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Eccrine carcinoma

MedGen UID:
724404
•Concept ID:
C1302864
•
Neoplastic Process
Synonyms: carcinoma of eccrine sweat gland; carcinoma, eccrine gland, malignant; eccrine adenocarcinoma; eccrine adenocarcinoma (morphologic abnormality); Eccrine Carcinoma; eccrine carcinoma; Eccrine carcinoma of skin; eccrine carcinoma of skin; eccrine sweat gland adenocarcinoma; eccrine sweat gland carcinoma
SNOMED CT: Eccrine carcinoma of skin (400173004)
 
Monarch Initiative: MONDO:0024240

Definition

An adenocarcinoma with eccrine differentiation arising from the sweat glands. It includes the following subtypes: ductal eccrine adenocarcinoma, papillary eccrine carcinoma, and eccrine porocarcinoma. [from NCI]

Professional guidelines

PubMed

Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?
Schukow C, McCalmont TH, Surprenant D, Yang HH
Am J Dermatopathol 2023 Oct 1;45(10):728-730. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002503. PMID: 37506277
Treatment of Malignant Cutaneous Adnexal Neoplasms.
Bernárdez C, Requena L
Actas Dermosifiliogr (Engl Ed) 2018 Jan-Feb;109(1):6-23. Epub 2017 Oct 6 doi: 10.1016/j.ad.2017.04.005. PMID: 28988763
Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends.
Kallini JR, Hamed N, Khachemoune A
Int J Dermatol 2015 Feb;54(2):130-40. Epub 2014 Nov 27 doi: 10.1111/ijd.12553. PMID: 25428226

Recent clinical studies

Etiology

Poorly differentiated eccrine carcinomas are associated with increased risk for poor outcomes.
Gupta N, Conomikes A, Murad F, Ruiz ES
J Am Acad Dermatol 2023 Jan;88(1):210-212. Epub 2022 Apr 27 doi: 10.1016/j.jaad.2022.04.039. PMID: 35489550
Cutaneous Eccrine Carcinoma: A Retrospective Review of Epidemiologic Features and Clinical Outcomes.
Marous M, Scott G, Ibrahim SF
Dermatol Surg 2022 Oct 1;48(10):1115-1117. Epub 2022 Sep 2 doi: 10.1097/DSS.0000000000003588. PMID: 36095255
Primary mucinous eccrine carcinoma of the buccal space: A case report and review of the literature.
Lozada KN, Qazi MS, Khorsandi AS, Chai RL
Am J Otolaryngol 2018 Mar-Apr;39(2):242-246. Epub 2018 Jan 5 doi: 10.1016/j.amjoto.2017.12.020. PMID: 29331306
Squamoid Eccrine Ductal Carcinoma: A Clinicopathologic Study of 30 Cases.
van der Horst MP, Garcia-Herrera A, Markiewicz D, Martin B, Calonje E, Brenn T
Am J Surg Pathol 2016 Jun;40(6):755-60. doi: 10.1097/PAS.0000000000000599. PMID: 26796504
Syringoid eccrine carcinoma.
Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522

Diagnosis

Eccrine carcinoma masquerading as metastatic breast cancer.
Merrill AL, Smith SM, Peters SB, Agnese DM
Breast J 2020 Feb;26(2):284-286. Epub 2019 Sep 3 doi: 10.1111/tbj.13543. PMID: 31478586
Syringoid eccrine carcinoma.
Abedi SM, Yu R, Salama S, Alowami S
Cutis 2015 Sep;96(3):162,191-2. PMID: 26562272
It's more than you know.
McCalmont TH
J Cutan Pathol 2013 Aug;40(8):699-700. doi: 10.1111/cup.12194. PMID: 23859701
Unusual skin tumors: Merkel cell carcinoma, eccrine carcinoma, glomus tumors, and dermatofibrosarcoma protuberans.
Kampshoff JL, Cogbill TH
Surg Clin North Am 2009 Jun;89(3):727-38. doi: 10.1016/j.suc.2009.02.005. PMID: 19465208
EPIDERMOTROPIC ECCRINE CARCINOMA. A CASE COMBINING FEATURES OF ECCRINE POROMA AND PAGET'S DERMATOSIS.
PINKUS H, MEHREGAN AH
Arch Dermatol 1963 Nov;88:597-606. doi: 10.1001/archderm.1963.01590230105015. PMID: 14060075

Therapy

Central Nervous System-Invading Eccrine Gland Carcinoma: A Clinicopathologic Case Series and Literature Review.
Gupta S, Hulsbergen AFC, Segar DJ, Hauser BM, Bernstock JD, Nazarian RM, Lawrence DP, Nahed BV, Broekman MLD, Smith TR
World Neurosurg 2020 Jun;138:e17-e25. Epub 2020 Mar 3 doi: 10.1016/j.wneu.2020.01.111. PMID: 32142948
Limax Nd:YAG laser-assisted thoracoscopic resection of pulmonary metastases; a single centre's initial experience.
Mc Loughlin JB, O'Sullivan KE, Brown RH, Eaton DA
Ir J Med Sci 2019 Aug;188(3):771-776. Epub 2018 Oct 31 doi: 10.1007/s11845-018-1924-9. PMID: 30382512
Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors.
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Dermal Substitutes Use in Reconstructive Surgery for Skin Tumors: A Single-Center Experience.
Campagnari M, Jafelicci AS, Carneiro HA, Brechtbühl ER, Bertolli E, Duprat Neto JP
Int J Surg Oncol 2017;2017:9805980. Epub 2017 Jul 2 doi: 10.1155/2017/9805980. PMID: 28751990Free PMC Article
Carcinoma of eccrine sweat gland: experience with chemotherapy, autopsy findings in a patient with metastatic eccrine carcinoma, and a review of the literature.
Morris DM, Sanusi ID, Lanehart WH
J Surg Oncol 1986 Jan;31(1):26-30. doi: 10.1002/jso.2930310105. PMID: 3511326

Prognosis

Poorly differentiated eccrine carcinomas are associated with increased risk for poor outcomes.
Gupta N, Conomikes A, Murad F, Ruiz ES
J Am Acad Dermatol 2023 Jan;88(1):210-212. Epub 2022 Apr 27 doi: 10.1016/j.jaad.2022.04.039. PMID: 35489550
Mucinous Eccrine Carcinoma of the Sweat Glands: Characteristics, Treatment, and Survival Outcomes of a Rare Malignancy.
Urias D, Sylejmani GB, Rakovica L, Dumire R, Gassman A
Am Surg 2018 Aug 1;84(8):e307-e308. PMID: 30401051
Unusual skin tumors: Merkel cell carcinoma, eccrine carcinoma, glomus tumors, and dermatofibrosarcoma protuberans.
Kampshoff JL, Cogbill TH
Surg Clin North Am 2009 Jun;89(3):727-38. doi: 10.1016/j.suc.2009.02.005. PMID: 19465208
Syringoid eccrine carcinoma.
Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522
Response of eccrine adenocarcinoma to tamoxifen.
Sridhar KS, Benedetto P, Otrakji CL, Charyulu KK
Cancer 1989 Jul 15;64(2):366-70. doi: 10.1002/1097-0142(19890715)64:2<366::aid-cncr2820640204>3.0.co;2-r. PMID: 2736482

Clinical prediction guides

Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors.
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Primary mucinous eccrine carcinoma of the buccal space: A case report and review of the literature.
Lozada KN, Qazi MS, Khorsandi AS, Chai RL
Am J Otolaryngol 2018 Mar-Apr;39(2):242-246. Epub 2018 Jan 5 doi: 10.1016/j.amjoto.2017.12.020. PMID: 29331306
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature.
Ohta M, Hiramoto M, Fujii M, Togo T
Dermatol Surg 2004 Sep;30(9):1265-8. doi: 10.1111/j.1524-4725.2004.30390.x. PMID: 15355375
Response of eccrine adenocarcinoma to tamoxifen.
Sridhar KS, Benedetto P, Otrakji CL, Charyulu KK
Cancer 1989 Jul 15;64(2):366-70. doi: 10.1002/1097-0142(19890715)64:2<366::aid-cncr2820640204>3.0.co;2-r. PMID: 2736482
"Clear cell" atypical fibroxanthoma.
Patterson JW, Konerding H, Kramer WM
J Dermatol Surg Oncol 1987 Oct;13(10):1109-14. doi: 10.1111/j.1524-4725.1987.tb00919.x. PMID: 3655081

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