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Grade 2 Colon Adenocarcinoma

MedGen UID:
232252
Concept ID:
C1333859
Neoplastic Process
Synonyms: Grade II Colon Adenocarcinoma; Moderately Differentiated Colon Adenocarcinoma

Definition

A colon adenocarcinoma characterized by the presence of a malignant cellular infiltrate with 50-95% glandular formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Colon Adenocarcinoma

Professional guidelines

PubMed

Bourke MJ, Lo SK, Buerlein RCD, Das KK
Gastroenterology 2025 Jan;168(1):169-175. Epub 2024 Nov 16 doi: 10.1053/j.gastro.2024.10.008. PMID: 39545885
Rutter MD, East J, Rees CJ, Cripps N, Docherty J, Dolwani S, Kaye PV, Monahan KJ, Novelli MR, Plumb A, Saunders BP, Thomas-Gibson S, Tolan DJM, Whyte S, Bonnington S, Scope A, Wong R, Hibbert B, Marsh J, Moores B, Cross A, Sharp L
Gut 2020 Feb;69(2):201-223. Epub 2019 Nov 27 doi: 10.1136/gutjnl-2019-319858. PMID: 31776230Free PMC Article
Pimentel-Nunes P, Dinis-Ribeiro M, Ponchon T, Repici A, Vieth M, De Ceglie A, Amato A, Berr F, Bhandari P, Bialek A, Conio M, Haringsma J, Langner C, Meisner S, Messmann H, Morino M, Neuhaus H, Piessevaux H, Rugge M, Saunders BP, Robaszkiewicz M, Seewald S, Kashin S, Dumonceau JM, Hassan C, Deprez PH
Endoscopy 2015 Sep;47(9):829-54. Epub 2015 Aug 28 doi: 10.1055/s-0034-1392882. PMID: 26317585

Recent clinical studies

Etiology

Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Fléjou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V
PLoS Med 2013;10(5):e1001453. Epub 2013 May 21 doi: 10.1371/journal.pmed.1001453. PMID: 23700391Free PMC Article
André T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, Topham C, Zaninelli M, Clingan P, Bridgewater J, Tabah-Fisch I, de Gramont A; Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators
N Engl J Med 2004 Jun 3;350(23):2343-51. doi: 10.1056/NEJMoa032709. PMID: 15175436
Snapper SB, Syngal S, Friedman LS
Dig Dis 1998 Mar-Apr;16(2):81-7. doi: 10.1159/000016851. PMID: 9571373

Diagnosis

Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Cuk P, Kjær MD, Mogensen CB, Nielsen MF, Pedersen AK, Ellebæk MB
Surg Endosc 2022 Jan;36(1):32-46. Epub 2021 Nov 1 doi: 10.1007/s00464-021-08782-7. PMID: 34724576Free PMC Article
Lichtblau D, Stoean C
PLoS One 2019;14(1):e0209274. Epub 2019 Jan 16 doi: 10.1371/journal.pone.0209274. PMID: 30650087Free PMC Article
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Fléjou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V
PLoS Med 2013;10(5):e1001453. Epub 2013 May 21 doi: 10.1371/journal.pmed.1001453. PMID: 23700391Free PMC Article

Therapy

Chalabi M, Verschoor YL, Tan PB, Balduzzi S, Van Lent AU, Grootscholten C, Dokter S, Büller NV, Grotenhuis BA, Kuhlmann K, Burger JW, Huibregtse IL, Aukema TS, Hendriks ER, Oosterling SJ, Snaebjornsson P, Voest EE, Wessels LF, Beets-Tan RG, Van Leerdam ME, Schumacher TN, van den Berg JG, Beets GL, Haanen JB
N Engl J Med 2024 Jun 6;390(21):1949-1958. doi: 10.1056/NEJMoa2400634. PMID: 38838311
Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Antoniotti C, Rossini D, Pietrantonio F, Catteau A, Salvatore L, Lonardi S, Boquet I, Tamberi S, Marmorino F, Moretto R, Ambrosini M, Tamburini E, Tortora G, Passardi A, Bergamo F, Kassambara A, Sbarrato T, Morano F, Ritorto G, Borelli B, Boccaccino A, Conca V, Giordano M, Ugolini C, Fieschi J, Papadopulos A, Massoué C, Aprile G, Antonuzzo L, Gelsomino F, Martinelli E, Pella N, Masi G, Fontanini G, Boni L, Galon J, Cremolini C; GONO Foundation Investigators
Lancet Oncol 2022 Jul;23(7):876-887. Epub 2022 May 27 doi: 10.1016/S1470-2045(22)00274-1. PMID: 35636444
Fingerhut A, Tzu-Liang Chen W, Boni L, Uranues S
Minerva Chir 2019 Apr;74(2):148-159. Epub 2018 Jul 23 doi: 10.23736/S0026-4733.18.07777-5. PMID: 30037177
André T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, Topham C, Zaninelli M, Clingan P, Bridgewater J, Tabah-Fisch I, de Gramont A; Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators
N Engl J Med 2004 Jun 3;350(23):2343-51. doi: 10.1056/NEJMoa032709. PMID: 15175436

