U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Locally Advanced Microsatellite Stable Colorectal Carcinoma

MedGen UID:
1660261
Concept ID:
C4745036
Neoplastic Process

Definition

A microsatellite stable colorectal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Microsatellite Stable Colorectal Carcinoma

Professional guidelines

PubMed

Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S
J Clin Oncol 2024 Oct;42(28):3355-3375. Epub 2024 Aug 8 doi: 10.1200/JCO.24.01160. PMID: 39116386
Xiao W, Luo H, Yao Y, Wang Y, Liu S, Sun R, Chen G
Front Immunol 2023;14:1149122. Epub 2023 Mar 24 doi: 10.3389/fimmu.2023.1149122. PMID: 37033988Free PMC Article
Bando H, Tsukada Y, Ito M, Yoshino T
Clin Colorectal Cancer 2022 Mar;21(1):3-9. Epub 2021 Oct 16 doi: 10.1016/j.clcc.2021.10.001. PMID: 34776358

Recent clinical studies

Etiology

Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S
J Clin Oncol 2024 Oct;42(28):3355-3375. Epub 2024 Aug 8 doi: 10.1200/JCO.24.01160. PMID: 39116386
Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Yu JH, Xiao BY, Li DD, Jiang W, Ding Y, Wu XJ, Zhang RX, Lin JZ, Wang W, Han K, Kong LH, Zhang XK, Chen BY, Mei WJ, Pan ZZ, Tang JH, Zhang XS, Ding PR
Lancet Oncol 2024 Jul;25(7):843-852. Epub 2024 Jun 6 doi: 10.1016/S1470-2045(24)00203-1. PMID: 38852601
Chatila WK, Kim JK, Walch H, Marco MR, Chen CT, Wu F, Omer DM, Khalil DN, Ganesh K, Qu X, Luthra A, Choi SH, Ho YJ, Kundra R, Groves KI, Chow OS, Cercek A, Weiser MR, Widmar M, Wei IH, Pappou EP, Nash GM, Paty PB, Shi Q, Vakiani E, Duygu Selcuklu S, Donoghue MTA, Solit DB, Berger MF, Shia J, Pelossof R, Romesser PB, Yaeger R, Smith JJ, Schultz N, Sanchez-Vega F, Garcia-Aguilar J
Nat Med 2022 Aug;28(8):1646-1655. Epub 2022 Aug 15 doi: 10.1038/s41591-022-01930-z. PMID: 35970919Free PMC Article
Eng C, Kim TW, Bendell J, Argilés G, Tebbutt NC, Di Bartolomeo M, Falcone A, Fakih M, Kozloff M, Segal NH, Sobrero A, Yan Y, Chang I, Uyei A, Roberts L, Ciardiello F; IMblaze370 Investigators
Lancet Oncol 2019 Jun;20(6):849-861. Epub 2019 Apr 16 doi: 10.1016/S1470-2045(19)30027-0. PMID: 31003911

