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Grade 2 Colorectal Adenocarcinoma

MedGen UID:
272680
Concept ID:
C1333860
Neoplastic Process
Synonyms: Grade II Colorectal Adenocarcinoma; Low Grade Colorectal Adenocarcinoma; Moderately Differentiated Colorectal Adenocarcinoma

Definition

A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with 50-95% glandular formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Colorectal Adenocarcinoma

Professional guidelines

PubMed

Yonemura Y, Ishibashi H, Mizumoto A, Fujita T, Liu Y, Wakama S, Sako S, Takao N, Kitai T, Katayama K, Kamada Y, Taniguchi K, Fujimoto D
Gan To Kagaku Ryoho 2022 Dec;49(13):1723-1726. PMID: 36732979
Ott C, Gerken M, Hirsch D, Fest P, Fichtner-Feigl S, Munker S, Schnoy E, Stroszczynski C, Vogelhuber M, Herr W, Evert M, Reng M, Schlitt HJ, Klinkhammer-Schalke M, Teufel A
Digestion 2018;98(3):143-152. Epub 2018 Jun 5 doi: 10.1159/000487710. PMID: 29870979
Kim JH, Kim KJ, Bae JM, Rhee YY, Cho NY, Lee HS, Kang GH
J Clin Pathol 2015 Jan;68(1):22-8. Epub 2014 Oct 16 doi: 10.1136/jclinpath-2014-202603. PMID: 25322692

Recent clinical studies

Etiology

Liao CK, Hsu YJ, Chern YJ, Yu YL, Lin YC, Hsieh PS, Chiang JM, You JF
Eur J Surg Oncol 2024 Dec;50(12):108687. Epub 2024 Sep 11 doi: 10.1016/j.ejso.2024.108687. PMID: 39288563
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Cats A, Jansen EPM, van Grieken NCT, Sikorska K, Lind P, Nordsmark M, Meershoek-Klein Kranenbarg E, Boot H, Trip AK, Swellengrebel HAM, van Laarhoven HWM, Putter H, van Sandick JW, van Berge Henegouwen MI, Hartgrink HH, van Tinteren H, van de Velde CJH, Verheij M; CRITICS investigators
Lancet Oncol 2018 May;19(5):616-628. Epub 2018 Apr 9 doi: 10.1016/S1470-2045(18)30132-3. PMID: 29650363
Hayashi T, Yoshikawa T, Aoyama T, Hasegawa S, Yamada T, Tsuchida K, Fujikawa H, Sato T, Ogata T, Cho H, Oshima T, Rino Y, Masuda M
Gastric Cancer 2015 Apr;18(2):368-74. Epub 2014 Mar 17 doi: 10.1007/s10120-014-0361-3. PMID: 24634097
de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A
J Clin Oncol 2000 Aug;18(16):2938-47. doi: 10.1200/JCO.2000.18.16.2938. PMID: 10944126

Diagnosis

Lin JR, Wang S, Coy S, Chen YA, Yapp C, Tyler M, Nariya MK, Heiser CN, Lau KS, Santagata S, Sorger PK
Cell 2023 Jan 19;186(2):363-381.e19. doi: 10.1016/j.cell.2022.12.028. PMID: 36669472Free PMC Article
Görgec B, Benedetti Cacciaguerra A, Lanari J, Russolillo N, Cipriani F, Aghayan D, Zimmitti G, Efanov M, Alseidi A, Mocchegiani F, Giuliante F, Ruzzenente A, Rotellar F, Fuks D, D'Hondt M, Vivarelli M, Edwin B, Aldrighetti LA, Ferrero A, Cillo U, Besselink MG, Abu Hilal M
JAMA Surg 2021 Aug 1;156(8):e212064. Epub 2021 Aug 11 doi: 10.1001/jamasurg.2021.2064. PMID: 34076671Free PMC Article
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Neuhaus H
Gastrointest Endosc Clin N Am 2014 Apr;24(2):295-311. Epub 2014 Jan 16 doi: 10.1016/j.giec.2013.11.002. PMID: 24679240