Prognosis

Wang Y, Zhang Y, Wang F, Li T, Song X, Shi H, Du J, Zhang H, Jing H, Han J, Tong D, Zhang J
Sci Rep 2022 Nov 2;12(1):18518. doi: 10.1038/s41598-022-21328-8. PMID: 36323715Free PMC Article
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Fingerhut A, Tzu-Liang Chen W, Boni L, Uranues S
Minerva Chir 2019 Apr;74(2):148-159. Epub 2018 Jul 23 doi: 10.23736/S0026-4733.18.07777-5. PMID: 30037177
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Fléjou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V
PLoS Med 2013;10(5):e1001453. Epub 2013 May 21 doi: 10.1371/journal.pmed.1001453. PMID: 23700391Free PMC Article

Clinical prediction guides

Chalabi M, Verschoor YL, Tan PB, Balduzzi S, Van Lent AU, Grootscholten C, Dokter S, Büller NV, Grotenhuis BA, Kuhlmann K, Burger JW, Huibregtse IL, Aukema TS, Hendriks ER, Oosterling SJ, Snaebjornsson P, Voest EE, Wessels LF, Beets-Tan RG, Van Leerdam ME, Schumacher TN, van den Berg JG, Beets GL, Haanen JB
N Engl J Med 2024 Jun 6;390(21):1949-1958. doi: 10.1056/NEJMoa2400634. PMID: 38838311
Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group
J Clin Oncol 2023 Mar 10;41(8):1541-1552. Epub 2023 Jan 19 doi: 10.1200/JCO.22.00046. PMID: 36657089Free PMC Article
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE
JAMA 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809. PMID: 29800214Free PMC Article
Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, Kirzin S, Chazal M, Fléjou JF, Benchimol D, Berger A, Lagarde A, Pencreach E, Piard F, Elias D, Parc Y, Olschwang S, Milano G, Laurent-Puig P, Boige V
PLoS Med 2013;10(5):e1001453. Epub 2013 May 21 doi: 10.1371/journal.pmed.1001453. PMID: 23700391Free PMC Article
Compton CC
Dig Dis 1999;17(2):67-79. doi: 10.1159/000016908. PMID: 10545712

Recent systematic reviews

Hassan C, Rizkala T, Mori Y, Spadaccini M, Misawa M, Antonelli G, Rondonotti E, Dekker E, Houwen BBSL, Pech O, Baumer S, Li JW, von Renteln D, Haumesser C, Maselli R, Facciorusso A, Correale L, Menini M, Schilirò A, Khalaf K, Patel H, Radadiya DK, Bhandari P, Kudo SE, Sultan S, Vandvik PO, Sharma P, Rex DK, Foroutan F, Repici A; CADx analysis study group
Lancet Gastroenterol Hepatol 2024 Nov;9(11):1010-1019. Epub 2024 Sep 17 doi: 10.1016/S2468-1253(24)00222-X. PMID: 39303733
Chitkara A, Kaur N, Desai A, Mehta D, Anamika F, Sarkar S, Gowda N, Sethi P, Thawani R, Chen EY
Cancer Med 2023 Dec;12(24):21579-21591. Epub 2023 Dec 8 doi: 10.1002/cam4.6662. PMID: 38069531Free PMC Article
Cuk P, Kjær MD, Mogensen CB, Nielsen MF, Pedersen AK, Ellebæk MB
Surg Endosc 2022 Jan;36(1):32-46. Epub 2021 Nov 1 doi: 10.1007/s00464-021-08782-7. PMID: 34724576Free PMC Article
Hassan C, Spadaccini M, Iannone A, Maselli R, Jovani M, Chandrasekar VT, Antonelli G, Yu H, Areia M, Dinis-Ribeiro M, Bhandari P, Sharma P, Rex DK, Rösch T, Wallace M, Repici A
Gastrointest Endosc 2021 Jan;93(1):77-85.e6. Epub 2020 Jun 26 doi: 10.1016/j.gie.2020.06.059. PMID: 32598963
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088Free PMC Article

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