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Locally Advanced Rectal Carcinoma

MedGen UID:
1760248
•Concept ID:
C5418787
•
Neoplastic Process

Definition

Rectal carcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Pre-treatment carcinoembryonic antigen and outcome of patients with rectal cancer receiving neo-adjuvant chemo-radiation and surgical resection: a systematic review and meta-analysis.
Colloca G, Venturino A, Vitucci P
Med Oncol 2017 Sep 7;34(10):177. doi: 10.1007/s12032-017-1037-8. PMID: 28884291
Neoadjuvant treatment intensification or adjuvant chemotherapy for locally advanced carcinoma rectum: The optimum treatment approach remains unresolved.
Mallick S, Benson R, Haresh KP, Rath GK
J Egypt Natl Canc Inst 2015 Dec;27(4):179-85. Epub 2015 Jun 10 doi: 10.1016/j.jnci.2015.05.003. PMID: 26071798
Preoperative versus postoperative treatment for locally advanced rectal carcinoma.
Pasetto LM
Future Oncol 2005 Apr;1(2):209-20. doi: 10.1517/14796694.1.2.209. PMID: 16555993

Recent clinical studies

Etiology

Nodal staging with MRI after neoadjuvant chemo-radiotherapy for locally advanced rectal cancer: a fast and reliable method.
Crimì F, Cabrelle G, Campi C, Schillaci A, Bao QR, Pepe A, Spolverato G, Pucciarelli S, Vernuccio F, Quaia E
Eur Radiol 2024 May;34(5):3205-3214. Epub 2023 Nov 6 doi: 10.1007/s00330-023-10265-3. PMID: 37930408
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Accuracy of MRI in Restaging Locally Advanced Rectal Cancer After Preoperative Chemoradiation.
van den Broek JJ, van der Wolf FS, Lahaye MJ, Heijnen LA, Meischl C, Heitbrink MA, Schreurs WH
Dis Colon Rectum 2017 Mar;60(3):274-283. doi: 10.1097/DCR.0000000000000743. PMID: 28177989
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article
Pelvic exenteration for locally advanced rectal carcinoma: factors predicting improved survival.
Meterissian SH, Skibber JM, Giacco GG, el-Naggar AK, Hess KR, Rich TA
Surgery 1997 May;121(5):479-87. doi: 10.1016/s0039-6060(97)90100-8. PMID: 9142144

Diagnosis

Nodal staging with MRI after neoadjuvant chemo-radiotherapy for locally advanced rectal cancer: a fast and reliable method.
Crimì F, Cabrelle G, Campi C, Schillaci A, Bao QR, Pepe A, Spolverato G, Pucciarelli S, Vernuccio F, Quaia E
Eur Radiol 2024 May;34(5):3205-3214. Epub 2023 Nov 6 doi: 10.1007/s00330-023-10265-3. PMID: 37930408
Stability of radiomic features of apparent diffusion coefficient (ADC) maps for locally advanced rectal cancer in response to image pre-processing.
Traverso A, Kazmierski M, Shi Z, Kalendralis P, Welch M, Nissen HD, Jaffray D, Dekker A, Wee L
Phys Med 2019 May;61:44-51. Epub 2019 Apr 28 doi: 10.1016/j.ejmp.2019.04.009. PMID: 31151578
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Accuracy of MRI in Restaging Locally Advanced Rectal Cancer After Preoperative Chemoradiation.
van den Broek JJ, van der Wolf FS, Lahaye MJ, Heijnen LA, Meischl C, Heitbrink MA, Schreurs WH
Dis Colon Rectum 2017 Mar;60(3):274-283. doi: 10.1097/DCR.0000000000000743. PMID: 28177989
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article