Therapy

Wang ZX, Peng J, Liang X, Cheng Y, Deng Y, Chen K, Zhang M, Zhang J, Wang W, Cao B, Jin Y, Sun M, Lin Y, Luo S, Li Z, Yang L, Ke Y, Yu H, Li J, Wang Q, Zhu J, Wang F, Xu RH
Med 2024 Sep 13;5(9):1150-1163.e3. Epub 2024 Jun 12 doi: 10.1016/j.medj.2024.05.009. PMID: 38870931
Thompson HM, Omer DM, Lin S, Kim JK, Yuval JB, Verheij FS, Qin LX, Gollub MJ, Wu AJ, Lee M, Patil S, Hezel AF, Marcet JE, Cataldo PA, Polite BN, Herzig DO, Liska D, Oommen S, Friel CM, Ternent CA, Coveler AL, Hunt SR, Garcia-Aguilar J; OPRA Consortium
JAMA Netw Open 2024 Jan 2;7(1):e2350903. doi: 10.1001/jamanetworkopen.2023.50903. PMID: 38194231Free PMC Article
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Xu RH, Muro K, Morita S, Iwasa S, Han SW, Wang W, Kotaka M, Nakamura M, Ahn JB, Deng YH, Kato T, Cho SH, Ba Y, Matsuoka H, Lee KW, Zhang T, Yamada Y, Sakamoto J, Park YS, Kim TW
Lancet Oncol 2018 May;19(5):660-671. Epub 2018 Mar 16 doi: 10.1016/S1470-2045(18)30140-2. PMID: 29555258
de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A
J Clin Oncol 2000 Aug;18(16):2938-47. doi: 10.1200/JCO.2000.18.16.2938. PMID: 10944126

Prognosis

Liao CK, Hsu YJ, Chern YJ, Yu YL, Lin YC, Hsieh PS, Chiang JM, You JF
Eur J Surg Oncol 2024 Dec;50(12):108687. Epub 2024 Sep 11 doi: 10.1016/j.ejso.2024.108687. PMID: 39288563
Patel C, Behring M, Al Diffalha S, Dhall D, Lee G, Shanmugam C, Grizzle WE, Manne U
Cancer Med 2023 Apr;12(8):9637-9643. Epub 2023 Mar 14 doi: 10.1002/cam4.5803. PMID: 36916704Free PMC Article
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Hayashi T, Yoshikawa T, Aoyama T, Hasegawa S, Yamada T, Tsuchida K, Fujikawa H, Sato T, Ogata T, Cho H, Oshima T, Rino Y, Masuda M
Gastric Cancer 2015 Apr;18(2):368-74. Epub 2014 Mar 17 doi: 10.1007/s10120-014-0361-3. PMID: 24634097
Fuchs CS, Marshall J, Mitchell E, Wierzbicki R, Ganju V, Jeffery M, Schulz J, Richards D, Soufi-Mahjoubi R, Wang B, Barrueco J
J Clin Oncol 2007 Oct 20;25(30):4779-86. doi: 10.1200/JCO.2007.11.3357. PMID: 17947725

Clinical prediction guides

Shen Y, Gong X, He Y, Meng W, Zeng H, Wei M, Qiu M, Wang Z
Radiology 2024 Aug;312(2):e232908. doi: 10.1148/radiol.232908. PMID: 39189908
Zhang F, Wang X, Zhu Y, Xia P
Pathol Oncol Res 2023;29:1611396. Epub 2023 Nov 30 doi: 10.3389/pore.2023.1611396. PMID: 38099242Free PMC Article
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Cats A, Jansen EPM, van Grieken NCT, Sikorska K, Lind P, Nordsmark M, Meershoek-Klein Kranenbarg E, Boot H, Trip AK, Swellengrebel HAM, van Laarhoven HWM, Putter H, van Sandick JW, van Berge Henegouwen MI, Hartgrink HH, van Tinteren H, van de Velde CJH, Verheij M; CRITICS investigators
Lancet Oncol 2018 May;19(5):616-628. Epub 2018 Apr 9 doi: 10.1016/S1470-2045(18)30132-3. PMID: 29650363
Hayashi T, Yoshikawa T, Aoyama T, Hasegawa S, Yamada T, Tsuchida K, Fujikawa H, Sato T, Ogata T, Cho H, Oshima T, Rino Y, Masuda M
Gastric Cancer 2015 Apr;18(2):368-74. Epub 2014 Mar 17 doi: 10.1007/s10120-014-0361-3. PMID: 24634097

Recent systematic reviews

Gupta N, Verma N, Patel B
J Gastrointest Cancer 2024 Dec;55(4):1485-1497. Epub 2024 Aug 20 doi: 10.1007/s12029-024-01103-w. PMID: 39160369
Lauricella S, Fabris S, Sylla P
Surg Endosc 2023 Jan;37(1):48-61. Epub 2022 Aug 3 doi: 10.1007/s00464-022-09462-w. PMID: 35920906
van Dorp M, Bousema JE, Torensma B, Dickhoff C, van den Broek FJC, Schreurs WH, Gonzalez M, Kazemier G, Heineman DJ
Eur J Surg Oncol 2022 Jan;48(1):253-260. Epub 2021 Oct 11 doi: 10.1016/j.ejso.2021.09.020. PMID: 34656390
Aalami AH, Abdeahad H, Mesgari M, Sahebkar A
Eur J Clin Invest 2021 Feb;51(2):e13448. Epub 2020 Dec 5 doi: 10.1111/eci.13448. PMID: 33244751
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088Free PMC Article

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