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Locally Advanced Unresectable Renal Cell Carcinoma

MedGen UID:
1650694
Concept ID:
C4744334
Neoplastic Process

Definition

A renal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Renal Cell Carcinoma

Professional guidelines

PubMed

Omland LH, Joensen UN, Toft BG, Lund CM, Lindberg H, Knudsen MB, Tolver A, Suetta C, Pappot H
Acta Oncol 2022 Sep;61(9):1036-1042. Epub 2022 Aug 25 doi: 10.1080/0284186X.2022.2114378. PMID: 36017555
Tomita Y
Int J Urol 2016 Jan;23(1):13-21. Epub 2015 Sep 7 doi: 10.1111/iju.12899. PMID: 26347163
Gomez P, Lacouture ME
Oncologist 2011;16(11):1508-19. Epub 2011 Oct 20 doi: 10.1634/theoncologist.2011-0115. PMID: 22016478Free PMC Article

Recent clinical studies

Etiology

Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Califano G, Ouzaid I, Verze P, Hermieu JF, Mirone V, Xylinas E
World J Urol 2021 May;39(5):1357-1367. Epub 2020 Oct 31 doi: 10.1007/s00345-020-03502-7. PMID: 33128595
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Tomita Y
Int J Urol 2016 Jan;23(1):13-21. Epub 2015 Sep 7 doi: 10.1111/iju.12899. PMID: 26347163

Diagnosis

Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Omland LH, Joensen UN, Toft BG, Lund CM, Lindberg H, Knudsen MB, Tolver A, Suetta C, Pappot H
Acta Oncol 2022 Sep;61(9):1036-1042. Epub 2022 Aug 25 doi: 10.1080/0284186X.2022.2114378. PMID: 36017555
Albiges L, Schmidinger M, Taguieva-Pioger N, Perol D, Grünwald V, Guemas E
Future Oncol 2022 Mar;18(8):915-926. Epub 2021 Dec 16 doi: 10.2217/fon-2021-1006. PMID: 34911359
Nakahara S, Takenaka Y, Ogawa K, Nishiike S, Yamamoto Y, Seo Y, Isohashi F, Suzuki O, Yoshioka Y, Sumida I, Yoshii T, Tomiyama Y, Inohara H
Int J Clin Oncol 2016 Dec;21(6):1030-1037. Epub 2016 Jun 15 doi: 10.1007/s10147-016-0997-6. PMID: 27306220
Poole ME, Sailer SL, Rosenman JG, Tepper JE, Weissler MC, Shockley WW, Yarbrough WG, Pillsbury HC 3rd, Schell MJ, Bernard SA
Arch Otolaryngol Head Neck Surg 2001 Dec;127(12):1446-50. doi: 10.1001/archotol.127.12.1446. PMID: 11735812

Therapy

Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Delsante M, Monroy-Trujillo JM, Carter-Monroe N, Ball DW, Rosenberg AZ
Virchows Arch 2022 Feb;480(2):467-473. Epub 2021 May 6 doi: 10.1007/s00428-021-03114-5. PMID: 33959820
Mavratzas A, Seitz J, Smetanay K, Schneeweiss A, Jäger D, Fremd C
Future Oncol 2020 Jan;16(3):4439-4453. Epub 2019 Dec 12 doi: 10.2217/fon-2019-0468. PMID: 31829043
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Tomita Y
Int J Urol 2016 Jan;23(1):13-21. Epub 2015 Sep 7 doi: 10.1111/iju.12899. PMID: 26347163

Prognosis

Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Hihara J, Hamai Y, Emi M, Murakami Y, Kenjo M, Nagata Y, Okada M
Dis Esophagus 2016 Nov;29(8):1115-1120. Epub 2015 Oct 15 doi: 10.1111/dote.12433. PMID: 26471962
Tomita Y
Int J Urol 2016 Jan;23(1):13-21. Epub 2015 Sep 7 doi: 10.1111/iju.12899. PMID: 26347163
Salem ME, Shah SN, Elson P, Garcia JA, Wood LS, Medsinge A, Campbell S, Dreicer R, Rini BI
Clin Genitourin Cancer 2014 Apr;12(2):117-23. Epub 2013 Oct 12 doi: 10.1016/j.clgc.2013.08.001. PMID: 24126239
Karakiewicz PI, Hutterer GC
Curr Opin Urol 2007 Sep;17(5):295-302. doi: 10.1097/MOU.0b013e3282a4a6b7. PMID: 17762620

Clinical prediction guides

Di Giacomo AM, Schenker M, Medioni J, Mandziuk S, Majem M, Gravis G, Cornfeld M, Ranganathan S, Lou S, Csoszi T
ESMO Open 2024 Mar;9(3):102387. Epub 2024 Feb 23 doi: 10.1016/j.esmoop.2024.102387. PMID: 38401247Free PMC Article
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Salem ME, Shah SN, Elson P, Garcia JA, Wood LS, Medsinge A, Campbell S, Dreicer R, Rini BI
Clin Genitourin Cancer 2014 Apr;12(2):117-23. Epub 2013 Oct 12 doi: 10.1016/j.clgc.2013.08.001. PMID: 24126239
Karakiewicz PI, Hutterer GC
Curr Opin Urol 2007 Sep;17(5):295-302. doi: 10.1097/MOU.0b013e3282a4a6b7. PMID: 17762620

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