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Gastric gastrin-producing neuroendocrine tumor

MedGen UID:
232230
•Concept ID:
C1333767
•
Neoplastic Process
Synonyms: gastric G-cell gastrin producing tumor; gastric G-cell gastrin producing tumour; Gastric Gastrin Producing Tumor; gastric gastrin producing tumor; gastric gastrin producing tumour; Gastric Gastrin-Producing NET; gastric gastrin-producing NET; Gastric Gastrin-Producing Neuroendocrine Tumor; gastric gastrin-producing neuroendocrine tumor; Gastric Gastrinoma; gastric gastrinoma; Gastrin Producing Neuroendocrine Tumor of the Stomach; gastrin producing neuroendocrine tumor of the stomach; gastrin producing neuroendocrine tumour of the stomach; Gastrin Producing Tumor of the Stomach; gastrin producing tumor of the stomach; gastrin producing tumour of the stomach; gastrin-producing neuroendocrine tumor of stomach; Gastrin-Producing Neuroendocrine Tumor of the Stomach; gastrin-producing neuroendocrine tumor of the stomach; gastrin-producing neuroendocrine tumour of stomach; gastrin-producing neuroendocrine tumour of the stomach; stomach gastrin-producing neuroendocrine tumor; stomach gastrin-producing neuroendocrine tumour
 
Monarch Initiative: MONDO:0003524

Definition

A well differentiated neuroendocrine tumor that arises from the stomach. It produces gastrin and it may be associated with Zollinger-Ellison syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric gastrin-producing neuroendocrine tumor

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.
Kawasaki K, Toshimitsu K, Matano M, Fujita M, Fujii M, Togasaki K, Ebisudani T, Shimokawa M, Takano A, Takahashi S, Ohta Y, Nanki K, Igarashi R, Ishimaru K, Ishida H, Sukawa Y, Sugimoto S, Saito Y, Maejima K, Sasagawa S, Lee H, Kim HG, Ha K, Hamamoto J, Fukunaga K, Maekawa A, Tanabe M, Ishihara S, Hamamoto Y, Yasuda H, Sekine S, Kudo A, Kitagawa Y, Kanai T, Nakagawa H, Sato T
Cell 2020 Nov 25;183(5):1420-1435.e21. Epub 2020 Nov 6 doi: 10.1016/j.cell.2020.10.023. PMID: 33159857
Gastrinomas: Medical or Surgical Treatment.
Norton JA, Foster DS, Ito T, Jensen RT
Endocrinol Metab Clin North Am 2018 Sep;47(3):577-601. doi: 10.1016/j.ecl.2018.04.009. PMID: 30098717Free PMC Article

Recent clinical studies

Etiology

Management of Gastric Neuroendocrine Tumors: A Review.
Sok C, Ajay PS, Tsagkalidis V, Kooby DA, Shah MM
Ann Surg Oncol 2024 Mar;31(3):1509-1518. Epub 2023 Dec 7 doi: 10.1245/s10434-023-14712-9. PMID: 38062290Free PMC Article
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.
Lee L, Ramos-Alvarez I, Ito T, Jensen RT
Int J Mol Sci 2019 Oct 16;20(20) doi: 10.3390/ijms20205128. PMID: 31623145Free PMC Article
Chronic hypergastrinemia: causes and consequences.
Orlando LA, Lenard L, Orlando RC
Dig Dis Sci 2007 Oct;52(10):2482-9. Epub 2007 Apr 6 doi: 10.1007/s10620-006-9419-3. PMID: 17415644

Diagnosis

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Gastric Carcinoids.
Grozinsky-Glasberg S, Alexandraki KI, Angelousi A, Chatzellis E, Sougioultzis S, Kaltsas G
Endocrinol Metab Clin North Am 2018 Sep;47(3):645-660. Epub 2018 Jul 11 doi: 10.1016/j.ecl.2018.04.013. PMID: 30098721
Zollinger-Ellison syndrome: recent advances and controversies.
Ito T, Igarashi H, Jensen RT
Curr Opin Gastroenterol 2013 Nov;29(6):650-61. doi: 10.1097/MOG.0b013e328365efb1. PMID: 24100728Free PMC Article
Pharmacotherapy of Zollinger-Ellison syndrome.
Ito T, Igarashi H, Uehara H, Jensen RT
Expert Opin Pharmacother 2013 Feb;14(3):307-21. Epub 2013 Jan 30 doi: 10.1517/14656566.2013.767332. PMID: 23363383Free PMC Article