Diagnosis

Yang L, Cui X, Wu F, Chi Z, Xiao L, Wang X, Liang Z, Li X, Yu Q, Lin X, Gao C
Front Immunol 2024;15:1392499. Epub 2024 May 15 doi: 10.3389/fimmu.2024.1392499. PMID: 38846948Free PMC Article
Fornaro L, Lonardi S, Catanese S, Nappo F, Pietrantonio F, Pellino A, Angerilli V, Signorini F, Salani F, Murgioni S, Neculaescu IA, Bruno R, Vivaldi C, Ricagno G, Masi G, Bergamo F, Ugolini C, Fassan M
Gastric Cancer 2023 Nov;26(6):958-968. Epub 2023 Jun 29 doi: 10.1007/s10120-023-01411-3. PMID: 37382783
Cercek A, Dos Santos Fernandes G, Roxburgh CS, Ganesh K, Ng S, Sanchez-Vega F, Yaeger R, Segal NH, Reidy-Lagunes DL, Varghese AM, Markowitz A, Wu C, Szeglin B, Sauvé CG, Salo-Mullen E, Tran C, Patel Z, Krishnan A, Tkachuk K, Nash GM, Guillem J, Paty PB, Shia J, Schultz N, Garcia-Aguilar J, Diaz LA, Goodman K, Saltz LB, Weiser MR, Smith JJ, Stadler ZK
Clin Cancer Res 2020 Jul 1;26(13):3271-3279. Epub 2020 Mar 6 doi: 10.1158/1078-0432.CCR-19-3728. PMID: 32144135Free PMC Article
Eng C, Kim TW, Bendell J, Argilés G, Tebbutt NC, Di Bartolomeo M, Falcone A, Fakih M, Kozloff M, Segal NH, Sobrero A, Yan Y, Chang I, Uyei A, Roberts L, Ciardiello F; IMblaze370 Investigators
Lancet Oncol 2019 Jun;20(6):849-861. Epub 2019 Apr 16 doi: 10.1016/S1470-2045(19)30027-0. PMID: 31003911
Du C, Zhao J, Xue W, Dou F, Gu J
Histopathology 2013 Apr;62(5):723-30. Epub 2013 Feb 21 doi: 10.1111/his.12069. PMID: 23425253

Therapy

Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S
J Clin Oncol 2024 Oct;42(28):3355-3375. Epub 2024 Aug 8 doi: 10.1200/JCO.24.01160. PMID: 39116386
Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Wang F, Jin Y, Wang M, Luo HY, Fang WJ, Wang YN, Chen YX, Huang RJ, Guan WL, Li JB, Li YH, Wang FH, Hu XH, Zhang YQ, Qiu MZ, Liu LL, Wang ZX, Ren C, Wang DS, Zhang DS, Wang ZQ, Liao WT, Tian L, Zhao Q, Xu RH
Nat Med 2024 Apr;30(4):1035-1043. Epub 2024 Mar 4 doi: 10.1038/s41591-024-02813-1. PMID: 38438735
Kasi PM, Hidalgo M, Jafari MD, Yeo H, Lowenfeld L, Khan U, Nguyen ATH, Siolas D, Swed B, Hyun J, Khan S, Wood M, Samstein B, Rocca JP, Ocean AJ, Popa EC, Hunt DH, Uppal NP, Garrett KA, Pigazzi A, Zhou XK, Shah MA, Hissong E
Oncogene 2023 Oct;42(44):3252-3259. Epub 2023 Sep 21 doi: 10.1038/s41388-023-02835-y. PMID: 37731056Free PMC Article
Bando H, Tsukada Y, Inamori K, Togashi Y, Koyama S, Kotani D, Fukuoka S, Yuki S, Komatsu Y, Homma S, Taketomi A, Uemura M, Kato T, Fukui M, Wakabayashi M, Nakamura N, Kojima M, Kawachi H, Kirsch R, Yoshida T, Suzuki Y, Sato A, Nishikawa H, Ito M, Yoshino T
Clin Cancer Res 2022 Mar 15;28(6):1136-1146. doi: 10.1158/1078-0432.CCR-21-3213. PMID: 35063964Free PMC Article

Prognosis

Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S
J Clin Oncol 2024 Oct;42(28):3355-3375. Epub 2024 Aug 8 doi: 10.1200/JCO.24.01160. PMID: 39116386
Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Oaknin A, Pothuri B, Gilbert L, Sabatier R, Brown J, Ghamande S, Mathews C, O'Malley DM, Kristeleit R, Boni V, Gravina A, Banerjee S, Miller R, Pikiel J, Mirza MR, Dewal N, Antony G, Dong Y, Zografos E, Veneris J, Tinker AV
Clin Cancer Res 2023 Nov 14;29(22):4564-4574. doi: 10.1158/1078-0432.CCR-22-3915. PMID: 37363992Free PMC Article
Bando H, Tsukada Y, Inamori K, Togashi Y, Koyama S, Kotani D, Fukuoka S, Yuki S, Komatsu Y, Homma S, Taketomi A, Uemura M, Kato T, Fukui M, Wakabayashi M, Nakamura N, Kojima M, Kawachi H, Kirsch R, Yoshida T, Suzuki Y, Sato A, Nishikawa H, Ito M, Yoshino T
Clin Cancer Res 2022 Mar 15;28(6):1136-1146. doi: 10.1158/1078-0432.CCR-21-3213. PMID: 35063964Free PMC Article
Eng C, Kim TW, Bendell J, Argilés G, Tebbutt NC, Di Bartolomeo M, Falcone A, Fakih M, Kozloff M, Segal NH, Sobrero A, Yan Y, Chang I, Uyei A, Roberts L, Ciardiello F; IMblaze370 Investigators
Lancet Oncol 2019 Jun;20(6):849-861. Epub 2019 Apr 16 doi: 10.1016/S1470-2045(19)30027-0. PMID: 31003911

