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Breast Ductal Carcinoma In Situ and Lobular Carcinoma

MedGen UID:: 1786106
•Concept ID:: C5445178
•: Neoplastic Process

Synonyms:

Breast Intraductal and Lobular Carcinoma; Intraductal and Lobular Carcinoma

Definition

A breast carcinoma characterized by the presence of a ductal carcinoma in situ component and an in situ or invasive lobular carcinomatous component. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBreast Ductal Carcinoma In Situ and Lobular Carcinoma

Neoplasm
- Epithelial neoplasm
  - Carcinoma
    - Adenocarcinoma
      - Breast adenocarcinoma
        Mixed lobular and ductal breast carcinoma
        Breast Ductal Carcinoma In Situ and Lobular Carcinoma
        Breast Ductal Carcinoma In Situ and Invasive Lobular Carcinoma
        Ductal breast carcinoma in situ and lobular carcinoma in situ

Professional guidelines

PubMed

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.

Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151

Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.

Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel Members
Ann Oncol 2015 Aug;26(8):1533-46. Epub 2015 May 4 doi: 10.1093/annonc/mdv221. PMID: 25939896 Free PMC Article

Treatment of breast cancer.

Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

See all (188)

Recent clinical studies

Etiology

Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.

Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684 Free PMC Article

Management of High-Risk Breast Lesions.

Bahl M
Radiol Clin North Am 2021 Jan;59(1):29-40. doi: 10.1016/j.rcl.2020.08.005. PMID: 33222998

Atypical Ductal Hyperplasia and Lobular Neoplasia: Update and Easing of Guidelines.

Lewin AA, Mercado CL
AJR Am J Roentgenol 2020 Feb;214(2):265-275. Epub 2019 Dec 11 doi: 10.2214/AJR.19.21991. PMID: 31825261

ACR Appropriateness Criteria® Ductal Carcinoma in Situ.

Kaufman SA, Harris EE, Bailey L, Chadha M, Dutton SC, Freedman GM, Goyal S, Halyard MY, Horst KC, Novick KL, Park CC, Suh WW, Toppmeyer D, Zook J, Haffty BG
Oncology (Williston Park) 2015 Jun;29(6):446-58, 460-1. PMID: 26089220

Outcomes and chemotherapy-related toxicity in HIV-infected patients with breast cancer.

Singh SN, Zhu Y, Chumsri S, Kesmodel S, Gilliam BL, Riedel DJ
Clin Breast Cancer 2014 Apr;14(2):e53-9. Epub 2013 Nov 20 doi: 10.1016/j.clbc.2013.11.002. PMID: 24418743 Free PMC Article

See all (1693)

Diagnosis

Lobular carcinoma in situ: diagnostic criteria and molecular correlates.

Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303

Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.

Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Overview of breast cancer.

Watkins EJ
JAAPA 2019 Oct;32(10):13-17. doi: 10.1097/01.JAA.0000580524.95733.3d. PMID: 31513033

Outcomes and chemotherapy-related toxicity in HIV-infected patients with breast cancer.

Singh SN, Zhu Y, Chumsri S, Kesmodel S, Gilliam BL, Riedel DJ
Clin Breast Cancer 2014 Apr;14(2):e53-9. Epub 2013 Nov 20 doi: 10.1016/j.clbc.2013.11.002. PMID: 24418743 Free PMC Article

Breast carcinoma in situ.

McDermott FT
Aust N Z J Surg 1992 Nov;62(11):841-8. doi: 10.1111/j.1445-2197.1992.tb06936.x. PMID: 20169700

See all (1472)

Therapy

Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study.

Lazzeroni M, Puntoni M, Guerrieri-Gonzaga A, Serrano D, Boni L, Buttiron Webber T, Fava M, Briata IM, Giordano L, Digennaro M, Cortesi L, Falcini F, Serra P, Avino F, Millo F, Cagossi K, Gallerani E, De Simone A, Cariello A, Aprile G, Renne M, Bonanni B, DeCensi A
J Clin Oncol 2023 Jun 10;41(17):3116-3121. Epub 2023 Mar 14 doi: 10.1200/JCO.22.02900. PMID: 36917758

Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia.

DeCensi A, Puntoni M, Guerrieri-Gonzaga A, Caviglia S, Avino F, Cortesi L, Taverniti C, Pacquola MG, Falcini F, Gulisano M, Digennaro M, Cariello A, Cagossi K, Pinotti G, Lazzeroni M, Serrano D, Branchi D, Campora S, Petrera M, Buttiron Webber T, Boni L, Bonanni B
J Clin Oncol 2019 Jul 1;37(19):1629-1637. Epub 2019 Apr 11 doi: 10.1200/JCO.18.01779. PMID: 30973790 Free PMC Article

Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.

