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Poorly Differentiated Hepatocellular Carcinoma

MedGen UID:
474668
Concept ID:
C3273035
Neoplastic Process

Definition

A hepatocellular carcinoma characterized by the presence of malignant pleomorphic cells forming solid patterns. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoorly Differentiated Hepatocellular Carcinoma

Professional guidelines

PubMed

Koga Y, Beppu T, Miyata T, Kitano Y, Tsuji A, Nakagawa S, Arima K, Kuramoto K, Okabe H, Imai K, Hayashi H, Nitta H, Yamashita YI, Chikamoto A, Ishiko T, Baba H
Anticancer Res 2018 Jul;38(7):4093-4099. doi: 10.21873/anticanres.12699. PMID: 29970535
Kakar S, Gown AM, Goodman ZD, Ferrell LD
Arch Pathol Lab Med 2007 Nov;131(11):1648-54. doi: 10.5858/2007-131-1648-BPIDIH. PMID: 17979482
Hytiroglou P, Theise ND
Semin Diagn Pathol 1998 Nov;15(4):285-99. PMID: 9845429

Recent clinical studies

Etiology

Wang S, Yao J, Li K, Yang H, Lu S, He G, Wu W, Cheng W, Jiang T, Ding H, Jing X, Yan Y, Liu F, Yu J, Han Z, Cheng Z, Tan S, Li X, Dou J, Li Y, Qi E, Zhang Y, Liang P, Yu X
Abdom Radiol (NY) 2023 Oct;48(10):3101-3113. Epub 2023 Jul 12 doi: 10.1007/s00261-023-03993-z. PMID: 37436451
Salehi O, Vega EA, Kutlu OC, Lunsford K, Freeman R, Ladin K, Alarcon SV, Kazakova V, Conrad C
HPB (Oxford) 2022 Jul;24(7):1100-1109. Epub 2021 Dec 10 doi: 10.1016/j.hpb.2021.12.001. PMID: 34969618
Guo HL, Zheng X, Cheng MQ, Zeng D, Huang H, Xie XY, Lu MD, Kuang M, Wang W, Xian MF, Chen LD
J Ultrasound Med 2022 May;41(5):1213-1225. Epub 2021 Aug 23 doi: 10.1002/jum.15812. PMID: 34423864
Ogasawara N, Saitoh S, Denpou H, Kinowaki K, Akuta N, Suzuki F, Hashimoto M, Fujiyama S, Kawamura Y, Sezaki H, Hosaka T, Kobayashi M, Suzuki Y, Arase Y, Ikeda K, Fujii T, Kumada H
Intern Med 2020 Feb 1;59(3):365-372. Epub 2019 Oct 17 doi: 10.2169/internalmedicine.3577-19. PMID: 31619599Free PMC Article
Krasnodębski M, Grąt M, Masior Ł, Wronka KM, Grąt K, Stypułkowski J, Bik E, Patkowski W, Krawczyk M
Transplant Proc 2016 Jun;48(5):1713-6. doi: 10.1016/j.transproceed.2016.01.067. PMID: 27496477

Diagnosis

Wang S, Yao J, Li K, Yang H, Lu S, He G, Wu W, Cheng W, Jiang T, Ding H, Jing X, Yan Y, Liu F, Yu J, Han Z, Cheng Z, Tan S, Li X, Dou J, Li Y, Qi E, Zhang Y, Liang P, Yu X
Abdom Radiol (NY) 2023 Oct;48(10):3101-3113. Epub 2023 Jul 12 doi: 10.1007/s00261-023-03993-z. PMID: 37436451
Nagao M, Fukuda A, Tsujimura M, Nishioka Y, Umeda M, Matsumura T, Seno H
Clin J Gastroenterol 2023 Oct;16(5):698-701. Epub 2023 May 11 doi: 10.1007/s12328-023-01813-x. PMID: 37166565
Guo HL, Zheng X, Cheng MQ, Zeng D, Huang H, Xie XY, Lu MD, Kuang M, Wang W, Xian MF, Chen LD
J Ultrasound Med 2022 May;41(5):1213-1225. Epub 2021 Aug 23 doi: 10.1002/jum.15812. PMID: 34423864
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Shen YF, Tsai MR, Chen SC, Leung YS, Hsieh CT, Chen YS, Huang FL, Obena RP, Zulueta MM, Huang HY, Lee WJ, Tang KC, Kung CT, Chen MH, Shieh DB, Chen YJ, Liu TM, Chou PT, Sun CK
Anal Chem 2015 Aug 4;87(15):7575-82. Epub 2015 Jul 16 doi: 10.1021/acs.analchem.5b01903. PMID: 26146882

