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Small Intestinal Mucinous Adenocarcinoma

MedGen UID:
328035
Concept ID:
C1710109
Neoplastic Process

Definition

An invasive adenocarcinoma that arises from the small intestine. It is composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Mucinous Adenocarcinoma

Professional guidelines

PubMed

Modlin IM, Kidd M, Bodei L, Drozdov I, Aslanian H
Am J Gastroenterol 2015 Aug;110(8):1223-32. Epub 2015 Jun 2 doi: 10.1038/ajg.2015.160. PMID: 26032155
Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD
Oncologist 2010;15(12):1294-309. Epub 2010 Dec 8 doi: 10.1634/theoncologist.2010-0151. PMID: 21147870Free PMC Article
Sugarbaker PH, Fernández-Trigo V, Shamsa F
Cancer Treat Res 1996;81:121-32. doi: 10.1007/978-1-4613-1245-1_11. PMID: 8834580

Recent clinical studies

Etiology

Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Kumagai R, Kohashi K, Takahashi S, Yamamoto H, Hirahashi M, Taguchi K, Nishiyama K, Oda Y
World J Gastroenterol 2015 Mar 7;21(9):2700-10. doi: 10.3748/wjg.v21.i9.2700. PMID: 25759539Free PMC Article
Gong H, Yu Y, Yao Y
Cell Biochem Biophys 2013 Apr;65(3):491-3. doi: 10.1007/s12013-012-9445-z. PMID: 23076636
Baiocchi G, Cestari LA, Macedo MP, Oliveira RA, Fukazawa EM, Faloppa CC, Kumagai LY, Badiglian-Filho L, Menezes AN, Cunha IW, Soares FA
J Surg Oncol 2011 Sep 1;104(3):250-4. Epub 2011 Apr 6 doi: 10.1002/jso.21940. PMID: 21472733
Sugarbaker PH, Kern K, Lack E
Dis Colon Rectum 1987 Oct;30(10):772-9. doi: 10.1007/BF02554625. PMID: 2820671

Diagnosis

Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Corvino A, Corvino F, Radice L, Catalano O
Clin Imaging 2015 May-Jun;39(3):538-42. Epub 2015 Jan 7 doi: 10.1016/j.clinimag.2014.12.019. PMID: 25744428
Takada T, Yasuda H, Amano H, Yoshida M, Hijikata H, Takada K
Hepatogastroenterology 1998 Nov-Dec;45(24):1967-72. PMID: 9951849
Kimura W, Kuroda A, Makuuchi M
Pancreas 1998 Apr;16(3):363-9. doi: 10.1097/00006676-199804000-00025. PMID: 9548680
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994

Therapy

Jedrzejko N, Wong A, MacNeill AJ, Hamilton TD
J Gastrointest Surg 2022 Oct;26(10):2176-2183. Epub 2022 Jun 29 doi: 10.1007/s11605-022-05394-x. PMID: 35852704
Sun WL, Hutarew G, Gradl J, Gratzl M, Denz H, Fiegl M
Cancer Biol Ther 2009 Aug;8(15):1459-62. Epub 2009 Aug 8 doi: 10.4161/cbt.8.15.8943. PMID: 19483475
Roberts PL, Veidenheimer MC, Cassidy S, Silverman ML
Arch Surg 1989 Apr;124(4):497-9. doi: 10.1001/archsurg.1989.01410040107025. PMID: 2539068
Sugarbaker PH, Kern K, Lack E
Dis Colon Rectum 1987 Oct;30(10):772-9. doi: 10.1007/BF02554625. PMID: 2820671
Wise L, Pizzimbono C, Dehner LP
Am J Surg 1976 Feb;131(2):141-8. doi: 10.1016/0002-9610(76)90087-8. PMID: 56140

Prognosis

Hoshimoto A, Tatsuguchi A, Yamada T, Kuriyama S, Hamakubo R, Nishimoto T, Omori J, Akimoto N, Gudis K, Mitsui K, Tanaka S, Fujimori S, Hatori T, Shimizu A, Iwakiri K
Am J Surg Pathol 2024 Feb 1;48(2):127-139. Epub 2023 Dec 4 doi: 10.1097/PAS.0000000000002161. PMID: 38062562Free PMC Article
Gundamaraju R, Chong WC
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188579. Epub 2021 Jun 15 doi: 10.1016/j.bbcan.2021.188579. PMID: 34139275
Agaram NP, Shia J, Tang LH, Klimstra DS
Am J Clin Pathol 2010 May;133(5):772-80. doi: 10.1309/AJCPGDDE8PLLDRCC. PMID: 20395525
Kimura W, Kuroda A, Makuuchi M
Pancreas 1998 Apr;16(3):363-9. doi: 10.1097/00006676-199804000-00025. PMID: 9548680
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994

Clinical prediction guides

Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Ideno N, Ohtsuka T, Matsunaga T, Kimura H, Watanabe Y, Tamura K, Aso T, Aishima S, Miyasaka Y, Ohuchida K, Ueda J, Takahata S, Oda Y, Mizumoto K, Tanaka M
Pancreas 2015 Mar;44(2):311-20. doi: 10.1097/MPA.0000000000000258. PMID: 25479586
Baiocchi G, Cestari LA, Macedo MP, Oliveira RA, Fukazawa EM, Faloppa CC, Kumagai LY, Badiglian-Filho L, Menezes AN, Cunha IW, Soares FA
J Surg Oncol 2011 Sep 1;104(3):250-4. Epub 2011 Apr 6 doi: 10.1002/jso.21940. PMID: 21472733
Agaram NP, Shia J, Tang LH, Klimstra DS
Am J Clin Pathol 2010 May;133(5):772-80. doi: 10.1309/AJCPGDDE8PLLDRCC. PMID: 20395525
Kimura Y, Hirata K, Mukaiya M, Mizuguchi T, Koito K, Katsuramaki T
Am J Surg 2005 Jun;189(6):734-7. doi: 10.1016/j.amjsurg.2005.03.017. PMID: 15910728

Recent systematic reviews

Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358

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