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Locally Advanced Carcinoma

MedGen UID:
1665275
•Concept ID:
C4724834
•
Neoplastic Process

Definition

A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Carcinoma

Professional guidelines

PubMed

Management of Locally Advanced Carcinoma Oesophagus with Radiation/Chemoradiation: Single Institute Experience.
Kumaran D, John S, Isiah R, Das S
J Gastrointest Cancer 2016 Sep;47(3):313-7. doi: 10.1007/s12029-016-9825-5. PMID: 27146042
The epidemiology, diagnosis, and treatment of Barrett's carcinoma.
Labenz J, Koop H, Tannapfel A, Kiesslich R, Hölscher AH
Dtsch Arztebl Int 2015 Mar 27;112(13):224-33; quiz 234. doi: 10.3238/arztebl.2015.0224. PMID: 25869347Free PMC Article
American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: high-dose-rate brachytherapy.
Viswanathan AN, Beriwal S, De Los Santos JF, Demanes DJ, Gaffney D, Hansen J, Jones E, Kirisits C, Thomadsen B, Erickson B; American Brachytherapy Society
Brachytherapy 2012 Jan-Feb;11(1):47-52. doi: 10.1016/j.brachy.2011.07.002. PMID: 22265437Free PMC Article

Recent clinical studies

Etiology

Comment on Prospective Study to Compare Efficacy of Conventional Chemoradiotherapy with Hypofractionated Chemoradiotherapy in Locally Advanced Carcinoma of Oropharynx.
Topkan E, Somay E, Selek U
Asian Pac J Cancer Prev 2024 Feb 1;25(2):367-368. doi: 10.31557/APJCP.2024.25.2.367. PMID: 38415519Free PMC Article
Pain relief with short-term irradiation in locally advanced carcinoma of the pancreas.
Morganti AG, Trodella L, Valentini V, Barbi S, Macchia G, Mantini G, Turriziani A, Cellini N
J Palliat Care 2003 Winter;19(4):258-62. PMID: 14959596
Dose escalation in locally advanced carcinoma of the prostate.
Blanco AI, Michalski JM
Semin Radiat Oncol 2003 Apr;13(2):87-97. doi: 10.1053/srao.2003.50017. PMID: 12728438
Results of treatment in locally advanced carcinoma of the endometrium.
Ahmad K, Kim YH, Deppe G, Malone J, Herskovic A, Ratanatharathorn V, Sakr WA, Medina A, Malviya V
Acta Oncol 1990;29(2):203-9. doi: 10.3109/02841869009126546. PMID: 2185804
Neoadjuvant chemotherapy in locally advanced carcinoma of the cervix uteri.
Sardi J, Sananes C, Giaroli A, Maya G, di Paola G
Gynecol Oncol 1990 Sep;38(3):486-93. doi: 10.1016/0090-8258(90)90096-4. PMID: 1699851

Diagnosis

Bilateral Synchronous Locally Advanced Carcinoma of the Breast in a Woman Over 100 Years Old.
Sedloev T, Spirdonov J, Terziev I, Spiridonova T, Usheva S
Br J Hosp Med (Lond) 2022 Dec 2;83(12):1-3. Epub 2022 Dec 29 doi: 10.12968/hmed.2022.0440. PMID: 36594771
Management of Locally Advanced Carcinoma Oesophagus with Radiation/Chemoradiation: Single Institute Experience.
Kumaran D, John S, Isiah R, Das S
J Gastrointest Cancer 2016 Sep;47(3):313-7. doi: 10.1007/s12029-016-9825-5. PMID: 27146042
The epidemiology, diagnosis, and treatment of Barrett's carcinoma.
Labenz J, Koop H, Tannapfel A, Kiesslich R, Hölscher AH
Dtsch Arztebl Int 2015 Mar 27;112(13):224-33; quiz 234. doi: 10.3238/arztebl.2015.0224. PMID: 25869347Free PMC Article
Silicone breast implant with intracapsular rupture coexisting with locally advanced carcinoma.
Leung TK, Huang PJ, Sun LM, Chu JS, Chen CS, Lee CM, Wu CH, Chao JS
Breast J 2012 Jan-Feb;18(1):76-7. Epub 2011 Nov 8 doi: 10.1111/j.1524-4741.2011.01187.x. PMID: 22060279
Pain relief with short-term irradiation in locally advanced carcinoma of the pancreas.
Morganti AG, Trodella L, Valentini V, Barbi S, Macchia G, Mantini G, Turriziani A, Cellini N
J Palliat Care 2003 Winter;19(4):258-62. PMID: 14959596