Therapy

Chen X, Chen Y, Chen H, Zhu J, Huang R, Xie J, Zhang T, Xie A, Li Y
Abdom Radiol (NY) 2023 Aug;48(8):2525-2536. Epub 2023 May 11 doi: 10.1007/s00261-023-03870-9. PMID: 37169988
Yang X, Yuan C, Zhang Y, Wang Z
Medicine (Baltimore) 2021 May 14;100(19):e25838. doi: 10.1097/MD.0000000000025838. PMID: 34106622Free PMC Article
Filippi L, Di Costanzo GG, D'Agostini A, Tortora R, Pelle G, Cianni R, Schillaci O, Bagni O
Nucl Med Commun 2018 Sep;39(9):845-852. doi: 10.1097/MNM.0000000000000879. PMID: 29901488
Shinoda M, Kishida N, Itano O, Ei S, Ueno A, Kitago M, Abe Y, Hibi T, Yagi H, Masugi Y, Tanabe M, Aiura K, Sakamaoto M, Tanimoto A, Kitagawa Y
World J Surg Oncol 2015 Apr 9;13:144. doi: 10.1186/s12957-015-0559-9. PMID: 25889667Free PMC Article
Akamatsu M, Ishikawa T, Shiratori Y, Koike Y, Shiina S, Teratani T, Hamamura K, Obi S, Sato S, Tateishi R, Fujishima T, Imai Y, Yoshida H, Omata M
Hepatogastroenterology 2005 Mar-Apr;52(62):391-7. PMID: 15816443

Prognosis

Wang S, Yao J, Li K, Yang H, Lu S, He G, Wu W, Cheng W, Jiang T, Ding H, Jing X, Yan Y, Liu F, Yu J, Han Z, Cheng Z, Tan S, Li X, Dou J, Li Y, Qi E, Zhang Y, Liang P, Yu X
Abdom Radiol (NY) 2023 Oct;48(10):3101-3113. Epub 2023 Jul 12 doi: 10.1007/s00261-023-03993-z. PMID: 37436451
Koga Y, Beppu T, Miyata T, Kitano Y, Tsuji A, Nakagawa S, Arima K, Kuramoto K, Okabe H, Imai K, Hayashi H, Nitta H, Yamashita YI, Chikamoto A, Ishiko T, Baba H
Anticancer Res 2018 Jul;38(7):4093-4099. doi: 10.21873/anticanres.12699. PMID: 29970535
Zhao S, Su G, Yang W, Yue P, Bai B, Lin Y, Zhang J, Ba Y, Luo Z, Liu X, Zhao L, Xie Y, Xu Y, Li S, Meng W, Xie X, Li X
Technol Cancer Res Treat 2017 Dec;16(6):1092-1101. Epub 2017 Sep 25 doi: 10.1177/1533034617732426. PMID: 29332450Free PMC Article
Kawada M, Hayami N, Suwabe T, Hoshino J, Sumida K, Mise K, Hamanoue S, Yamanouchi M, Sawa N, Takaichi K, Fujii T, Ubara Y
Intern Med 2015;54(15):1891-6. Epub 2015 Aug 1 doi: 10.2169/internalmedicine.54.3924. PMID: 26234231
Nakachi K, Tamai H, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M
Cancer Imaging 2014 Apr 22;14(1):7. doi: 10.1186/1470-7330-14-7. PMID: 25608454Free PMC Article

Clinical prediction guides

Vinh Hanh N, Thi Thanh Thuy L, Ngoc Hieu V, Hai H, Ikenaga H, Sato-Matsubara M, Uchida-Kobayashi S, Urushima H, Van Khanh N, Thi Ha N, Shinkawa H, Kubo S, Ohtani N, Enomoto M, Tamori A, Kawada N
Am J Pathol 2024 Jul;194(7):1230-1247. Epub 2024 Mar 26 doi: 10.1016/j.ajpath.2024.03.004. PMID: 38548267
Wang S, Yao J, Li K, Yang H, Lu S, He G, Wu W, Cheng W, Jiang T, Ding H, Jing X, Yan Y, Liu F, Yu J, Han Z, Cheng Z, Tan S, Li X, Dou J, Li Y, Qi E, Zhang Y, Liang P, Yu X
Abdom Radiol (NY) 2023 Oct;48(10):3101-3113. Epub 2023 Jul 12 doi: 10.1007/s00261-023-03993-z. PMID: 37436451
Yang X, Yuan C, Zhang Y, Wang Z
Medicine (Baltimore) 2021 May 14;100(19):e25838. doi: 10.1097/MD.0000000000025838. PMID: 34106622Free PMC Article
Koga Y, Beppu T, Miyata T, Kitano Y, Tsuji A, Nakagawa S, Arima K, Kuramoto K, Okabe H, Imai K, Hayashi H, Nitta H, Yamashita YI, Chikamoto A, Ishiko T, Baba H
Anticancer Res 2018 Jul;38(7):4093-4099. doi: 10.21873/anticanres.12699. PMID: 29970535
Nakachi K, Tamai H, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M
Cancer Imaging 2014 Apr 22;14(1):7. doi: 10.1186/1470-7330-14-7. PMID: 25608454Free PMC Article

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