Clinical prediction guides

Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S
J Clin Oncol 2024 Oct;42(28):3355-3375. Epub 2024 Aug 8 doi: 10.1200/JCO.24.01160. PMID: 39116386
Wang F, Jin Y, Wang M, Luo HY, Fang WJ, Wang YN, Chen YX, Huang RJ, Guan WL, Li JB, Li YH, Wang FH, Hu XH, Zhang YQ, Qiu MZ, Liu LL, Wang ZX, Ren C, Wang DS, Zhang DS, Wang ZQ, Liao WT, Tian L, Zhao Q, Xu RH
Nat Med 2024 Apr;30(4):1035-1043. Epub 2024 Mar 4 doi: 10.1038/s41591-024-02813-1. PMID: 38438735
Kasi PM, Hidalgo M, Jafari MD, Yeo H, Lowenfeld L, Khan U, Nguyen ATH, Siolas D, Swed B, Hyun J, Khan S, Wood M, Samstein B, Rocca JP, Ocean AJ, Popa EC, Hunt DH, Uppal NP, Garrett KA, Pigazzi A, Zhou XK, Shah MA, Hissong E
Oncogene 2023 Oct;42(44):3252-3259. Epub 2023 Sep 21 doi: 10.1038/s41388-023-02835-y. PMID: 37731056Free PMC Article
Oaknin A, Pothuri B, Gilbert L, Sabatier R, Brown J, Ghamande S, Mathews C, O'Malley DM, Kristeleit R, Boni V, Gravina A, Banerjee S, Miller R, Pikiel J, Mirza MR, Dewal N, Antony G, Dong Y, Zografos E, Veneris J, Tinker AV
Clin Cancer Res 2023 Nov 14;29(22):4564-4574. doi: 10.1158/1078-0432.CCR-22-3915. PMID: 37363992Free PMC Article
Bando H, Tsukada Y, Inamori K, Togashi Y, Koyama S, Kotani D, Fukuoka S, Yuki S, Komatsu Y, Homma S, Taketomi A, Uemura M, Kato T, Fukui M, Wakabayashi M, Nakamura N, Kojima M, Kawachi H, Kirsch R, Yoshida T, Suzuki Y, Sato A, Nishikawa H, Ito M, Yoshino T
Clin Cancer Res 2022 Mar 15;28(6):1136-1146. doi: 10.1158/1078-0432.CCR-21-3213. PMID: 35063964Free PMC Article

Recent systematic reviews

Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S
J Clin Oncol 2024 Oct;42(28):3355-3375. Epub 2024 Aug 8 doi: 10.1200/JCO.24.01160. PMID: 39116386
Yang L, Cui X, Wu F, Chi Z, Xiao L, Wang X, Liang Z, Li X, Yu Q, Lin X, Gao C
Front Immunol 2024;15:1392499. Epub 2024 May 15 doi: 10.3389/fimmu.2024.1392499. PMID: 38846948Free PMC Article
O'Connell E, Reynolds IS, McNamara DA, Prehn JHM, Burke JP
Surg Oncol 2020 Sep;34:57-62. Epub 2020 Apr 2 doi: 10.1016/j.suronc.2020.03.009. PMID: 32891354

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...