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Metastatic HER2-Low Breast Carcinoma

MedGen UID:
1794008
Concept ID:
C5557567
Neoplastic Process
Synonyms: Metastatic HER2 Low Breast Adenocarcinoma; Metastatic HER2 Low Breast Carcinoma; Metastatic HER2-Low Breast Adenocarcinoma

Definition

A HER2-low breast adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic HER2-Low Breast Carcinoma

Professional guidelines

PubMed

Roy AM, Kumarasamy VM, Dhakal A, O'Regan R, Gandhi S
Cancer 2023 Sep 15;129(18):2773-2788. Epub 2023 Jun 22 doi: 10.1002/cncr.34904. PMID: 37349954Free PMC Article
Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905
Rugo HS, Bianchini G, Cortes J, Henning JW, Untch M
ESMO Open 2022 Aug;7(4):100553. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100553. PMID: 35964548Free PMC Article

Recent clinical studies

Etiology

Ivanova M, Porta FM, D'Ercole M, Pescia C, Sajjadi E, Cursano G, De Camilli E, Pala O, Mazzarol G, Venetis K, Guerini-Rocco E, Curigliano G, Viale G, Fusco N
Virchows Arch 2024 Jan;484(1):3-14. Epub 2023 Sep 28 doi: 10.1007/s00428-023-03656-w. PMID: 37770765Free PMC Article
Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905
Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno NT, Prat A, Chae YS, Lee KS, Niikura N, Park YH, Xu B, Wang X, Gil-Gil M, Li W, Pierga JY, Im SA, Moore HCF, Rugo HS, Yerushalmi R, Zagouri F, Gombos A, Kim SB, Liu Q, Luo T, Saura C, Schmid P, Sun T, Gambhire D, Yung L, Wang Y, Singh J, Vitazka P, Meinhardt G, Harbeck N, Cameron DA; DESTINY-Breast04 Trial Investigators
N Engl J Med 2022 Jul 7;387(1):9-20. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2203690. PMID: 35665782Free PMC Article
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Lee J, Park YH
Future Oncol 2022 Jan;18(1):7-19. Epub 2021 Nov 26 doi: 10.2217/fon-2021-0550. PMID: 34823373

Diagnosis

Ivanova M, Porta FM, D'Ercole M, Pescia C, Sajjadi E, Cursano G, De Camilli E, Pala O, Mazzarol G, Venetis K, Guerini-Rocco E, Curigliano G, Viale G, Fusco N
Virchows Arch 2024 Jan;484(1):3-14. Epub 2023 Sep 28 doi: 10.1007/s00428-023-03656-w. PMID: 37770765Free PMC Article
Viale G, Basik M, Niikura N, Tokunaga E, Brucker S, Penault-Llorca F, Hayashi N, Sohn J, Teixeira de Sousa R, Brufsky AM, O'Brien CS, Schmitt F, Higgins G, Varghese D, James GD, Moh A, Livingston A, de Giorgio-Miller V
ESMO Open 2023 Aug;8(4):101615. Epub 2023 Aug 8 doi: 10.1016/j.esmoop.2023.101615. PMID: 37562195Free PMC Article
Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Yao M, Fu P
Chin Clin Oncol 2018 Jun;7(3):27. doi: 10.21037/cco.2018.05.04. PMID: 30056729

Therapy

Mosele F, Deluche E, Lusque A, Le Bescond L, Filleron T, Pradat Y, Ducoulombier A, Pistilli B, Bachelot T, Viret F, Levy C, Signolle N, Alfaro A, Tran DTN, Garberis IJ, Talbot H, Christodoulidis S, Vakalopoulou M, Droin N, Stourm A, Kobayashi M, Kakegawa T, Lacroix L, Saulnier P, Job B, Deloger M, Jimenez M, Mahier C, Baris V, Laplante P, Kannouche P, Marty V, Lacroix-Triki M, Diéras V, André F
Nat Med 2023 Aug;29(8):2110-2120. Epub 2023 Jul 24 doi: 10.1038/s41591-023-02478-2. PMID: 37488289Free PMC Article
Tarantino P, Viale G, Press MF, Hu X, Penault-Llorca F, Bardia A, Batistatou A, Burstein HJ, Carey LA, Cortes J, Denkert C, Diéras V, Jacot W, Koutras AK, Lebeau A, Loibl S, Modi S, Mosele MF, Provenzano E, Pruneri G, Reis-Filho JS, Rojo F, Salgado R, Schmid P, Schnitt SJ, Tolaney SM, Trapani D, Vincent-Salomon A, Wolff AC, Pentheroudakis G, André F, Curigliano G
Ann Oncol 2023 Aug;34(8):645-659. Epub 2023 Jun 1 doi: 10.1016/j.annonc.2023.05.008. PMID: 37269905
Rugo HS, Bianchini G, Cortes J, Henning JW, Untch M
ESMO Open 2022 Aug;7(4):100553. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100553. PMID: 35964548Free PMC Article
Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno NT, Prat A, Chae YS, Lee KS, Niikura N, Park YH, Xu B, Wang X, Gil-Gil M, Li W, Pierga JY, Im SA, Moore HCF, Rugo HS, Yerushalmi R, Zagouri F, Gombos A, Kim SB, Liu Q, Luo T, Saura C, Schmid P, Sun T, Gambhire D, Yung L, Wang Y, Singh J, Vitazka P, Meinhardt G, Harbeck N, Cameron DA; DESTINY-Breast04 Trial Investigators
N Engl J Med 2022 Jul 7;387(1):9-20. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2203690. PMID: 35665782Free PMC Article
Deeks ED
Drugs 2021 Nov;81(16):1929-1935. doi: 10.1007/s40265-021-01614-x. PMID: 34661865

