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Gastric Poorly Cohesive Adenocarcinoma

MedGen UID:
459619
•Concept ID:
C2987393
•
Neoplastic Process
Synonyms: Gastric Poorly Cohesive Carcinoma; Poorly Cohesive Gastric Adenocarcinoma; Poorly Cohesive Gastric Carcinoma

Definition

An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates. This category includes signet ring cell adenocarcinomas, adenocarcinomas that are composed of malignant cells resembling lymphocytes and histiocytes, and adenocarcinomas that are composed of malignant cells with deeply eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Poorly Cohesive Adenocarcinoma

Professional guidelines

PubMed

Making It Stick: Management of Gastroesophageal Junction Adenocarcinoma with Poorly-Cohesive Cells (PCC).
Bouriez D, Gronnier C, Najah H, Collet D
Dig Dis Sci 2022 Jun;67(6):2005-2009. Epub 2022 Apr 16 doi: 10.1007/s10620-022-07437-4. PMID: 35430699
Emerging evidence supports grouping by location of early gastric carcinoma for appropriate clinical management in Chinese patients.
Huang Q, Li R, Xu GF, Zhou D, Fan XS, Zou XP
J Dig Dis 2018 Dec;19(12):730-736. Epub 2018 Nov 14 doi: 10.1111/1751-2980.12674. PMID: 30270559
Very well-differentiated gastric carcinoma of intestinal type: analysis of diagnostic criteria.
Ushiku T, Arnason T, Ban S, Hishima T, Shimizu M, Fukayama M, Lauwers GY
Mod Pathol 2013 Dec;26(12):1620-31. Epub 2013 May 31 doi: 10.1038/modpathol.2013.98. PMID: 23723017

Recent clinical studies

Etiology

Clinicopathological features and cancer transcriptomic profiling of poorly cohesive gastric carcinoma subtypes.
Yen HH, Chen PY, Huang RY, Jeng JM, Lai IR
J Pathol Clin Res 2024 Jul;10(4):e12387. doi: 10.1002/2056-4538.12387. PMID: 38860888Free PMC Article
Total Versus Subtotal Gastrectomy for Distal Gastric Poorly Cohesive Carcinoma.
Boubaddi M, Teixeira Farinha H, Lambert C, Pereira B, Piessen G, Gualtierotti M, Voron T, Mantziari S, Pezet D, Gronnier C; French Association of Surgery
Ann Surg Oncol 2024 Feb;31(2):744-752. Epub 2023 Nov 16 doi: 10.1245/s10434-023-14496-y. PMID: 37971616
Genetic landscape and PD-L1 expression in Epstein-Barr virus-associated gastric cancer according to the histological pattern.
Park JH, Cho HJ, Seo J, Park KB, Kwon YH, Bae HI, Seo AN, Kim M
Sci Rep 2023 Nov 9;13(1):19487. doi: 10.1038/s41598-023-45930-6. PMID: 37945587Free PMC Article
Clinicopathological characteristics and prognosis of poorly cohesive cell subtype of gastric cancer.
Nakamura K, Eto K, Iwagami S, Ogawa K, Sawayama H, Ishimoto T, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Baba H
Int J Clin Oncol 2022 Mar;27(3):512-519. Epub 2022 Jan 27 doi: 10.1007/s10147-021-02069-6. PMID: 35084597
Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges.
Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article

Diagnosis

Clinicopathological characteristics and prognosis of poorly cohesive cell subtype of gastric cancer.
Nakamura K, Eto K, Iwagami S, Ogawa K, Sawayama H, Ishimoto T, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Baba H
Int J Clin Oncol 2022 Mar;27(3):512-519. Epub 2022 Jan 27 doi: 10.1007/s10147-021-02069-6. PMID: 35084597
The updated WHO classification of digestive system tumours-gastric adenocarcinoma and dysplasia.
Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
Signet ring cell percentage in poorly cohesive gastric cancer patients: A potential novel predictor of survival.
Roviello F, Marano L, Ambrosio MR, Resca L, D'Ignazio A, Petrelli F, Petrioli R, Costantini M, Polom K, Macchiarelli R, Biviano I, Marrelli D
Eur J Surg Oncol 2022 Mar;48(3):561-569. Epub 2021 Sep 7 doi: 10.1016/j.ejso.2021.09.003. PMID: 34511269
FGFR2 alteration as a potential therapeutic target in poorly cohesive gastric carcinoma.
Wang Y, Shi T, Wang X, Hu J, Yu L, Liu Q, Wu N, Liu B, Wei J
J Transl Med 2021 Sep 22;19(1):401. doi: 10.1186/s12967-021-03079-8. PMID: 34551773Free PMC Article
Hereditary gastric cancer: what's new? Update 2013-2018.
van der Post RS, Oliveira C, Guilford P, Carneiro F
Fam Cancer 2019 Jul;18(3):363-367. doi: 10.1007/s10689-019-00127-7. PMID: 30989426

