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Rectal neuroendocrine tumor G1

MedGen UID:
233389
•Concept ID:
C1335678
•
Neoplastic Process
Synonyms: carcinoid of rectum; carcinoid of the rectum; carcinoid tumor of rectum; carcinoid tumor of the rectum; carcinoid tumour of rectum; carcinoid tumour of the rectum; grade 1 neuroendocrine neoplasm of rectum; rectal carcinoid; rectal carcinoid tumor; rectal carcinoid tumour; Rectal NET G1; rectal NET G1; Rectal Neuroendocrine Tumor G1; rectal neuroendocrine tumor G1; rectum carcinoid tumor; rectum carcinoid tumor (disease); rectum carcinoid tumour; rectum carcinoid tumour (disease); rectum NET G1; rectum neuroendocrine neoplasm G1; rectum neuroendocrine tumor, well differentiated, low grade
 
Monarch Initiative: MONDO:0021534

Definition

A well differentiated, low grade neuroendocrine neoplasm that arises from the rectum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal neuroendocrine tumor G1

Professional guidelines

PubMed

Evaluation of radical surgical treatment in the management of 58 locally advanced rectal neuroendocrine neoplasms, one multicenter retrospective study.
Wang Z, Liu Z, Wen Z, Li R, An K, Mei S, Chen J, Shen H, Li J, Zhao F, Wei F, Xiao T, Liu Q
Eur J Surg Oncol 2021 Dec;47(12):3166-3174. Epub 2021 Jul 15 doi: 10.1016/j.ejso.2021.07.010. PMID: 34294465
Gastro-entero-pancreatic neuroendocrine neoplasia: The rules for non-operative management.
Panzuto F, Massironi S, Partelli S, Campana D, Rinzivillo M, Invernizzi P, Andreasi V, Lamberti G, Falconi M
Surg Oncol 2020 Dec;35:141-148. Epub 2020 Aug 20 doi: 10.1016/j.suronc.2020.08.015. PMID: 32877883
Neuroendocrine neoplasms of rectum: A management update.
Bertani E, Ravizza D, Milione M, Massironi S, Grana CM, Zerini D, Piccioli AN, Spinoglio G, Fazio N
Cancer Treat Rev 2018 May;66:45-55. Epub 2018 Apr 6 doi: 10.1016/j.ctrv.2018.04.003. PMID: 29684743

Recent clinical studies

Etiology

The meaning of R1 resection after endoscopic removal of gastric, duodenal and rectal neuroendocrine tumors.
Esposito G, Dell'Unto E, Ligato I, Marasco M, Panzuto F
Expert Rev Gastroenterol Hepatol 2023 Jul-Dec;17(8):785-793. Epub 2023 Jul 31 doi: 10.1080/17474124.2023.2242261. PMID: 37497604
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours.
Rinke A, Ambrosini V, Dromain C, Garcia-Carbonero R, Haji A, Koumarianou A, van Dijkum EN, O'Toole D, Rindi G, Scoazec JY, Ramage J
J Neuroendocrinol 2023 Jun;35(6):e13309. Epub 2023 Jun 22 doi: 10.1111/jne.13309. PMID: 37345509
Clinicopathological characteristics of rectal multiple neuroendocrine neoplasms and literature review.
Zheng X, Wu M, Li S, Er L, Deng H, Guo S, Liu Z
BMC Surg 2023 Jun 2;23(1):147. doi: 10.1186/s12893-023-02050-2. PMID: 37264328Free PMC Article
Epidemiologic Trends of and Factors Associated With Overall Survival for Patients With Gastroenteropancreatic Neuroendocrine Tumors in the United States.
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Neuroendocrine neoplasms of rectum: A management update.
Bertani E, Ravizza D, Milione M, Massironi S, Grana CM, Zerini D, Piccioli AN, Spinoglio G, Fazio N
Cancer Treat Rev 2018 May;66:45-55. Epub 2018 Apr 6 doi: 10.1016/j.ctrv.2018.04.003. PMID: 29684743