Prognosis

Lin M, Luo T, Jin Y, Zhong X, Zheng D, Zeng C, Guo Q, Wu J, Shao ZM, Hu X, Yang W, Zhang J
Cancer 2024 Mar 15;130(6):851-862. Epub 2023 Nov 7 doi: 10.1002/cncr.35101. PMID: 37933913
Ivanova M, Porta FM, D'Ercole M, Pescia C, Sajjadi E, Cursano G, De Camilli E, Pala O, Mazzarol G, Venetis K, Guerini-Rocco E, Curigliano G, Viale G, Fusco N
Virchows Arch 2024 Jan;484(1):3-14. Epub 2023 Sep 28 doi: 10.1007/s00428-023-03656-w. PMID: 37770765Free PMC Article
Schettini F, Venturini S, Giuliano M, Lambertini M, Pinato DJ, Onesti CE, De Placido P, Harbeck N, Lüftner D, Denys H, Van Dam P, Arpino G, Zaman K, Mustacchi G, Gligorov J, Awada A, Campone M, Wildiers H, Gennari A, Tjan-Heijnen V, Bartsch R, Cortes J, Paris I, Martín M, De Placido S, Del Mastro L, Jerusalem G, Curigliano G, Prat A, Generali D
Cancer Treat Rev 2022 Dec;111:102468. Epub 2022 Sep 28 doi: 10.1016/j.ctrv.2022.102468. PMID: 36202026
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Yao M, Fu P
Chin Clin Oncol 2018 Jun;7(3):27. doi: 10.21037/cco.2018.05.04. PMID: 30056729

Clinical prediction guides

Ivanova M, Porta FM, D'Ercole M, Pescia C, Sajjadi E, Cursano G, De Camilli E, Pala O, Mazzarol G, Venetis K, Guerini-Rocco E, Curigliano G, Viale G, Fusco N
Virchows Arch 2024 Jan;484(1):3-14. Epub 2023 Sep 28 doi: 10.1007/s00428-023-03656-w. PMID: 37770765Free PMC Article
Mosele F, Deluche E, Lusque A, Le Bescond L, Filleron T, Pradat Y, Ducoulombier A, Pistilli B, Bachelot T, Viret F, Levy C, Signolle N, Alfaro A, Tran DTN, Garberis IJ, Talbot H, Christodoulidis S, Vakalopoulou M, Droin N, Stourm A, Kobayashi M, Kakegawa T, Lacroix L, Saulnier P, Job B, Deloger M, Jimenez M, Mahier C, Baris V, Laplante P, Kannouche P, Marty V, Lacroix-Triki M, Diéras V, André F
Nat Med 2023 Aug;29(8):2110-2120. Epub 2023 Jul 24 doi: 10.1038/s41591-023-02478-2. PMID: 37488289Free PMC Article
Rugo HS, Bianchini G, Cortes J, Henning JW, Untch M
ESMO Open 2022 Aug;7(4):100553. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100553. PMID: 35964548Free PMC Article
Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno NT, Prat A, Chae YS, Lee KS, Niikura N, Park YH, Xu B, Wang X, Gil-Gil M, Li W, Pierga JY, Im SA, Moore HCF, Rugo HS, Yerushalmi R, Zagouri F, Gombos A, Kim SB, Liu Q, Luo T, Saura C, Schmid P, Sun T, Gambhire D, Yung L, Wang Y, Singh J, Vitazka P, Meinhardt G, Harbeck N, Cameron DA; DESTINY-Breast04 Trial Investigators
N Engl J Med 2022 Jul 7;387(1):9-20. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2203690. PMID: 35665782Free PMC Article
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776

Recent systematic reviews

Qureshi Z, Altaf F, Jamil A, Siddique R, Fatima E
Am J Clin Oncol 2024 Nov 1;47(11):535-541. Epub 2024 Jul 2 doi: 10.1097/COC.0000000000001126. PMID: 38951994
Petrelli F, Rea C, Parati MC, Borgonovo K, Ghilardi M, Dottorini L, Luciani A, Ghidini M, Ruatta F, Garrone O, Tomasello G
Anticancer Res 2023 Oct;43(10):4303-4313. doi: 10.21873/anticanres.16625. PMID: 37772569
Soares LR, Vilbert M, Rosa VDL, Oliveira JL, Deus MM, Freitas-Junior R
ESMO Open 2023 Aug;8(4):101613. Epub 2023 Jul 23 doi: 10.1016/j.esmoop.2023.101613. PMID: 37481956Free PMC Article
Molinelli C, Jacobs F, Agostinetto E, Nader-Marta G, Ceppi M, Bruzzone M, Blondeaux E, Schettini F, Prat A, Viale G, Del Mastro L, Lambertini M, de Azambuja E
ESMO Open 2023 Aug;8(4):101592. Epub 2023 Jul 4 doi: 10.1016/j.esmoop.2023.101592. PMID: 37413762Free PMC Article
Schettini F, Venturini S, Giuliano M, Lambertini M, Pinato DJ, Onesti CE, De Placido P, Harbeck N, Lüftner D, Denys H, Van Dam P, Arpino G, Zaman K, Mustacchi G, Gligorov J, Awada A, Campone M, Wildiers H, Gennari A, Tjan-Heijnen V, Bartsch R, Cortes J, Paris I, Martín M, De Placido S, Del Mastro L, Jerusalem G, Curigliano G, Prat A, Generali D
Cancer Treat Rev 2022 Dec;111:102468. Epub 2022 Sep 28 doi: 10.1016/j.ctrv.2022.102468. PMID: 36202026

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