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Metastatic Endometrial Mixed Cell Adenocarcinoma

MedGen UID:
1780499
•Concept ID:
C5446650
•
Neoplastic Process

Definition

Endometrial mixed cell adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Endometrial Mixed Cell Adenocarcinoma

Professional guidelines

PubMed

The role of vaginal brachytherapy in the treatment of surgical stage I papillary serous or clear cell endometrial cancer.
Barney BM, Petersen IA, Mariani A, Dowdy SC, Bakkum-Gamez JN, Haddock MG
Int J Radiat Oncol Biol Phys 2013 Jan 1;85(1):109-15. Epub 2012 Apr 28 doi: 10.1016/j.ijrobp.2012.03.011. PMID: 22543202
Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions.
Hayes MM, Matisic JP, Chen CJ, Mohamed A, Anderson GH, LeRiche JC, Amy R
Cytopathology 1997 Dec;8(6):397-408. doi: 10.1111/j.1365-2303.1997.tb00570.x. PMID: 9439892

Recent clinical studies

Etiology

Malignant peritoneal cytology and increased mortality risk in stage I non-endometrioid endometrial cancer.
Matsuo K, Nusbaum DJ, Matsuzaki S, Chang EJ, Roman LD, Wright JD, Harter P, Klar M
Gynecol Oncol 2020 Oct;159(1):43-51. Epub 2020 Jul 18 doi: 10.1016/j.ygyno.2020.07.010. PMID: 32690393Free PMC Article
Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.
Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E
Am J Surg Pathol 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684. PMID: 27340747
Comparison of pure and mixed-type clear cell carcinoma of the ovary: a clinicopathological analysis of 341 Chinese patients.
Ye S, You Y, Yang J, Cao D, Bai H, Huang H, Wu M, Chen J, Lang J, Shen K
Int J Gynecol Cancer 2014 Nov;24(9):1590-6. doi: 10.1097/IGC.0000000000000275. PMID: 25254564
Outcome and patterns of failure in pathologic stages I-IV clear-cell carcinoma of the endometrium: implications for adjuvant radiation therapy.
Murphy KT, Rotmensch J, Yamada SD, Mundt AJ
Int J Radiat Oncol Biol Phys 2003 Apr 1;55(5):1272-6. doi: 10.1016/s0360-3016(02)04404-8. PMID: 12654437
Small cell neuroendocrine carcinoma of the endometrium.
van Hoeven KH, Hudock JA, Woodruff JM, Suhrland MJ
Int J Gynecol Pathol 1995 Jan;14(1):21-9. doi: 10.1097/00004347-199501000-00005. PMID: 7883422

Diagnosis

Primary mixed large cell neuroendocrine and high grade serous carcinoma of the endometrium.
Hardy LE, Chaudry Z, Wan K, Ayres C
BMJ Case Rep 2020 Sep 2;13(9) doi: 10.1136/bcr-2020-234977. PMID: 32878852Free PMC Article
Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review.
Tu YA, Chen YL, Lin MC, Chen CA, Cheng WF
Taiwan J Obstet Gynecol 2018 Feb;57(1):144-149. doi: 10.1016/j.tjog.2017.12.025. PMID: 29458887
Clinicopathological analysis of mixed endometrial carcinomas: clinical relevance of different neoplastic components.
Rossi ED, Bizzarro T, Monterossi G, Inzani F, Fanfani F, Scambia G, Zannoni GF
Hum Pathol 2017 Apr;62:99-107. Epub 2016 Dec 30 doi: 10.1016/j.humpath.2016.12.015. PMID: 28041971
Endometrial carcinomas: a review emphasizing overlapping and distinctive morphological and immunohistochemical features.
Bartosch C, Manuel Lopes J, Oliva E
Adv Anat Pathol 2011 Nov;18(6):415-37. doi: 10.1097/PAP.0b013e318234ab18. PMID: 21993268
Endometrioid carcinoma of the endometrium: pathologic and molecular features.
Azueta A, Gatius S, Matias-Guiu X
Semin Diagn Pathol 2010 Nov;27(4):226-40. doi: 10.1053/j.semdp.2010.09.001. PMID: 21309258