Therapy

Sequential therapies in gastric gastrinoma.
Rosiek V
Endokrynol Pol 2022;73(1):171-172. doi: 10.5603/EP.a2021.0101. PMID: 35381105
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.
Lee L, Ramos-Alvarez I, Ito T, Jensen RT
Int J Mol Sci 2019 Oct 16;20(20) doi: 10.3390/ijms20205128. PMID: 31623145Free PMC Article
Gastroduodenal neuroendocrine neoplasms including gastrinoma - management guidelines (recommended by the Polish Network of Neuroendocrine Tumours).
Rydzewska G, Cichocki A, Ćwikła JB, Foltyn W, Hubalewska-Dydejczyk A, Kamiński G, Lewczuk A, Nasierowska-Guttmejer A, Nowakowska-Duława E, Pilch-Kowalczyk J, Sowa-Staszczak A, Kos-Kudła B; Consensus Conference; Polish Network of Neuroendocrine Tumours
Endokrynol Pol 2013;64(6):444-58. doi: 10.5603/EP.2013.0030. PMID: 24431117
Pharmacotherapy of Zollinger-Ellison syndrome.
Ito T, Igarashi H, Uehara H, Jensen RT
Expert Opin Pharmacother 2013 Feb;14(3):307-21. Epub 2013 Jan 30 doi: 10.1517/14656566.2013.767332. PMID: 23363383Free PMC Article
Proton pump inhibitory therapy: then and now.
Schepp W
Yale J Biol Med 1996 Mar-Apr;69(2):175-86. PMID: 9112749Free PMC Article

Prognosis

Management of Gastric Neuroendocrine Tumors: A Review.
Sok C, Ajay PS, Tsagkalidis V, Kooby DA, Shah MM
Ann Surg Oncol 2024 Mar;31(3):1509-1518. Epub 2023 Dec 7 doi: 10.1245/s10434-023-14712-9. PMID: 38062290Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Gastric Carcinoids.
Grozinsky-Glasberg S, Alexandraki KI, Angelousi A, Chatzellis E, Sougioultzis S, Kaltsas G
Endocrinol Metab Clin North Am 2018 Sep;47(3):645-660. Epub 2018 Jul 11 doi: 10.1016/j.ecl.2018.04.013. PMID: 30098721
Zollinger-Ellison syndrome: recent advances and controversies.
Ito T, Igarashi H, Jensen RT
Curr Opin Gastroenterol 2013 Nov;29(6):650-61. doi: 10.1097/MOG.0b013e328365efb1. PMID: 24100728Free PMC Article
Gastrinoma--morphological aspects.
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

Clinical prediction guides

Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.
Lee L, Ramos-Alvarez I, Ito T, Jensen RT
Int J Mol Sci 2019 Oct 16;20(20) doi: 10.3390/ijms20205128. PMID: 31623145Free PMC Article
Neuroendocrine pathology of the stomach: the Parma contribution.
Bordi C
Endocr Pathol 2014 Jun;25(2):171-80. doi: 10.1007/s12022-014-9315-x. PMID: 24782101
The consequences of hypergastrinemia.
Creutzfeldt W
Yale J Biol Med 1994 May-Aug;67(3-4):181-94. PMID: 7502528Free PMC Article
Hepatic gastrinoma.
Moriura S, Ikeda S, Hirai M, Naiki K, Fujioka T, Yokochi K, Gotou S
Cancer 1993 Sep 1;72(5):1547-50. doi: 10.1002/1097-0142(19930901)72:5<1547::aid-cncr2820720510>3.0.co;2-c. PMID: 8348490

Recent systematic reviews

Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours: a Systematic Literature Review.
Cockburn KC, Toumi Z, Mackie A, Julyan P
J Gastrointest Surg 2021 Dec;25(12):3244-3257. Epub 2021 Sep 10 doi: 10.1007/s11605-021-05115-w. PMID: 34506015Free PMC Article

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