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Breast Ductal Carcinoma In Situ and Invasive Lobular Carcinoma

MedGen UID:
1779389
•Concept ID:
C5441547
•
Neoplastic Process
Synonyms: DCIS and ILC; DCIS and Infiltrating Lobular Carcinoma; Ductal Breast Carcinoma In Situ and Invasive Lobular Carcinoma; Ductal Carcinoma in situ and Infiltrating Lobular Carcinoma; Non-Infiltrating Ductal Carcinoma and ILC; Non-Infiltrating Ductal Carcinoma and Infiltrating Lobular Carcinoma

Definition

A breast carcinoma characterized by the presence of a ductal carcinoma in situ component and an invasive lobular carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Ductal Carcinoma In Situ and Invasive Lobular Carcinoma

Professional guidelines

PubMed

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.
Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel Members
Ann Oncol 2015 Aug;26(8):1533-46. Epub 2015 May 4 doi: 10.1093/annonc/mdv221. PMID: 25939896Free PMC Article
Treatment of breast cancer.
Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

Recent clinical studies

Etiology

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
ACR Appropriateness Criteria® Ductal Carcinoma in Situ.
Kaufman SA, Harris EE, Bailey L, Chadha M, Dutton SC, Freedman GM, Goyal S, Halyard MY, Horst KC, Novick KL, Park CC, Suh WW, Toppmeyer D, Zook J, Haffty BG
Oncology (Williston Park) 2015 Jun;29(6):446-58, 460-1. PMID: 26089220
In situ breast cancer.
Henry-Tillman RS, Klimberg VS
Curr Treat Options Oncol 2000 Aug;1(3):199-209. doi: 10.1007/s11864-000-0031-z. PMID: 12057162
Non-invasive breast carcinoma.
Posner MC, Wolmark N
Breast Cancer Res Treat 1992;21(3):155-64. doi: 10.1007/BF01974998. PMID: 1325215

Diagnosis

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Overview of breast cancer.
Watkins EJ
JAAPA 2019 Oct;32(10):13-17. doi: 10.1097/01.JAA.0000580524.95733.3d. PMID: 31513033
Non-invasive breast carcinoma.
Posner MC, Wolmark N
Breast Cancer Res Treat 1992;21(3):155-64. doi: 10.1007/BF01974998. PMID: 1325215

Therapy

Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study.
Lazzeroni M, Puntoni M, Guerrieri-Gonzaga A, Serrano D, Boni L, Buttiron Webber T, Fava M, Briata IM, Giordano L, Digennaro M, Cortesi L, Falcini F, Serra P, Avino F, Millo F, Cagossi K, Gallerani E, De Simone A, Cariello A, Aprile G, Renne M, Bonanni B, DeCensi A
J Clin Oncol 2023 Jun 10;41(17):3116-3121. Epub 2023 Mar 14 doi: 10.1200/JCO.22.02900. PMID: 36917758
Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia.
DeCensi A, Puntoni M, Guerrieri-Gonzaga A, Caviglia S, Avino F, Cortesi L, Taverniti C, Pacquola MG, Falcini F, Gulisano M, Digennaro M, Cariello A, Cagossi K, Pinotti G, Lazzeroni M, Serrano D, Branchi D, Campora S, Petrera M, Buttiron Webber T, Boni L, Bonanni B
J Clin Oncol 2019 Jul 1;37(19):1629-1637. Epub 2019 Apr 11 doi: 10.1200/JCO.18.01779. PMID: 30973790Free PMC Article
Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.
Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel Members
Ann Oncol 2015 Aug;26(8):1533-46. Epub 2015 May 4 doi: 10.1093/annonc/mdv221. PMID: 25939896Free PMC Article
Treatment of breast cancer.
Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754
Non-invasive breast carcinoma.
Posner MC, Wolmark N
Breast Cancer Res Treat 1992;21(3):155-64. doi: 10.1007/BF01974998. PMID: 1325215