Therapy

Clinicopathological features and cancer transcriptomic profiling of poorly cohesive gastric carcinoma subtypes.
Yen HH, Chen PY, Huang RY, Jeng JM, Lai IR
J Pathol Clin Res 2024 Jul;10(4):e12387. doi: 10.1002/2056-4538.12387. PMID: 38860888Free PMC Article
Total Versus Subtotal Gastrectomy for Distal Gastric Poorly Cohesive Carcinoma.
Boubaddi M, Teixeira Farinha H, Lambert C, Pereira B, Piessen G, Gualtierotti M, Voron T, Mantziari S, Pezet D, Gronnier C; French Association of Surgery
Ann Surg Oncol 2024 Feb;31(2):744-752. Epub 2023 Nov 16 doi: 10.1245/s10434-023-14496-y. PMID: 37971616
Clinical implications and chemo-sensitivity of adjuvant chemotherapy in patients with poorly cohesive cells-gastric cancer.
Baek JH, Kang BW, Kang H, Cho M, Kwon OK, Park JY, Park KB, Seo AN, Kim JG
Cancer Chemother Pharmacol 2023 Oct;92(4):279-290. Epub 2023 Jul 22 doi: 10.1007/s00280-023-04564-1. PMID: 37480406
Livedoid cutaneous metastasis of signet-ring cell gastric carcinoma.
Demircioğlu D, Öztürk Durmaz E, Demirkesen C, Şahin S
J Cutan Pathol 2021 Jun;48(6):785-788. Epub 2021 Feb 8 doi: 10.1111/cup.13969. PMID: 33476049
Breast cancer metastasizing to the stomach mimicking primary gastric cancer: A case report.
Yim K, Ro SM, Lee J
World J Gastroenterol 2017 Mar 28;23(12):2251-2257. doi: 10.3748/wjg.v23.i12.2251. PMID: 28405154Free PMC Article

Prognosis

Clinicopathological features and cancer transcriptomic profiling of poorly cohesive gastric carcinoma subtypes.
Yen HH, Chen PY, Huang RY, Jeng JM, Lai IR
J Pathol Clin Res 2024 Jul;10(4):e12387. doi: 10.1002/2056-4538.12387. PMID: 38860888Free PMC Article
Total Versus Subtotal Gastrectomy for Distal Gastric Poorly Cohesive Carcinoma.
Boubaddi M, Teixeira Farinha H, Lambert C, Pereira B, Piessen G, Gualtierotti M, Voron T, Mantziari S, Pezet D, Gronnier C; French Association of Surgery
Ann Surg Oncol 2024 Feb;31(2):744-752. Epub 2023 Nov 16 doi: 10.1245/s10434-023-14496-y. PMID: 37971616
Clinicopathological characteristics and prognosis of poorly cohesive cell subtype of gastric cancer.
Nakamura K, Eto K, Iwagami S, Ogawa K, Sawayama H, Ishimoto T, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Baba H
Int J Clin Oncol 2022 Mar;27(3):512-519. Epub 2022 Jan 27 doi: 10.1007/s10147-021-02069-6. PMID: 35084597
Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges.
Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article
Consensus on the pathological definition and classification of poorly cohesive gastric carcinoma.
Mariette C, Carneiro F, Grabsch HI, van der Post RS, Allum W, de Manzoni G; European Chapter of International Gastric Cancer Association
Gastric Cancer 2019 Jan;22(1):1-9. Epub 2018 Aug 25 doi: 10.1007/s10120-018-0868-0. PMID: 30167905

Clinical prediction guides

Genomic and Pathologic Profiling of Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type: A Study With Emphasis on Diffuse-Type Transformation.
Rokutan H, Arai Y, Kunita A, Yamasaki S, Nakamura H, Hama N, Nakayama A, Hosoda F, Totoki Y, Fujishiro M, Seto Y, Shibata T, Ushiku T
Am J Surg Pathol 2024 Jun 1;48(6):652-661. Epub 2024 Apr 8 doi: 10.1097/PAS.0000000000002222. PMID: 38584451Free PMC Article
Total Versus Subtotal Gastrectomy for Distal Gastric Poorly Cohesive Carcinoma.
Boubaddi M, Teixeira Farinha H, Lambert C, Pereira B, Piessen G, Gualtierotti M, Voron T, Mantziari S, Pezet D, Gronnier C; French Association of Surgery
Ann Surg Oncol 2024 Feb;31(2):744-752. Epub 2023 Nov 16 doi: 10.1245/s10434-023-14496-y. PMID: 37971616
Genetic landscape and PD-L1 expression in Epstein-Barr virus-associated gastric cancer according to the histological pattern.
Park JH, Cho HJ, Seo J, Park KB, Kwon YH, Bae HI, Seo AN, Kim M
Sci Rep 2023 Nov 9;13(1):19487. doi: 10.1038/s41598-023-45930-6. PMID: 37945587Free PMC Article
Clinical implications and chemo-sensitivity of adjuvant chemotherapy in patients with poorly cohesive cells-gastric cancer.
Baek JH, Kang BW, Kang H, Cho M, Kwon OK, Park JY, Park KB, Seo AN, Kim JG
Cancer Chemother Pharmacol 2023 Oct;92(4):279-290. Epub 2023 Jul 22 doi: 10.1007/s00280-023-04564-1. PMID: 37480406
Breast cancer metastasizing to the stomach mimicking primary gastric cancer: A case report.
Yim K, Ro SM, Lee J
World J Gastroenterol 2017 Mar 28;23(12):2251-2257. doi: 10.3748/wjg.v23.i12.2251. PMID: 28405154Free PMC Article

Recent systematic reviews

Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges.
Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article

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