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High-Grade Biliary Intraepithelial Neoplasia

MedGen UID:
418146
•Concept ID:
C2348875
•
Neoplastic Process
Synonyms: Biliary Intraepithelial Neoplasia-3; Grade 3 Biliary Intraepithelial Neoplasia; High Grade Biliary Intraepithelial Neoplasia; High Grade BilIN; High-Grade BilIN

Definition

Biliary intraepithelial neoplasia characterized by the presence of high grade epithelial dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh-Grade Biliary Intraepithelial Neoplasia

Professional guidelines

PubMed

Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement.
Zen Y, Aishima S, Ajioka Y, Haratake J, Kage M, Kondo F, Nimura Y, Sakamoto M, Sasaki M, Shimamatsu K, Wakasa K, Park YN, Chen MF, Atomi Y, Nakanuma Y
Pathol Int 2005 Apr;55(4):180-8. doi: 10.1111/j.1440-1827.2005.01816.x. PMID: 15826244

Recent clinical studies

Etiology

Prognostic implication of high grade biliary intraepithelial neoplasia in bile duct resection margins in patients with resected perihilar cholangiocarcinoma.
Shin D, Lee S, Lee JH, Hong SM, Park SY, Yoo C, Lee W, Song KB, Hwang DW, Kim SC
J Hepatobiliary Pancreat Sci 2020 Sep;27(9):604-613. Epub 2020 Aug 16 doi: 10.1002/jhbp.800. PMID: 32639085
HER2 gene (ERBB2) amplification is a low-frequency driver with potential predictive value in gallbladder carcinoma.
Albrecht T, Rausch M, Roessler S, Geissler V, Albrecht M, Halske C, Seifert C, Renner M, Singer S, Mehrabi A, Vogel MN, Pathil-Warth A, Busch E, Köhler B, Rupp C, Weiss KH, Springfeld C, Röcken C, Schirmacher P, Goeppert B
Virchows Arch 2020 Jun;476(6):871-880. Epub 2019 Dec 14 doi: 10.1007/s00428-019-02706-6. PMID: 31838585
HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis.
Albrecht T, Rausch M, Rössler S, Albrecht M, Braun JD, Geissler V, Mehrabi A, Vogel MN, Pathil-Warth A, Mechtersheimer G, Renner M, Rupp C, Weiss KH, Busch E, Köhler B, Springfeld C, Schirmacher P, Goeppert B
BMC Cancer 2019 Dec 5;19(1):1191. doi: 10.1186/s12885-019-6320-y. PMID: 31805897Free PMC Article
DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data.
Goeppert B, Roessler S, Becker N, Zucknick M, Vogel MN, Warth A, Pathil-Warth A, Mehrabi A, Schirmacher P, Mollenhauer J, Renner M
Histopathology 2017 Jun;70(7):1064-1071. Epub 2017 Mar 28 doi: 10.1111/his.13175. PMID: 28130841
Precancerous bile duct pathology in end-stage primary sclerosing cholangitis, with and without cholangiocarcinoma.
Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC
Am J Surg Pathol 2010 Jan;34(1):27-34. doi: 10.1097/PAS.0b013e3181bc96f9. PMID: 19898228

Diagnosis

A giant biliary cyst of Todani IA in a young woman: A case report.
Mrowiec S, Jabłońska B, Baron J, Gajda M, Stelmach A, Zemła P, Liszka Ł
Medicine (Baltimore) 2021 Jan 15;100(2):e24022. doi: 10.1097/MD.0000000000024022. PMID: 33466146Free PMC Article
HER2 gene (ERBB2) amplification is a low-frequency driver with potential predictive value in gallbladder carcinoma.
Albrecht T, Rausch M, Roessler S, Geissler V, Albrecht M, Halske C, Seifert C, Renner M, Singer S, Mehrabi A, Vogel MN, Pathil-Warth A, Busch E, Köhler B, Rupp C, Weiss KH, Springfeld C, Röcken C, Schirmacher P, Goeppert B
Virchows Arch 2020 Jun;476(6):871-880. Epub 2019 Dec 14 doi: 10.1007/s00428-019-02706-6. PMID: 31838585
Pyloric gland adenoma of the cystic duct with malignant transformation: report of a case with a review of the literature.
Schaefer IM, Cameron S, Middel P, Homayounfar K, Schwörer H, Vieth M, Veits L
BMC Cancer 2012 Dec 4;12:570. doi: 10.1186/1471-2407-12-570. PMID: 23206236Free PMC Article
Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement.
Zen Y, Aishima S, Ajioka Y, Haratake J, Kage M, Kondo F, Nimura Y, Sakamoto M, Sasaki M, Shimamatsu K, Wakasa K, Park YN, Chen MF, Atomi Y, Nakanuma Y
Pathol Int 2005 Apr;55(4):180-8. doi: 10.1111/j.1440-1827.2005.01816.x. PMID: 15826244