Prognosis

Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia.
DeCensi A, Puntoni M, Guerrieri-Gonzaga A, Caviglia S, Avino F, Cortesi L, Taverniti C, Pacquola MG, Falcini F, Gulisano M, Digennaro M, Cariello A, Cagossi K, Pinotti G, Lazzeroni M, Serrano D, Branchi D, Campora S, Petrera M, Buttiron Webber T, Boni L, Bonanni B
J Clin Oncol 2019 Jul 1;37(19):1629-1637. Epub 2019 Apr 11 doi: 10.1200/JCO.18.01779. PMID: 30973790Free PMC Article
Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015.
Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel Members
Ann Oncol 2015 Aug;26(8):1533-46. Epub 2015 May 4 doi: 10.1093/annonc/mdv221. PMID: 25939896Free PMC Article
Management of lobular carcinoma in-situ and atypical lobular hyperplasia of the breast--a review.
Hussain M, Cunnick GH
Eur J Surg Oncol 2011 Apr;37(4):279-89. doi: 10.1016/j.ejso.2011.01.009. PMID: 21306860
Non-invasive breast carcinoma.
Posner MC, Wolmark N
Breast Cancer Res Treat 1992;21(3):155-64. doi: 10.1007/BF01974998. PMID: 1325215

Clinical prediction guides

Avoiding "False Positive" and "False Negative" Immunohistochemical Results in Breast Pathology.
Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Estimating the magnitude of clinical benefit of systemic therapy in patients with DCIS or pre-invasive disease of the breast.
Lazzeroni M, Puntoni M, Provinciali N, Webber TB, Briata IM, D'Amico M, Giuliano S, Siri G, Cagnacci S, DeCensi A
Breast 2019 Nov;48 Suppl 1:S39-S43. doi: 10.1016/S0960-9776(19)31121-X. PMID: 31839158
Ductal carcinoma in situ of the breast: an update for the pathologist in the era of individualized risk assessment and tailored therapies.
Hanna WM, Parra-Herran C, Lu FI, Slodkowska E, Rakovitch E, Nofech-Mozes S
Mod Pathol 2019 Jul;32(7):896-915. Epub 2019 Feb 13 doi: 10.1038/s41379-019-0204-1. PMID: 30760859

Recent systematic reviews

MR Imaging for Selection of Patients for Partial Breast Irradiation: A Systematic Review and Meta-Analysis.
Di Leo G, Trimboli RM, Benedek A, Jereczek-Fossa BA, Fossati P, Leonardi MC, Carbonaro LA, Orecchia R, Sardanelli F
Radiology 2015 Dec;277(3):716-26. Epub 2015 Jun 4 doi: 10.1148/radiol.2015142508. PMID: 26043263
Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.
Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, Klimberg S, Chavez-MacGregor M, Freedman G, Houssami N, Johnson PL, Morrow M
Int J Radiat Oncol Biol Phys 2014 Mar 1;88(3):553-64. doi: 10.1016/j.ijrobp.2013.11.012. PMID: 24521674Free PMC Article
Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.
Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, Klimberg S, Chavez-MacGregor M, Freedman G, Houssami N, Johnson PL, Morrow M
Ann Surg Oncol 2014 Mar;21(3):704-16. Epub 2014 Feb 10 doi: 10.1245/s10434-014-3481-4. PMID: 24515565
Non-mass-like lesions on breast ultrasonography: a systematic review.
Uematsu T
Breast Cancer 2012 Oct;19(4):295-301. Epub 2012 Mar 29 doi: 10.1007/s12282-012-0364-z. PMID: 22456924
Risk of invasive breast cancer after lobular intra-epithelial neoplasia: review of the literature.
Ansquer Y, Delaney S, Santulli P, Salomon L, Carbonne B, Salmon R
Eur J Surg Oncol 2010 Jul;36(7):604-9. Epub 2010 Jun 11 doi: 10.1016/j.ejso.2010.05.019. PMID: 20541352

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