Treatment of breast cancer.

Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

The management of ductal and lobular breast cancer.

Styblo TM, Wood WC
Surg Oncol 1999 Aug;8(2):67-75. doi: 10.1016/s0960-7404(99)00048-1. PMID: 10732958

See all (381)

Prognosis

Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.

Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.

Outcomes and chemotherapy-related toxicity in HIV-infected patients with breast cancer.

Singh SN, Zhu Y, Chumsri S, Kesmodel S, Gilliam BL, Riedel DJ
Clin Breast Cancer 2014 Apr;14(2):e53-9. Epub 2013 Nov 20 doi: 10.1016/j.clbc.2013.11.002. PMID: 24418743 Free PMC Article

Proposal for standardized definitions for efficacy end points in adjuvant breast cancer trials: the STEEP system.

Hudis CA, Barlow WE, Costantino JP, Gray RJ, Pritchard KI, Chapman JA, Sparano JA, Hunsberger S, Enos RA, Gelber RD, Zujewski JA
J Clin Oncol 2007 May 20;25(15):2127-32. doi: 10.1200/JCO.2006.10.3523. PMID: 17513820

The management of ductal and lobular breast cancer.

Styblo TM, Wood WC
Surg Oncol 1999 Aug;8(2):67-75. doi: 10.1016/s0960-7404(99)00048-1. PMID: 10732958

See all (1263)

Clinical prediction guides

Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.

Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684 Free PMC Article

Papillary lesions of the breast.

Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332 Free PMC Article

Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.

Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Ductal carcinoma in situ of the breast: an update for the pathologist in the era of individualized risk assessment and tailored therapies.

Hanna WM, Parra-Herran C, Lu FI, Slodkowska E, Rakovitch E, Nofech-Mozes S
Mod Pathol 2019 Jul;32(7):896-915. Epub 2019 Feb 13 doi: 10.1038/s41379-019-0204-1. PMID: 30760859

Determination of size in invasive breast carcinoma: pathologic considerations and clinical implications.

Shin SJ, Osborne MP, Moore A, Hayes MK, Hoda SA
Am J Clin Pathol 2000 May;113(5 Suppl 1):S19-29. doi: 10.1309/XPPV-D8M9-KL6M-MR1U. PMID: 11993706

See all (960)

Recent systematic reviews

Atypical ductal or lobular hyperplasia, lobular carcinoma in-situ, flat epithelial atypia, and future risk of developing breast cancer: Systematic review and meta-analysis.

Baker J, Noguchi N, Marinovich ML, Sprague BL, Salisbury E, Houssami N
Breast 2024 Dec;78:103807. Epub 2024 Sep 11 doi: 10.1016/j.breast.2024.103807. PMID: 39270543 Free PMC Article

PATHOLOGIC FINDINGS IN GENDER-AFFIRMING MASTECTOMY: A SYSTEMATIC REVIEW.

Jahromi H, Horen S, Ho K, Tran E, Roth A, Schechter L
Georgian Med News 2022 Dec;(333):6-12. PMID: 36780614

The positive predictive value of vacuum assisted biopsy (VAB) in predicting final histological diagnosis for breast lesions of uncertain malignancy (B3 lesions): A systematic review & meta-analysis.

Cullinane C, Byrne J, Kelly L, O Sullivan M, Antony Corrigan M, Paul Redmond H
Eur J Surg Oncol 2022 Jul;48(7):1464-1474. Epub 2022 Apr 15 doi: 10.1016/j.ejso.2022.04.005. PMID: 35491362

MR Imaging for Selection of Patients for Partial Breast Irradiation: A Systematic Review and Meta-Analysis.

Di Leo G, Trimboli RM, Benedek A, Jereczek-Fossa BA, Fossati P, Leonardi MC, Carbonaro LA, Orecchia R, Sardanelli F
Radiology 2015 Dec;277(3):716-26. Epub 2015 Jun 4 doi: 10.1148/radiol.2015142508. PMID: 26043263

Risk of invasive breast cancer after lobular intra-epithelial neoplasia: review of the literature.

Ansquer Y, Delaney S, Santulli P, Salomon L, Carbonne B, Salmon R
Eur J Surg Oncol 2010 Jul;36(7):604-9. Epub 2010 Jun 11 doi: 10.1016/j.ejso.2010.05.019. PMID: 20541352

See all (12)

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Breast Ductal Carcinoma In Situ and Lobular Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity