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Locally Advanced Unresectable Prostate Carcinoma

MedGen UID:
1659574
•Concept ID:
C4744716
•
Neoplastic Process

Definition

A prostatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Prostate Carcinoma

Professional guidelines

PubMed

Beyond chemoradiotherapy: improving treatment outcomes for patients with stage III unresectable non-small-cell lung cancer through immuno-oncology and durvalumab (Imfinzi®▼, AstraZeneca UK Limited).
Patel P, Alrifai D, McDonald F, Forster M; AstraZeneca UK Limited
Br J Cancer 2020 Dec;123(Suppl 1):18-27. doi: 10.1038/s41416-020-01071-5. PMID: 33293672Free PMC Article
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430

Recent clinical studies

Etiology

Metformin in Combination With Chemoradiotherapy in Locally Advanced Non-Small Cell Lung Cancer: The OCOG-ALMERA Randomized Clinical Trial.
Tsakiridis T, Pond GR, Wright J, Ellis PM, Ahmed N, Abdulkarim B, Roa W, Robinson A, Swaminath A, Okawara G, Wierzbicki M, Valdes M, Levine M
JAMA Oncol 2021 Sep 1;7(9):1333-1341. doi: 10.1001/jamaoncol.2021.2328. PMID: 34323924Free PMC Article
Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS).
Grivas P, Loriot Y, Morales-Barrera R, Teo MY, Zakharia Y, Feyerabend S, Vogelzang NJ, Grande E, Adra N, Alva A, Necchi A, Rodriguez-Vida A, Gupta S, Josephs DH, Srinivas S, Wride K, Thomas D, Simmons A, Loehr A, Dusek RL, Nepert D, Chowdhury S
BMC Cancer 2021 May 24;21(1):593. doi: 10.1186/s12885-021-08085-z. PMID: 34030643Free PMC Article
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430
Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413
The importance of palliative care in urology.
Brierly RD, O'Brien TS
Urol Int 2008;80(1):13-8. Epub 2008 Jan 18 doi: 10.1159/000111723. PMID: 18204227

Diagnosis

Definitive treatment of androgen receptor-positive salivary duct carcinoma with androgen deprivation therapy and external beam radiotherapy.
Soper MS, Iganej S, Thompson LD
Head Neck 2014 Jan;36(1):E4-7. Epub 2013 Sep 17 doi: 10.1002/hed.23383. PMID: 23720164

Therapy

Metformin in Combination With Chemoradiotherapy in Locally Advanced Non-Small Cell Lung Cancer: The OCOG-ALMERA Randomized Clinical Trial.
Tsakiridis T, Pond GR, Wright J, Ellis PM, Ahmed N, Abdulkarim B, Roa W, Robinson A, Swaminath A, Okawara G, Wierzbicki M, Valdes M, Levine M
JAMA Oncol 2021 Sep 1;7(9):1333-1341. doi: 10.1001/jamaoncol.2021.2328. PMID: 34323924Free PMC Article
Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS).
Grivas P, Loriot Y, Morales-Barrera R, Teo MY, Zakharia Y, Feyerabend S, Vogelzang NJ, Grande E, Adra N, Alva A, Necchi A, Rodriguez-Vida A, Gupta S, Josephs DH, Srinivas S, Wride K, Thomas D, Simmons A, Loehr A, Dusek RL, Nepert D, Chowdhury S
BMC Cancer 2021 May 24;21(1):593. doi: 10.1186/s12885-021-08085-z. PMID: 34030643Free PMC Article
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430
Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413
Triplet chemotherapy combinations with new agents: is there a rationale?
Bunn PA Jr
Semin Oncol 1998 Aug;25(4 Suppl 9):55-61. PMID: 9728586

Prognosis

Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS).
Grivas P, Loriot Y, Morales-Barrera R, Teo MY, Zakharia Y, Feyerabend S, Vogelzang NJ, Grande E, Adra N, Alva A, Necchi A, Rodriguez-Vida A, Gupta S, Josephs DH, Srinivas S, Wride K, Thomas D, Simmons A, Loehr A, Dusek RL, Nepert D, Chowdhury S
BMC Cancer 2021 May 24;21(1):593. doi: 10.1186/s12885-021-08085-z. PMID: 34030643Free PMC Article
Definitive treatment of androgen receptor-positive salivary duct carcinoma with androgen deprivation therapy and external beam radiotherapy.
Soper MS, Iganej S, Thompson LD
Head Neck 2014 Jan;36(1):E4-7. Epub 2013 Sep 17 doi: 10.1002/hed.23383. PMID: 23720164
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430
Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413

Clinical prediction guides

Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS).
Grivas P, Loriot Y, Morales-Barrera R, Teo MY, Zakharia Y, Feyerabend S, Vogelzang NJ, Grande E, Adra N, Alva A, Necchi A, Rodriguez-Vida A, Gupta S, Josephs DH, Srinivas S, Wride K, Thomas D, Simmons A, Loehr A, Dusek RL, Nepert D, Chowdhury S
BMC Cancer 2021 May 24;21(1):593. doi: 10.1186/s12885-021-08085-z. PMID: 34030643Free PMC Article
Addition of an induction regimen of antiangiogenesis and antitumor immunity to standard chemotherapy improves survival in advanced malignancies.
Lasalvia-Prisco E, Goldschmidt P, Galmarini F, Cucchi S, Vázquez J, Aghazarian M, Lasalvia-Galante E, Golomar W, Gordon W
Med Oncol 2012 Dec;29(5):3626-33. Epub 2012 Jul 19 doi: 10.1007/s12032-012-0301-1. PMID: 22810591Free PMC Article
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430
The importance of palliative care in urology.
Brierly RD, O'Brien TS
Urol Int 2008;80(1):13-8. Epub 2008 Jan 18 doi: 10.1159/000111723. PMID: 18204227
Clinical trials of neutron radiotherapy in the United States.
Lindsley KL, Cho P, Stelzer KJ, Koh WJ, Austin-Seymour M, Russell KJ, Laramore GE, Griffin TW
Bull Cancer Radiother 1996;83 Suppl:78s-86s. doi: 10.1016/0924-4212(96)84889-4. PMID: 8949756

Recent systematic reviews

Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413

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