Therapy

HER2 gene (ERBB2) amplification is a low-frequency driver with potential predictive value in gallbladder carcinoma.
Albrecht T, Rausch M, Roessler S, Geissler V, Albrecht M, Halske C, Seifert C, Renner M, Singer S, Mehrabi A, Vogel MN, Pathil-Warth A, Busch E, Köhler B, Rupp C, Weiss KH, Springfeld C, Röcken C, Schirmacher P, Goeppert B
Virchows Arch 2020 Jun;476(6):871-880. Epub 2019 Dec 14 doi: 10.1007/s00428-019-02706-6. PMID: 31838585
Precancerous bile duct pathology in end-stage primary sclerosing cholangitis, with and without cholangiocarcinoma.
Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC
Am J Surg Pathol 2010 Jan;34(1):27-34. doi: 10.1097/PAS.0b013e3181bc96f9. PMID: 19898228

Prognosis

A giant biliary cyst of Todani IA in a young woman: A case report.
Mrowiec S, Jabłońska B, Baron J, Gajda M, Stelmach A, Zemła P, Liszka Ł
Medicine (Baltimore) 2021 Jan 15;100(2):e24022. doi: 10.1097/MD.0000000000024022. PMID: 33466146Free PMC Article
Prognostic implication of high grade biliary intraepithelial neoplasia in bile duct resection margins in patients with resected perihilar cholangiocarcinoma.
Shin D, Lee S, Lee JH, Hong SM, Park SY, Yoo C, Lee W, Song KB, Hwang DW, Kim SC
J Hepatobiliary Pancreat Sci 2020 Sep;27(9):604-613. Epub 2020 Aug 16 doi: 10.1002/jhbp.800. PMID: 32639085
HER2 gene (ERBB2) amplification is a low-frequency driver with potential predictive value in gallbladder carcinoma.
Albrecht T, Rausch M, Roessler S, Geissler V, Albrecht M, Halske C, Seifert C, Renner M, Singer S, Mehrabi A, Vogel MN, Pathil-Warth A, Busch E, Köhler B, Rupp C, Weiss KH, Springfeld C, Röcken C, Schirmacher P, Goeppert B
Virchows Arch 2020 Jun;476(6):871-880. Epub 2019 Dec 14 doi: 10.1007/s00428-019-02706-6. PMID: 31838585
DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data.
Goeppert B, Roessler S, Becker N, Zucknick M, Vogel MN, Warth A, Pathil-Warth A, Mehrabi A, Schirmacher P, Mollenhauer J, Renner M
Histopathology 2017 Jun;70(7):1064-1071. Epub 2017 Mar 28 doi: 10.1111/his.13175. PMID: 28130841
Precancerous bile duct pathology in end-stage primary sclerosing cholangitis, with and without cholangiocarcinoma.
Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC
Am J Surg Pathol 2010 Jan;34(1):27-34. doi: 10.1097/PAS.0b013e3181bc96f9. PMID: 19898228

Clinical prediction guides

HER2 gene (ERBB2) amplification is a low-frequency driver with potential predictive value in gallbladder carcinoma.
Albrecht T, Rausch M, Roessler S, Geissler V, Albrecht M, Halske C, Seifert C, Renner M, Singer S, Mehrabi A, Vogel MN, Pathil-Warth A, Busch E, Köhler B, Rupp C, Weiss KH, Springfeld C, Röcken C, Schirmacher P, Goeppert B
Virchows Arch 2020 Jun;476(6):871-880. Epub 2019 Dec 14 doi: 10.1007/s00428-019-02706-6. PMID: 31838585
HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis.
Albrecht T, Rausch M, Rössler S, Albrecht M, Braun JD, Geissler V, Mehrabi A, Vogel MN, Pathil-Warth A, Mechtersheimer G, Renner M, Rupp C, Weiss KH, Busch E, Köhler B, Springfeld C, Schirmacher P, Goeppert B
BMC Cancer 2019 Dec 5;19(1):1191. doi: 10.1186/s12885-019-6320-y. PMID: 31805897Free PMC Article
Pyloric gland adenoma of the cystic duct with malignant transformation: report of a case with a review of the literature.
Schaefer IM, Cameron S, Middel P, Homayounfar K, Schwörer H, Vieth M, Veits L
BMC Cancer 2012 Dec 4;12:570. doi: 10.1186/1471-2407-12-570. PMID: 23206236Free PMC Article
Precancerous bile duct pathology in end-stage primary sclerosing cholangitis, with and without cholangiocarcinoma.
Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC
Am J Surg Pathol 2010 Jan;34(1):27-34. doi: 10.1097/PAS.0b013e3181bc96f9. PMID: 19898228
Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement.
Zen Y, Aishima S, Ajioka Y, Haratake J, Kage M, Kondo F, Nimura Y, Sakamoto M, Sasaki M, Shimamatsu K, Wakasa K, Park YN, Chen MF, Atomi Y, Nakanuma Y
Pathol Int 2005 Apr;55(4):180-8. doi: 10.1111/j.1440-1827.2005.01816.x. PMID: 15826244

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