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Locally Advanced Pancreatic Neuroendocrine Carcinoma

MedGen UID:
1662180
•Concept ID:
C4744458
•
Neoplastic Process

Definition

A pancreatic neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Pancreatic Neuroendocrine Carcinoma

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Pancreatic neuroendocrine tumors: Nosography, management and treatment.
Orditura M, Petrillo A, Ventriglia J, Diana A, Laterza MM, Fabozzi A, Savastano B, Franzese E, Conzo G, Santini L, Ciardiello F, De Vita F
Int J Surg 2016 Apr;28 Suppl 1:S156-62. Epub 2015 Dec 18 doi: 10.1016/j.ijsu.2015.12.052. PMID: 26708853
Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Recent clinical studies

Etiology

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Everolimus.
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Is there a role of radiotherapy in the management of pancreatic neuroendocrine tumors (PNET)?
Saif MW, Ng J, Chang B, Russo S
JOP 2012 Mar 10;13(2):174-6. PMID: 22406594
Neuroendocrine tumors of the pancreas.
Ehehalt F, Saeger HD, Schmidt CM, Grützmann R
Oncologist 2009 May;14(5):456-67. Epub 2009 May 1 doi: 10.1634/theoncologist.2008-0259. PMID: 19411317

Diagnosis

All you need to know about gastrinoma today | Gastrinoma and Zollinger-Ellison syndrome: A thorough update.
Chatzipanagiotou O, Schizas D, Vailas M, Tsoli M, Sakarellos P, Sotiropoulou M, Papalambros A, Felekouras E
J Neuroendocrinol 2023 Apr;35(4):e13267. Epub 2023 Apr 11 doi: 10.1111/jne.13267. PMID: 37042078
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Zollinger-Ellison syndrome: recent advances and controversies.
Ito T, Igarashi H, Jensen RT
Curr Opin Gastroenterol 2013 Nov;29(6):650-61. doi: 10.1097/MOG.0b013e328365efb1. PMID: 24100728Free PMC Article
Pharmacotherapy of Zollinger-Ellison syndrome.
Ito T, Igarashi H, Uehara H, Jensen RT
Expert Opin Pharmacother 2013 Feb;14(3):307-21. Epub 2013 Jan 30 doi: 10.1517/14656566.2013.767332. PMID: 23363383Free PMC Article
Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Therapy

Treatment options of metastatic and nonmetastatic VIPoma: a review.
Azizian A, König A, Ghadimi M
Langenbecks Arch Surg 2022 Nov;407(7):2629-2636. Epub 2022 Aug 5 doi: 10.1007/s00423-022-02620-7. PMID: 35931878Free PMC Article
Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.
Marabelle A, Le DT, Ascierto PA, Di Giacomo AM, De Jesus-Acosta A, Delord JP, Geva R, Gottfried M, Penel N, Hansen AR, Piha-Paul SA, Doi T, Gao B, Chung HC, Lopez-Martin J, Bang YJ, Frommer RS, Shah M, Ghori R, Joe AK, Pruitt SK, Diaz LA Jr
J Clin Oncol 2020 Jan 1;38(1):1-10. Epub 2019 Nov 4 doi: 10.1200/JCO.19.02105. PMID: 31682550Free PMC Article
Pharmacotherapy of Zollinger-Ellison syndrome.
Ito T, Igarashi H, Uehara H, Jensen RT
Expert Opin Pharmacother 2013 Feb;14(3):307-21. Epub 2013 Jan 30 doi: 10.1517/14656566.2013.767332. PMID: 23363383Free PMC Article
Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Gastrinoma.
Li ML, Norton JA
Curr Treat Options Oncol 2001 Aug;2(4):337-46. doi: 10.1007/s11864-001-0027-3. PMID: 12057114

Prognosis

Molecular radionuclide imaging of pancreatic neoplasms.
Panda A, Garg I, Johnson GB, Truty MJ, Halfdanarson TR, Goenka AH
Lancet Gastroenterol Hepatol 2019 Jul;4(7):559-570. doi: 10.1016/S2468-1253(19)30081-0. PMID: 31169124
Advances in the diagnosis and treatment of pancreatic neuroendocrine neoplasms in Japan.
Ito T, Hijioka S, Masui T, Kasajima A, Nakamoto Y, Kobayashi N, Komoto I, Hijioka M, Lee L, Igarashi H, Jensen RT, Imamura M
J Gastroenterol 2017 Jan;52(1):9-18. Epub 2016 Aug 18 doi: 10.1007/s00535-016-1250-9. PMID: 27539256
Pancreatic neuroendocrine tumors: Nosography, management and treatment.
Orditura M, Petrillo A, Ventriglia J, Diana A, Laterza MM, Fabozzi A, Savastano B, Franzese E, Conzo G, Santini L, Ciardiello F, De Vita F
Int J Surg 2016 Apr;28 Suppl 1:S156-62. Epub 2015 Dec 18 doi: 10.1016/j.ijsu.2015.12.052. PMID: 26708853
Zollinger-Ellison syndrome: recent advances and controversies.
Ito T, Igarashi H, Jensen RT
Curr Opin Gastroenterol 2013 Nov;29(6):650-61. doi: 10.1097/MOG.0b013e328365efb1. PMID: 24100728Free PMC Article
Is there a role of radiotherapy in the management of pancreatic neuroendocrine tumors (PNET)?
Saif MW, Ng J, Chang B, Russo S
JOP 2012 Mar 10;13(2):174-6. PMID: 22406594

Clinical prediction guides

Surgery in Patients with Gastro-Entero-Pancreatic Neuroendocrine Carcinomas, Neuroendocrine Tumors G3 and High Grade Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.
Holmager P, Langer SW, Kjaer A, Ringholm L, Garbyal RS, Pommergaard HC, Hansen CP, Federspiel B, Andreassen M, Knigge U
Curr Treat Options Oncol 2022 Jun;23(6):806-817. Epub 2022 Apr 1 doi: 10.1007/s11864-022-00969-x. PMID: 35362798
The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets.
van Riet J, van de Werken HJG, Cuppen E, Eskens FALM, Tesselaar M, van Veenendaal LM, Klümpen HJ, Dercksen MW, Valk GD, Lolkema MP, Sleijfer S, Mostert B
Nat Commun 2021 Jul 29;12(1):4612. doi: 10.1038/s41467-021-24812-3. PMID: 34326338Free PMC Article
The surgical management of pancreatic neuroendocrine tumors.
Azimuddin K, Chamberlain RS
Surg Clin North Am 2001 Jun;81(3):511-25. doi: 10.1016/s0039-6109(05)70140-7. PMID: 11459268
Intraoperative methods to stage and localize pancreatic and duodenal tumors.
Norton JA
Ann Oncol 1999;10 Suppl 4:182-4. PMID: 10436817
Evaluation and clinical value of neuroendocrine differentiation in human prostatic tumors.
Cussenot O, Villette JM, Cochand-Priollet B, Berthon P
Prostate Suppl 1998;8:43-51. PMID: 9690663

Recent systematic reviews

Should platinum-based chemotherapy be preferred for germline BReast CAncer genes (BRCA) 1 and 2-mutated pancreatic ductal adenocarcinoma (PDAC) patients? A systematic review and meta-analysis.
Rebelatto TF, Falavigna M, Pozzari M, Spada F, Cella CA, Laffi A, Pellicori S, Fazio N
Cancer Treat Rev 2019 Nov;80:101895. Epub 2019 Sep 6 doi: 10.1016/j.ctrv.2019.101895. PMID: 31542591
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

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