Therapy

Cerebral venous thrombosis: an unanticipated consequence of unilateral internal jugular vein ligation.
Moideen A, Panda S, Parihar J, Meena SK
BMJ Case Rep 2024 Oct 14;17(10) doi: 10.1136/bcr-2024-261523. PMID: 39406452
A prospective randomized trial comparing accelerated concurrent chemoradiotherapy with conventional concurrent chemoradiotherapy in locally advanced carcinoma cervix (IIA-IVA).
Vias P, Angural H, Seam RK, Gupta MK, Gupta M, Fotedar V, Negi A
J Cancer Res Ther 2021 Jul-Sep;17(4):1012-1016. doi: 10.4103/jcrt.JCRT_626_19. PMID: 34528557
Role of multimodality therapy in the management of locally advanced carcinoma of the breast.
Heys SD, Eremin JM, Sarkar TK, Hutcheon AW, Ah-See A, Eremin O
J Am Coll Surg 1994 Oct;179(4):493-504. PMID: 7921405
Neoadjuvant chemotherapy in locally advanced carcinoma of the cervix uteri.
Sardi J, Sananes C, Giaroli A, Maya G, di Paola G
Gynecol Oncol 1990 Sep;38(3):486-93. doi: 10.1016/0090-8258(90)90096-4. PMID: 1699851
Simple mastectomy under local anaesthesia.
Dennison AR, Watkins RM, Ward ME, Lee EC
Ann R Coll Surg Engl 1985 Jul;67(4):243-4. PMID: 4037637Free PMC Article

Prognosis

A prospective randomized trial comparing accelerated concurrent chemoradiotherapy with conventional concurrent chemoradiotherapy in locally advanced carcinoma cervix (IIA-IVA).
Vias P, Angural H, Seam RK, Gupta MK, Gupta M, Fotedar V, Negi A
J Cancer Res Ther 2021 Jul-Sep;17(4):1012-1016. doi: 10.4103/jcrt.JCRT_626_19. PMID: 34528557
Pain relief with short-term irradiation in locally advanced carcinoma of the pancreas.
Morganti AG, Trodella L, Valentini V, Barbi S, Macchia G, Mantini G, Turriziani A, Cellini N
J Palliat Care 2003 Winter;19(4):258-62. PMID: 14959596
New approaches to radiation therapy in locally advanced carcinoma of the cervix.
Calkins A, Stitt JA, Fowler JF
Semin Oncol 1994 Feb;21(1):42-6. PMID: 8310308
Prognostic factors in locally advanced carcinoma of the cervix treated with radiation therapy.
Stehman FB, Thomas GM
Semin Oncol 1994 Feb;21(1):25-9. PMID: 8310305
Neoadjuvant chemotherapy in locally advanced carcinoma of the cervix uteri.
Sardi J, Sananes C, Giaroli A, Maya G, di Paola G
Gynecol Oncol 1990 Sep;38(3):486-93. doi: 10.1016/0090-8258(90)90096-4. PMID: 1699851

Clinical prediction guides

Prediction of response to radiotherapy in locally advanced carcinoma cervix using multiparametric MRI: A prospective, single-center, longitudinal study.
Verma A, Kumar I, Patel DS, Ranjan R, Singh M, Pradhan S, Shukla RC
Asia Pac J Clin Oncol 2023 Feb;19(1):79-86. Epub 2022 Apr 18 doi: 10.1111/ajco.13761. PMID: 35437940
Pain relief with short-term irradiation in locally advanced carcinoma of the pancreas.
Morganti AG, Trodella L, Valentini V, Barbi S, Macchia G, Mantini G, Turriziani A, Cellini N
J Palliat Care 2003 Winter;19(4):258-62. PMID: 14959596
Neoadjuvant chemotherapy in locally advanced carcinoma of the cervix uteri.
Sardi J, Sananes C, Giaroli A, Maya G, di Paola G
Gynecol Oncol 1990 Sep;38(3):486-93. doi: 10.1016/0090-8258(90)90096-4. PMID: 1699851
A possible new trend in the management of the carcinoma of the cervix uteri.
Sardi JE, di Paola GR, Cachau A, Ortiz OC, Sananes C, Giaroli A, Martins D, Peluffo M
Gynecol Oncol 1986 Oct;25(2):139-49. doi: 10.1016/0090-8258(86)90095-8. PMID: 2428700
Combined transcatheter arterial embolization and regional chemotherapy for locally advanced carcinoma of the breast. A preliminary investigation.
Morimoto K, Takatsuka Y, Sugitachi A, Miyata Y, Choi S, Hashimoto T, Hara K
Acta Radiol Oncol 1985 May-Jun;24(3):241-5. doi: 10.3109/02841868509134394. PMID: 2994374

Recent systematic reviews

Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma.
Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Leung SF, Thephamongkhol K, Pignon JP; MAC-NPC Collaborative Group
Cochrane Database Syst Rev 2006 Oct 18;2006(4):CD004329. doi: 10.1002/14651858.CD004329.pub2. PMID: 17054200Free PMC Article

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