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Esophageal dysplasia

MedGen UID:
108322
•Concept ID:
C0586354
•
Disease or Syndrome
Synonyms: Esophageal Dysplasia; Esophageal Intraepithelial Neoplasia; Intraepithelial Neoplasia of Esophagus; Intraepithelial Neoplasia of the Esophagus
SNOMED CT: Esophageal dysplasia (308857008)

Definition

A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma. Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade. In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications. (WHO, 2000) [from NCI]

Professional guidelines

PubMed

Antireflux surgery is required after endoscopic treatment for Barrett's esophagus.
Tyselskyi V, Poylin V, Tkachuk O, Kebkalo A
Pol Przegl Chir 2021 May 14;93(5):1-5. doi: 10.5604/01.3001.0014.8863. PMID: 34552027
p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia.
Yokoyama A, Tanaka Y, Yokoyama T, Mizukami T, Matsui T, Maruyama K, Omori T
Cancer Lett 2011 Sep 1;308(1):112-7. Epub 2011 May 23 doi: 10.1016/j.canlet.2011.04.020. PMID: 21601984
Cryotherapy in the management of esophageal dysplasia and malignancy.
Halsey KD, Greenwald BD
Gastrointest Endosc Clin N Am 2010 Jan;20(1):75-87, vi-vii. doi: 10.1016/j.giec.2009.07.009. PMID: 19951795

Recent clinical studies

Etiology

Artificial Intelligence and Its Role in Identifying Esophageal Neoplasia.
Syed T, Doshi A, Guleria S, Syed S, Shah T
Dig Dis Sci 2020 Dec;65(12):3448-3455. Epub 2020 Oct 15 doi: 10.1007/s10620-020-06643-2. PMID: 33057945Free PMC Article
Emerging endoscopic techniques for the identification of esophageal disease.
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Endoscopic mucosal resection and endoscopic submucosal dissection for esophageal dysplasia and carcinoma.
Inoue H, Minami H, Kaga M, Sato Y, Kudo SE
Gastrointest Endosc Clin N Am 2010 Jan;20(1):25-34, v-vi. doi: 10.1016/j.giec.2009.08.005. PMID: 19951792
Endoscopic imaging for the detection of esophageal dysplasia and carcinoma.
Shahid MW, Wallace MB
Gastrointest Endosc Clin N Am 2010 Jan;20(1):11-24, v. doi: 10.1016/j.giec.2009.08.006. PMID: 19951791
Barrett's esophagus.
Bonino JA, Sharma P
Curr Opin Gastroenterol 2005 Jul;21(4):461-5. PMID: 15930989

Diagnosis

Artificial Intelligence and Its Role in Identifying Esophageal Neoplasia.
Syed T, Doshi A, Guleria S, Syed S, Shah T
Dig Dis Sci 2020 Dec;65(12):3448-3455. Epub 2020 Oct 15 doi: 10.1007/s10620-020-06643-2. PMID: 33057945Free PMC Article
Esophagus with Extensive Nodularity.
Trinh VQ, Yachimski PS
Gastroenterology 2020 Sep;159(3):835-837. Epub 2020 Mar 20 doi: 10.1053/j.gastro.2020.03.034. PMID: 32205166
Emerging endoscopic techniques for the identification of esophageal disease.
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Endoscopic mucosal resection and endoscopic submucosal dissection for esophageal dysplasia and carcinoma.
Inoue H, Minami H, Kaga M, Sato Y, Kudo SE
Gastrointest Endosc Clin N Am 2010 Jan;20(1):25-34, v-vi. doi: 10.1016/j.giec.2009.08.005. PMID: 19951792
Endoscopic imaging for the detection of esophageal dysplasia and carcinoma.
Shahid MW, Wallace MB
Gastrointest Endosc Clin N Am 2010 Jan;20(1):11-24, v. doi: 10.1016/j.giec.2009.08.006. PMID: 19951791

