graham DY, Genta RM
Clin Gastroenterol Hepatol 2013 Nov;11(11):1374-84. Epub 2013 Apr 10 doi: 10.1016/j.cgh.2013.03.019. PMID: 23583466Free PMC Article
Tumorigenic aspects.
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811

Therapy

A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Case-control study of human papillomavirus and oropharyngeal cancer.
D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML
N Engl J Med 2007 May 10;356(19):1944-56. doi: 10.1056/NEJMoa065497. PMID: 17494927
A review of lower genital intraepithelial neoplasia and the use of topical 5-fluorouracil.
Sillman FH, Sedlis A, Boyce JG
Obstet Gynecol Surv 1985 Apr;40(4):190-220. doi: 10.1097/00006254-198504000-00002. PMID: 2984615
Tumorigenic aspects.
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811

Prognosis

A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639
Histological assessment of oesophageal columnar mucosa.
Flejou JF
Best Pract Res Clin Gastroenterol 2008;22(4):671-86. doi: 10.1016/j.bpg.2008.03.003. PMID: 18656824

Clinical prediction guides

Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions.
Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M
Cancer Discov 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. PMID: 37021392Free PMC Article
A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Gastrointestinal dysplasia.
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738
Pathology of early lower GI cancer.
Geboes K, Ectors N, Geboes KP
Best Pract Res Clin Gastroenterol 2005 Dec;19(6):963-78. doi: 10.1016/j.bpg.2005.04.005. PMID: 16338652

Recent systematic reviews

Whether long-term use of proton pump inhibitor increases the risk of precancerous lesions in the stomach: A systematic review and meta-analysis of randomized controlled trials.
Lv F, Wang J, Mao L, Zhou X, Zhang T, Zhou S
Medicine (Baltimore) 2023 Sep 22;102(38):e35062. doi: 10.1097/MD.0000000000035062. PMID: 37747015Free PMC Article
Comprehensive characterisation of acinar cystic transformation of the pancreas: a systematic review.
Mattiolo P, Wang H, Basturk O, Brosens LAA, Hong SM, Adsay V, Scarpa A, Luchini C
J Clin Pathol 2023 Nov;76(11):740-746. Epub 2023 Aug 29 doi: 10.1136/jcp-2023-209103. PMID: 37643836
Use of folic acid supplementation to halt and even reverse the progression of gastric precancerous conditions: a meta-analysis.
Lei J, Ren F, Li W, Guo X, Liu Q, Gao H, Pang Y, He Y, Guo J, Zeng J
BMC Gastroenterol 2022 Aug 2;22(1):370. doi: 10.1186/s12876-022-02390-y. PMID: 35918654Free PMC Article
Diagnostic yield of EUS-FNA-based cytology distinguishing malignant and benign IPMNs: a systematic review and meta-analysis.
Suzuki R, Thosani N, Annangi S, Guha S, Bhutani MS
Pancreatology 2014 Sep-Oct;14(5):380-4. Epub 2014 Jul 22 doi: 10.1016/j.pan.2014.07.006. PMID: 25278308
Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article

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