Diagnosis

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours.
Rinke A, Ambrosini V, Dromain C, Garcia-Carbonero R, Haji A, Koumarianou A, van Dijkum EN, O'Toole D, Rindi G, Scoazec JY, Ramage J
J Neuroendocrinol 2023 Jun;35(6):e13309. Epub 2023 Jun 22 doi: 10.1111/jne.13309. PMID: 37345509
Clinicopathological characteristics of rectal multiple neuroendocrine neoplasms and literature review.
Zheng X, Wu M, Li S, Er L, Deng H, Guo S, Liu Z
BMC Surg 2023 Jun 2;23(1):147. doi: 10.1186/s12893-023-02050-2. PMID: 37264328Free PMC Article
Prognosis of incompletely resected small rectal neuroendocrine tumor using endoscope without additional treatment.
Cha B, Shin J, Ko WJ, Kwon KS, Kim H
BMC Gastroenterol 2022 Jun 9;22(1):293. doi: 10.1186/s12876-022-02365-z. PMID: 35681149Free PMC Article
Epidemiologic Trends of and Factors Associated With Overall Survival for Patients With Gastroenteropancreatic Neuroendocrine Tumors in the United States.
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Rectal neuroendocrine tumor with extracapsular lymph node metastasis: a case report.
Sakamoto A, Nozawa H, Sonoda H, Hinata M, Ishii H, Emoto S, Anzai H, Yokoyama Y, Murono K, Sasaki K, Kawai K, Ushiku T, Ishihara S
Clin J Gastroenterol 2021 Oct;14(5):1426-1430. Epub 2021 May 24 doi: 10.1007/s12328-021-01447-x. PMID: 34028785

Therapy

Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Prognosis

The meaning of R1 resection after endoscopic removal of gastric, duodenal and rectal neuroendocrine tumors.
Esposito G, Dell'Unto E, Ligato I, Marasco M, Panzuto F
Expert Rev Gastroenterol Hepatol 2023 Jul-Dec;17(8):785-793. Epub 2023 Jul 31 doi: 10.1080/17474124.2023.2242261. PMID: 37497604
Clinicopathological characteristics of rectal multiple neuroendocrine neoplasms and literature review.
Zheng X, Wu M, Li S, Er L, Deng H, Guo S, Liu Z
BMC Surg 2023 Jun 2;23(1):147. doi: 10.1186/s12893-023-02050-2. PMID: 37264328Free PMC Article
Prognosis of incompletely resected small rectal neuroendocrine tumor using endoscope without additional treatment.
Cha B, Shin J, Ko WJ, Kwon KS, Kim H
BMC Gastroenterol 2022 Jun 9;22(1):293. doi: 10.1186/s12876-022-02365-z. PMID: 35681149Free PMC Article
Epidemiologic Trends of and Factors Associated With Overall Survival for Patients With Gastroenteropancreatic Neuroendocrine Tumors in the United States.
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Gastro-entero-pancreatic neuroendocrine neoplasia: The rules for non-operative management.
Panzuto F, Massironi S, Partelli S, Campana D, Rinzivillo M, Invernizzi P, Andreasi V, Lamberti G, Falconi M
Surg Oncol 2020 Dec;35:141-148. Epub 2020 Aug 20 doi: 10.1016/j.suronc.2020.08.015. PMID: 32877883

Clinical prediction guides

Epidemiologic Trends of and Factors Associated With Overall Survival for Patients With Gastroenteropancreatic Neuroendocrine Tumors in the United States.
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Clinical outcomes of cap-assisted endoscopic resection for small rectal subepithelial tumors.
Wang J, Lin S, Qiao W, Liu S, Zhi F
Gastroenterol Hepatol 2021 Jun-Jul;44(6):418-423. Epub 2020 Nov 6 doi: 10.1016/j.gastrohep.2020.08.016. PMID: 33303284
Prediction of the World Health Organization Grade of rectal neuroendocrine tumors based on CT histogram analysis.
Liang P, Xu C, Tan F, Li S, Chen M, Hu D, Kamel I, Duan Y, Li Z
Cancer Med 2021 Jan;10(2):595-604. Epub 2020 Dec 1 doi: 10.1002/cam4.3628. PMID: 33263225Free PMC Article
Transanal minimally invasive surgery for rectal neuroendocrine tumors.
Hayashi S, Takayama T, Ikarashi M, Hagiwara K, Matsuno Y, Suzuki T
Surg Endosc 2021 Dec;35(12):6746-6753. Epub 2020 Nov 25 doi: 10.1007/s00464-020-08178-z. PMID: 33237462
Clinical and prognostic features of rectal neuroendocrine tumors.
Weinstock B, Ward SC, Harpaz N, Warner RR, Itzkowitz S, Kim MK
Neuroendocrinology 2013;98(3):180-7. Epub 2013 Nov 5 doi: 10.1159/000355612. PMID: 24080744

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