Therapy

Which is the best neoadjuvant (pre-surgery) chemoradiation regimen for locally advanced rectal carcinoma? Short or long course of radiation therapy? Do we have new data?
Koukourakis G
J BUON 2020 Jan-Feb;25(1):51-61. PMID: 32277614
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article
Neoadjuvant treatment intensification or adjuvant chemotherapy for locally advanced carcinoma rectum: The optimum treatment approach remains unresolved.
Mallick S, Benson R, Haresh KP, Rath GK
J Egypt Natl Canc Inst 2015 Dec;27(4):179-85. Epub 2015 Jun 10 doi: 10.1016/j.jnci.2015.05.003. PMID: 26071798
Preoperative versus postoperative treatment for locally advanced rectal carcinoma.
Pasetto LM
Future Oncol 2005 Apr;1(2):209-20. doi: 10.1517/14796694.1.2.209. PMID: 16555993

Prognosis

Which is the best neoadjuvant (pre-surgery) chemoradiation regimen for locally advanced rectal carcinoma? Short or long course of radiation therapy? Do we have new data?
Koukourakis G
J BUON 2020 Jan-Feb;25(1):51-61. PMID: 32277614
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Accuracy of MRI in Restaging Locally Advanced Rectal Cancer After Preoperative Chemoradiation.
van den Broek JJ, van der Wolf FS, Lahaye MJ, Heijnen LA, Meischl C, Heitbrink MA, Schreurs WH
Dis Colon Rectum 2017 Mar;60(3):274-283. doi: 10.1097/DCR.0000000000000743. PMID: 28177989
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article
Pelvic exenteration for locally advanced rectal carcinoma: factors predicting improved survival.
Meterissian SH, Skibber JM, Giacco GG, el-Naggar AK, Hess KR, Rich TA
Surgery 1997 May;121(5):479-87. doi: 10.1016/s0039-6060(97)90100-8. PMID: 9142144

Clinical prediction guides

Stability of radiomic features of apparent diffusion coefficient (ADC) maps for locally advanced rectal cancer in response to image pre-processing.
Traverso A, Kazmierski M, Shi Z, Kalendralis P, Welch M, Nissen HD, Jaffray D, Dekker A, Wee L
Phys Med 2019 May;61:44-51. Epub 2019 Apr 28 doi: 10.1016/j.ejmp.2019.04.009. PMID: 31151578
Muscle wasting and survival following pre-operative chemoradiotherapy for locally advanced rectal carcinoma.
Levolger S, van Vledder MG, Alberda WJ, Verhoef C, de Bruin RWF, IJzermans JNM, Burger JW
Clin Nutr 2018 Oct;37(5):1728-1735. Epub 2017 Jul 13 doi: 10.1016/j.clnu.2017.06.028. PMID: 28756039
Accuracy of MRI in Restaging Locally Advanced Rectal Cancer After Preoperative Chemoradiation.
van den Broek JJ, van der Wolf FS, Lahaye MJ, Heijnen LA, Meischl C, Heitbrink MA, Schreurs WH
Dis Colon Rectum 2017 Mar;60(3):274-283. doi: 10.1097/DCR.0000000000000743. PMID: 28177989
Outcomes of neoadjuvant chemoradiotherapy in Japanese locally advanced rectal carcinoma patients.
Tokuhara K, Ueyama Y, Nakatani K, Yoshioka K, Kon M
World J Surg Oncol 2016 Apr 30;14:136. doi: 10.1186/s12957-016-0898-1. PMID: 27129578Free PMC Article
Pelvic exenteration for locally advanced rectal carcinoma: factors predicting improved survival.
Meterissian SH, Skibber JM, Giacco GG, el-Naggar AK, Hess KR, Rich TA
Surgery 1997 May;121(5):479-87. doi: 10.1016/s0039-6060(97)90100-8. PMID: 9142144

Recent systematic reviews

Pre-treatment carcinoembryonic antigen and outcome of patients with rectal cancer receiving neo-adjuvant chemo-radiation and surgical resection: a systematic review and meta-analysis.
Colloca G, Venturino A, Vitucci P
Med Oncol 2017 Sep 7;34(10):177. doi: 10.1007/s12032-017-1037-8. PMID: 28884291

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