Therapy

Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review.
Tu YA, Chen YL, Lin MC, Chen CA, Cheng WF
Taiwan J Obstet Gynecol 2018 Feb;57(1):144-149. doi: 10.1016/j.tjog.2017.12.025. PMID: 29458887
Carboplatin and nonpegylated liposomal doxorubicin in primary advanced or recurrent endometrial cancer: a phase 2 trial conducted by AGO Austria.
Volgger B, Zeimet AG, Reinthaller A, Petru E, Schauer C, Klein M, Sevelda-Schwarzgruber U, Bogner G, Wolfram G, Marth C
Int J Gynecol Cancer 2015 Feb;25(2):257-62. doi: 10.1097/IGC.0000000000000352. PMID: 25611899
Endometrial carcinoma recurring as carcinosarcoma: report of two cases.
Ferrandina G, Zannoni GF, Martinelli E, Vellone V, Prisco MG, Scambia G
Pathol Res Pract 2007;203(9):677-81. Epub 2007 Jul 23 doi: 10.1016/j.prp.2007.05.008. PMID: 17646054
Outcome and patterns of failure in pathologic stages I-IV clear-cell carcinoma of the endometrium: implications for adjuvant radiation therapy.
Murphy KT, Rotmensch J, Yamada SD, Mundt AJ
Int J Radiat Oncol Biol Phys 2003 Apr 1;55(5):1272-6. doi: 10.1016/s0360-3016(02)04404-8. PMID: 12654437

Prognosis

Clinicopathological analysis of mixed endometrial carcinomas: clinical relevance of different neoplastic components.
Rossi ED, Bizzarro T, Monterossi G, Inzani F, Fanfani F, Scambia G, Zannoni GF
Hum Pathol 2017 Apr;62:99-107. Epub 2016 Dec 30 doi: 10.1016/j.humpath.2016.12.015. PMID: 28041971
Comparison of pure and mixed-type clear cell carcinoma of the ovary: a clinicopathological analysis of 341 Chinese patients.
Ye S, You Y, Yang J, Cao D, Bai H, Huang H, Wu M, Chen J, Lang J, Shen K
Int J Gynecol Cancer 2014 Nov;24(9):1590-6. doi: 10.1097/IGC.0000000000000275. PMID: 25254564
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767
Endometrioid carcinoma of the endometrium: pathologic and molecular features.
Azueta A, Gatius S, Matias-Guiu X
Semin Diagn Pathol 2010 Nov;27(4):226-40. doi: 10.1053/j.semdp.2010.09.001. PMID: 21309258
Outcome and patterns of failure in pathologic stages I-IV clear-cell carcinoma of the endometrium: implications for adjuvant radiation therapy.
Murphy KT, Rotmensch J, Yamada SD, Mundt AJ
Int J Radiat Oncol Biol Phys 2003 Apr 1;55(5):1272-6. doi: 10.1016/s0360-3016(02)04404-8. PMID: 12654437

Clinical prediction guides

Mixed high-grade serous and large cell neuroendocrine carcinoma arising from rectal endometriosis 11 years after hysterectomy.
Yanagita T, Hikichi T, Waragai Y, Shimizu H, Takahashi Y, Abe N, Hashimoto C, Kumakawa H, Kobayakawa M, Ohira H
Clin J Gastroenterol 2023 Jun;16(3):366-371. Epub 2023 Feb 10 doi: 10.1007/s12328-023-01769-y. PMID: 36763235
Clinicopathological analysis of mixed endometrial carcinomas: clinical relevance of different neoplastic components.
Rossi ED, Bizzarro T, Monterossi G, Inzani F, Fanfani F, Scambia G, Zannoni GF
Hum Pathol 2017 Apr;62:99-107. Epub 2016 Dec 30 doi: 10.1016/j.humpath.2016.12.015. PMID: 28041971
Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.
Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E
Am J Surg Pathol 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684. PMID: 27340747
Comparison of pure and mixed-type clear cell carcinoma of the ovary: a clinicopathological analysis of 341 Chinese patients.
Ye S, You Y, Yang J, Cao D, Bai H, Huang H, Wu M, Chen J, Lang J, Shen K
Int J Gynecol Cancer 2014 Nov;24(9):1590-6. doi: 10.1097/IGC.0000000000000275. PMID: 25254564
Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma.
Soslow RA, Wethington SL, Cesari M, Chiappetta D, Olvera N, Shia J, Levine DA
Am J Surg Pathol 2012 Dec;36(12):1771-81. doi: 10.1097/PAS.0b013e318273591a. PMID: 23154767

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