Therapy

PARP1-targeted fluorescence molecular endoscopy as novel tool for early detection of esophageal dysplasia and adenocarcinoma.
Marcazzan S, Braz Carvalho MJ, Nguyen NT, Strangmann J, Slotta-Huspenina J, Tenditnaya A, Tschurtschenthaler M, Rieder J, Proaño-Vasco A, Ntziachristos V, Steiger K, Gorpas D, Quante M, Kossatz S
J Exp Clin Cancer Res 2024 Feb 21;43(1):53. doi: 10.1186/s13046-024-02963-7. PMID: 38383387Free PMC Article
Artificial Intelligence and Its Role in Identifying Esophageal Neoplasia.
Syed T, Doshi A, Guleria S, Syed S, Shah T
Dig Dis Sci 2020 Dec;65(12):3448-3455. Epub 2020 Oct 15 doi: 10.1007/s10620-020-06643-2. PMID: 33057945Free PMC Article
High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.
Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M
Gastroenterology 2019 Aug;157(2):492-506.e2. Epub 2019 Apr 15 doi: 10.1053/j.gastro.2019.04.013. PMID: 30998992Free PMC Article
CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma.
Fang HY, Münch NS, Schottelius M, Ingermann J, Liu H, Schauer M, Stangl S, Multhoff G, Steiger K, Gerngroß C, Jesinghaus M, Weichert W, Kühl AA, Sepulveda AR, Wester HJ, Wang TC, Quante M
Clin Cancer Res 2018 Mar 1;24(5):1048-1061. Epub 2017 Dec 5 doi: 10.1158/1078-0432.CCR-17-1756. PMID: 29208671
Chemoprevention of esophageal squamous cell carcinoma.
Stoner GD, Wang LS, Chen T
Toxicol Appl Pharmacol 2007 Nov 1;224(3):337-49. Epub 2007 Mar 15 doi: 10.1016/j.taap.2007.01.030. PMID: 17475300Free PMC Article

Prognosis

Machine learning for grading and prognosis of esophageal dysplasia using mass spectrometry and histological imaging.
Beuque M, Martin-Lorenzo M, Balluff B, Woodruff HC, Lucas M, de Bruin DM, van Timmeren JE, Boer OJ, Heeren RM, Meijer SL, Lambin P
Comput Biol Med 2021 Nov;138:104918. Epub 2021 Oct 4 doi: 10.1016/j.compbiomed.2021.104918. PMID: 34638018
Esophageal dysplasia and adenocarcinoma: a study with double immunostaining for intestinal and gastric markers.
Chlumská A, Mukenšnabl P, Waloschek T, Zámečník M
Cesk Patol 2018 Summer;54(2):81-85. PMID: 30441967
Emerging endoscopic techniques for the identification of esophageal disease.
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Progression of esophageal dysplasia to cancer.
Appelman HD, Matejcic M, Parker MI, Riddell RH, Salemme M, Swanson PE, Villanacci V
Ann N Y Acad Sci 2014 Sep;1325:96-107. doi: 10.1111/nyas.12523. PMID: 25266019
New therapeutic strategies for squamous cell cancer and adenocarcinoma.
Wijnhoven BPL, Toxopeus ELA, Vallböhmer D, Knoefel WT, Krasna MJ, Perez K, van Rossum PSN, Ruurda JP, van Hillegersberg R, Schiesser M, Schneider P, Felix VN
Ann N Y Acad Sci 2013 Oct;1300:213-225. doi: 10.1111/nyas.12247. PMID: 24117644

Clinical prediction guides

High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.
Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M
Gastroenterology 2019 Aug;157(2):492-506.e2. Epub 2019 Apr 15 doi: 10.1053/j.gastro.2019.04.013. PMID: 30998992Free PMC Article
Emerging endoscopic techniques for the identification of esophageal disease.
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis.
Findlay JM, Middleton MR, Tomlinson I
Dig Dis Sci 2016 Jan;61(1):25-38. Epub 2015 Oct 7 doi: 10.1007/s10620-015-3884-5. PMID: 26445852Free PMC Article
Progression of esophageal dysplasia to cancer.
Appelman HD, Matejcic M, Parker MI, Riddell RH, Salemme M, Swanson PE, Villanacci V
Ann N Y Acad Sci 2014 Sep;1325:96-107. doi: 10.1111/nyas.12523. PMID: 25266019
New therapeutic strategies for squamous cell cancer and adenocarcinoma.
Wijnhoven BPL, Toxopeus ELA, Vallböhmer D, Knoefel WT, Krasna MJ, Perez K, van Rossum PSN, Ruurda JP, van Hillegersberg R, Schiesser M, Schneider P, Felix VN
Ann N Y Acad Sci 2013 Oct;1300:213-225. doi: 10.1111/nyas.12247. PMID: 24117644

Recent systematic reviews

Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis.
Findlay JM, Middleton MR, Tomlinson I
Dig Dis Sci 2016 Jan;61(1):25-38. Epub 2015 Oct 7 doi: 10.1007/s10620-015-3884-5. PMID: 26445852Free PMC Article

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